regulation of cellular morphology and function

Regulation of subcellular localization and functions of RGK proteins by 14 3 3 and calmodulin

Ngày tải lên : 14/09/2015, 18:28

... relocalization of RGK proteins by 14-3-3 3-3A Regulation of localization of Kir/Gem by 14-3-3 3-3B Regulation of localization of Rad by 14-3-3 3-3C Regulation of localization of Rem1 by 14-3-3 3-3D Regulation ... of work Kir/Gem, Rad, Rem and Rem2 (RGK) are members of a distinct family of Ras GTPases Two important functions of RGK proteins are the regulation of voltage gated calcium channels (VDCCs) and ... localization of Kir/Gem W269G and mutants by 14-3-3 3-5B Binding of 14-3-3 to Kir/Gem mutants lacking CaM binding 3-5C Regulation of localization of Rad L281G and mutants by 14-3-3 3-5D Regulation of localization...

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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx

Ngày tải lên : 06/03/2014, 01:20

... dysfunction SH2 domain dysfunction SH3 and SH2 domain dysfunction Deletion of N-terminal, SH3 and SH2 domain of active n-Src Deletion of N-terminal, SH3 and SH2 domain of kinase-dead n-Src of ... ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21] After PP2 application, peak amplitudes of ... NR2A C-tail is independent of its kinase activity, and that dysfunction of the SH3 and ⁄ or SH2 domains does not affect this interaction The regulation of NMDARs by Src and other SFKs [7–12] has...

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Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"

Ngày tải lên : 25/10/2012, 11:18

... between NS1 and PARP Since PARP is active at the site of single strand DNA breaks, and single-strand nicking is a known activity of NS1 protein, it is likely that NS1 is nicking the cellular DNA, ... case of specific integration of AAV We present here evidence suggesting that NS1 is attached to DNA in a covalent manner, and that both DNA-helix distorting and single strand nick forms of DNA ... multiple types of DNA lesions and that are often caused by collapsed replication forks (44) NS1 could easily cause double strand breaks through the simple mechanism of nicking both DNA strands a short...

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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

Ngày tải lên : 08/03/2014, 08:20

... establish the importance of GSK3 in the acute regulation of glucose transport in terms of its regulatory control of GS in muscle and fat cells we have investigated the effects of Li and the anilinomaleimide, ... elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and SB-415286 on cell signalling events we assessed their effects and that of insulin on p70S6K, PKB, ... and myotubes with antibodies against GSK3a and b Fig 1B shows that whilst preadipocytes express both GSK3 isoforms, the abundance of the b isoform declines by 85%, whereas that of the a isoform...

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Characteristics and Regulation of Exempt Institutions and the Implications of Removing the Exemptions pptx

Ngày tải lên : 15/03/2014, 09:20

... corporation Office of the Comptroller of the Currency Office of Thrift Supervision savings and loans Securities and Exchange Commission Summary of Deposits Department of the Treasury This is a work of ... availability and allocation of credit, the stability of the financial system and the economy, and the safe and sound operations of such institutions To determine the number of certain types of financial ... other hand, accounted for about percent of credit card loans, but they accounted for less than percent of construction and land development loans and almost none of any other type of loan Grandfathered...

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Báo cáo khoa học: E2A participates in a ﬁne control of pre-mature B-cell apoptosis mediated by B-cell receptor signaling via transcriptional regulation of survivin, IAP2 and caspase-8 genes pot

Ngày tải lên : 16/03/2014, 04:20

... apoptosis of E2A-/- is brought about by increased amounts of survivin and IAP2, and reduced activity of caspase-3 Next we examined the effect of PMA/ionomycin treatment on cellular protein levels of ... factors and CAD/ICAD) mediated by PMA/ionomycin results in suppression of activities of caspase-3, caspase-8 and caspase-9, and alterations in the protein levels of survivin, IAP2 and ICAD (and probably ... control of pre-mature B-cell apoptosis by E2A B C Fig Analyses of apoptosis in E2A)/) (A) Effects of PMA/ionomycin and etoposide treatments on cell-cycle distributions of DT40 and E2A)/) DT40 and...

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Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot

Ngày tải lên : 28/03/2014, 22:21

... levels of regulation of cytokine production Itk and the regulation of cytokineproducing innate T-cell populations The contributions of TFKs to peripheral T-cell activation and effector function ... regulators of cytokine production downstream of TCR stimulation Such studies reveal that mutation of the TFKs can profoundly inﬂuence the development, differentiation and function of cytokine-producing ... Cytokine regulation by Itk and Rlk ⁄ Txk J Gomez-Rodriguez et al common effects may involve activation of NFAT transcription factors, as seen for Th2 and Th17 cytokine regulation, or the regulation of...

