role of cytokines in brain development and synaptic plasticity
Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf
... zinc ion each, and binds to the minor groove of the DNA [6] Dmrts were originally described to play important roles during sex determination in flies and worms by regulating several aspects of ... by a conserved DNA-binding motif known as the Doublesex- and Mab-3-related (DM) domain Being a noncanonical cysteine-rich DNAbinding motif, this domain has two highly intertwined finger structures ... fish species An amazing variety of sex-determining systems is found in fish Although information is emerging about sex determination in lampreys, sharks, rays and sturgeons, most of our knowledge...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... residue in the L1 loop is involved in the functional DNA binding during strand exchange Tryptophan-scanning mutagenesis of the HsRad51-L1 loop To gain further information about DNA binding by ... Roles of the HsRad51 L1 and L2 loops D231W (L1 loop) Table Changes in the fluorescence of tryptophan probes inserted in the L1 and L2 loop upon binding of nucleotides and DNA The fluorescence of ... identified in these eukaryotic and archaeal proteins (Fig 1A) Like the case of bacterial RecA, the L1 and L2 loops of the eukaryotic Rad51 proteins face A Roles of the HsRad51 L1 and L2 loops inside of...
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Báo cáo khoa học: In vitro analysis of the relationship between endonuclease and maturase activities in the bi-functional doc
... available and its binding affinity is not altered by the presence of DNA in the DNA binding site Interestingly, when nM RNA and 10 nM DNA were added simultaneously to a limiting amount of protein in ... stringent concentration of KCl, there was a correlation between inhibition of endonuclease activity and inhibition of splicing activity indicating that RNA binding can be monitored by measuring ... determine the relative stoichiometry of RNA and DNA binding, nitrocellulose filter binding assays were performed (Fig 4A) Both DNA and RNA substrates saturated limiting amounts of protein in the...
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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
... regulation of IL-18 in the murine brain: (1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized ... corresponds to the time-point of maximal extent of intracerebral inflammation in the model of CHI used in this study [17] For assessment of intracerebral IL-18 levels, the murine brains were immediately ... i.c.v injection of 200 ng mouse-recombinant TNF (R&D Systems) elicited an evident induction of inflammatory changes in the murine CNS, such as intracranial recruitment of leukocytes and development...
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Báo cáo hóa học: " Research Article Analysis of the Tradeoff between Delay and Source Rate in Multiuser Wireless Systems" docx
... constraint given in terms of a delay constraint and a BER The delay constraint consists of a target delay Dt and the probability of exceeding it, ε Three simple and widely employed disciplines ... scheduling algorithm It is intended to improve Best Channel by maintaining a balance between two competing interests: maximizing the total wireless network throughput while allowing a minimum ... distribution of cu [n] which in turn depends on the scheduling algorithm Three scheduling disciplines will be detailed in next sections Finally, the total system capacity CDt , is obtained as the sum of...
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Báo cáo khoa học: "Evaluation of the nuclear DNA content and GC percent in four varieties of Fagus sylvatica L" potx
... is extremely rapid and convenient: it allows determinations of nuclear DNA content [13] and of AT/GC base composition in a genome [15] Favre and Brown [ 12] developed a fast and simple flow cytometry ... Conversion of mass values into base-pair number was carried out according to Bennett and Smith [6]: pg 965 Mbp The proportion of GC was using the relationship of Godelle et al [ 15]: = determined where ... iodide and mithramycin stainings Results are listed in table II In F sylvatica, the GC content was 40.0 ± 0.2 %; in the tortuosa variety, 39.8 ± 0.2 % These values are not significantly different and...
