rns and induction of t cell response the possible link to auto immunity in vitiligo
Báo cáo y học: "T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation" pdf
... these cells in the synovial tissue of patients with RA, again postulating that the gain in cytotoxic function is of functional importance in maintaining chronic synovitis Regulatory genes of the ... activation of the c-Jun N-terminal kinase pathway, and it is important in lowering the threshold in response to TCR stimulation In essence, the aging T- cell compartment is characterized by the ... accepted control mechanisms include the induction of apoptosis in the responding T- cell population, and feedback control by inhibitory receptors and regulatory T cells Remarkably, diversity of the...
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Pricing and Hedging of Credit Derivatives via the Innovations Approach to Nonlinear Filtering pptx
... on the one hand, at fixed current time t one needs to determine π t , the current value of the process π On the other hand, the model parameters (the generator matrix of X and parameters of the ... frailty model in Section Here we concentrate on the determination of π t The key point is the observation that the set of all probability vectors consistent with the price information at t can ... generates a trajectory of X Given this trajectory, the loss distribution can then be evaluated using one of the known methods for computing the distribution of the sum of independent (but not identically...
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Báo cáo sinh học: " Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" docx
... and mature DCs, resulting in tolerogenic interaction with T cells in SIT We found that the combination of DNA vaccination with Fc and OVA had better effects onOVAinduced alterations in the spleen ... pathway of regulation of type immunity in asthma Competing interests The authors declare that they have no competing interests Authors' contributions YL performed all analyses and wrote the initial ... directly to DCs may a new alternative of therapies for patients with allergic asthma These findings suggest that spleen DCs and Foxp3+Tregs prevents the generation and activation of Th2 effector cells...
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Báo cáo hóa học: " Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection" pdf
... it is not the virus bearing the epitope nor local virus replication that results in the decreased functionality of CD8+ CTL in lungs, but rather the pulmonary site of residence of the cells Therefore, ... present study contains a disrupted thymidine kinase gene due to the M2 insert [10] This disruption has been shown to result in attenuation compared to its strain WR parent, yet the virus still ... somewhat lower response (15%) of tetramer+CD8+ cells was detected in the lungs after IN infection with VV-M2 Interestingly, despite the lack of VV-M2 replication in the lungs after ID inoculation,...
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Báo cáo y học: "Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies" ppt
... contributed to interpretation of the data Competing interests The authors declare that they have no competing interests Page of (page number not for citation purposes) Acknowledgements The set of EBV ... arguments to investigate a potential EBV reactivation during MTX and/ or TNFα antagonist therapy as a possible first step of lymphoma induction During primary EBV infection, specific cytotoxic CD8+ T ... under treatment (a) Spondylarthropathy patient with infliximab + methotrexate (b) Rheumatoid arthritis patient with adalimumab + methotrexate Both responses to latent peptides and lytic peptides...
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Immunodominance and immunoprotection of anti viral specific CD8+ t cell response during HBV infection
... development of the adaptive immune response and the outcome of the infection 6 Background Adaptive Immunity Phase The important role of the adaptive immunity in determining the outcome of a HBV infection ... with the absence or mild symptoms of hepatitis, while patients who resolve the infection often experience acute hepatitis 20 This led to the suggestion that the ability of the innate immunity ... 54-56 The influence that virus heterogeneity and the distinct HLA-profile of the infected subjects have on the repertoire and hierarchy of T cell responses is difficult to predict The existence of...
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Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt
... addition to the primary structure of the peptide To confirm our hypothesis that the b-turn structures are important for the inhibitory activities of the peptides, the structures of the cyclic peptides ... interaction This correlates with the higher inhibitory activity of the cEL peptide and the very low inhibitory activity of the cYT peptide compared to other peptides The flanking residue of the b-turn, ... their toxicity using the MTT assay [17] All the four peptides tested in the study resulted in 90–100% viability indicating that these peptides were not toxic to cells and the inhibition data observed...
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Báo cáo khoa học: "Large-Scale Induction and Evaluation of Lexical Resources from the Penn-II Treebank" potx
... subcategorisation details To incorporate CFG details into the extracted semantic forms, we add an extra feature to the generated f-structures, the value of which is the syntactic category of the pred at ... each of the CF-PSG constituents The elements of the constituent structure are indexed, and referenced in the :gs field This mapping between constituent structure and functional structure makes the ... constituent structure of the subcategorisation frame, which lists the syntactic CF-PSG constituents in sequence The value of the :gs feature is the grammatical structure which indicates the functional...
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Báo cáo khoa học: "REVERSIBLE AUTOMATA AND INDUCTION OF THE ENGLISH AUXILIARY SYSTEM" doc
... with state 5, resulting in the bottom overgeneralized version 73 in the language by taking different paths from initial state to final state The bottom, overgeneralized, automaton is generated ... remaining 17 strings of that pattern Further adding two length-four strings from the awkward second pattern will yield the remaining 18 strings of that pattern, nine of which are of length five This ... states have a c o m m o n OF k-leader and either -both states are accepting states or -both states arc to a c o m m o n state on the same word After finding the range of values of/ C to work with,...
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báo cáo hóa học:" Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients" potx
... indicates an important role of the TRB chain in fine-tuning TR affinity of Melan-A-specific T cells of melanoma patients and argues against the hypothesis that high affinity TRs against self-Ags, like ... Frequent contribution of T cell clonotypes with public TCR features to the chronic response against a dominant EBV-derived epitope: application to direct detection of their molecular imprint on the ... prognostic information, contributing to the design of efficient antimelanoma vaccines Competing interests The authors declare that they have no competing interests Authors' contributions FS, and AS have...
