regulation of salivary gland secretions
báo cáo khoa học: " Multi-modality curative treatment of salivary gland cancer liver metastases with drug-eluting bead " pot
... treatment of the disease recurrence with minimal invasion In conclusion, this case is a rare manifestation of adenoid cystic carcinoma of the salivary glands Additionally, it is an example of inoperable ... outcome of patients with malignant salivary gland tumors J Oral Maxillofac Surg 2005, 63:917-928 Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L: Major and minor salivary gland tumors ... cancer with features of primary disease from a cystic adenoid carcinoma of the salivary gland Neck CT was performed, which revealed a 1.5 cm hypodense area on the left submandibular gland (Figure 1),...
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Báo cáo khoa học: "Malignant mixed tumor in the salivary gland of a cat" potx
... GAH, Robinson M Mixed tumor of salivary gland showing histological evidence of malignancy in a cat J Comp Pathol 1975, 85, 77-85 17 Withrow SJ Cancer of the salivary glands In: Withrow SJ, MacEwen ... Carcinosarcoma of the submandibular salivary gland: clinical case and review of the literature J Otolaryngol 2005, 34, 66-69 Gnepp DR Malignant mixed tumors of the salivary glands: a review Pathol Annu ... Malignant mixed tumor in the salivary gland of a cat 333 adenoma, and several case reports describing such tumors are available; however, the incidence of this type of tumor in cats is believed...
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Báo cáo y học: "Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren''''s syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate" pptx
... identification of IL-18-producing cells in salivary glands of patients with SS and chronic sialoadenitis IL-18 expression in inflammatory foci On the basis of the histological evaluation of the salivary glands ... production of autoantibodies and cell-mediated mechanisms of tissue damage Although the presence of Th2 cytokines in salivary glands of patients with SS has been demonstrated [4,5], several lines of ... parameters of this condition Second, since SS is mainly a localized disorder, we examined the expression and distribution of IL-18 in salivary glands of SS Third, we characterized the nature of IL-18-producing...
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Báo cáo y học: "Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren’s syndrome" pptx
... the salivary glands of patients with SS There is clear evidence of an inflammatory environment with presentation of self-antigens characteristic of SS [22] that may permit the production of autoantibodies ... the CDR of VH and VL gene rearrangements of B cells obtained by minor salivary gland biopsies from two patients with SS [6] Detailed analyses of the frequency of occurrence and mutations of the ... each codon of productively rearranged VL genes of B cells isolated from peripheral blood and from the parotid gland of a patient with Sjögren’s syndrome The frequency of mutation of each codon...
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Báo cáo khoa học: "Primary pleomorphic adenoma of minor salivary gland in the parapharyngeal space" ppt
... Discussion Tumours arising in the minor salivary glands account for 22% of all salivary gland neoplasms [4] Majority of them are malignant with only 18% being benign Of all the benign tumours pleomorphic ... Repeat CT scan done after years of follow up does not show any evidence of residual or recurrent disease Though most of the benign tumours of the minor salivary gland in the oral cavity present ... Cawson RA: Tumour of the minor (oropharyngeal) salivary gland: demographic study of 336 cases J Oral Pathol 1985, 14:500-509 Cohen MA: Pleomorphic adenoma of the cheek Int J Oral maxillofac surg 1986,...
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Báo cáo y học: "Multilevel examination of minor salivary gland biopsy for Sjögren''''s syndrome significantly improves diagnostic performance of AECG classification criteria" ppsx
... results and diagnostic accuracy No of patients aThe focus score (FS) is the number of inflammatory infiltrates of at least 50 cells present in mm2 of salivary gland area bVery low specificity is ... of grade I (FS = 0), 44.4% of grade II (0 < FS < 1), 88.8% of grade III (1 ≤ FS < 2), and 40% of grade IV (FS ≥ 2) biopsies [13] The authors of that paper recommended that multiple sections of ... increasing the cutoff value of positive FS resulted in a substantial reduction of specificity [16] To explain the increased specificity observed with examination of multilevel salivary gland biopsies,...