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Báo cáo khoa học: Galanin-like peptide and the regulation of feeding behavior and energy metabolism pptx

Ngày tải lên : 29/03/2014, 21:20

... alternate transcript of the GALP gene Further elucidation of the function of GALP and alarin will provide the necessary basis for the treatment and prevention of obesity and related disorders ... identiﬁcation of a speciﬁc receptor for GALP is of considerable importance if the physiological functions and mechanism of action of GALP are to be fully understood Little is known about the role of alarin, ... rat brain Injection of GALP into the third ventricle induces c-Fos expression, a marker of cell activation, in the horizontal limb of the diagonal band of Broca, POA, ARC and median eminence...

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Báo cáo khoa học: Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 ﬁbroblasts doc

Ngày tải lên : 30/03/2014, 15:20

... phosphorylation of IjB and activation of NF-jB Thus, the effect of longterm exposure to TNFa, and most probably to H2O2, on taurine uptake could involve modulation of the NF-jB mediated regulation of the ... of TauT (Fig 7B) and most probably as a result of restoration of normal cellular taurin level Ó FEBS 2004 TauT expression, activity and subcellular localization (Eur J Biochem 271) 4657 Subcellular ... stimulation of PKC and PKA Stimulation of PKC and PKA has no detectable effect on the expression of TauT in NIH3T3 ﬁbroblasts (data not shown) and most probably does not involve modulation of the...

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báo cáo hóa học:" Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients" pdf

Ngày tải lên : 20/06/2014, 07:20

... expression levels of 17 of the highest upregulated and 18 of the highest downregulated miRNAs in undifferenThe comparative expression levels of 17 of the highest upregulated and 18 of the highest ... expression of pluripotency markers Oct4 and Nanog and increased expression of differentiation markers Ncam1, Eno3 and Afp (Figure 4) While eIF6 expression was unaltered, that of Drosha and Dicer ... gene expression in differentiated NTera2 and 2102Ep cells The expression of markers of pluripotency (Oct4 and Nanog) and of endoderm (Afp), ectoderm (Ncam1) and mesoderm (Eno3) differentiation is...

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Báo cáo sinh học: "Co-regulation of mouse genes predicts function" pps

Ngày tải lên : 06/08/2014, 18:21

... vocabulary consisting of three structured networks of defined terms that are used to describe the attributes of gene products in terms of Molecular Function, Biological Process and Cellular Component ... geneticists to test some of the predictions that come out of the current study And he wants to understand more about the correlation between co -regulation patterns and gene function “As a yeast researcher ... Ontology to provide preliminary functional annotation for thousands of genes of unknown function is a major advance.” The Hogenesch group is also creating an atlas of mammalian genes [5] “This approach...

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Báo cáo khoa học: " Water flux in boreal forest during two hydrologically contrasting years; species specific regulation of canopy conductance and transpiration" pps

Ngày tải lên : 09/08/2014, 04:20

... calculated as a simple linear function of short-wave radiation with intercept and slope parameters of 23.8 and 0.77 W m respectively, as found , -2 over a stand of similar age and species composition ... biomass functions of Marklund [26] The species foliage mass represented 14 and 86 % of the total actual stand foliage mass for pine and spruce, respectively Using the current basal area for stand and ... the goodness of fit were standard error of the estimate and coefficient of deter- ) mination (r 2.5 Effect of soil drought on water and carbon fluxes - quantification The effect of drought on...

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Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx

Ngày tải lên : 09/08/2014, 06:23

... and induces the expression of IFN-responsive genes in SOCS3- Regulation of lipopolysaccharide (LPS) signaling by STAT3 (signal transduction and activators of transcription 3) and suppressor of ... system, reduced thickness of the cerebral cortex and disorganization of the subcommissural organ [55] Thus, SOCS7 is important in the functioning of neuronal cells SOCS1 and innate immunity SOCS1 ... activators of transcription 1) pathway SOCS1 is probably induced by STAT1 and NF-κB, and then suppresses both STAT1 and NF-κB One possible mechanism of NF-κB suppression is the induction of degradation...

