... and useful information about the cost ofrelapseand its cost components inthe United States, the predictors of relapse, andthe important role of previous relapse, above and beyond information ... plan, the interpretation ofthe results, and assisted in drafting the manuscript DS and ES participated inthe design ofthe study, the analytical plan, the interpretation ofthe results, and assisted ... outpatient services and medication costs Findings highlight the economic impact ofrelapseandthe importance of prior relapse as a predictor of subsequent relapse for clinicians and other health care...
... J: Influence of age, renal, and liver impairment on the pharmacokinetics of risperidone in man Psychopharmacology 1995, 122:223-229 DeVane CL, Nemeroff CB: Clinical pharmacokinetics of quetiapine: ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained inthe therapeutic range by intraperitoneal administration of lithium during continuous ... R, Singlas E: Pharmacokinetics of lamotrigine in patients with renal impairment: influence of haemodialysis Drugs Exp Clin Res 1993, 19:25-32 McLean MJ: Clinical pharmacokinetics of gabapentin...
... study and during the study, other than multivitamin and mineral supplements containing vitamins and minerals as the sole medicinal ingredients Use of concomitant prohibited medication (narcotics, ... arthritis or other types of pain) or is unwilling to stop taking other medications for thetreatmentof OA Any other condition that, inthe opinion ofthe investigator, would adversely affect the subject's ... Subjects inthe UC-II group were instructed to take two “sugar pills” inthe morning to protect blinding and two UC-II capsules inthe evening accounting for a daily dose of 40 mg UC-II containing...
... proopiomelanocortin and cocaine and amphetamine regulated transcript Taken together, these findings provide a compelling argument for the role for malonyl-CoA in regulating feeding behavior The question ... changes in malonyl-CoA level inthe hypothalamus correlate closely and rapidly with reciprocal changes inthe levels ofthe orexigenic and anorectic Signaling mediators inthetreatmentof obesity ... from the public health aspects ofthe affects of fructose on food intake, these findings lend further support to the mechanism by which malonyl-CoA participates inthe regulation of feeding behavior...
... at each phase ofthe cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors andthe retinoblastoma protein (RB), as well ... deficiency in Skp2, the substrate-binding subunit ofthe SCFSkp2 complex, contributes to the degradation of p27Kip1, resulting in an induced resistance to obesity due to inhibition of preadipocyte ... inthe adipocyte is tightly regulated by interaction between the cell-cycle regulators andthe differentiating factors, and creates a cascade of events leading to the commitment of cells into the...
... 81.7 and Oxford Knee score 21 The patient will continue to have regular clinical and radiological implant surveillance Figure Fluoroscopic image ofthe left knee showing the introducing cannula and ... loosening Laboratory screening including erythrocyte sedimenta- Page of tion rate and C-reactive protein was normal Plain radiographs revealed areas of periprosthetic osteolysis inthe femur andthe ... obtained from the patient for publication of this case report and any accompanying images A copy ofthe written consent is available for review by the Editor -in- Chief of this journal Author information...
... Annals of General Psychiatry 2009, 8:16 thetreatmentof acute mania, the approval of quetiapine andthe olanzapine-fluoxetine combination against acute bipolar depression andthe approval of olanzapine, ... dose at the end ofthe study was 15.5 mg daily The results suggest that in weeks to and then again at week there is a significant reductioninthe MADRS scores inthe aripiprazole group in comparison ... group (41%) and 13 out ofthe 27 inthe placebo group (48.1%)) The only difference concerned manic relapses (nine inthe placebo and six inthe aripiprazole group) Again the YMRS score significantly...
... effective inthetreatmentof psychotic major depression, andthe switch to sertraline worsened the psychotic symptoms inthe patient The mechanisms underlying the opposite effects of these two ... fluvoxamine binds to sigma-1 receptors inthe intact human brain at therapeutic doses [25], suggesting that sigma-1 receptors are involved inthe active mechanisms of fluvoxamine [19] Interestingly, ... that activation ofthe dopaminergic system by the inhibition of dopamine transporter may be involved inthe mechanism of unwanted effects (deterioration of psychosis) of sertarline in this case,...
... take advantages of both stereotactic radiotherapy and conventional fractionation while minimising the risks of RT-inducing brain injury like radiation necrosis and cognitive decline The optimal radiation ... Authors’ contributions All ofthe authors have been involved in drafting this paper and have read and approved the final manuscript KG conceived the idea ofthe paper, reported the case, performed the ... paper concerning radiotherapy and followed up the patient at his out-patient clinic AK was the radiologist performing the preoperative and postoperative CT and MRI scans and wrote the part of the...
... HT at the Tomotherapy Unit ofthe Grupo IMO inthe context of multidisciplinary national and international treatment protocols All the patients were treated with curative intent, including those ... treatment time was composed of time required for patient set-up and anesthesia inside thetreatment room, time of MVCT acquisition, time of review/match and applying couch correction inside the ... to the Tomotherapy treatment planning system (Tomotherapy Inc., Madison, WI) to perform inverse treatment planning The planning goal was to deliver the prescription dose to at least 95% of the...
