receptors and somatic antigens
advances in cancer research
... IFN-y receptors are different from the receptors of the other IFNs (Branca and Baglioni, 1981; Aguet et aZ., 1982) Consequently, the designations “Type I” for the IFN-a and IFN-/3 receptors and ... I1 IFNs and NK Cells 111 Other Effector Systems IV Immunoregulatory Circuits V 36 44 54 55 vi CONTENTS Chapter Effects on Other Parameters I Receptors and Somatic Antigens ... activation and proliferation This may be of importance with respect to the anticancer role of dietary pro-vitamin A V IFNs and Prostaglandins The interactions between the I F N and prostaglandin systems...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... recognized by other receptors For example, vertebrate steroid hormone receptors (such as GRs, mineralcorticoid receptors, progesterone receptors and androgen Arthropod nuclear receptors receptors) bind ... hormone receptors (TRs), retinoic acid receptors (RARs), vitamin D receptors (VDRs) and peroxisome proliferator-activated receptors (PPARs) in mammals The second family, NR2, contains RXRs and hepatocyte ... (NRs) and cofactors, and then summarize the study of arthropod ecdysteroid receptors, including sequences, functions, ligand-binding characteristics and the application of ligand–receptor complexes...
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Báo cáo khoa học: Cloning of a rat gene encoding the histo-blood group A enzyme Tissue expression of the gene and of the A and B antigens potx
... tongue, the oesophagus, the parotid gland, the uterus, the seminal vesicle, the thyroid and parathyroid glands and the Fig Immunohistochemical analysis of the A and B antigens expression in BDIX rat ... submaxillary gland, the A antigen was expressed in the secretory cells and the B antigen in the duct cells The A and B antigens were only coexpressed in the pancreas acinar cells (Fig 5d) and in some ... indication of the intensity of the detected band is given, with +++ corresponding to the strongest signal and – to no detectable signal The A and B antigens were detected by immunohistochemistry...
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nuclear envelope dynamics in embryos and somatic cells
... editors and publishers believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and ... in Embryos and Somatic Cells, edited by Philippe Collas ©2002 Eurekah.com and Kluwer Academic/Plenum Publishers 2 Nuclear Envelope Dynamics in Embryos and Somatic Cells filaments and lamin-binding ... DYNAMICS IN EMBRYOS AND SOMATIC CELLS Molecular Biology Intelligence Unit 23 Landes Bioscience / Eurekah.com and Kluwer Academic / Plenum Publishers Copyright ©2002 Eurekah.com and Kluwer Academic/Plenum...
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báo cáo hóa học: " All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2" potx
... and activate retinoid nuclear receptors, including retinoic acid receptors (RARs) and/ or retinoid X receptors (RXRs), each having three isotypes, α, β and γ RARs and RXRs have been identified ... development of several tissues and organs [4], including the brain and the spinal cord [3,5] Retinoids are also present in the brain and spinal cord of adult rats and mice [6,7] and are involved in functions ... the study and performed the statistical analysis FJLC conceived of the study, and participated in its design and coordination and helped to draft the manuscript All authors have read and approved...
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Báo cáo hóa học: " Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma" potx
... carcinogenic pathway and that at least one gene should be altered in both forms This has been confirmed with the cloning of the VHL gene and the identification of germline and somatic mutations ... epidemiology and to establish correlations between the localization of the mutation and specific phenotypes In a previous study, Beroud et al [14-16] have shown that the somatic and germline ... Medicine and Toxicology 2007, 2:13 between and times either at the germline or somatic level in the VHL Mutation Database [25] Interestingly, it is reported in the literature that a VHL somatic...
