radiotherapy in advanced cancer
Báo cáo khoa học: "Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients" pot
... (morning and evening), beginning days before starting radiotherapy and continuing everyday during radiotherapy In the other control group, an the identical-appearing placebo was administered in ... treatment of gynecological cancer Maintaining intestinal integrity during radiotherapy significantly influences the quality of life of patients Usually severe radiation-induced diarrhea is treated ... changes in intestinal flora mediated through fermented milk intake FEMS Immunol Med Microbiol 1994, 10:55-64 19 Salminen E, Elomaa I, Minkkinen J, Vapaatalo H, Salminen S: Preservation of intestinal...
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Báo cáo khoa học: "The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study" doc
... RT in rectal cancer with synchronous liver metastasis has not been defined In this study, we investigated the clinical implications of adjuvant pelvic RT following primary tumor resection in ... consisted of irinotecan at 180 mg/m2 on day one with leucovorin at 400 mg/m administered as a two hour infusion before 5-FU at 400 mg/m2 being administered as an intravenous bolus injection, followed ... quality of life in these cases According to 2010 National Comprehensive Cancer Network (NCCN) guideline, preoperative CCRT has become the standard care in locally advanced rectal cancer However,...
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Báo cáo sinh học: "Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review" pdf
... 42 43 in advanced cancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic ... cancer patients Many clinical trials have been conducted using active specific immunotherapy (ASI) in CRC, including autologous tumor cell vaccines, define-tumor protein vaccines, monoclonal antibodies ... suspected minimal residual colorectal cancer (suspected minimal residual CRC), and reviewed the objective clinical outcomes of ASI in advanced colorectal cancer (advanced CRC) during the past...
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Báo cáo toán học: "Molecular Predictors of EGFR-TKI Sensitivity in Advanced Non–small Cell Lung Cancer" ppsx
... probably could introduce new insight into clinical practice to assure better clinical outcomes By comparing the gene expression patterns of gefitinib sensitive and gefitinib resistant lung cancer, Balko ... lung cancer Ann Oncol 2007; 18(1): 99-103 Sequist LV, Martins RG, Spigel D, et al First-Line Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer Harboring Somatic EGFR Mutations J Clin ... factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib J Clin Oncol 2005;...
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Báo cáo khoa học: "Can primary optimal cytoreduction be predicted in advanced epithelial ovarian cancer preoperatively?" pdf
... debulking in patients with advanced epithelial ovarian cancer has been compared with chemotherapy and interval debulking in different studies Equal survival has been reported in patients undergoing ... with advanced epithelial ovarian cancer In America 95% of patients with advanced epithelial ovarian cancer are treated with primary surgery [15] Regarding that residual tumor is more than cm in ... indications have not yet determined A critical point in order to define indications of neoadjuvant chemotherapy for advanced ovarian cancer is determination of uniform selection criteria that can...
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Báo cáo khoa học: "Concurrent radiochemotherapy in advanced hypopharyngeal cancer" doc
... approach in patients with advanced hypopharyngeal cancer Concerning the radiotherapy technique in the treatment of hypopharyngeal cancer, we recommend the adoption of IMRT in the routine clinical ... effective in combination with radiotherapy in previously untreated patients in a single controlled clinical trial [46,47] The recently started phase III trial (RTOG 0522) exploring cisplatin-based ... observed in other studies investigating the effectiveness of combined radiotherapy and chemotherapy for advanced hypopharyngeal carcinoma Yoon et al [30] reported a complete response rate of 82.0% in...
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Báo cáo khoa học: " Intensity-Modulated Radiotherapy in Patients with Cervical Cancer. An intra-individual Comparison of Prone and Supine Positioning" ppt
... sparing for definitive pelvic radiotherapy with IMRT in the supine position, but not in patients who had a hysterectomy In the present study, no emphasis was placed on bladder or rectum filling, ... Köhler C, Schneider A, Seiler F, Hinkelbein W: Interindividual variability of lymph drainages in patients with cervical cancer Implication on irradiation planning Strahlenther Onkol 2006, 182:80-85 ... this article as: Stromberger et al., Intensity-Modulated Radiotherapy in Patients with Cervical Cancer An intra-individual Comparison of Prone and Supine Positioning Radiation Oncology 2010, 5:63...
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Báo cáo khoa học: "F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters" pdf
... volume delineation in head-and-neck cancer using CT and PET/CT fusion Int J Radiat Oncol Biol Phys 2006, 65:726-732 Black QC, Grills IS, Kestin LL, Wong CY, Wong JW, Martinez AA: Defining a radiotherapy ... tumor was determined when using 20% isodensity volumes (pink line) CT-based GTV was outlined by red line Table also showed there was no demonstrated single sTL or sSUV method for achieving optimized ... also a great need for delineating tumor tissue more precisely, particularly in IMRT era Various methods for incorporating PET into the RT plan have been reported; including visual comparisons,...
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Báo cáo khoa học: "Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome" docx
... both occurring since the date of the diagnosis Contralateral breast cancer was either ductal carcinoma in situ (DCIS) or invasive carcinoma Distant disease was defined as breast carcinoma recurrences ... we attempted to assess the incidence of radio-induced malignancies in a prospective cohort of families with germ-line p53 mutations, focusing on breast cancer occurring as the first malignancy ... in the regulation of apoptosis through the induction of pro-apoptotic proteins such as Bax, Apaf 1, PUMA, p53AIP1, PIDD and NOXA; (iii) in DNA repair; (iv) in angiogenesis and in metastasis inhibition...
