relative potency within a series response at one variable dose and slope of dose amp 8211 response curve known
Báo cáo " ISO 14001 ENVIRONMENTAL MANAGEMENT SYSTEM FOR UNIVERSITIES: A CASE STUDY AT HO CHI MINH CITY UNIVERSITY OF TECHNOLOGY IN VIETNAM " pptx
... USA Habib M Alshuwaikhat, Ismaila Abubakar, 2008, An integrated approach to achieving campus sustainability: assessment of the current campus environmental management practices, Journal of Cleaner ... sanitariness and environmental protection of the university based on the national standards, the national and local technical regulations Environmental organizational structure - To arrange at least one ... 5937:2005 (Air quality – Ambient air quality standards) and TCVN 5938:2005 (Air quality – Maximum allowable concentration of harzardous substances in ambient air) To collect and treat To collect and...
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![Tài liệu Báo cáo khoa học: Specific targeting of a DNA-alkylating reagent to mitochondria Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide doc](https://media.store123doc.com/images/document/14/br/vp/small_vpv1392870032.jpg)
Tài liệu Báo cáo khoa học: Specific targeting of a DNA-alkylating reagent to mitochondria Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide doc
... expression One approach to increase the duration of PNA binding to DNA is to conjugate it to a DNAalkylating reagent so that the PNA becomes covalently bound to its target sequence To this a DNA alkylating ... synthesis and characterization of a novel mitochondria-targeted alkylating reagent and show that it alkylates DNA in vitro and is taken up by mitochondria However, in spite of its substantial import, ... its ability to alkylate DNA and high micromolar concentrations of mitoDC-81 are sufficient to alkylate linear, circular and supercoiled DNA As these concentrations of mitoDC-81 are easily achieved...
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Tài liệu Báo cáo Y học: A novel meta-cleavage dioxygenase that cleaves a carboxyl-groupsubstituted 2-aminophenol Purification and characterization of 4-amino-3-hydroxybenzoate 2,3-dioxygenase from Bordetella sp. strain 10d doc
... those of extradiol dioxygenases available in the FASTA AND BLAST database programs at the DNA Data Bank of Japan The gene encoding 4-amino-3-hydroxybenzoate 2,3-dioxygenase is currently being cloned; ... Crystallization and characterization J Biol Chem 243, 2673–2681 Murakami, S., Nakanishi, Y., Kodama, N., Takenaka, S., Shinke, R & Aoki, K (1998) Purification, characterization, and gene analysis of catechol ... Morphological and phenotypic characterization Physiological and biochemical parameters, such as Gram reaction, flagella type, catalase activity, oxidase activity and OF test, were determined using classical...
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Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf
... The data for the PA catalysed hydrolysis of PhAc-Asp and PhAc-Glu [13] and our data for PhAc-pAB, PhAc-mAB and PhAcoAB (Table 2) imply that the COOH group has to be positioned as in NIPAB for ... no reasonable explanation of the PA activity with substrates like PhAc-pAB, PhAc-mAB, PhAc-oAB vs phenylacetyl 4-nitroanilide (PhAc-pNA), NIPAB and iso-NIPAB, but it suggests an explanation of ... Table Distances (A) between polar substrates groups (CO2– and A NO2) and the two ArgB263 and ArgA145 residues of penicillin acylase as a result of AM1 optimization of the corresponding substrate...
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Báo cáo khoa học: Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles pdf
... methods and analyzed with a microscope, BZ-8100 (Keyence, Osaka, Japan) Acknowledgements We greatly appreciate Dr Masatoshi Maki and Dr Hideki Shibata in our laboratory for providing valuable suggestions ... rat coagulating gland secretion Post-translational modification and activation by phosphatidic acids J Biol Chem 271, 27416–27423 11 Candi E, Oddi S, Paradisi A, Terrinoni A, Ranalli M, Teofoli ... Dimethylcasein (Sigma) was used as a positive control at a final concentration of 200 ngÆlL)1 The reaction mixture was incubated at 37 °C and then separated by 12.5% SDS ⁄ PAGE A fluorograph of the...
