recall viral antigens in asymptomatic clinical progressors and seronegative controls

**Báo cáo khoa học: "Tissue distribution of bovine viral diarrhea virus antigens in persistently infected cattle Taekyun Shin* and Helen Acland1" ppt**

Ngày tải lên : 07/08/2014, 14:23

... antigen-containing cells: -= no staining: += faint minimal staining: ++= moderate staining: +++= intense staining 1) Kupffer’s cells also contained BVDV antigen and moderate number of hepatocytes ... BVDV was localized in the cells of pancreatic islets and in the exocrine glandular acini (Fig Tissue distribution of bovine viral diarrhea virus antigens in persistently infected cattle 83 Table ... connective tissues in the body including the lamina propria of the intestine These cells are probably macrophages, and may contribute to viral spread in the body Glomeruli in the kidneys were...

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Báo cáo y học: "Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance" ppt

Ngày tải lên : 10/08/2014, 05:21

... potent antiretroviral treatment in previously naive HIV1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaboration ... Patients were included in the analysis if they had attained and sustained HIV-RNA viral load ≤ 400 copies per ml at 6, 12 and 24 months The chi square test was used to compare the baseline clinical ... a center of excellence in HIV care, training, and research at Makerere University Medical School and Mulago Teaching Hospital in Kampala, Uganda Since 2004, the IDI clinic (IDC) has provided...

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Báo cáo y học: "Bench-to-bedside review: Rare and common viral infections in the intensive care unit – linking pathophysiology to clinical presentatio" ppt

Ngày tải lên : 13/08/2014, 11:22

... the release of kinins and cytokines [106,107] The syndrome’s clinical presentation, rapid resolution, and histopathologic findings of interstitial infiltrates of T lymphocytes and alveolar pulmonary ... tears, semen, and breast milk, and from mucosal surfaces, including the throat and cervix [85-88] Detection of cells that contain CMV intranuclear inclusions in renal epithelial tissue and in pulmonary ... antiviral medications have been used: (a) M2 inhibitors (amantadine and rimantadine) inhibit the M2 ion channel needed for viral replication [24] These are not active against influenza B and C and...

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Báo cáo y học: "Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial"

Ngày tải lên : 25/10/2012, 10:35

... 250) in the standard insulin group and 36.6% (93 of 254) in the intensive insulin group ICU mortality was similar for patients of the standard insulin group and in those from the intensive insulin ... standard insulin group and 83 of 254 (32.7%) in the intensive insulin group The mean calorie intake in 24 hours was 23.1 ± 12.7 kcal/kg in the standard insulin group and 25.5 ± 14.4 kcal/kg in the intensive ... 14 patients in the standard insulin group (5.6%) and 14 in the intensive insulin group (5.5%) The remaining patients received total-enteral feeding exclusively In the standard insulin group 47%...

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Tài liệu Clinical presentation and outcome of patients diagnosed with active pulmonary tuberculosis in a large critical care unit docx

Ngày tải lên : 15/02/2014, 12:20

... observed to be more sensitive than staining in 69% of total aspirates, including cases that were found negative with gram staining Cultures are more specific in diagnosing early stage tuberculosis (21) ... were clinically assessed by the physician present in the ICU at the time of admission Symptoms are summarized in Table Treatment was initiated on the basis of the clinical diagnosis made during ... diagnosed on the bases of clinical judgement only Using our standard ICU database, microbiology laboratory records and other referenced documents, patient related information and relevant data were...

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Tài liệu HEMATOPOIETIC GROWTH FACTORS IN ONCOLOGY BASIC SCIENCE AND CLINICAL THERAPEUTICS pptx

Ngày tải lên : 16/02/2014, 07:20

... have delineated the potential beneﬁcial activities of HGF in current clinical use, including studies exploring dosing and scheduling parameters that inform the clinical use of these agents in the ... and clinical use Blood 1997; 89:3897–3908 113 Turner KJ, Clark SC Interleukin-11: Biological and clinical perspectives In: Mertelsmann R, Herrmann F, eds., Hematopoietic Growth Factors in Clinical ... cytokines in vivo in murine models of leukemia and myeloproliferative disease based on BCR-ABL and several leukemogenic TEL-tyrosine kinase fusion oncoproteins (84,85); in all models, combined...

