regulation of sex determination in drosophila melanogaster
Báo cáo khoa học: Role of the structural domains in the functional properties of pancreatic lipase-related protein 2 pot
... protein bearing the N2 domain than in the protein bearing the Nc domain Thus, the accessibility of the active site in the N2 proteins was independent of the nature of the C-terminal domain, in contrast ... protein The chimeric protein composed of the N-terminal domain of hoPL and of the C-terminal domain of hoPLRP2 was named NcC2 Conversely, the other chimeric protein, bearing the N-terminal domain ... the N-terminal and C-terminal domains of hoPL were involved in the inactivation of the protein at the water–triglyceride interface The inactivation of N2Cc in the absence of bile salts was prevented...
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Báo cáo khoa học: Expression and characterization of soluble forms of the extracellular domains of the b, c and e subunits of the human muscle acetylcholine receptor pot
... organ of the marine ray, Torpedo californica [3] The acquisition of the crystallographic structure of the mollusc acetylcholine-binding protein [11] has provided an insight into the ligandbinding ... ligand-binding extracellular domain of the human alpha7 acetylcholine receptor expressed in yeast: replacement of the hydrophobic cysteine loop by the hydrophilic loop of the ACh-binding protein enhances ... cleavage of the signal peptide) consists of three domains, an extracellular domain (ECD) (210–220 residues), a membrane-spanning domain, and an intracellular domain [3] The N-terminal ECD of each of...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... epitopes of gp130 are involved in ligand binding: the Ig-like domain and the CBM [9–11] In the case of LIF-induced heterodimerization of LIFR with gp130, the cytokine first binds to the Ig-like domain ... epitopes involved in ligand binding are unchanged Replacement of D6 of gp130 by the corresponding domain of the GCSFR leads to the abrogation of signal transduction of all tested cytokines As ... tyrosine motifs of gp130 that predominantly recruit STAT3 were replaced by the STAT1 recruiting motif of the interferon-c receptor resulting in a chimeric protein designated gp130c In order to investigate...
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Báo cáo khoa học: The role of the Fe-S cluster in the sensory domain of nitrogenase transcriptional activator VnfA from Azotobacter vinelandii potx
... purification of an AnfA variant reported by Austin et al [22] In their study, the N-terminal domain of AnfA was truncated to prevent the intrinsic aggregation of the intact form during purification ... absence of the N-terminal domain in this variant Because sensing is a principal function of regulatory proteins, the isolation of VnfA and AnfA with their sensor (GAF) domains is highly desirable In ... effect of the nucleotide binding was reported in a study of the limited trypsin digestion with NifA + MgADP, in which binding MgADP to the central AAA+ domain is ascribed to the trigger of a conformational...
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Báo cáo khoa học: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site pdf
... bioconversion of chitin into valuable oligosaccharide derivatives for various industrial applications Pf-ChiA has a unique multidomain structure containing two chitin-binding domains (ChBD1 and ... number of amino acid residues contribute to the binding of the substrate by hydrogen bonding and ⁄ or hydrophobic interactions Using the ligplot program [31], we investigated the specific interactions ... degree of sequence similarity The catalytic domain of family 19 chitinases comprises two lobes, each of which is rich in a-helical structure [16,17] In contrast, family 18 includes chitinases...
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Báo cáo khoa học: Dissecting the role of the N-terminal metal-binding domains in activating the yeast copper ATPase in vivo pptx
... domain–domain interactions are relieved by binding of the metal to the N-terminus of the ATPase To further study the role of the Ccc2 N-terminus in the overall function of the ATPase in vivo, we engineered ... distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson’s disease protein J Biol Chem 278, 32212–32218 40 Bal N, Wu CC, Catty P, Guillain F & Mintz ... cysteines are involved in binding Cu(I) [12,13] Ccc2 and the mammalian copper ATPases all possess a cytosolic N-terminus made of between two and six metal-binding domains (MBD) and each of these...
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Báo cáo khoa học: Mycobacterium tuberculosis ClpC1 Characterization and role of the N-terminal domain in its function ppt
... additional N-domain, homologous to the N-domains of ClpA or ClpB, and a linker domain homologous to, but half the size of, the linker domain of ClpB [19] The N-terminal region contains two 32-amino acid ... activity in preventing the aggregation of luciferase and reactivating heat-inactivated luciferase Deletion of the N-terminal conserved repeat I (amino acids 1–38) resulted in an alteration in the ... caused by deletion of amino acids 1–38 rendered ClpC1D1 prone to heat denaturation Deletion of N-terminal conserved repeat I along with the intervening amino acids linking it to N-terminal conserved...
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Báo cáo hóa học: " Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function" docx
... Diagram 1of the HRSV F protein Diagram of the HRSV F protein A linear representation of the HRSV F precursor protein (A2 strain) is shown Amino acid positions of individual domains are indicated ... These findings are intriguing given that these three cysteine residues are absolutely conserved not only in the F proteins of other Pneumovirinae, but also in the F proteins of the Paramyxovirinae ... reduced binding of all four antibodies, while mutation of cysteine mutants C382S, and C422S retained similar levels of antibody binding as the wildtype F protein (Table 1) As the same set of cysteine...
