role in regulation of coronary blood flow and cardiac electrophysiology

ROLE OF ADENOSINE A1 RECEPTORS IN NATIVE CORONARY ATHEROSCLEROSIS, IN-STENT STENOSIS, AND CORONARY BLOOD FLOW REGULATION IN METABOLIC SYNDROME AND EXERCISE

Ngày tải lên : 24/08/2014, 13:30

... signal-regulated protein kinases and (ERK1/2) signaling pathways, thus suggesting A1R dysregulation could play a role in coronary artery disease (CAD), restenosis, and regulation of coronary blood flow (CBF) ... native coronary atherosclerosis and in- stent stenosis .154 6.3 Adenosine and adenosine receptors in regulation of coronary blood flow 156 6.4 Beneficial effects of exercise in ... Introduction Deployment of a stent in a coronary artery in the setting of flow- limiting stable coronary artery disease (CAD) results in initial improvement in functional capacity and quality of life 98 ...

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Báo cáo y học: " The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures" potx

Ngày tải lên : 12/08/2014, 15:21

... factor, interleukin or interferon, since previous studies have shown an inducible expression of IP-10 in a wide variety of tissues and cells under the influence of stimuli including interferons, interleukins, ... types including lung epithelial cells [5] Increased levels of both IP-10 and CXCR3 have been shown in patients with COPD, and subsequently this chemokine has been suggested to be involved in the inflammatory ... resulting in induction of Th1 differentiation, proliferation, IFNγ production and increased cytotoxic activity [16] Th1 cytokine phenotype has been demonstrated in peripheral blood [17] and in lung...

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Báo cáo y học: "The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo" pps

Ngày tải lên : 13/08/2014, 13:20

... Figure of intra-portal injection of (a) ATP and (b) adenosine on changes in hepatic arterial flow (∆ HAF) in vivo The effect The effect of intra-portal injection of (a) ATP and (b) adenosine on ... in the degree of inhibition of HA responses by 8-SPT between intra-arterial and intra-portal injection of ATP despite a longer lag-time between injection and response following intra-portal injection ... prosthesis inserted into the portal vein and the inferior vena cava of the in vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein and the inferior vena cava of...

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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx

Ngày tải lên : 20/06/2014, 04:20

... BMP-2 maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc ... FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing ... visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying the samples, we mounted the coverslips on microscope slides using Fluoromount and examined and photographed...

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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf

Ngày tải lên : 20/06/2014, 07:20

... BMP-2 maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc ... FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing ... visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying the samples, we mounted the coverslips on microscope slides using Fluoromount and examined and photographed...

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báo cáo khoa học: "Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy" ppt

Ngày tải lên : 10/08/2014, 22:20

... with increasing dose of LA (E) Subcellular distribution of immunoreactive AIF and Cyt C in the cytosol, mitochondria and nucleus in control and 24 and 48 h LA-treated HL-60 cells Actin and histone ... cell killing and eradication The mechanism by which LA acts in dual cell cycle checkpoint control may be complex and appears to involve at least the down regulation of cyclin E/cdk2 and cyclin B1/cdk1 ... AIF and cytochrome c (Cyt C) expression in 48 h LA treated cells (D) The actin-adjusted level of bax and bcl-2 and changes in the ratio of bax to bcl-2 in HL-60 cells treated for 48 h with increasing...

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Báo cáo khoa học: "Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats" pptx

Ngày tải lên : 13/08/2014, 02:24

... Dopexamine improved intestinal microvascular blood flow in a sepsis model in rats • Dopexamine reduced endotoxin-induced leucocyte adherence in venules of the intestinal submucosa • Dopexamine infusion ... increased jejunum and ileum blood flow, estimated using LDF [17] In an experimental setting in pigs, jejunal mucosal blood flow was not influenced by dopexamine infusion during intestinal hypotension, ... all organs and to the gut in particular In addition to noradrenaline (norepinephrine), adrenaline (epinephrine), dopamine and dobutamine, dopexamine has been the subject to various investigations...

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THE ROLE OF THE CTD PHOSPHATASE RTR1 AND POST-TRANSLATIONAL MODIFICATIONS IN REGULATION OF RNA POLYMERASE II

Ngày tải lên : 24/08/2014, 09:44

... staining and removal of proteins isolated in the gel, making this method both time consuming due to the need to excise individual spots of protein from the gel and limiting in the number of low ... Phosphorylated serine of yeast RNA polymerase II C-terminal domain S7 Serine of yeast RNA polymerase II C-terminal domain S7-P Phosphorylated serine of yeast RNA polymerase II C-terminal domain S cerevisiae ... repeats (described in detail below and reviewed in Heidemann, Hintermair, Voss, & Eick, 2013) In addition, modifications of interacting protein factors aid in the regulation of the transcription...

