reactive oxygen species generation on nanoparticulate material
báo cáo hóa học:" Airborne particulate matter PM2.5 from Mexico City affects the generation of reactive oxygen species by blood neutrophils from asthmatics: an in vitro approach" docx
... citation purposes) Journal of Occupational Medicine and Toxicology 2009, 4:17 Figure by neutrophils in contact with PM2.5 In vitro generation of reactive oxygen and nitrogen species In vitro generation ... nitrogen species In vitro generation of reactive oxygen and nitrogen species by neutrophils in contact with PM2.5 A In vitro production of reactive oxygen and nitrogen species by neutrophils from healthy ... production On the other hand, sulfates appear to be produced on a regional scale There are indications of new particle formation and growth events when sulfur dioxide (SO2) concentrations are...
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báo cáo khoa học: "Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells" pdf
... the induction of cellular reactive oxygen species (ROS) accumulation in cancer cells To our knowledge, this is the first report showing that saikosaponininduced cellular ROS accumulation mediates ... increasing concentrations of saikosaponin-d or fixed concentration of cisplatin (8 μM) alone or both for 48 hours Cell death was measured as described in (A) (D) HeLa cells were treated with fixed concentration ... accumulation Thus, the combination of saikosaponins with cisplatin could increase the therapeutic effect of cisplatin against solid tumors Additional material Additional file 1: Figure S1 Saikosaponins...
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Báo cáo y học: " Helicobacter pylori induces mitochondrial DNA mutation and reactive oxygen species level in AGS cells"
... simulation for different durations The mutation rates increased with the prolongation of stimulation by Hp extracts After h, h, 12 h and 24 h of stimulation, the mutation rates of mtDNA D-loop region ... Fig.7 mutation rates in the mtDNA D-loop region of the AGS cells after stimulation by Hp extracts of various concentrations The mutation rates increased with the increase in the concentration of Hp ... Hp11638M stimulation for corresponding duration (P
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Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells doc
... demonstrated that mitochondria work as the central executioner in apoptotic signaling pathways Various pro-apoptosis stimuli converge on the mitochondria, leading to mitochondrial depolarization ... activation in oridonin-induced L929 cells Interestingly, we found that inhibition of p38 decreased oridonin-induced NF-jB activation, indicating that oridonin-induced p38 activation contributes ... indicate that ROS generation induced by oridonin contributes to the activation of mitochondrial and ERK signaling pathways in oridonin-induced L929 cell apoptosis Moreover, oridonin-induced autophagy...
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Báo cáo khoa học: Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species pptx
... Structure, regulation and evolution of Nox H Sumimoto Introduction Reactive oxygen species (ROS) are conventionally regarded as inevitable deleterious byproducts of aerobic metabolism On the other ... activated to reduce molecular oxygen to superoxide anion (O2)), a precursor of microbicidal ROS, in conjunction with oxidation of NADPH As the rapid increase in oxygen consumption during phagocytosis ... muscle contraction [70] Oxidases of this subfamily build on the basic structure of the Nox prototype, adding an N-terminal extension that contains four EF-hands: three canonical motifs and one noncanonical...
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Báo cáo khoa học: Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines pot
... Determination of intracellular reactive oxygen species as function of cell density Methods Enzymol 352, 91–100 44 Zuo, L & Clanton, T.L (2002) Detection of reactive oxygen and nitrogen species in tissues ... production, we assessed aconitase reactivation in these subcellular fractions Reactivated aconitase showed a dramatic increase in cytosolic fractions of bone q0 cells (Fig 8), whereas in mitochondria-enriched ... the conversion of this enzyme to the iron regulatory protein-1 (IRP-1), that serves to regulate iron homeostasis [46], and mitochondrial aconitase inactivation serves as a protective response...