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Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection" doc
... Expression of HIV co -receptors CXCR4 and CCR5 Several previous studies have reported expression of the principal HIV co -receptors, CXCR4 and CCR5, on cultured epithelial cells [32,48,49] and that oral ... damage and repair in ex vivo tonsil organ culture and HIV infection of tonsil cells Epithelial damage and repair in ex vivo tonsil organ culture and HIV infection of tonsil cells Small randomly ... HIV virions and exposed mucosal surfaces and that both the properties of the inoculum (cell free HIV virions and/ or cell associated infectivity in the form of HIV-infected cells) and the characteristics...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... can bind to ephrinA and ephrinB ligands, and ephrinA5 which can 264 also bind to EphB2 [2, 3] Figure Domain structure of Eph receptors and ephrinA and ephrinB ligands Eph receptors have an extracellular ... EphB and Eph A receptors and ligands have been implicated in synaptic plasticity, and play a role in repair of the nervous system following injury [30-32] Cancer Eph receptor and ephrin ligand ... between EphA receptors and ephrinA ligands can regulate glucose homeostasis and insulin secretion [54, 55] EphA recep- 266 tors and ephrin ligands are expressed by β cells in the pancreas, and forward...
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Báo cáo y học: "Phobic memory and somatic vulnerabilities in anorexia nervosa: a necessary unity" ppsx
... cognitive and somatic manifestations of AN "Laparophobia" and K+ channels Young women with AN are recognized for commonly manifesting greater levels of general inhibition, loneliness, and social ... subunits in specific areas and how they are related to changes of cellular functions translated to the diverse clinical features of AN along its course and co-morbidities Somatic and cognitive aberrations: ... Belohlavkova and colleagues [87] compared the inhibitory effect of ritanserin, an antagonist of 5-HT2 receptors, on fenfluramine- and 5-HT-induced vasoconstriction As expected, both 5-HT and fenfluramine...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... self and microbial antigens, by somatic hypermutation to generate high-affinity autoantibodies There have been only a limited number of studies on the immunoglobulin V gene repertoire and somatic ... germinal centre (GC) A and GC B, and B-cell clusters C and D were derived Groups of sequences were deemed to be clonally related when they used the same V, D, J and CDR3, and differed only by base ... GC B were 7.6 and 15.8, respectively, and for clusters C and D they were 15 and 14.9, respectively This is significantly higher than the Taq polymerase error rate, demonstrating somatic hypermutation...
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Báo cáo khoa học: "Probing the link between oestrogen receptors and oesophageal cancer" ppt
... females is age-related and occurs postmenopausally [27] Measuring and correlating systemic sex steroid hormone levels and their interaction with their receptors in pre- and postmenopausal women ... growth factors, cytokines and enzymes and has been linked with hormone-independent growth, loss of cell-cell adhesion and angiogenesis Proliferation and apoptosis The mitogenic and growth-promoting ... principally via ERa and ERb first cloned from rat prostate [32] This discovery led to a reappraisal and new perspective on the significance of the ER in health and disease The ERa and ERb, isoforms...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... activated by single-stranded RNA containing U and G rich motifs [17,18] Thus, highly U/G-rich U and Y RNAs bound respectively to snRNP and Ro/La autoantigens both stimulate TLR7 and/ or TLR8 [19] Methylated ... [32,33] They harbor both TLR7 and TLR9 receptors and are exquisitely sensitive to RNA and DNA stimulation Conventional DCs (cDCs) express and respond to TLR stimuli and might promote autoimmunity ... immunogens and adjuvants Innate immune sensors The nucleic acid binding TLRs appear to play pivotal roles in SLE TLR7 and TLR8 bind to single-stranded RNA, TLR3 to double-stranded RNA, and TLR to...
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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf
... contributions SUM, KR and ST performed all experiments and analyzed the data SUM drafted the manuscript MJK conceived and designed the study and helped to draft the manuscript All authors read and approved ... thank Emily Lewis B.Sc and Jennifer Johnson B.Sc for obtaining patient blood samples; Taejah Vemuri, Marc Anderson and Amanda Bradke B.Sc for help with blood processing and cell culture; Emily ... microbes, as well as ligands expressed on apoptotic and malignant endogenous cells Additionally, they can interact with other pattern recognition receptors such as Toll-like receptors DCs express...
