regional treatment of other tumors
advances in cancer research
... IFN Treatment of Other HPV-Associated Tumors 99 102 106 Chapter Regional Treatment of Other Tumors I I1 I11 IV V VI VII VIII IX Intra- and Peritumoral IFN Therapy Local Treatment ... XVI Systemic Treatment of Brain Tumors XVII Systemic Treatment of Neuroblastoma XVIII Systemic Treatment of Prostate Carcinoma XIX Systemic Treatment of Carcinoma of the Uterine ... Neurological Tumors Local Treatment of Head and Neck Tumors Local Treatment of Lung Tumors Local Treatment of Bladder Tumors Intraarterial IFN Therapy 108...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... the OH group of the tyrosine amino acid residue are observed in three EcRs (Tyr408 of HvEcR, Tyr296 of BtEcR and Tyr427 of TcEcR), illustrating conservation of binding characteristics of the molting ... interaction of USP with EcR is isoform-dependent [145] The phosphorylation of USP inhibits ecdysteroid biosynthesis in M sexta [146] and is required for normal induction of expression of the 20E ... of DmEcR-A [139] and to that of the EcR-A of M sexta (MsEcRA) [156], and the amino-terminus of AmEcR-A3 is similar in size to that of DmEcR-B2 [139] The DBD and LBD of AmEcRs share 86% and 64%...
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Báo cáo khoa học: Cloning of a rat gene encoding the histo-blood group A enzyme Tissue expression of the gene and of the A and B antigens potx
... group enzyme Examination of the tissue distribution of the corresponding mRNA and of the A and B antigens in the BDIX strain of rat was performed, allowing some aspects of the ABO genetics in this ... sequences Of note, the presence of a conserved potential N-glycosylation site at the beginning of the catalytic domain Previous studies of the human ABO transferases underscored the major importance of ... presence of the acceptor Values of the specific activities are given in pmolÆh)1Æmg protein)1 of either [14C]galactose or [14C]N-acetylgalactosamine transferred tion of cDNA and lack of contamination...
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nuclear envelope dynamics in embryos and somatic cells
... main structures (Fig 1), each of which are reviewed in more detail in other Chapters of this volume The first of these, the nuclear lamina consists of lamins, proteins of the intermediate filament ... otefin share a region of sequence similarity of approximately 50 amino acids called the LEM-domain.10,12 Nurim, another protein of the INM, was identified using a visual screen of a green fluorescent ... commonly composed of one or two short stretches of basic amino acids (reviewed in ref 20) The targeting of integral membrane proteins, however, often requires several regions of the protein, and...
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báo cáo hóa học: " All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2" potx
... elements (RAREs) located in regulatory regions of target genes [11] Other signalling pathways may also mediate the effects of retinoids and, in the context of the present work, it is particularly relevant ... medium supplemented with 0.5% FBS ATRA treatment did not induce morphological features of differentiation Page of (page number not for citation purposes) Journal of Neuroinflammation 2007, 4:1 Transient ... co-amplification of 18 S RNA, respectively Normalized density ratio of COX-2 over either α-actin or 18 S RNA is indicated for each band Page of (page number not for citation purposes) Journal of Neuroinflammation...
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Báo cáo hóa học: " Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma" potx
... with 15 mM of MgCl2, 0.8 mM of dNTP mix, 0.3 µM of each forward and reverse primers and 0.5 U of HotStarTaq® DNA Polymerase (Qia- Page of (page number not for citation purposes) Journal of Occupational ... (12 of 17) of the formalin-fixed samples, and 38% (10 of 26) of the Bouin's fixed tissues Thus, the VHL gene was entirely sequenced (ie 100% of the coding sequence analysed) for a total of 26 ... compare exposed and non exposed cases of clear cell RCC in terms of prevalence of mutations in both groups Page of (page number not for citation purposes) Journal of Occupational Medicine and Toxicology...
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Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection" doc
... (Figure 2b, c) Another indicator of immune activation in palatine tonsil was revealed by the identification of clusters of T cells that had invaded the basal and suprabasal layers of stratified ... into the design of the experiments, the interpretation of the data and the overall organization of the text PJS was responsible for the broad design of the study, processing of the tonsil tissue ... immunocytochemistry and completion of the submitted version of the text All of the authors made meaningful contributions to the process of revising draft versions of the text 10 11 12 13 14 15 Acknowledgements...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... coupling of bone resorption and bone formation is critical during the normal process of bone remodeling, and the dysregulation of this coupling results in the development of a range of pathological ... expression of ephrinA1 specifically in bone metastases [93] Giant cell tumors of bone are primary bone tumors associated with osteolysis Microarray analysis comparing primary and recurrent giant cell tumors ... recurrent tumors [94] This decreased expression was confirmed at the protein level by immunohistochemistry, implicating EphA1 in the progression of giant cell tumors of bone 270 CONFLICT OF INTERESTS...
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Báo cáo y học: "Phobic memory and somatic vulnerabilities in anorexia nervosa: a necessary unity" ppsx
... activation of K+ channels may be among other regulators of pacemaker activity of interneurons that govern the quasi-periodic repetition of group activities and EEG synchronization The excitability of ... distribution of SK channels and the fundamental role of K+ currents in controlling membrane excitability of diverse organ systems pose a question of their role in regulation and dysregulation of the ... studies of EEG in behavioral disorders of childhood, eating disorders were not even mentioned [102] However, the absence of clear indices of epileptiform abnormalities is not a critical violation of...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... Analysis of V gene sequences indicated that a Two other areas, shown in Fig (e and f) appeared to be made up entirely of B cells because there was no positive staining for any of the other cell ... [7,8] demonstrated the presence of autoantibody-producing B cells in the spleen of an SLE patient by analysis of hybridomas generated from splenic B cells The aims of the present study were to identify ... encountered a vast range of antigens, including many environmental antigens, over a prolonged period of time, whereas germinal centres (GCs) in the spleen or lymph nodes provide a profile of B cells that...
