recently little was known about molecular structure of telomeres however during the last few years telomeres have been isolated and characterized from several sp
... superimposed on the X-ray structure (dark blue colour) and (B) structure alignment ofthe fragment 4–7 ofthe 13 ensemble structures of AII to the fragment 3–6 ofthe X-ray structureof AII Residue ... 5B,b) The first turn involves residues Asp1 and Arg2 and brings the N-terminus ofthe peptide in spatial proximity to the C-terminus ofthe peptide It was suggested that the stabilization of such ... family ofthe 48 structures, 13 structures were selected having the best allowed regions in the Ramachandran plot (Fig 4) The RMSD value ofthe ensemble ofthe 13 calculated structures, with respect...
... angles of ()30°, 120°) and ()70°, 180°), respectively Secondary structureoftheSP analogues [(R)-b2-HAla9 ]SP, [(S)-b3-HAla9 ]SP as well as [(R)-b2HPhe7 ]SP and [(R)-b2-HPhe8 ]SP havebeen synthesized ... regarding the differences in biological activities between [Ala9 ]SP and [Gly9 ]SP on the one hand, and [b2-HAla9 ]SP and [HGly9 ]SP on the other hand Indeed, the higher pharmacological potency of [b2-HAla9 ]SP ... domain ofSPand [Aib9 ]SP The aN (i, i + 4) and ab (i, i + 3) NOEs were not detected in [b2-HAla9 ]SP, [b3HAla9 ]SP and [HGly9 ]SP, indicating more flexible helical structures The C-terminal part of SP...
... crystallography [15–18] and NMR spectroscopy [19,20], including Ec-CspA, Bs-CspB andthe CSP from Bacillus caldolyticus (Bc-Csp) and Thermotoga maritima (Tm-Csp) The peptide chains ofthe CSP are arranged ... sequences with the highest degree of divergence fromthe profile were added to the sequences of Bc-Csp and Bs-CspB and arranged for display in Fig 9B The level of conservation was calculated for ... single-strand binding to the cold shock domain chain shows great conformational flexibility in the set of ligand-free CSP structures and interacts with the nucleobase group in thestructureof Bs-CspBÆdT6...
... Strictly speaking, the suite is the definition ofthe protocols, andthe stack is the software implementation of them 24 Network Protocols At the human level, some communication rules are formal and ... also TSPs Connect their customers to the Internet The Internet – ISPs connected to other ISPs 20 The Internet – A Network of Networks •Although there are benefits to using a LAN or WAN, most of ... – The amount of data andthe speed at which it must be transmitted – The cost ofthe media and installation 17 Local Area Network (LAN) Local Area Network (LAN) An individual network usually spans...
... pathways havebeen described, the classical andthe alternative pathway In inflammation, the classical NF-κB pathway is the more important ofthe two, and it is activated by a large number of stimuli, ... through the influence of cis-elements and chromatin structure [23] This is dependent on the location of insertion and a strategy to eliminate the problem is site specific insertion ofthe transgene ... and viral products, and stress-inducing stimuli such as γ-radiation, ultraviolet light and reactive oxygen species These stimuli induce the degradation of IκBα andthe nuclear translocation of...
... pathways havebeen described, the classical andthe alternative pathway In inflammation, the classical NF-κB pathway is the more important ofthe two, and it is activated by a large number of stimuli, ... through the influence of cis-elements and chromatin structure [23] This is dependent on the location of insertion and a strategy to eliminate the problem is site specific insertion ofthe transgene ... and viral products, and stress-inducing stimuli such as γ-radiation, ultraviolet light and reactive oxygen species These stimuli induce the degradation of IκBα andthe nuclear translocation of...
... institution was patronized by many pupils fromthe South, andduring my mother's time John C Calhoun was one of its students A fewyears ago a history ofthe school was published, and a copy ofthe book ... until three The principal ofthe school wasthe daughter of John Forbes, who for thirty yearswasthe librarian ofthe New York Society Library He was a native of Aberdeen in Scotland, andwas brought ... translation ofthe first two volumes ofthe Comte de Paris's "History ofthe Civil War in America." His devotion to my husband was pathetic, and I have frequently heard the Count say duringthelast years...
... were subjected to several rounds of stringent washing The DNA was purified fromthe chromatin fragments and analyzed by realtime quantitative PCR using pairs of primers specific for the murine or human ... expression during erythroid differentiation of mouse ES cells RNA wasisolatedfrom ES cells incubated in the presence of EPO for or 12 days, as indicated The RNA was reverse transcribed and subjected ... differentiation of mouse ES cells RNA wasisolatedfromthe cells at the indicated time points after addition of EPO and subjected to quantitative RT-PCR analysis using primers specific for the bmajglobin...
... It has been truly said that "the power of slavery lies in the ignorance, the degradation, the servility ofthe slaves, andofthe non-slaveholding whites ofthe South, andofthe corresponding ... negroes; they had killed aboutand wounded 12 more In their flight some of them shot themselves, others their wives, and then themselves; some absconded a few days, and then killed themselves ... before Such wasthe conduct ofthe negroes for the first nine months after their liberation, up to the middle of 1794 Ofthe conduct ofthe negroes duringthe year 1795, and part of 1796, I find...