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Báo cáo y học: "NOD-like receptors and inflammation" pot
... and colleagues [129] reporting similar responses to TLR ligands in wildtype and NOD2-/- cells, and indeed an increase in IL-6 in wild-type NOD2 cells on stimulation with Pam3CSK4, a TLR2 ligand ... 1), and NALP1 (NACHT, leucine rich repeat and PYD [pyrin domain] containing 1) termed NLRP1 (NLR family, pyrin domain containing 1), and so on.We again refer to the historic terminology of NOD and ... antagonists (IL-1 receptor antagonist) and biological molecules such as monoclonal antibodies and soluble receptors that block IL-1β (see below) Martinon and coworkers [57] demonstrated that the...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... transformed the understanding and management of these disorders and has implications for future therapies in rheumatic diseases Important links and synergies are evident between TLRs and NLRs TLRs are ... John Wiley and Sons cells) as well as TLR ligands of microbial origin Similar to the microbial TLR ligands, endogenous TLR ligands have been found in the joints or serum of RA patients and their ... Osteoarthritis and Toll-like receptors Synovial inflammation is increasingly recognised as an important pathophysiological process in OA, and endogenous ligands released as a consequence of synovial and...
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Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
... exists in both transmembrane and soluble isoforms and is critical for ligand binding and signal transduction through the receptor [27,28] Negative regulators of IFN and other proinflammatory cytokine ... metric and complete linkage method was applied, and results were depicted as a heatmap and dendogram generated using Java Treeview software [36] A full list of antigens included on the array and ... signaling, including suppressor of cytokine signaling (SOCS1) and the Tyro-3, Axl, and Mer (TAM) receptors, have been shown to associate with, and regulate signaling through, the IFNAR1 chain [29,30]...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... mycobacteria, spirochetes, mycoplasma and yeast antigens [1,45] (Table 3) Other ligands in TLR signaling The concept of innate immunity demands the presence of non-clonal receptors that recognize a variety ... Toll and 18W contain multiple leucine-rich repeats and carboxyl-terminal cysteine-rich domains [12] Drosophila Toll signaling pathway The homologies and interconnections between the Toll-like receptors ... these human TLRs, the microbial ligands for TLR2, TLR4, TLR9 and, most recently, for TLR5, and perhaps TLR3, have been identified (see following sections) Understanding the regulation of TLR expression...
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Báo cáo y học: "A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion" pps
... Assessment of injury and apoptosis For light microscopy, samples of lung tissue were embedded in paraffin, cut into µm slices, and stained with hematoxylin and eosin The slides were coded and examined ... ischemia/reperfusion; iii, iv and v = IB-MECA 50 µg/kg, 100 µg/kg and 300 µg/kg, respectively, administered hour before reperfusion; vi and vii = MRS3558 50 µg/kg and 100 µg/kg, respectively, ... reperfusion; and viii = MRS1191 pretreatment before MRS3558 (100 µg/kg) and beginning of reperfusion *P < 0.05 versus the other groups (i, ii, iii, and viii) Western blotting for JNK, p38, and ERK...
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Báo cáo khoa học: " Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis" ppt
... authors read and approved the manuscript Acknowledgements The authors thank Leandro Martins and Camila Valentin for their help in the recruitment of patients, and Maria da Luz Fernandes and Maria ... Neutrophil and monocyte ROS generation in septic patients (n = 41) and controls (n = 17) constitutively and after PMA, fMLP, LPS and S aureus stimulation Values are expressed in median and ranges ... constitutively and after PMA, fMLP, LPS and S aureus stimulation (p < 0.001 in all tested conditions) The median GMFI and range values in the patient group and control group at baseline and after...
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Báo cáo sinh học: " Developmental temperature and somatic excision rate of mariner transposable element in three natural populations of Drosophila simulans" pps
... bands may occur In this analysis 30, 22 and 21 isofemale lines were tested for Bordeaux, Loua and Agadir, respectively, and the ANC per line are 7.9 ±1.2 for Agadir, 5.2 t 0.5 for Bordeaux and ... modify the transcription and/ or the transposition rate of transposable elements (Strand and McDonald, 1985; Junakovic et al, 1986; lVIcDonald et al, 1987) On the other hand, populational factors, ... genes MATERIALS AND METHODS Natural populations and breeding temperature The populations used in this work came from Loua (Congo), Agadir (Morocco) and Bordeaux (France) Season and average temperature...
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