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Báo cáo lâm nghiệp: " A flow cytometric evaluation of the nuclear DNA content and GC percent in genomes of European oak species" pptx
... ploidy level of Quercus plants on the basis of genome size relative to a standard plant of known ploidy MATERIALS AND METHODS The plant material was leaves of in vitro cloned plantlets of Q petraea ... Willd and Q robur L Petunia hybrida cv Px Pc (2C 2.85 pg; 41 % GC) was selected as an internal standard The Q petraea and Q robur clones originated from donor trees in northeastern France (Lorraine) ... four leaves of a single in vitro grown 2-month-old plantlet were chopped with a razor blade together with a leaf fragment of Petunia in mL of Marie’s nuclear isolation buffer (Marie and Brown,...
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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
... the role of cytokines in RP, either in patients or in the corresponding animal models In the CIA model, several cytokines have been shown to play major roles in the inflammatory process, anti-inflammatory ... as influx of cells and antibody production In addition, to investigate the role of inflammatory mediators in MIRP, we immunized mice devoid of IL-10 in order to determine whether this cytokine, ... proinflammatory ones The cytokine interleukin-10 (IL-10) has been in focus for many years in autoimmune arthritis and in other autoimmune diseases The human recombinant protein is currently being...
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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
... factor in T4 and is involved in the transcription of structural proteins [45] Homologues of the T4-genes g33 and g45 which are also involved in late transcription in T4 are all found in Clokie ... function In addition to maintaining PSII centres and altering bilin synthesis, a further mechanism for diverting the flow of electrons during photosynthesis may occur A plastoquinol terminal oxidase ... manipulation of the physiology of the infected cell and are likely to be of potential importance in biotechnology as well as being intrinsically interesting However, there are three main features...
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Báo cáo khoa học: "The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs" pot
... seen in m longissimus dorsi and in m semitendinosus, muscles thus considered to be less involved during training on a treadmill [10] In both genotypes training adaptations in the fibres of m ... reductase stains (C, F) Note that type I fibres have a high staining intensity, whereas staining intensity varies among the subgroups of type II fibres Granlund et al Acta Veterinaria Scandinavica ... with myosin ATPase stains and type I and IIA+ IIX with myosin heavy chain antibodies NADH-tetrazolium reductase staining intensity was subjectively evaluated as low, medium and high in the different...
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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
... viral load in HIV1 and HIV-2 singly and dually infected individuals in GuineaBissau, West Africa: significantly lower plasma virus set point in HIV-2 infection than in HIV-1 infection Arch Intern ... concentrated in the C2 region The four N-glycosylation sites in C2 and the site in the beginning of V3 were highly conserved in all patients throughout infection which is strongly indicative of convergent ... in this process is the V3 loop of the surface glycoprotein which is essential for HIV coreceptor usage [29-32] and for inducing the production of neutralizing and nonneutralizing antibodies in...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... with surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental ... YL, Eng LF: Inflammation in traumatic brain injury: role of cytokines and chemokines Neurochem Res 1998, 23:329-340 60 Ransohoff RM, Tani M: Do chemokines mediate leukocyte recruitment in post-traumatic ... assessment of Evans Blue (EB) extravasation in four animals per experimental condition Briefly, 20 μl of a 2% solution of EB in saline was injected into the tail vein one hour before harvesting of brains...
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Báo cáo y học: "Endothelial Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients" potx
... for inflammation and bacterial infection in clinical routine, CRP and PCT reached AUC statistics of 0.524/0.531 and 0.545/0.550 In comparison with these biomarkers of organ dysfunction and inflammation, ... tissue invasion in malignant diseases by converting plasminogen into plasmin, resulting in degradation of extracellular matrix [1-4] Migration of inflammatory cells from the blood stream into tissues ... including markers of inflammation/infection (CRP, PCT), hepatic (albumin, international normalized ratio (INR)) and renal (creatinine) function at admission, suPAR remained an independent significant...
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In this paper, we investigate the relationship between migration and species distribution in multizone environment. We present a discrete model for migration of three competing species over three zones. We prove that the migration tactics of species leads
... remaining of the DFT PAND gate (F,F,F) (T,F,T) (T,T,T) Fig Left: Markov chain of the PAND gate with two inputs Failure transitions are in black straight lines and the repairing transitions in ... processors and the initial paths are in black while the correction step is in dotted red lines of the simulation For instance in the left part of Fig 1, the exact sample path is computed after round of ... [5]) and vector (X1 , Xn , W1 , Wp ) where n is the number of components of the models (and leaves of the DFT) and p is the number of PAND gates in the model Xi represent the state of component...