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Báo cáo khoa học: "A biologically competitive 21 days hypofractionation scheme with weekly concomitant boost in breast cancer radiotherapy feasibility acute sub-acute and short term late effects" pot
... outcome [6-8] In order to intensify treatment, a simultaneous boost dose, concomitant or integrated, has been introduced in clinics by using 3-D conformal radiotherapy or intensity-modulated radiotherapy ... stage I-II breast carcinoma as defined by the international Union Against Cancer (fifth edition) and had gone through macroscopic total resection of the primary tumor and sentinel node biopsy Three ... It may be worth noting that this factor of tumor kill is normally not included in mathematical models for BED calculation Volumes of interest and treatment planning A planning CT scan was carried...
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Báo cáo khoa học: "Palliative radiotherapy in patients with a symptomatic pelvic mass of metastatic colorectal cancer" pot
... chemoradiotherapy (CCRT) with palliative intent in gastrointestinal cancer [22,26-30] In this study, we evaluated the palliative role of RT and defined the effectiveness of chemotherapy combined ... IG: Radiotherapy of carcinoma of the rectum In Dukes C, ed Cancer of the Rectum E&S Livingston, Edinburgh 1960, 210-219 Whiteley HW Jr, Stearns MW Jr, Leaming RH, Deddish MR: Radiation therapy in ... received CCRT with the following regimens: capecitabine in eight patients, fluorouracil in six patients, oral tegafur-uracil in five patients, and combination regimen in two patients Thirty-one...
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Báo cáo khoa học: "Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy" pdf
... observed Initial DNA damage levels in breast cancer patients Radiation-induced apoptosis in breast cancer patients Initial DNA damage was determined as radiationinduced double-strand breaks (DSB) in ... performed in a FACScalibur (Becton Dickinson, San José, CA) using a 488 nm argon laser, and each sample was analyzed in a Macintosh Quadra 650 minicomputer (Apple computer Inc., Cupertino, CA) ... Annexin-V-FITC and 10 μl of propidium iodure (PI), cells were incubated during 15 minutes at room temperature in the dark Finally, 400 μl of Annexin V buffer Kit were added Every assay was made in...
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Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx
... training, testing and validating the network showed curve flattening after a few training epochs, this indicated that no overtraining occurred However, if such a model is to be applied on clinical ... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination ... cannula with saline-diluted Gd-DTPA (Magnevist ® , Schering, Berlin, Germany) was inserted into the tail vein Dynamic T1-weighted (T1W) imaging was acquired by performing 20 minutes of dynamic...
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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt
... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became a major concern in prostate cancer; ... participating in the non-self recognition of prostate cancer cells Thus we can hypothesize, according to results of Hurwitz et al [12] that the enhanced immune function, involving resting and terminally ... with a Becton Dickinson LSRII instrument (BD Biosciences) We included single-stain controls for further offline compensation Measurement and subsequent analysis was performed using FACSDiva (BD...
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Báo cáo khoa học: "High-dose intensity-modulated radiotherapy for prostate cancer using daily fiducial marker-based position verification: acute and late toxicity in 331 patients" potx
... months, continuing scoring of toxicity is needed, because an increase in GU complications has been reported after three years [27] In conclusion, a dose of 76 Gy in 35 fractions using IMRT and ... determine the incidence of late toxicity Until now, no longitudinal study of physician-reported toxicity including baseline measurements has been published for patients treated with IMRT using ... resulted in a minimum follow-up time of 31 months for all patients The prostate was delineated on a CT-scan and a margin of mm was applied to the prostate and seminal vesicles to create a planning...
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Báo cáo khoa học: "A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma" doc
... demonstrated that gemcitabine is a potent radiosensitizer in human cancer cell lines including pancreatic cancer cell lines [9-12] Thus integration of gemcitabine with radiation in a CRT protocol represents ... [13,15,16] In a phase I study by McGinn et al to find the MTD of gemcitabine in association with RT to 50.4 Gy in 1.8 Gy daily fractions in patients with locally advanced nonresectable pancreatic cancer, ... achieved by increasing the fraction size in increments of 0.2 Gy, keeping the duration of radiation constant at weeks The starting dose was 30 Gy (in Gy fractions) and the final dose investigated...
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Báo cáo khoa học: "Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: report from the Quality Assurance Working Party of the randomised phase III ROSEL study" pps
... [17,18] In order to facilitate the clinical use of these recommendations, we divided the process of implementing high-dose radiotherapy into the following headings: CT scanning and patient positioning, ... internal target volumes using slow CT alone or in combination with thin-slice CT under breath-holding conditions during the planning of stereotactic radiotherapy for lung cancer Radiother Oncol ... reconstruction generated without breathing phase binning Treatment execution It is advised to keep the inter-fraction interval at a minimum of 40 hours, in line with the RTOG protocol 0618 Page...
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Báo cáo khoa học: "Reproducibility of patient setup by surface image registration system in conformal radiotherapy of prostate cancer" pdf
... that defined in this regard the setup margin and the internal margin around the CTV to obtain the final PTV Methods The system for surface image registration installed in the Department of Radiotherapy ... obtaining informed consent following the rules of our institution All patients were affected by prostate cancer with Gleason score ranging from to (median 7.5) and PSA level at diagnosis ranging ... position inside the body that may change in relation with rectum and bladder filling In this sense, a correct patient setup can reduce the so-called setup margin but not the internal margin as defined...
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Báo cáo khoa học: " Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy" docx
... performed on-line by repositioning the target according to the internal markers, moving the treatment couch manually To calculate the minimum required margin width around the clinical target ... the interobserver variability is low Therefore implanted markers and EPID based methods are used for targeting in radiotherapy of prostate cancer with increasing frequency Our results provide information ... histograms for deriving treatment margins in radiotherapy Int J Radiat Oncol Biol Phys 2000, 47:1121-35 Poulsen PR, Muren LP, Høyer M: Residual set-up errors and margins in on-line image-guided...
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