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Tài liệu Nutrition in Pediatrics Basic Science and Clinical Applications - THIRD EDITION docx

Ngày tải lên : 16/02/2014, 07:20

... albumin, S total protein, U protein (dipstick) S transferrin, prealbumin, S retinol-binding protein, creatinine height index U hydroxyproline index; S amino acid profiles, indices; nitrogen balance; ... C, D ↓Vitamin D ↓Vitamin C ↓Protein, calories ↓Thiamin ↓Thiamin, vitamin E ↓Vitamin E ↓Vitamins B12, E ↓Iodine ↓Chromium ↓Zinc ↓Vitamin C, zinc Adapted from Hubbard VA, Hubbard LR Clinical assessment ... iron deficiency, or infection, as well as protein deficiency.75 Prealbumin is secreted by the liver in a complex containing retinol, retinol-binding protein, and thyroxine (T4) and thus is also...

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Tài liệu Pathophysiology and Clinical Aspects of Venous Thromboembolism in Neonates, Renal Disease and Cancer Patients Edited by Mohammed A. Abdelaal ppt

Ngày tải lên : 19/02/2014, 23:20

... :events initially develop antenatally (Monagle et al., 2008; Veldman, 2008) Presenting symptoms and clinical findings are different in neonates and older patients and are influenced by the extent and ... tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand and platelet P-selectin J Exp Med, 197, 1585-1598 14 Pathophysiology and Clinical Aspects ... methionine and since homocysteine is an intermediate within this cycle, the body in this way is provided with all organic homocysteine The term homocysteine is used to define the combined pool...

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OUTBREAK OF HAND, FOOT AND MOUTH DISEASE IN BHUBANESWAR, ODISHA: EPIDEMIOLOGY AND CLINICAL FEATURES doc

Ngày tải lên : 05/03/2014, 12:20

... Enrollment of cases in hospital, clinical examination and recording, data interpretation and manuscript preparation; BD: Field investigation, Clinical examination and recording, data interpretation, ... showing INDIAN PEDIATRICS JUNE 10, 2012 [E-PUB AHEAD OF PRINT] KAR, et al HAND, FOOT AND MOUTH DISEASE eosinophilia and two cases with neutrophilia Routine and microscopic examination of stool and ... investigation Routine blood examinations including complete blood count, Erythrocyte sedimentation rate, urine routine and microscopy and stool routine and microscopy were done in all cases Histopathology...

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PULMONARY TUBERCULOSIS IN HIV INFECTION IN TANZANIA clinical and immunological studies pdf

Ngày tải lên : 22/03/2014, 18:20

... PULMONARY TUBERCULOSIS IN HIV INFECTION IN TANZANIA clinical and immunological studies Gibson S Kibiki PULMONARY TUBERCULOSIS IN HIV INFECTION IN TANZANIA clinical and immunological studies ... chapter discusses the findings from the above studies, puts the findings into perspective, and winds up by outlining avenues for future research 21 Chapter One: Introduction and outline of the thesis ... be infected Conclusion HIV infection remains a major cause for admission and mortality in this population A policy of routine testing would increase case finding and potentially enhance care and...

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From Cancer Patient to Cancer Survivor - Lost in Transition: An American Society of Clinical Oncology and Institute of Medicine Symposium pot

Ngày tải lên : 22/03/2014, 20:21

... implementing the cancer survivorship care plan and coordinating care; (3) developing guidelines, instituting quality improvement, and strengthening professional education programs; and (4) addressing ... evidence-based clinical practice guidelines, assessment tools, and screening instruments to help identify and manage late effects of cancer and its treatment Existing guidelines should be refined and new ... public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine Dr Ralph J Cicerone and Dr Wm A Wulf are chair and vice...

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Exploring Challenges, Progress, and New Models for ENGAGING THE PUBLIC in the CLINICAL RESEARCH ENTERPRISE Clinical Research Roundtable Workshop Summary pot

Ngày tải lên : 29/03/2014, 13:20

... in clinical research across all practice settings and emerging health care systems; the timely incorporation into clinical practice of new research findings and findings on health outcomes; and ... essential coordination of clinical research within and between research entities and disciplines; the ability of academic health centers to conduct clinical research and training; the broad participation ... improving the public’s understanding of and participation in clinical studies The stakeholders involved in the CRR include individuals from the academic health community, federal agencies sponsoring...

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báo cáo sinh học:" Postoperative outcome of caesarean sections and other major emergency obstetric surgery by clinical officers and medical officers in Malawi" docx

Ngày tải lên : 18/06/2014, 17:20

... methodology and contributed with the design in collaboration with SB FK, AC and EM contributed in preparing the documents and the protocol for implementing the study CP, GCC, SB and EM prepared and completed ... rates by specific preoperative morbidity in this group of CS patients are presented in Table 10, indicating that eclampsia and clinical signs of uterine rupture had the highest rates at around ... (100.0%) Table 3: Institution where the clinical officers did their internship against the Institution of intership District Hospital CHAM Hospital Central Hospital Outside Malawi Not indicated Total...