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The u s presidency and executive power in the works of thomas pynchon, philip roth and cormac mccarthy
... identified in the Border Trilogy (All the Pretty Horses, The Crossing, and Cities of the Plain) an “imaginative and thematic debt to the changing political and cultural landscape of America beginning in ... which, in fact, was one of the prime targets of McCarthy’s investigation This was, also, of course, the decade of the evolution of rock and roll, and the beginning of the countercultural awakening ... communities and labyrinthine plots being present in V (1963) and The Crying of Lot 49 (1966), which would find full fruition in the multiple paranoid and opaque systems of Gravity’s Rainbow (1973),...
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Sumary: The difference of the culture between Vietnam and US (lesson in the university)
... meal in day - No talking while eating - Using folk and knife - Eating full enough - Eating more fat and less fiber - Drinking soft drink like milk, orange juice,… while eating Vietnam - Diner ... Riding on a bus with people you don’t know Waiting in a doctor’s office Waiting in line Eating lunch in a restaurant or café Talking to your boss or teacher Talking to friends in a group Talking ... Diner is a biggest meal in day - Chatting while eating - Using chopsticks to eat - Eating as much as possible - Eating more protein and less fat - Drink mineral water while eating ...
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Construing the world: conceptual metaphors and event-construal in news stories potx
... event-construals Event-construals in texts In the following sections I intend to show the important role of tapping into conceptual metaphors and employing other linguistic and semiotic devices to construe ... corridors (Lakoff and Johnson 1980: 53; see also Lakoff and Turner 1989 for an analysis of conceptual metaphors in poetry along this line) Let me point out that I am not interested in this paper in the ... the metaphorical style of literary texts) as well as with Lakoff (1992), while differing from these studies in broadening the focus to an examination of the interaction of linguistic means to establish...
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Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc
... to interact with Calp1 This indicates the presence of a calpain binding site in the C-terminal domain of smooth muscle a-actinin Involvement of the C-terminal domain of ask in Calp1 binding In ... Calp1 binding site is included in the C-terminal domain of the ask molecule, and this binding is independent of the susceptibility of the a-actinin isoform to calpain proteolysis Identification of ... the interface linking calpain to skeletal muscle a-actinin Colocalization of microcalpain and a-actinin in myogenic cells Calpains and a-actinin were previously located in Z-disks [44], and adhesion...
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Báo cáo khoa học: "INTEGRATING TEACHING THE ENGLISH TENSE: NAIVE AND FORMAL GRAMMARS IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING" pdf
... of the main concerns in designing the knowledge base for this module has been that of maintaining the wealth of ideas and intuitions existing in the naive account of tenses while developing at ... are in fact incomplete and even inconsistent As a result, ET-1 was sometimes incapable of solving a given exercise since the rules of the grammar did not cover that particular case In other instances ... (during tl t2) (during tl t3) (during t3 t2))) Each exercise is usually constituted by one or two clauses in which some of the verbs are given in the infinitive form and have to be conjugated into...
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Connecting Developmental Constructions to the Internet: Identity Presentation and Sexual Exploration in Online Teen Chat Rooms pot
... functions of the Internet become increasingly important for people in general and adolescents in particular, it is vital to think in terms of construction and co-construction processes In teen ... U.S., 36% of males and 39% of females have had vaginal intercourse (Mosher, Chandra, & Jones, 2005) During adolescence, the rate of sexual activity increases with age (Cubbin, Santelli, Brindis, ... examining teen explorations of sexuality and identity construction in chat rooms Monitoring of Chat Rooms Monitoring of chat rooms addressed concerns regarding sexual harassment (Mitchell, Finkelhor,...
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