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Báo cáo y học: " Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes" potx
... by addition of uninfected cells and culture medium Lysates of equal numbers of cells, now containing equal percentages of infected cells, were prepared, and protein determination using standard ... (
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Báo cáo y học: "Role of the long cytoplasmic domain of the SIV Env glycoprotein in early and late stages of infection" ppt
... were compared in dividing and non-dividing cells (Fig 2) Similar levels of blue staining nuclei were observed in dividing and non-dividing cells in all samples, including cells infected by Ebola ... particle infectivity was determined by dividing the number of infected cells in wells inoculated with particles collected from supernatants of SIV infected non-dividing cells by the number in wells inoculated ... glycoproteins of retroviruses play an important role in the initial steps of infection involving the binding to cell surface receptors and entry by membrane fusion The Env glycoprotein also plays...
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The role of the n terminal extension domain of vamp4 in the regulation of its recycling to the TRANS GOLGI network
... preceding N-terminal domain Habc with preceding N-terminal domain Habc with preceding N-terminal domain Habc with preceding N-terminal domain Habc with preceding N-terminal domain Habc with preceding ... with preceding N-terminal domain Habc with preceding N-terminal domain Habc with preceding N-terminal domain Habc with preceding N-terminal domain Habc Habc with preceding N-terminal domain Habc ... motor proteins such as myosin, dynein or kinesin Kinesin and dynein are two major superfamilies of microtubule motor proteins, and myosin is responsible for the transport along actin tracks (Hammer...
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Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
... Huang S, Shao G, Liu L The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression J ... of the PR domain of human retinoblastoma protein-binding zinc finger protein (RIZ1) Int J Mol Sci 2008; 9: 943-50 21 Chen L, Ling B, Alcorn J, Yang J Analysis of the expression of human N-myristoyltransferase ... up-regulates insulin-like growth factor-binding protein (IGFBP2) and secreted glycoprotein SPARC (secreted protein, acidic and rich in cysteine) [23], both of which are highly expressed in malignant...
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Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
... bacteria gain access to integrins and inject CagA The basal injection model of CagA can also explain why H pylori does not cause more gastric damage in infected individuals and may only inject virulence ... (19 of 28) No ulcers were found in gerbils infected with the cagE mutant (0 of 27) or in controls (0 of 27) Intestinal metaplasia was also found in gerbils infected with the wild-type (14 of Type ... colonization of the corpus mucosa as a consequence of increased acid tolerance, or indirectly, via promoting enhanced in ammation Interestingly, infection of gerbils by H pylori led to the development of...
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Tài liệu Rethinking the Role of the State in Finance doc
... Rethinking the Role of the State in Finance Global Financial Development Report 2013 Rethinking the Role of the State in Finance Washington, D.C © 2012 International Bank for ... especially in providing supervision, ensuring healthy competition, and strengthening financial infrastructure Incentives are crucial in the financial sector The main challenge of financial sector ... measurement would involve the following determinations: in terms of producing information about possible investments and allocating capital, the financial 21 22 e n c h m a r k i n g b financial systems...
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Tài liệu Báo cáo khoa học: An autoinhibitory effect of the homothorax domain of Meis2 ppt
... containing two copies of the Hox ARE r3 element, which binds Hox and Pbx proteins (E) The effect of expressing increasing amounts of either the Meis2e splice variant or the AD deletion mutant of ... domain inhibits the activity of a linked AD To further delineate the region required for the inhibitory effect of the Hth domain, we created a series of GDB fusion proteins (Fig 4F) Deletion of ... creating a similar isoform It has been suggested that Pbx proteins are the major DNA-binding partners for Meis proteins, consistent with the presence of an intact Hth domain in the majority of...
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Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
... loops of a1-antichymotrypsin and heparin cofactor II contain leucine instead of arginine as P1 residues, which explains why the formation of a stable inhibitory complexes of these serpins is ... identity of (the) physiologically relevant inhibitor(s) of DESC1 remain uncertain Another commonly observed type of inhibition for serine proteinases is the inhibition by serine proteinase inhibitors ... proteinases mediate interaction of the two b-barrels, formation of the catalytic machinery and structures required for binding of the main chain of the substrate peptide and proper positioning of the scissile...
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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx
... characteristic signatures in the sequences are present in both proteins, tyrosinases and catechol oxidases; these include the six histidine residues involved in the binding of a pair of copper ions and ... have found two different genes in R solanacearum coding for putative PPO proteins that contain the typical signatures of tyrosinases, including the CuA and CuB binding sites to ligand the copper ... or absence of a seventh FEBS Journal 273 (2006) 257–270 ª 2005 FEBS histidine, adjacent to the sixth histidine involved in copper binding Preceding the sixth histidine (H3B according to the nomenclature...
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Tài liệu Báo cáo khóa học: The PAS fold A redefinition of the PAS domain based upon structural prediction ppt
... structure of the N-terminal PAS domain of human PAS kinase [1] have also been determined Recently, two further structures of PAS-like domains have been solved; the periplasmic ligand-binding domain of ... Structure and interactions of PAS kinase N-terminal PAS domain Model for intramolecular kinase regulation Structure 10, 1349– 1361 Zhulin, I.B., Taylor, B.L & Dixon, R (1997) PAS domain S-boxes in Archaea, ... containing multiple PAS domains, created a list of 958 PAS sequences The PFAM-alignment of the PAS domains was used as an initial alignment All amino acid residues extending from the N-terminal...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... domain extending into the intermembrane space In the third mutant (V79-G35) one might expect a protein to be inserted into the inner membrane, but it is missing a major portion of the domain localized ... protein is not assembled into the human complex I Inspection of the amino acid sequences of the known mammalian ESSS proteins reveals a high degree of conservation in the C-terminal domain (including ... protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible From the comparative studies with a series of Chinese...
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