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Role of p73 in regulation of cell death specific role in mitotic cell death and potential regulation of caspase 2s

Ngày tải lên : 13/09/2015, 21:21

... with each other (Irwin and Kaelin, Jr., 2001) Each of them consists of a N-terminus trans-activation domain, a central DNA binding domain and a C-terminus regulatory domain (Illustration 1) All ... during mitosis, thus allowing chromatids to separate during anaphase towards opposing poles In the cells, the spindle checkpoint is kept active through the binding of inhibitory proteins BubR1 and ... ROLE OF P73 IN REGULATION OF CELL DEATH: SPECIFIC ROLE IN MITOTIC CELL DEATH AND POTENTIAL REGULATION OF CASPASE-2s TOH WEN HONG NATIONAL UNIVERSITY OF SINGAPORE 2007 ACKNOWLEDGMENT...

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The role of TRIP br proteins in the regulation of mammalian gene transcription and cell cycle progression

Ngày tải lên : 16/09/2015, 17:12

... Features PHD zinc finger protein PHD zinc finger protein Composite PHD zinc fingerbromodomain proteins PHD zinc finger protein Bromodomain protein PHD zinc finger proteins PHD zinc finger protein Composite ... Prominent examples of PHD zinc finger and/ or bromodomaincontaining proteins The (*) label designates disease-associated PHD zinc finger and/ or bromodomain-containing proteins Conservation of the ... function of the PHD-bromodomain-interacting domain of TRIP-Br proteins 1.1 Designing peptides that antagonize physical 51 interactions between TRIP-Br proteins and PHD zinc fingers and/ or bromodomain-containing...

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Anger regulation and culture role of culture in consequences of anger expression, suppression and reappraisal

Ngày tải lên : 29/09/2015, 13:01

... style of Chinese Results of a study comparing anger expression style among American, Greek, Chinese and West Indian 48 students are in line with the finding of the present study by indicating that ... score of included items Internal consistency of the emotion rating scale was examined by calculating the Cronbach’s α at the baseline and during the role play in the present study As illustrated in ... death and non-fatal acute myocardial infarction (AMI) The results indicated that a point increase in the four-point Anger-out subscale of STAXI was associated with a 42% increase in the risk of cardiac...

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Cardiovascular magnetic resonance imaging in the assesment of myocardial blood flow, viability, and diffuse fibrosis in congenital and acquired heart disease

Ngày tải lên : 20/05/2016, 20:50

... started after minutes of an infusion of adenosine (Adenoscan®, Sanofi-Synthelabo Ltd, Berlin, Germany) with adenosine doses increasing every minutes (70µg/kg/min, 100µg/kg/min, 140µg/kg/min), or when ... leading cause of myocardial infarction and sudden cardiac death In children, it may occur after surgery for CHD involving the coronary arteries, in congenital coronary artery anomalies, and in ... coronary artery; B: origin of LAD and CFX from the right coronary sinus; C: origin of LAD from right sinus of Valsalva or RCA; D: origin of CFX from right sinus or right coronary artery (Roberts...

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Báo cáo y học: "Changes of uterine blood flow after vaginal radical trachelectomy (VRT) in patients with early-stage uterine invasive cervical cancer"

Ngày tải lên : 25/10/2012, 11:48

... early in the second trimester in spite of no signs of threatened abortion Daily vaginal disinfection with popidone iodine, bed rest, and administration of ritodrine and an ulinastatin vaginal ... isthmus In this procedure, we usually ligate and cut the descending branches of the uterine arteries and vaginal arteries These arteries mainly supply blood to the lower segment of the uterus Fig and ... CT imaging of a patient with normal uterus after the delivery A: Ascending branch of right uterine artery B: Ascending branch of left uterine artery C: Descending branch of right uterine artery...

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Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf

Ngày tải lên : 08/03/2014, 09:20

... postulated obligatory role of the protein in steroidogenesis, we detected the protein and its mRNA in all steroidogenic tissues including placenta and brain [32] Inhibition of ACTH release and steroid ... Fig Combined eﬀect of triacsin C and NDGA on steroid hormone synthesis Y1 cells were preincubated in the presence or the absence of increasing concentrations of triacsin C (4 h, 37 °C) and of NDGA ... critical role of acyl-CoA synthetases and thioesterases in the regulation of intracellular levels of AA and steroid production This study further suggests a new concept in the regulation of intracellular...

