... Localgovernment reform since 1997 With the advent of Tony Blair’s rst administration in 1997, the key plank oflocalgovernment reform was Best Value. Under theLocalGovernment Act (1999), councils ... imposed ‘caps’ on local expenditure. With the New Labour government (inuenced by the concepts ofthe third way), the emphasis seemed to be much more on reforming local government rather than constraining ... national government has raised aggregate levels of funding to local government, the distribution ofthe increases has varied with a general favouring ofthe metropolitan authorities in the north...
... satisfy the open set condition (see [2]), so the studying thelocal dimension of this measure in this case is verydifficult. Another convenient way to look at à is as the distribution ofthe random ... al. / VNU Journal of Science, Mathematics - Physics 25 (2009) 57-68 65From (13), (14) and (15), the assertion ofthe corollary follows.2.2 The proof ofthe main theoremLemma 2. Let x = (x1, ... , xn).+) If yn−3= 0 then the form (4) is similar to the form (3). Thus, by repeating about argumentwe get the proof ofthe proposition in this case of n.ii) The case n is odd.Assume...
... at the time of execution, and will reflect the terms ofthe contracts and other characteristics. 5 The subsidy cost for TARP support of FHA Refinance guarantees is estimated with the ... UNDERLYING THE 2012 SUBSIDY ESTIMATES—Continued(In percentages, unless noted otherwise)Composition of SubsidyLoan CharacteristicsDefaults, net of recoveriesInterest Fees All otherLoan ... 100.00Department ofthe TreasuryDepartmental Offices: Troubled Asset Relief Program, Housing Programs FHA Refi Letter of Credit 5 5.34 5.34 30 5.18 5.34 15.57Department of Veterans AffairsBenefits...
... ongoing initiatives in the FATF and the OECD, the Report ofthe OFCs Working Group ofthe Financial Stability Forum (FSF) has made recommendations to enhance OFCs’ observance of international standards ... characterized by the high mobility of funds and the rapid development of new payment tools. To secure the benefits ofthe international financial system, we, the Finance Ministers ofthe G-7 countries, ... access to the financial system. If there is obscurity about their ownership, banks and other financial institutions may not be able to discover the identity ofthe beneficiary ofthe account...
... altered [88].These results shed light on the regulatory mechanismssteering the developmental expression pattern of HSF2, and they also provide the first example of involvement of miRNAs in the HSF ... HSF4promotes the DNA-binding activity of another mem-ber ofthe HSF family, through modulating the chro-matin status [106].Conclusions and perspectivesNearly 10% ofthe genes in the human genome ... development of the lens and maintenance ofthe olfactory epithelium [102]. The first evidence for a developmental function of HSF4 was provided by population genetic studies wheremutations ofthe Hsf4...
... lip prevented binding ofthe C-terminalresidues over the active site, or the absence of the C-terminal residues caused the movement ofthe lip(Fig. 1B). In addition, the Cachain between aminoacid ... mechanism of regulation that generates the apparently attractive feature of anincrease in both S0.5and the sigmoidity ofthe satura-tion curve for dCTP in response to the binding of dTTP to the ... rates) prior to and after the transition ofthe enzyme to amore active form, respectively, t is the time and s is the lag-time. The rate constant, k, for the activation ofthe enzyme isobtained...
... conditions. The ectodo-mains of both monomers in the dimer are required forthis effect, suggesting that the epitope tag of onemonomer is masked by the ectodomain ofthe othermonomer in the dimer, ... GST-LAR(Fig. 2D). The tryptic cleavage sites were localizedthroughout the cytoplasmic domains of these fourRPTPs. One site was conserved in three ofthe fourRPTPs at the )5 position relative to the TyrTrpPro-motif. ... Takentogether, these limited tryptic proteolysis suggest thatoxidation induced a change in conformation of the intracellular domain of this panel of RPTPs.A functional consequence ofthe change...
... determine the format ofthe notification. EN 27 EN of the functioning ofthe rules in this Regulation and the experience acquired in applying them, including: (a) the extent to which the designation ... of revocation shall put an end to the delegation ofthe power specified in that decision. It shall take effect the day following the publication ofthe decision in the Official Journal ofthe ... threshold of EUR 500 million or, in the Member States where the Euro is not the official currency, the corresponding value in the national currency on the date ofthe entry into force of this Regulation. ...
... connected to the DEC1 E-boxes(Fig. 2), while deletion ofthe Orange domain ( DEC1DOr-ange) had no effect on the suppressive activity, indicating the importance of t he bHLH region of DEC1. The HXXXXXXXR ... conclude that the basic region, p artic-ularly the conserved A rg65, but not His57, is essential for the suppressive activity of DEC1.Determination ofthe binding domain of DEC1 to BMAL1 The interaction ... that the C-terminal region, including the PAS-Bdomain of BMAL1, is required for the binding to DEC1,Fig. 4. Identification ofthe domain of D EC1that interacts with BMAL 1. Interactions of various...
... solution. On the other hand, the acceleration ofthe sliding velocity (and the lower number of stops) of thin filaments could be related toa diminution o f the load in the actin–myosin interface. The ... properties of an additional naturalcomponent ofthe thin filament framework, nebulin.Nebulin spans the entire length of thin filaments and iscapable of modulating the r ate of formation ofthe a ... in the absence of Ca2+, inde-pendent ofthe addition of T800. This result, togetherwith the fact that T800 increased the average andmaximum velocity v alues of moving filaments, both inthe...
... success of national responses to the DESD. The most crucial element to the Decade’s success is the scope ofthe human resources brought together, including these enthusiastic volunteers and others ... on the DESD for several years and held its regional launch ofthe Decade in Lithuania, in March of 2005. The UNECE region has the following as the aim of their implementation strategy: The ... objectives ofthe Decade, and its relationship to other key education movements. It emphasizes the importance of partnership in the eventual success ofthe Decade and outlines how these might...
... clarify the distinct roles of Sp1 and Sp3 atdifferent phases ofthe cell cycle. The transcriptional cofactor p300 is coprecipitated incomplexes with Sp1 [38]. The activation ofthe promoter of thegeneforp21Waf1/Cip1by ... [11,12]. Furthermore, p300appears to play a critical role in progression ofthe cellcycle and the differentiation of cells [11,12]. The methylation of DNA plays a role in the regulation of gene ... Characterization ofthe promoter ofthe mouse Dnmt1 gene. (A)Transcriptional activity ofthe mouse Dnmt1promoterinNIH3T3cells. The top diagram shows the mouse Dnmt1geneandthelowerdiagram shows the variously...
... notinto the incubation medium as this would have required the use of a modified incubation medium containing either ablocker of endocannabinoid uptake or BSA [22]. Further-more, detection of these ... ofthe enzymes mostly involvedin endocannabinoid inactivation. The heterogeneous distri-bution of CB2receptors among cells ofthe immune systemsuggests that these receptors might exert their ... against asequence between the N-terminal and the first trans-membrane domain ofthe protein ofthe human and ratCB2receptor. The specificity ofthe CB1and CB2antibodieswas described in...