... better understand the mechanism of action of HRSV neutralizing antibodies and the impact of resistance to these antibodies upon the fusion activity ofthe F protein. A summary of these resultsis ... performed the fusion assays.PB and ND performed the flow cytometry. LG conductedsitedirected mutagenesis ofthe HRSV F protein. AD and RS participated in the design, oversight ofthe conduct of the ... under-standing ofthe mechanism by which the F protein medi-ates cell fusion. Such studies may provide additionalinsights into the function ofthe F protein, and help in the selection and development...
... better understand the mechanism of action of HRSV neutralizing antibodies and the impact of resistance to these antibodies upon the fusion activity ofthe F protein. A summary of these resultsis ... expression, and fusion activity. Functional analysis ofthe fusionactivity ofthe panel of mutations revealed that the fusion activity ofthe F protein is tolerant tomultiple changes in the site II and ... purposes)Virology JournalOpen AccessShort report Relationship betweenthe loss of neutralizing antibody binding and fusion activity ofthe F protein of human respiratory syncytial virusChangbao...
... about the thermodynamics and kinetics ofthe binding of guanidines and N-hydroxy-guanidines to iNOS. Removal ofthe a-amino ora-carboxylate moiety of l-Arg has important effects on the ability of ... bulge between the two heme propionates in contact with the heme andthe side chain of a conserved valine (V338). The decrease ofthe affinity of homo-l-Arg and homo-NOHA compared with l-Arg and ... ser-ies, the kcatvalue for the production of NO from the oxidation ofthe N-hydroxyguanidines varied by lessthan a factor 2, whereas the kcatvalue for the produc-tion of NO from the oxidation of...
... en-ter of Sun Yat-Sen University. All the patients under-went radical surgery, and none of them had undergoneeither chemotherapy or radiotherapy before the collec-tion ofthe samples. The histopathologic ... Committee of our institution. Patients were informed ofthe investiga-tional nature ofthe study and provided their writteninformed consent.Follow-up of patientsFollow-up was provided to all ofthe ... used the chi-square test to assess the relationships between the distribution of mast cells and clinicopathologiccharacteristics. The results show that MCCalnm (the mastcell count in the normal...
... en-ter of Sun Yat-Sen University. All the patients under-went radical surgery, and none of them had undergoneeither chemotherapy or radiotherapy before the collec-tion ofthe samples. The histopathologic ... Committee of our institution. Patients were informed ofthe investiga-tional nature ofthe study and provided their writteninformed consent.Follow-up of patientsFollow-up was provided to all ofthe ... used the chi-square test to assess the relationships between the distribution of mast cells and clinicopathologiccharacteristics. The results show that MCCalnm (the mastcell count in the normal...
... result ofthe presence of negatively-charged residues at P2 and P2Â that arenot accommodated within the b2-tryptase active sitebecause ofthe presence of Asp147 and Asp143within the S2 andthe ... result ofthe absence of a disulfide bond between Cys191 and Cys220, which is conserved in the neutrophil serine proteases HNE and PR3. The presence of a Glu at position 226 at the bottom of the CG ... however, the same result wasobtained with chymase, further confirming the similarspecificity of these two proteases.Table 1. Influence of residues at P1, P1Â and P2Â on the specicity of CG and chymase...
... (1990) and Laux and Ng (1991) support the second. The second relationship also supports the model of Brock and Kleidon (1990) where the link between variationsin demand andthe variability of prices ... R, spR, and nRare the standard deviation of the percentage change of an exchange rate, the averagespread, andthe number of quotations within the tth half-hour interval, andthe system ... predetermined, and reported on another part of the Reuters system, the FXNB page. The stochastic element insuch cases is the actual announcement, not the timing of it.In general, the majority ofthe US...
... bysuccessive tandem duplications and divergence of asingle ancestral gene, as has been suggested for the evolution of some ofthe globin gene clusters [28].Last, the ancestral gene of fabp11 andthe ... in the retina of developingembryos at 24 h postfertilization (hpf) in the pig-mented epithelium, starting in the proximal part of the retina. fabp11b transcripts spread across this layer of the ... tosequence identity and their relationship in the phylo-genetic tree (Fig. 6), fabp4 and fabp4-like may havearisen in the frog genome as a result of tandemduplication of an ancestral gene...
... strong relationshipbetweenthe generic EQ-5DHRQoL measure andthe disease-specific SAQ. For most of the SAQ scales (and some other variables studied), therewas a smaller relationshipbetweenthe ... because there was a small proportion of women inmany ofthe studies, so further work could be done instudies with more women to assess the robustness of the estimate oftherelationshipbetween ... strong relationship across differentlevels of CHD severity with sex, the scales ofthe SAQ and CCS angina severity class and a smaller relationship withage and ETT. The variation seen in the relationship between...
... is available. The CDS rate quoted for any particular CDS depends on the term ofthe CDS andthe credit quality ofthe underlying asset. The vast majority of quotes lie between 0 and 300 basis ... distribution of all adjusted spread levels We then counted the total score for all the observations in each category. The test ofthe significance ofthe results is the same as that given above for the ... When there were both bid and offer quotes for a reference entity on a day we calculated U, the maximum ofthe bid quotes and V, the minimum ofthe offer quotes. If U and V were less than 30...