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Báo cáo khoa học: Improvement of a monopartite ecdysone receptor gene switch and demonstration of its utility in regulation of transgene expression in plants pdf

Ngày tải lên : 16/03/2014, 06:20

... a highly ﬂexible ligand-binding pocket [34] Mutational analysis in the LBD of CfEcR showed that the ligand-binding pocket of this EcR is highly ﬂexible and that a single amino acid substitu- FEBS ... format generally consist of a transcriptional activation domain fused to a DNAbinding domain (DBD) and a ligand-binding domain (LBD) The chimeric gene (transactivation domain– DBD–LBD) is expressed ... microgram of protein shown are the mean of three replicates ± SD (A,C) Fold induction values (B,D) shown were calculated by dividing RLUÆlg)1 protein in the presence of ligand with RLUÆlg)1 protein in...

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Simulation of Ground-Water Flow and Evaluation of Water-Management Alternatives in the Assabet River Basin, Eastern Massachusetts pptx

Ngày tải lên : 17/03/2014, 15:20

... conditions, in average annual inflows to and outflows from the surficial layer of the simulated groundwater -flow system in subbasins of the A, Assabet River Main Stem; and B, tributary subbasins, in a ... conditions, in average annual inflows to and outflows from the surficial layer of the simulated ground-water -flow system in subbasins of the A, Assabet River Main Stem; and B, tributary subbasins, in ... average, as indicated by flows at streamflow-gaging stations in and near the basin (fig and table 5) For streamflow-gaging stations in the basin, mean annual and monthly nonstorm streamflow for...

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Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx

Ngày tải lên : 18/03/2014, 01:20

... the difference in linking number of pBR322 in the respective sample and of pBR322 isolated from cells incubated for 30 with 0.1 mgámL)1 of coumermycin and 0.2 mgámL)1 rifampicin Topoisomerase ... esupercoilingI and esupercoiling , re¯ecting the sensitivity of transcription of topoisomerase I and DNA gyrase for DNA supercoiling Certain simpli®cations were made in [25], i.e grouping of transcription ... ®ts in Fig to an aLk of (corresponding to coumermycin inhibition) indicates a 2.8-fold induction Fusion of the topA promoters to the galactokinase gene showed a twofold to fourfold inhibition of...

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Báo cáo khoa học: Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover pptx

Ngày tải lên : 23/03/2014, 18:20

... form a network of proteins involved in the regulation of phospholipid metabolism Materials and methods Strains and culture conditions Yeast strains used in this study are listed in Table Cells ... integrative versions of C-terminal yEGFP fusions in frame with the ORF of interest Thus, yEGFP fusions were present in single copy in the genome and driven by the native promoter of the ORF of ... formation, indicating that Sec14p and the two homologues act as inhibitors of Plb1p in vivo This observation explains at least in part the low Plb1p activity in wild-type cells Interestingly, the inhibitory...

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Báo cáo khoa học: Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins Implications in mechanical stress-associated pathologies pptx

Ngày tải lên : 30/03/2014, 10:20

... focused on the regulation of CTGF In the network of interacting signaling mediators, RhoA GTPase seems to play a major role in maintaining the basal turnover of CTGF mRNA and also in the stimulated ... of the matrix [66] Integrins are coupled via adaptor molecules, such as integrin linked kinase, to the actin cytoskeleton and to various signaling molecules including mitogen-activated protein ... pressure and was associated with the induction of program cell death of mesangial cells [23] Thus, both in vivo and in vitro studies stress an important role of mechanical strain in the kidney and...

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báo cáo hóa học: " Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey" ppt

Ngày tải lên : 20/06/2014, 15:20

... paid to baseline angina and gastrointestinal symptom intensity and frequency during the 14 days prior to the start of the study, any therapy undergone and the number of nitroglycerin tablets taken ... placebo in the improvement of HRQL relating mainly to gastrointestinal symptom relief In a multivariate analysis, van Rossum et al also did not find any influence of clinical data on changes in the ... mimicking precordial symptoms originating in the heart [10,11] These are mainly due to the coexistence of gastroesophageal reflux (GER), aspirin-induced gastrointestinal tract damage, and musculoskeletal...

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