... percent ofthe IMRT Group had grade or hearing loss, compared to 64% ofthe conventional-RT group The sparing ofthe hearing apparatus is of special importance since several modern combined chemotherapy ... treatmentofthe children HB is responsible for the anaesthesia management ofthe children PH is responsible for the clinical treatmentofthe children as head ofthe division of radiation oncology in ... a Ewing's sarcoma ofthe left orbit, infiltrating the dura mater andthe left ethmoid sinus The patient received multiagent chemotherapy (7 cycles VIDE (vincristine, ifosfamide, doxorubicin,...
... radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: The Lyon R90-01 randomized trial J Clin Oncol 1999, 17:2396-2402 Valentini V, Coco C, Cellini ... treatment was temporarily interrupted The decision of performing this weekly CT schedule instead of during the first and last week of RT course had the objective of maximize the radiation effect Adjuvant ... according to the actuarial method of Kaplan and Meier [24] The calculation of OS, DFS and LC was performed from the date of diagnosis to the date ofthe event Survival was measured from the date of...
... months including clinical examination and MRI scans Depending on clinical and radiological findings the period between individual follow-ups was increased after the second year The measurement of ... evaluation ofthe patients revealed complete remission in patients (8%), partial remission in patients (24%), and no change inthe remaining patients according to the WHO definitions None ofthe patients ... material wrapped around the head ofthe patient Serial mm CT slices oftheofthe whole treatment area plus a superior margin of cm and an adequate inferior margin to cover the neck lymph nodes...
... Outcome The primary goal ofthe analyses was to compare the response rates of R-CVP and R-CHOP inthetreatmentof patients with FL as frontline therapy or as re -treatment in patients with relapsed ... studies were considered appropriate for the first analysis [5-7] and four for the second [4-7] Two studies involved randomized controlled trials comparing treatment protocols of either R-CHOP ... evaluating only for complete response Odds ratios of 2.86 (95% CI: 1.81–4.51) inthe first analysis and 1.48 (95% CI: 991–2.22) inthe second Anthracyclines are always included inthe treatment...
... care costs and cost components for switchers and continuers Average4 Average 1-year total health care costs and cost components for switchers and continuers sychotic switching Competing interests ... assessed the proportion of patients receiving the service, the rate of use and rate of admissions, the time to first use ofthe service, andthe annual health care cost, in terms of total health ... during the study and initiated therapy with a different antipsychotic within 14 days of discontinuation ofthe initial therapy Data on the occurrence of acute-care service use, the time to the...
... Organization Competing interests The authors declare that they have no competing interests Authors' contributions SG was involved inthe conceptual design of this study, inthe clinical management ofthe ... http://www.jmedicalcasereports.com/content/2/1/320 clinical management and contributed to writing and editing ofthe manuscript MB was involved inthe radiation treatmentofthe patient AR performed the neurological, clinical ... the clinical management and contributed to the writing and editing ofthe manuscript GM supervised the entire treatment, provided financial and administrative support and contributed inthe critical...
... ofthe healthcare system is not satisfactory There are limitations inthe reimbursement of anti-HBV therapy, either inthe selection of agent or the duration of dosing Therefore, lamivudine and ... telbivudine are more widely used intreatmentof CHB In this systematic review, we focus on the comparison ofthe efficay of lamivudine and telbivudine inthe Figure Effect of telbivudine vs lamivudine ... design, inthe collection, analysis, and interpretation ofthe data, inthe writing ofthe manuscript, or inthe decision to submit the manuscript for publication The contents are solely the responsibility...
... Structure of spleen tyrosine kinase (Syk) protein Syk includes two tandem SH2 domains and a tyrosine kinase domain Interdomain A is between the two SH2 domains, and interdomain B is between the tyrosine ... produce proinflammatory cytokines and enzymes, and contribute to thein ammatory process andthe eventual destruction ofthe joint A number of studies have claimed a role for Syk inthe function of FLSs ... (FLSs) represent a significant component ofthe synovial lining and contribute to the lubrication and preservation ofthe joint In rheumatoid arthritis (RA), FLSs expand in numbers, acquire immune...
... blinded physicians, nurses and patients to the intervention by covering the control panel ofthe ventilator Almost none ofthe studies reported or commented on blinding strategies Most of them ... ago, and seven years ago the first meta-analysis appeared, showing the efficacy of CPAP inthetreatmentof ACPE [10] Since then, several RCTs comparing the use of CPAP and Available online http://ccforum.com/content/10/2/R69 ... non-invasive ventilation (pooling CPAP and NPPV together) and consequently double counting control group patients in three studies (with three arms), inflating the number of patients included and...
... into consideration inthe interpretation ofthe clinical outcome in vasopressin studies The authors recognize several limitations inthe interpretation ofthe present findings The study was conducted ... literature ofthe epinephrine-vasopressin combination benefits and further evaluation of these results should be undertaken inthe future Key messages • The combination of vasopressin and epinephrine ... 0.675) during the eighth minute of untreated VF in both groups Inthe first minute of CPR, CPP rose significantly inthe VasoEpi group and remained statistically higher inthe second minute of CPR...