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Báo cáo hóa học: " Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients" docx
... Aim of the study was the application of mathematical markers to describe the global restriction of the αβ TCR repertoire in the different compartments rather than the detection of single expanded ... other tumor entities, which have been interpreted as indication for the induction of specific clones reactive to autologous tumor [26,42] In fact, this TCR repertoire restriction in tumor patients ... reflected by the CD and n(F) values was significantly higher in carcinoma patients confirming the results of former studies investigating Vβ-repertoire restrictions in blood of patients with other...
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Báo cáo sinh học: "The combined transduction of copper, zincsuperoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury" ppt
... the experiments, collected the data and analyzed the results JNW and JMT participated in the experimental design and interpretation of the results LZ performed some of the in vitro experiments ... Bioengineering Institute, China) Immunocytochemistry To directly visualize the transduction of PEP-1-SOD1 and PEP-1-CAT fusion protein into H9c2 cells, cells were treated with μM of control SOD1, ... enzymatic activities Our in vitro studies demonstrate that PEP-1-SOD1 and PEP-1-CAT together generate greater inhibitory effects than individual proteins on LDH release and apoptosis rates in cardiomyocyte...
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Báo cáo y học: " Chitosan Interferon-c Nanogene Therapy for Lung Disease: Modulation of T-Cell and Dendritic Cell Immune Responses" pps
... regulating Tcell activation and thus may participate in the protective effect of CIN therapy To determine whether CIN therapy affects the activity of lung dendritic cells, CD11c+ mononuclear cells ... allergen-induced lung pathology and that at least a part of the protective effect of CIN treatment can be attributed to a reduction in numbers of a specific CD8+ T- cell population Intranasal administration ... data in supporting the idea that CIN treatment decreases the inflammatory response to an allergen by inhibiting dendritic cell activation of OVA-specific T cells Alteration of Dendritic Cell...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
... for cytotoxic T- lymphocyte antigen-4 (CTLA-4) The traditional view of the function of CTLA-4 is that it is upregulated upon stimulation of the T cells and attenuates the response (top) The newly ... On the one hand, CTLA-4–/– Treg cells are able to downregulate the activation of target cells; on the other, blockade of CTLA-4 abrogates the inhibitory function of Treg cells [72] Interestingly, ... model puts together new insights into CTLA-4 functions (bottom) (1) During suboptimal T cell activation, CTLA-4 sets the threshold for activation (2) Already activated T cells are inhibited in their...
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Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot
... ameliorating anti-CD4 mAbs W3/25 and OX35 (but not the accelerating mAb, RIB5/2) numerically/significantly increased the DTH to the arthritogen M tuberculosis In the total T- cell population, two of the ... separate epitopes of the CD4 molecule could result in differential effects on T- cell functions by inducing distinct conformational changes of the extracellular and the intracellular parts of the ... reported [20], whereas the affinity of the other ameliorating mAb, OX35, was comparable to that of the accelerating mAb, RIB5/2 On the other hand, a contribution of the strikingly higher kdiss of...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... cytokine therapy might be an interesting new antirheumatic approach that could contribute to the prevention of joint destruction as an adjunct to anti-TNF and anti-IL-1 therapy Competing interests ... (IL-17) in relation to other key cytokines in the pathogenesis of arthritis RANKL, receptor activator of NF-κB ligand; TNF, tumor necrosis factor inactivation of IL-17 [40] In line with the situation ... inflammation In arthritis, IL-17 is a pro-inflammatory cytokine thought to contribute to the joint inflammatory process [38] Studies in IL-17-deficient mice revealed that IL-17 has an important function...
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Báo cáo y học: "Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin" pptx
... construction of a particular tree is then put back into that tree to test the validity of the classification obtained from the bootstrap sample In this way, a test set classification is obtained ... few months after symptom onset is distinct from that of other early inflammatory arthritides and of established RA The nature of the cytokines present in the synovial fluid of patients with early ... cytokine and chemokine data, analyzed and interpreted the data, and was involved in drafting the manuscript ET acquired the cytokine and chemokine data CYL participated in assessing patients and...
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Báo cáo y học: "E3 ubiquitin ligases and their control of T cell autoreactivity" potx
... specificity is determined by the binding of the target protein (either with or without the carboxyl terminus of Hsc70-interacting protein (CHIP) and Hsc70 containing pre-ubiquitin complex) to a particular ... carboxyl terminus of free ubiquitin to Lys48 of the previously attached ubiquitin protein [3] In contrast, monoubiquitination of target protein lysine residues results in altered trafficking to the ... synapse that forms between the T cell and the antigenpresenting cell during antigen recognition The end result of this strong costimulatory interaction is a maintenance of the high level of antigen...
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Báo cáo y học: "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen" pot
... therefore, an increasing need to model the anti-arthritic effects of methotrexate in combination with other therapies in order to optimise treatment regimens and to identify possible interactions Likewise, ... of inflammatory cell infiltration in the two strains In contrast, in late arthritis (6 to weeks after onset), inflammatory cell infiltration Page of (page number not for citation purposes) Arthritis ... persistent Tcell responses The maintained presence of inflammatory cell infiltrate and the response of the disease in B6 mice to antiarthritic drugs such as methotrexate show a good correlation with...
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