role of antioxidants and oxidative stress in cardiovascular diseases
Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... imposing a continuous load of calcium to the neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease ... by proteins resi-ding in both the inner and outer mitochondrialmembrane, that is activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons ... for a role of Trp proteins in the oxidative stress- induced membrane conductances of porcineaortic endothelial cells. Cardiovasc Res 42, 543–549.236 Wehage E, Eisfeld J, Heiner I, Jungling E,...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus ... a subset of NSAIDs(e.g. ibuprofen, flurbiprofen, indomethacin) reducedbrain inflammation and Aβ levels in addition to the dep-osition of Aβ in brain [13,14]. Despite this evidence, and the ... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16]. This finding sug-gests...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-dative stress also promotes angiogenesis [13]. The linkbetween oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... injury, oxidative stress, and impairedangiogenesis are prominent features of systemic sclerosis(SSc). We compared serum markers of these phenomena atbaseline and after treatment with nifedipine in ... haveacute and sustained beneficial effects on oxidative markers of damage in SSc patients [17].The aim of our study was, first, to investigate serumendothelial cell markers of adhesion (sVCAM-1) and...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... findings of NO involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this study the increased activity of NOS in anoxia may represent predominantly the nNOS form. In inflam-matory ... reperfusion damage in brain. The increased activities of AS and AL indicate the effective recycling of citrulline to arginine and suggest a functional role to citrulline –NO cycle enzymes in anoxia....
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The Role of Small and Large Businesses in Economic Development doc
... growth from the second quarter of 2000 into jobclasses using beginning size of firm, mean size of firm over the period, and end size of firm. If the beginning size of the firm is used to classifyfirms, ... enterprises with tax breaks, financial incentives, and other induce-ments. Instead, they are relying on building businesses from the groundup and supporting the growth of existing enterprises. This ... efficient at innovation. Small firmsare the great innovators in some industries, while large firms are thegreat innovators in others. Moreover, small and large businesses interact in innovative...
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The Role of Gestures and Facial Cues in Second Language Listening Comprehension pptx
... & Lynch, K. (1999).Offeringahand to pragmatic understanding: The role of speech and gesture in comprehension and memory. Journal of Memory and Language, 40,577–592.Lansing, C. R., & McConkie, ... area of an image for speech information. Following a speech-reading experiment using eye-tracking equipment with nativespeakers of English, Lansing and McConkie (1999) suggestedthat in terms of ... pottery and involved description and gesture use.Materials recording and editing. Two video-recording ses-sions using the same lecture outline were scheduled, each last-ing approximately 20 min....
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Bringing the Hidden Giants to the Footlight: the Role of Savings and Retail Banks in Increasing the Level of Access to Financial Services docx
... value to existing infrastructure.Data and evidence on the role of savings and retail banks in access to financeWSBI has conducted research into the role of savings banks in providing access ... use of their front and back of ce systems for disbursing of loans and collecting loan repayments. Another promising track for savings banks is to invest their savings deposits in microfinance ... microfinance institutions by specialising in wholesale lending to microfinance institutions for lending to their micro borrowers. Savings banks could refinance well-functioning microfinance institutions...
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Báo cáo y học: " Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilag" pps
... 2',7'-dichlorodihydrofluorescein diacetate.Results Basal and IL-1β-induced 2-DG uptake, including theaffinity (1.066 ± 0.284 and 1.49 ± 0.59 mM) and maximalvelocity (0.27 ± 0.08 and 0.33 ± 0.08 nmol/μg protein/hour), and ... Differentialroles of hydrogen peroxide and superoxide in mediating IL-1-induced NF-κB activation and iNOS expression in bovine artic-ular chondrocytes. J Cell Biochem 2003, 88:783-793.22. Henrotin ... found in theGLUT-1 protein content in normal and OA chondrocytes cul-tured in mannitol-supplemented medium relative to theirrespective control cells maintained in RGM (data not shown). Role of...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... significant insights into the roles and mechan-isms of PM2.5-associated physiology and pathology. In summary, our data demonstrate the importanteffects of PM2.5exposure on oxidative stress and ... effect of ambient PM2.5onWATandBATspecificgenesindifferent adipose depots. There are several major find-ings in this study. First, exposure to PM2.5resulted in oxidative stress in BAT. ... blot.A.RepresentativebandsofFAandPM2.5onUCP1 protein level in iBAT by Western blotting. B. Quantitative results of Western blotting of UCP1. n = 8. *P<0.05 vs. FA.Xu et al. Particle and Fibre Toxicology...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... College, Beijing, China2 Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Institute of Laboratory AnimalScience, Chinese Academy of Medical ... A rapid and sensitive method forthe quantitation of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.CYP2E1 causes apoptosis of cardiomyocytes ... overexpression of CYP2E1 both in vivo and in vitro is associated with several cellular markers of oxidative stress, including products of lipid peroxi-dation (e.g. 4-hydroxynonenal and malondialdehyde),as...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... C, Becker S. Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposedto fine(PM2.5) and coarse particles(PM10-2.5) in outdoor and indoor air. Toxicol Appl Pharmacol ... PM10suggesting that PM2.5 induced more oxidative stress thanPM10. In the single strand breakage assay using pBR322DNA, the ratio of changed form II/total plasmid DNA (formFig. 10. RT-PCR analysis of ... 11–18Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cellsJin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim1, Yoon-Shin Kim2, Nam-Hyun Chung3 and Myung-Haing Cho*Laboratory...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... flush, consisting of preformed leaves and the second flush as neoformed flush consisting of neoformed leavesas described by Gregory [18].2.1.2. Harvesting of seedlingsSeedlings were randomly harvested ... tubes for 5 min in boiling water. The colorimetric determination of NO2−was done by mixing 0.25 mL of incubation medium with0.25 mL 0.02% N-(1-Naphtyl) ethylenediamine and 0.25 mL of sul-fanilamide. ... processes.However, after 85 days, the NR activity in the seedlings waslower and decreased with increasing O3. At that time in theseason and with increasing oxidative stress, NH3may havebeen provided...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... Our findingsclearly show the presence of oxidative stress in degenerat-ing cartilage, and the resultant telomere erosion and dys-function of chondrocytes in vitro and in vivo, suggesting a role ... provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxi-dative stress induced genomic instability, especially tel-omere erosion, and chondrocyte ... A: Detection of nitro-tyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth...
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