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Báo cáo y học: "B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren''''s syndrome" ppt
... matched- Page of (page number not for citation purposes) pairs test with use of Analyse-it software (Analyse-it Software Ltd, Leeds, UK) for Microsoft Excel Results BAFF expression in salivary gland ... polyclonal rat immunoglobulin Page of (page number not for citation purposes) salivary glands ELISA results of BAFF secretion by salivary epithelial cells from minor salivary glands Results are from eight ... synoviocytes of patients with RA [45] Our results agree with findings of the absence of a major role of TNF-α in the pathogenesis of pSS, as illustrated by the lack of efficacy of TNF-α blockers...
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Báo cáo y học: "Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein" pptx
... Mathison et al.: Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein Journal of Inflammation 2010 ... anti-inflammatory agents The Neuroendocrine Axis The existence of salivary- derived, systemically acting, anti-inflammatory factors and the regulation of salivary gland function by the sympathetic nervous system ... Salivary Gland Extracts: SGP-T On the basis of the findings that salivary glands participate in modulating systemic inflammatory responses, bioactive factors were sought in saliva Extracts of submandibular...
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Regulation of S Phase
... initiation (Fig 1) The chromatin loading of MCM2-7 depends on the loading of Cdt1 and Cdc6, which in turn depend on the loading of ORC This step- Fig Regulation of the pre-RC The pre-RC functions to ... is also co-dependent with Cdc45, Dpb11, and Sld3; binding of any of Regulation of S Phase 47 these proteins depended on the presence of the others (Kubota et al., 2003; Takayama et al., 2003) ... characterization of Xlinked mutants of Drosophila melanogaster which are sensitive to mutagens Genetics 84:485–506 Brown GW, Kelly TJ (1999) Cell cycle regulation of Dfp1, an activator of the Hsk1...
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Regulation of navigation and vessel-source pollution in the Northern Sea Route - Article 234 and state practice
... accompaniment of the CCGS John A 40 41 42 43 See Arts and 10 of the NSR Regulations; Arts 14 and 15 of the Economic Zone Edict; Arts and 15 of the Environmental Edict; and Art 11 of the Decree of the ... the Decree of the Council of Ministers of the USSR, June 1990, ‘On Measures of Securing the Implementation of the Edict of the Presidium of the USSR Supreme Soviet of 26 November 1984 “On Intensifying ... the NSR Regulations, as stated in Article (quoted above), include regulation of navigation, on the basis of non-discrimination These regulations are to apply to all vessels, regardless of nationality,84...
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Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
... repression of their target genes Indeed, several examples of feedback regulation that involve miRNAs have been reported Below, we attempt to summarize our recent understanding of feedback regulation of ... finding that TPAinduced upregulation of miR-34a depends on the activation of the ERK signal cascade and that miR-34a downregulates MEK1, which is one of the main regulators of ERK signaling, indicates ... expression of estrogen receptor-a (ERa) is autoregulated by miR-18a, -19b and -20b, which in turn are upregulated by the activation of ERa This mechanism of regulation provides a wide range of coordinated...
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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc
... direct dephosphorylation of Ser112 and negative regulation of the ERK pathway via p38 MAPK, both of which lead to impaired phosphorylation of Ser112 [70] After dephosphorylation of Ser112, Ser136 becomes ... translocation of Bax and Bad to mitochondria independently of caspase activation [77,87] Phosphorylation of caspases Phosphorylation of caspases switches the cellular apoptotic signal on and off Caspase ... regulating the activity of an isoform of PP1, PP1a [3] Similarly, activation of caspase-8 and -3 is regulated through their phosphorylation and dephosphorylation Phosphorylation of caspase-8 at Tyr397...