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Báo cáo khoa học: Neuroglobin and cytoglobin expression in mice Evidence for a correlation with reactive oxygen species scavenging doc
... the normoxic condition (P ¼ 0.05) Fig Relative Ngb protein expression and H2O2 level in mice under hypoxic conditions and after reoxygenation Comparison between Ngb protein expression (normoxia ... conditions (48 h) and after reoxygenation (48R8, 48R24: 48 h of hypoxia, followed by h or 24 h of reoxygenation) Positive control: U937 monocytes treated with 50 lM etoposide for h such as reactive ... heme, other components may also contribute to ROS scavenging, Fig Western blot detection in mice under hypoxic conditions and after reoxygenation Cleaved caspase-3 protein expression in heart and...
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Báo cáo khoa học: 2-Amino-nonyl-6-methoxyl-tetralin muriate activity against Candida albicans augments endogenous reactive oxygen species production – a microarray analysis study doc
... biological functions In addition, measurements of endogenous reactive oxygen species (ROS) generation, mitochondrial membrane potential (DWm), intracellular ATP concentration, respiratory electron transport ... ROS production Although the generation of ROS is exponentially dependent on DWm [13], dysfunction of proton pumps can disrupt the positive correlation between endogenous ROS production and DWm ... of control) A Ratio (red fluorescence/ green fluorescence) 10b and endogenous reactive oxygen species ** 80 * 60 40 20 Control (µg·mL–1) C 10b concentration (µg·mL–1) 600 ATP concentration (nM)...
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Báo cáo khoa học: Is there more to aging than mitochondrial DNA and reactive oxygen species? pot
... oxidation and degradation of oxidized proteins by the mitochondrial Lon protease Therefore, it is important to take into consideration that an increased mitochondrial content of protein carbonyls ... usually considered This is mostly because early studies established that 1–2% of oxygen consumed by mitochondria can be converted to H2O2 Considering the constitutive nature of respiration, such ... generation of a single, mutagenic lesion in mtDNA, is accompanied by the generation of as many as 10 strand breaks, which leads to degradation of the entire molecule Components of the mitochondrial...
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Báo cáo Y học: Inactivation of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio alginolyticus by reactive oxygen species pot
... rupture and preparation of membrane vesicles of V alginolyticus cells were performed under exclusion of dioxygen In addition, the effect of enzymes that detoxify reactive oxygen species (superoxide ... determined under exclusion of air ND, not determined Conditions of cell rupture NADH oxidation (lmolÆmin)1Æmg)1) Q1 reduction (lmolÆmin)1Æmg)1) Ratio of NADH oxidation/ Q1 reduction activity + + + ... further reduction of the b-type cytochromes upon addition of dithionite was achieved In addition, reduction of air-oxidized membranes with NADH or dithionite did not increase the amount of reduced...
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báo cáo hóa học: " Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia" ppt
... activation We went on to examine the effect of NADPH oxidase and ROS production on MAPK activation in response Hu et al Journal of Neuroinflammation 2011, 8:123 http://www.jneuroinflammation.com/content/8/1/123 ... uninfected control; †p < 0.05 and †† p < 0.01 vs HSV alone Hu et al Journal of Neuroinflammation 2011, 8:123 http://www.jneuroinflammation.com/content/8/1/123 neurodegeneration [28] Restoration of ... been demonstrated to induce NADPH oxidase activation, with corresponding ROS generation, which subsequently activates NF-B to induce proinflammatory cytokine production [19-21] Following up on our...
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Báo cáo y học: "Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants" pps
... denaturation for 15 minutes at 95°C, followed by 37 cycles of denaturation at 95°C for 15 seconds, annealing at a temperature of 60°C for 30 seconds, elongation at 72°C (the elongation time depended on ... increased after stimulation with reactive oxygen species donors Results are shown as mean ± standard error of the mean for five separate experiments * p < 0.05 versus Con Con, control; NO, nitric oxide; ... free radicals, the term 'reactive oxygen species' (ROS) has prevailed, although ROS can be differentiated into reactive nitrogen species and other oxidant species The relationship between ROS and...