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báo cáo khoa học: "The grapevine guard cell-related VvMYB60 transcription factor is involved in the regulation of stomatal activity and is differentially expressed in response to ABA and osmotic stress" ppt

Ngày tải lên : 11/08/2014, 11:21

... activity of both VvMYB30 and VvMYB60 promoters A region of approximately kb located upstream of the ATG codon of VvMYB30 and VvMYB60 was fused to the b-glucuronidase (GUS) reporter gene and the ... sensitivity of guard cells to ABA [10] We used the atmyb60-1 allele to investigate the role of VvMYB60 in the regulation of stomatal activity and to Page of 14 explore the conservation of the MYB60 ... sealed chamber in the presence of 100 ml of commercial bleach and ml of 37% HCl, and germinated in Petri dishes containing Murashige and Skoog medium, 1% w/v sucrose and 0.8% w/v agar Plants were...

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báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx

Ngày tải lên : 11/08/2014, 12:20

... kinases, respectively The persistent upregulation of VEGF and PDGF in the majority of RCCs through inactivation of VHL fosters angiogenesis and growth of these tumors The multitargeted tyrosine ... genomics analysis of these functional RNAi datasets in breast and ovarian cancer, we have identified regulators of mitotic arrest and ceramide metabolism as mediators of taxane resistance and confirmed ... dysfunction of the Von Hippel Lindau tumor suppressor gene (VHL) in the majority of cases [5] The product of the VHL gene (pVHL) is a component of a ubiquitin ligase complex that mediates the cellular...

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Báo cáo y học: "Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells" docx

Ngày tải lên : 13/08/2014, 01:21

... activated, or partially activated After days of stimulation with μg/ml PHA-P in the presence of IL2, Nef enhances cellular activation of transduced and bystander CD4 and CD8 T cells in a manner that is ... may involve upregulation of tat-SF1, U1 SNRNP, and IRF-2 mRNAs [59] and enhancement of NFAT activity [20,23], thereby increasing the amount of viral particles produced per cell As we and others ... with a-CD3-FITC and a-CD25-PE or a-CD3-FITC and a-HLA-DRPE or isotypic controls and analyzed by flow cytometry %CD25+, %HLA-DR+, and CD25 and HLA-DR median fluorescence intensity of the CD3+ population...

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Báo cáo y học: "Non invasive in vivo investigation of hepatobiliary structure and function in STII medaka (Oryzias latipes): methodology and applications" ppsx

Ngày tải lên : 13/08/2014, 13:20

... structure and function at virtually all levels of organization, from subcellular to gross anatomical [12,47] Exhibiting no expression of leucophores and melanophores, and minimal expression of xanthophores ... applied to understanding the mechanisms and modes of actions involved in xenobiotic induced injury, a betterment of our comparative understanding, and ability to investigate and interpret hepatotoxicity ... and then give specific examples of the successful application of these methodologies to the evaluation of hepatobiliary structure, function, development, and xenobiotic response, in both 2D and...

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Báo cáo y học: "A comparative approach for the investigation of biological information processing: An examination of the structure and function of computer hard drives and DNA" doc

Ngày tải lên : 13/08/2014, 16:20

... The structure and function of this information-processing complex are of great interest in the study of both normal cellular functions (such as differentiation and metabolism) and pathological ... header portions of the genetic files offer a higher degree of freedom in terms of active control then the preset headers of the CHD The Page 18 of 29 D’Onofrio and An Theoretical Biology and Medical ... understanding the context of the operating system The parallel nature of cellular computing reinforces the concept of robustness and redundancy in cellular information processing and function; ...

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Báo cáo y học: "Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspect" potx

Ngày tải lên : 14/08/2014, 08:21

... first base of the first complete codon, and the last base the last of the final complete codon The first and last codons were then removed from each exon, and remaining codons within 70 bp of the ... number of synonymous SNPs per synonymous site The numbers of synonymous sites and non-synonymous sites were calculated using the method of Miyata and Yasunaga [74] The ratio for a set of proteins ... "inverse relationship between evolutionary rate and age of mammalian genes" is an artifact of increased genetic distance with rate of evolution and time of divergence Mol Biol Evol 2006, 23:1-3 32...

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Báo cáo y học: "Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristic" doc

Ngày tải lên : 14/08/2014, 18:20

... mDCs and moDCs [12] and moDCs and KG-1 cells [13], but no studies have compared the proteomes of all three cell types In this study we compare the proteomes of mDCs, moDCs and KG-1 cells, and ... cell functions The functional relevance of differentially expressed proteins was confirmed by analysis of surface marker expression, cytokine profile, endocytic and T cell activation abilities of ... presence of × 104 irradiated (3,000 rad 137Cs) immature mDCs and interactions Figure Cytokine expression profiles of cells Cytokine expression profiles of cells Cytokine production by mDCs and the...

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