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Tài liệu Regulation of cancer cell metabolism docx
... splicing The inclusion of exon in the PK mrnA leads to translation of the PKM1 isoform, whereas inclusion of exon 10 produces PKM2 (ReF 71) MyC upregulates the expression of heterogeneous nuclear ... required for the assembly of the cytochrome c oxidase complex of the electron transport chain61 Thus, the loss of p53 might also be a major force behind the acquisition of the glycolytic phenotype ... Publishers Limited All rights reserved REVIEWS of genes that increase glucose metabolism and reduce mitochondrial respiration One of these genes encodes an isoform of PDK (PDK4) that has the same function...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... general context of a promoter appears to be relevant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent transcription Deregulation is ... promoters, mutation of the CHR leads to a more pronounced deregulation than the alteration of the CDE [40] Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein ... investigating downregulation of the cyclin B2 promoter is that after deletion or mutation of constitutively activating sites, such as the destruction of CCAAT-boxes, small levels of reporter activity...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have ... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... development Analyses of AP-2a-null mice have demonstrated that AP-2a is a fundamental regulator of mammalian craniofacial development AP-2a knockout mice die perinatally with craniofacial defects,...
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Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc
... strict regulation becomes necessary for the correct expression of HSF2 target genes Indeed, when miR18-mediated regulation of HSF2 was disrupted in male germ cells in vivo, expression of HSF2 ... modifications of HSFs in different tissues and organs during development of an organism or differentiation of certain cell types This lack of knowledge severely hampers the understanding of the physiological ... HSEs, the Regulation of HSFs HSFs regulate different types of target genes that are involved in a broad range of cellular processes Therefore, the expression and activity of HSFs need to be under...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... the regulation of miR-27 expression Our data suggest that the miR-27 gene family is potentially an important class of negative regulators of adipogenesis and may play a role in the regulation of ... relevant role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 expression levels of both miR-27a ... suggesting that downregulation of miR-27 is not sufficient to promote adipogenesis We performed a time course study to gain further insights into the role of miR-27 during different stages of adipogenesis...
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Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx
... molecular weights of 161.8, 28.2 and 13.2 kDa, respectively Regulation of cathepsin B activity The formation of the cathepsin B ⁄ cystatin C complex was seen as a shift of the elution peak of cathepsin ... the presence of various concentrations of 2A2 mAb The binding of 2A2 mAb was followed by native gel electrophoresis Increasing the concentration of 2A2 mAb at a fixed molar ratio of cathepsin ... the conformational changes of the active site of cathepsin B, the results obtained in the present study provide a specific mechanism for the regulation of the activity of cathepsin B, which can...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx
... level of MLL1 mRNA Interestingly, upon downregulation of MLL1, E2-mediated upregulation of HOXC13 was slightly decreased (Fig 4A, lane 3) Similar results were observed for MLL2 and MLL4 downregulation ... ERE2, ERE3 and ERE4 of the HOXC13 promoter As seen in Fig 5A, no significant binding of actin was observed in any of the EREs, irrespective of the absence and presence of E2 Binding of ERa and ERb ... amount of binding of MLL1 was observed in ERE3, no significant E2-dependent binding of any of the MLLs was observed in ERE3 and ERE4 (Fig 5A, lanes 5–8) Significant amounts of constitutive binding of...
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Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt
... with dCTP (grey) and dTTP (yellow, cyan and magenta) (B) Stereoview of a superposition of one of the subunits of the E138A variant of E coli dCTP deaminase in complex with dTTP (yellow; chain B), ... Mutational analysis of amino acid residues involved in dTTP regulation of dCTP deaminase The design of the mutant enzymes H121A and V122G was inspired by the results from analysis of crystal structures ... roles of His121 and Val122 in catalysis and regulation of dCTP deaminase Removal of the imidazole ring in H121A was anticipated to relieve or reduce inhibition by dTTP by preventing expulsion of...
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