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Báo cáo y học: " Early The tripeptide feG regulates the production of intracellular reactive oxygen species by neutrophils" pps
... HJ, Kauffman H: Association between nonspecific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic air-flow obstruction Am Rev Respir Dis 1988, ... Anderson J, Wilson F, Shea-Donohue T, Tsokos GC: C5 is required for CD49d expression on neutrophils and VCAM expression on vascular endothelial cells following mesenteric ischemia/reperfusion Clin ... Dery RE, Ulanova M, Puttagunta L, Stenton GR, James D, Merani S, Mathison R, Davison J, Befus AD: Frontline: Inhibition of allergen-induced pulmonary inflammation by the tripeptide feG: a mimetic...
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báo cáo khoa học: " Reactive oxygen species and transcript analysis upon excess light treatment in wild-type Arabidopsis thaliana vs a photosensitive mutant lacking zeaxanthin and lutein" pps
... photosystems accumulation could not only involve chronic PQ reduction [32] and b) regulation of composition of photosynthetic components could be mainly at the level of protein turn-over In contrast to previous ... identified as one of the long-term responses that facilitate chloroplast acclimation to intense light [104] Chloroplasts respond to the accumulation of 1O2 by functional reorganization We found ... transferred from controlled conditions above described to a cold chamber (10°C) under low-light conditions (25 μmol photons m-2 s-1, continuous light) and maintained in this environment for 48 h...
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báo cáo khoa học: " Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets" ppsx
... high induction in the combined presence of sucrose and atrazine, and, respectively, a slight repression or no variation in the presence of atrazine in comparison to control condition In contrast ... little variation (Fig 5e) Discussion Characterisation of the impact of atrazine on ROS patterns ROS patterns appear to depend strongly on the nature and intensity of stress conditions applied to ... effect on H2O2 accumulation This is, to our knowledge, the first demonstration of rapid in vivo H2O2 accumulation under conditions of atrazine treatment The negative effect of sucrose on H2O2...
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Báo cáo khoa học: "A Reactive oxygen species: toxic molecules or spark of life" docx
... non-radicals Thus O2 is the most stable state of oxygen Superoxide (O2•–) has one more electron than O2 Since only one electron is unpaired in O2•–, it is simpler for it to accept an electron ... enzyme function and signal transduction pathways The amino acid tyrosine is particularly prone to attack by ROS, especially reactive nitrogen species such as OONO– [39] The product of OONO– and tyrosine ... function and the biological significance of oxidation of a particular protein needs to be confirmed by evidence of an alteration in function An example of a protein function altered by oxidation...
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Báo cáo y học: " Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads" potx
... 150 *** 100 50 Control BLV BLV Figure Generation of ROS in B lymphocyte mitochondria Generation of ROS in B lymphocyte mitochondria Confocal microscopy analysis of ROS production in B cells isolated ... physiological functions, including activation and modulation of signal transduction pathways, defense against infectious agents, induction of mitogenic response and regulation of mitochondrial apoptotic ... B-cells Control BLV A second important point to address concerns the apparent conflict between conclusions drawn from ex vivo and in vivo observations Why should BLV-infected cells (thus less prone...
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Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx
... inclusion) Consistent to this notion, it has been reported that SIVmac infection in macaques (MACs) is unable to respond to TGF-β1, whereas the nonpathogenic SIVagm infection in African green Monkeys(AGMs) ... Aronow B, Wojciechowski S, Kappler J, Marrack P: Control of Bcl-2 expression by reactive oxygen species Proc Natl Acad Sci USA 2003, 100:15035-15040 Hildeman DA, Mitchell T, Teague TK, Hanson ... importantly, to confirm that the TGF-β produced and activated in TCR-activated CD25- T cells was indeed responsible for Foxp3 expression, an anti-TGF-β monoclonal antibody (clone 1D11) was included...
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Bone Metabolism: The Role of STAT3 and Reactive Oxygen Species
... leads to accumulation of ROS (45-7) Therefore, inhibition of bone formation in the conditional STAT3 KO mice may result from the suppression of gene expression and elevation of ROS in osteoblasts ... activation in response to mechanical stimulation Especially, the conserved serine phosphorylation site on STAT3 is critical in regulation of mitochondrial activities (24) Next, we demonstrated ... occurs when bone formation and resorption occur on separate surfaces, is responsible for gain in skeletal mass, and occurs mainly during growth On the other hand, bone remodeling occurs continuously...
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