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Báo cáo khoa học: Proteome analysis of a rat liver nuclear insoluble protein fraction and localization of a novel protein, ISP36, to compartments in the interchromatin space pptx
... that associates with nuclear matrix DNA Cell Biol 17, 849–858 Lee JY, Nakane Y, Koshikawa N, Nakayama K, Hayashi M & Takenaga K (2000) Characterization of a zinc finger protein ZAN75: nuclear ... H2O2 and diaminobenzidine (B) A rat liver nuclear fraction was treated with DNase–RNase and the solubilized fraction (chromatin fraction, B5) was separated by centrifugation The pellet was extracted ... Thanumalayan S, Muralikrishna B, Rangaraj N, Karande AA & Parnaik VK (1999) Colocalization of intranuclear lamin foci with RNA splicing factors J Cell Sci 112, 4651–4661 11 Gueth-Hallonet C, Wang...
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PERIPHERAL NEUROPATHY - A NEW INSIGHT INTO THE MECHANISM, EVALUATION AND MANAGEMENT OF A COMPLEX DISORDER doc
... Kanbayashi and Toyoshi Hosokawa Preface Understanding the rapid changes in the evaluation and management of peripheral neuropa‐ thies, as well as the complexity of their mechanism, is a mandatory ... that generation of an AP or NT release as well as the associated pathophysiological changes can occur at either terminal Peripheral Neuropathy - A New Insight into the Mechanism, Evaluation and ... subcortical regions that manage a variety of aspects of cognition and perception Prominent examples include areas of the brain associated with motivation/reward, learning/memory, and somatosensation...
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Báo cáo hóa học: "One-Dimensional Nanostructures and Devices of II–V Group Semiconductors" ppt
... used as the evaporation sources At high reaction temperature, ZnS or CdS was evaporated and Fig Schematic illustration showing the formation of II–V nanotubes via the in situ nanorod template ... shows that long and straight nanobelts are obtained on a large scale Each nanobelt has a uniform width of 100–200 nm and length in the range of tens of micrometers A highmagnification SEM image shown ... behavior of Cd3P2 bicrystal nanobelts was also investigated at different temperatures and the results (Fig 8d) also suggested a dominant thermal activation of carriers transport mechanism Nanoscale...
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Báo cáo khoa học: "Skin cancers in albinos in a teaching Hospital in eastern Nigeria - presentation and challenges of care" ppt
... cancers are indeed a major cause of morbidity amongst albinos in the tropics These patients from a young age face a raging battle against these cancers; a battle the African albino often appears ... occupation, duration of symptoms, distribution of lesions, treatment offered and rate of completion of treatment were extracted Data were analyzed using descriptive statistics Results A total of ... Cotran RS, Kumar V, Collins T, Robbins SL: Pathologic basis of disease Philadelphia: WB Saunders 1974 Ramalingam VS, Sinnakirouchenan R, Thappa DM: Malignant transformation of actinic keratoses...
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Báo cáo khoa học: "Does the surgeon still have a role to play in the diagnosis and management of lymphomas?" docx
... in Wales with a ratio of 1:4 [1] Table 1: Anatomical location of lymphomatous lymph nodes (n = 62) Anatomical location Number of cases Cervical Inguinal Axillary Intra-abdominal Supraclavicular ... diagnosis of lymphomas as the tumours often contain malignant and reactive elements and the FNAC may only have sampled the reactive regions leading to false negative results Another disadvantage ... lymphomas, one of the important roles of FNAC is the exclusion of metastatic squamous carcinoma as this requires an alternative therapeutic approach There is a question as to the accuracy of FNAC...
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báo cáo khoa học: "Expression of a quantitative character radius incompletus, temperature effects, and localization of a mobile genetic element Dm-412 in Drosophila melanogaster" pptx
... the tree of uninformative Calculation of correlation coefficient A calculation of correlation coefficient for alternative characters standard methods (see, for example, U 1964) , RBAKH B The ... within all five lines are absent (table 2) Thus the patterns of MGE localization are stably maintained within the lines a Besides, in 1985-1986 we obtained additional data for small samples of ... figure (curves 3, A and B) Figure (d) demonstrates a typical phenotype, and table contains the statistical parameters of a stabilized line at the 140th generation « The second temperature-sensitive...
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Báo cáo y học: " Act In case of Depression: The evaluation of a care program to improve the detection and treatment of depression in nursing homes. Study Protocol" pptx
... recreational therapist, psychologist and elderly care physician, separately Data-analysis Primary effects will be calculated using multilevel regression analysis, for somatic and DSC units separately ... includes a personal day structure program, a behavioral management strategy developed by the psychologist and psycho education - especially of relatives Apart from that, psychological treatment is offered: ... long-term care residents with dementia, and Smalbrugge et al [6] found that depressed residents of somatic units had increased use of medication, and received medical specialist consultation and treatment...