... participant Any specialized handle (e.g., ball) needed by the participant was transferred to the joystick used for the experiment The tablet PC was mounted at the rear ofthe wheelchair and another tablet ... single standard deviation ofthe vector scatter plotted on the joystick, while the v marks the value ofthe mean well to the mid-wheelchair All ofthe novice participants used the lowest speed, ... (Figure 3A), and joystick direction The number of joystick movements was defined as the number of times during a trial where the joystick excursion exceeded the threshold of 5% maximum displacement...
... represents the standard deviation ofthe original signal x(i) Results Our objective in this study wasthe investigation of changes in the complexity ofthe central respiratory network ofthe piglets during ... beginning ofthe inspiratory period [19] On the other hand, the pattern exhibited in the bottom plot highly resembles the one on the top plot, indicating systems' full recovery after the critical respiratory ... considered the first bursts visible on the EMGdia following the apnea and they are the outcome ofthe systems' efforts to restore normal activity The end ofthe LCR was considered when regular (eupneic)...
... a landmark to separate the end ofthe swing phase fromthe beginning ofthe stance phase andthe first data point following the cessation of force application on the force plate designated the ... The small angular offset between the first PC calculated fromthe torque range data and a vector extending through the mean ofthe same data set fromthe origin ofthe coordinate space (Figure 7) ... participants and speeds When analyzing the time series data, the input array consisted of data from all participants, all trials andfrom each ofthe three joints The resulting input data set (either...
... ofthe foliation of spruce by means ofthe needle trace method], Dissertation Thesis, Univ Hamburg, 1997 [25] Sander C., Eckstein D., Reconstruction ofthe foliation of Picea abies by means of ... (SHED) of five spruces on their main axis, from Sander and Eckstein 1997, modified 161 Coherence of foliation of spruce with growth and climate Table II Correlation between foliation and growth ... cambium “suffers” from a loss of information andof mass transfer fromthe assimilative apparatus It should be mentioned that there was no indication of forest decline fromthe data obtained...
... be gained fromthe subjective meanings ofthe CDOs (gathered via field diary and interviews) andthe concepts they use to understand their practice [21]; much ofthe CDOs' practice (and program ... (from diary studies) as to the nature of 'respondent fatigue' [19] and whether diary entries and response rates decline over time A study ofthe effects of communal gardening on the health of ... andthe ways in which these structures enables the narrator to make sense ofand present their lives' [[14] p.89] It focuses attention on the interpretation of events rather than the events themselves...
... be gained fromthe subjective meanings ofthe CDOs (gathered via field diary and interviews) andthe concepts they use to understand their practice [21]; much ofthe CDOs' practice (and program ... (from diary studies) as to the nature of 'respondent fatigue' [19] and whether diary entries and response rates decline over time A study ofthe effects of communal gardening on the health of ... andthe ways in which these structures enables the narrator to make sense ofand present their lives' [[14] p.89] It focuses attention on the interpretation of events rather than the events themselves...
... an increase in the number of viroplasms and in the amount ofthe NSP2 protein was observed The size of viroplasms was observed to increase when higher MOI’s were used There are several possibilities ... MOI’s of 0.1 and 0.5 respectively), there were more viroplasms per cell [1.6 and 3.1 for a MOI of 0.1 and 2.4 and 4.1 for an MOI of 0.5 (2 and hpi respectively)], while at an MOI of 10, when 87% of ... if the small viroplasms, presumably generated by the aggregation of NSP2 and NSP5 require an additional priming signal, or if it is only the concentration of free NSP2 and NSP5 what dictates the...
... asthma and/ or respiratory Smoking 1during pregnancy andthe first two yearsofthe child Smoking during pregnancy andthe first two yearsofthe child and parents with or without asthma and/ or respiratory ... information i.e the number of cigarettes smoked both of mothers and fathers, was obtained in Q0 for the first two months, Q1 and Q2 for the first and second year of life, respectively In Q0 the parents ... years old 9.4 and 10%, respectively The corresponding reported postnatal exposure to paternal smoking was 16, 12 and 11%, respectively Any exposure to ETS duringthe first two yearsof life of...
... but at the expense of longer-term detriment [13] A greater understanding of both disease pathophysiology and iatrogenic harm will, I believe, lead to even better management, and thus further enhance ... continue to apply but must also develop still further The above advances have arisen from a realisation that overuse or misuse of drugs or devices, and/ or excessively striving for physiological ... AR, Young D, Black N, Rowan K: Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland Crit Care Med 2003, 31:2332-2338 Annane...
... data should speak for themselves 7) The DNA distribution of cells should be narrow in the synchronized cells and these distributions should then reflect the movement of cells through the division ... wishes to look at the response of genes to perturbation, then it is a good experiment The problem is whether the methods of Whitfield et al lead to an understanding of what happens in the normal, unperturbed ... on the variation in phase angle ofthe peak of expression If one had a particular cell growing with a 20 hour doubling time, and in some cells the peak was at hours, others 10 hours, and other...