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Báo cáo khoa học: "Probing the link between oestrogen receptors and oesophageal cancer" ppt
... Page of 10 Rashid et al World Journal of Surgical Oncology 2010, 8:9 http://www.wjso.com/content/8/1/9 Page of 10 Figure Pathways of oestrogen action The ERa/ERb is a simplified schematic of the ... [48] The effects of various doses of E on in vitro growth of these cell lines has established that one of the cell lines (ES-25C) showed significant inhibition at concentrations of 10 -10 and 10 ... and ERs in the pathogenesis of oesophageal cancer has not been reported to date but may introduce another level of complexity in the contribution of ER in the aetiology of this disease Potential...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... determined, but the role of TLR activation has been Page of (page number not for citation purposes) investigated in other models of autoimmunity (discussed below) The form of apoptotic versus necrotic ... models of autoimmunity The importance of TLR activation has been studied in several animal models of lupus In the MRL/lpr mouse, deletion of the fas gene leads spontaneously to the development of ... duplication of TLR7 [60] Originally identified in BXSB mice, Yaa accelerates autoimmunity in this and other murine models of SLE In B6 FcγRIIb-deleted mice (another murine model of lupus), Yaa...
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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf
... sites of potential antigen exposure Uptake of harmless environmental or self-antigens (often products of normal cellular senescence, apoptosis or necrosis) results in low-level migration to regional ... lymphocytes Uptake of pathogenic antigens in the presence of other stimulatory signals induces DC maturation, manifested by downregulation of phagocytic receptors and upregulation of antigen-presentation ... downregulation of an additional CTLR, DCSIGN, indicating a more global defect in expression of members of this family Interestingly, we detected no decrease in surface expression of CR3 or any of the...
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Báo cáo y học: "NOD-like receptors and inflammation" pot
... promotes formation of this inflammasome [85] The appearance of flagellin within the cytoplasm, which announces the arrival of a virulent form of bacteria, prompts the development of both an adaptive ... All of these SNPs affect the LRR region of the NOD2 protein, resulting in defective sensing of MDP [121] The inability of mutant NOD2 to detect microbial constituents translates into a lack of ... versus 31%), in cohorts of patients who were broadly matched for clinical indices of severity of disease This may represent the consequences of decreased intracellular sensing of bacterial products...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... al The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to ... T, Chan JH, Guiducci C, Coffman RL: Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms Eur ... inflammatory and regulatory roles in a murine model of lupus Immunity 2006, 25:417-428 Barrat FJ, Coffman RL: Development of TLR inhibitors for the treatment of autoimmune diseases Immunol Rev 2008, 223:...
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Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
... development of proteinuria in the mice, a measure of kidney disease, was therefore assessed Over the course of 12 months, of 10 (50%) pristane-treated WT mice developed proteinuria, whereas none of 10 ... the development of kidney damage in the pristane model of SLE Because the development of kidney disease in the pristane model is not as severe as in other spontaneous models of SLE, such as the ... hypergammaglobulinemia characterized by the production of high levels of IgG as well as increased levels of IgM [39] Importantly, pristane induces the production of high levels of IgG2a, a pathogenic isotype that...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... ever present threat of microbial pathogens The recent discovery of the TLR family now permits a detailed evaluation of the molecular pathogenesis of sepsis The availability of human and microbial ... mentioned, the intracellular part of members of the TLR family has a high degree of homology to the intracellular domain of the IL-1R This remarkable level of homology suggests similar intracellular ... Postreceptor signaling of the IL-1R is well understood Binding of the ligand causes receptor dimerization and, with involvement of IL-1RAP (an accessory protein), the intracellular part of the receptor...
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Báo cáo y học: "A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion" pps
... viii = MRS1191 pretreatment before MRS3558 (100 µg/kg) and beginning of reperfusion aTissue myeloperoxidase (MPO) activity is expressed in units of MPO/g of lung weight, each of which was defined ... lack of p38 activation with reperfusion of rat lung grafts Using type II rat pneumocytes, hours of hypoxia followed by hours of reoxygenation failed to activate p38 or JNK, whereas activation of ... of EG CW performed surgical proce- • Levels of phosphorylated JNK, p38, and ERK1/2 levels are increased following hours of ischemia and hours of reperfusion • The increase in the expression of...
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Báo cáo khoa học: " Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis" ppt
... stained with the following isotypes: 10 μl of mIgG2a-PE and μl of mIgG2b-APC (tube 1); 10 μl of TLR2-PE and μl of CD11c-APC (tube 2) or 20 μl of TLR4-PE and μl of CD11bAPC (tube 3) Samples were incubated ... expression of cell surface receptors was performed in whole blood, drawn in EDTA tubes A total of 100 μl of whole blood from patients and controls were stained with μl of CD14-PerCP and μl of CD66-FITC ... Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study Working group on "sepsis-related problems" of the...
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Báo cáo sinh học: " Developmental temperature and somatic excision rate of mariner transposable element in three natural populations of Drosophila simulans" pps
... the number of copies and the excision rate Finally, an analysis of mariner sequence in 5’ of the initiation site showed a 14-bp sequence with 50-57% of homology with promoter sequence of several ... definition of the classe The Estimation of the somatic excision rate The somatic excision rate, in each isofemale line, was estimated after a test-cross between males of the line tested and females of ... number of Mos-1 individuals decreases at 25°C and 29°C, while the average number of Mos-2 and Mos-3 individuals increases effects Average number of copies per isofemale line The average number of...
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