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Báo cáo sinh học: " Overcoming viral escape with vaccines that generate and display antigen diversity in vivo Albert García-Quintanilla" pot

Ngày tải lên : 18/06/2014, 18:20

... HIV-1 vaccine designed for global use Vaccine 2005, 23:4647-4657 Locher CP, Heinrichs V, Apt D, Whalen RG: Overcoming antigenic diversity and improving vaccines using DNA shuffling and screening technologies ... for cancer treatments under clinical trials using antibodies against self -antigens [25] Competing interests The final drawback is relative to current manufacturing and quality regulations that ... polyvalent vaccine candidates where each single vehicle generates and displays multiple antigen variants in vivo, is safe and will elicit a broad and long-lasting immune response able to avoid viral escape...

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Báo cáo sinh học: " Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages" docx

Ngày tải lên : 18/06/2014, 18:20

... cloning, and sequencing VS performed all biological experiments, including T-cells lines and primary cells infection experiments RR contributed in transfections and infection experiments SS and ... predominantly R5 even late in infection Syncytium inducing capacity of subtype C chimeras We examined the syncytium-inducing ability of the subtype C env chimeras by infecting MT-2 cell lines ... were infected in media containing serum and polybrene (8 μg/ml) incubated at 37°C and 5% CO2 for 16 hrs After incubation, the macrophages were washed in PBS to remove polybrene and resuspended in...

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Báo cáo sinh học: "Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review" pdf

Ngày tải lên : 18/06/2014, 19:20

... results in the treatment of CRC Since the discovery of tumor-associated antigens during the early 1990s, rapid progress has been made in identifying antigens and describing immune interactions in ... Many clinical trials have been conducted using active specific immunotherapy (ASI) in CRC, including autologous tumor cell vaccines, define-tumor protein vaccines, monoclonal antibodies and anti-idiotype ... disease without evidence of remaining macroscopic disease) Clinical outcomes to evaluate ASI in suspected minimal residual CRC were OS and DFS, and clinical outcomes of ASI in advanced CRC were complete...

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Báo cáo sinh học: "Shipping blood to a central laboratory in multicenter clinical trials: effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function" potx

Ngày tải lên : 18/06/2014, 19:20

... winter and early spring Two hundred and eightyfive blood specimens collected at participating clinical trial centers in Houston, TX and Philadelphia PA, were shipped to Charlottesville VA Clinical ... multi-center clinical trails at the national and international level [1-3] Both complex processing and delay before processing by individual laboratories increase the variability in specimen performance ... shipping temperatures and extreme changes in temperature on the cell yield for clinical trial specimens Package temperatures were lowest in winter months and highest in summer months, suggesting...

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Báo cáo sinh học: " The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting" doc

Ngày tải lên : 18/06/2014, 19:20

... patients, and in three out of nine patients two mutations were found in one or more tumor samples Five recurrent points of mutation were located in the KIT tyrosine kinase domain and in the ATP ... both in vitro and in vivo [10,50] and is also imatinib resistant in vivo and in vitro [30,53,54], whereas other mutations affecting exon 18 (D846Y, N848K, Y849K and HDSN845-848P) are imatinib ... Xiao S, Singer S, Fletcher CD, Fletcher JA: KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors Am J Pathol 2000, 156:791-795 Rubin BP, Singer S, Tsao C, Duensing A,...

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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot

Ngày tải lên : 19/06/2014, 22:20

... in the injured brain has not yet been investigated We sought to determine the interrelationship between intracranial TNF and IL-18 levels in a clinical study on patients with severe CHI and in ... Baseline CHI WT CHI TNF/LT- -/- vehicle injection TNF injection Intracerebral IL-18 concentrations in mice, as determined by ELISA in murine brain homogenates (n = 10 animals per group) Figure Intracerebral ... levels after traumatic brain injury have been previously reported in various clinical and experimental studies [21-26] In the present study, the individual daily TNF levels in CSF were up to 10-...

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báo cáo hóa học:" Virtual interactive musculoskeletal system (VIMS) in orthopaedic research, education and clinical patient care" pptx

Ngày tải lên : 20/06/2014, 00:20

... iterative in nature since each step of joint loading under the equilibrium condition, the joint compressive springs carrying tensile load (spring length increased from its resting length before loading) ... bridging type (with proximal pins in the diaphysis of the radius and distal pins in the metacarpal plus additional intermediate pin to fix the distal radial fracture fragment) and the non-bridging ... expertise in biomechanical analysis and graphic modeling to investigate joint and connective tissue mechanics and to visualize the results in both static and animated forms together with the system involved...

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