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báo cáo khoa học: " A hypothetical correlation between hyaluronic acid gel and development of cutaneous metaplastic synovial cyst" potx
... General Hospital, Bari, Italy, 3Department of "Head and Neck Diseases", Hospital "Fatebenefratelli", Rome, Italy, 4Department of Maxillofacial Surgery, Calabrodental, Crotone, Italy, 5Department of ... contributions FI: participated in the surgical treatment and in the follow-up of this patient, MT: drafted the manuscript and reviewed the literature, FMA: participated in the surgical treatment and in the ... follow-up of this patient, MM: participated in the design of this case study and in the follow-up of this patient, ADI: revised the literature sources, AS: participated in the surgical treatment and...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 1 ppsx
... Information 187 15 Data Analysis 189 Report Coverage 189 Understanding Data 190 Categories 190 Metric Data 192 Statistical Analysis 194 Categorical Data 196 Ordinal Data 197 Metric Data 198 An Example ... Data Management 241 Data Entry and Data Management 242 Small-Scale Clinical Studies 242 Clinical Database Managers 242 Data Analysis 243 Utilities 244 Sample Size Determination 244 Screen Capture ... Laboratory instruments Data storage and retrieval Data analysis Report preparation Submissions Put a PC or computer terminal everywhere data are to be gathered Computer-assisted data entry, that...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 2 pps
... the appropriate software for data entry, data management, and statistical analysis is normally divided among the lead software engineer, the data manager, and the statistician (subject, of course, ... beyond an understanding of the data management software to security (maintaining onsite and offsite backups) and quality control Programs for Data Analysis Development of programs for data analysis ... Prepare investigator manual Programmers 2+ Database Manager Develop data entry screens LP Develop data entry screens Integrity and security of data To say nothing of investigators, investigational...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 3 pps
... data (sometimes ordered and sometimes not) as we would see, for example, in a table of adverse events by type against treatment Data such as laboratory values and blood pressure that are measured ... us, and what levels of Type I and Type II error can be tolerated Here is an example: Suppose that in 20% of patients, an untreated headache goes away within the hour Do you want to demonstrate ... reach a final conclusion (at least one acceptable to the regulatory agency) until all the data are in, there may be sufficient evidence at an earlier stage to launch a second broader set of trials...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 4 potx
... detailed list of the information that is to be gathered (see Chapter 9) CHAPTER DOCUMENTATION 95 and a manual of the procedures that are to be followed in gathering and evaluating the information ... risk factors, laboratory values) align as closely as possible with those of patients who received the investigational intervention As the allocation of patients to treatment was not made at random, ... Bumbling proposal: “Secondary Response Variables and Multivariable Modeling Many secondary response variables may be evaluated The measurable responses fall under two broad testing categories: Subgroup...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 5 potx
... patients, 28% of the 702 patients for whom data was available were females, and the mean age for the 702 patients for whom birth data was available was 63.9 ± 4.6 • Click here to see a list of patients ... clarification or reworking of statistical data, which can delay the process for weeks CANDAs eliminate much of this delay By employing computer-assisted data entry you are automatically in a position ... copy of your final report and an electronic copy of your database and the programs you’re used to retrieve and analyze the data In the United States, the latter is termed an e-sub or CANDA (Computer-Aided...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 6 pdf
... inventors of the relational database is that SQL, the query language associated with System R, IBM’s first attempt at a relational database, has become a standardized part of all relational software, ... paths among the data as in a network access database Changes to the database structure are easily accommodated The structure of the database can be changed without having to change any applications ... spell of a salesperson) Three issues are discussed: Choice of data management software and the options available to you Transfer of data from data entry to data storage and from data storage to...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 7 pot
... the data will be yours alone Maintaining an Audit Trail To avoid even the appearance of fraud, and to satisfy government regulations, all changes to the database must be automatically tracked and ... data entered at each physician’s and each laboratory’s computer to the central database can be done in one of three ways: Enter directly at each physician’s computer Transfer the data automatically ... than one database would be redundant A good rule of thumb is to use the patient ID as a primary key to tie all the databases together and to use an examination date or some other value as a secondary...
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