radio telemetry blood pressure measurements in animal models of hypertension how it revolutionized hypertension research
Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... possible An alternative mode of imaging is the use of single photon imaging of γ-emitting isotopes like 11 1In or 99Tc Imaging of γ-emitting isotopes is referred to as single photon emission commuted ... Radioactive tracer imaging in intact animals Radioactive tracer studies offer greater penetration and quantitative integrity compared with optical imaging methods because the emissions from radioisotopes ... dynamics of lymphocyte interactions in the synovium has thus been established 168 Most of the work in intravital imaging of leukocytes has focused on the interaction of lymphocytes with endothelial...
- 7
- 294
- 0
Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... be injected into the enclosed joint cavity, with minimal risk of leakage to the blood circulation Because of this, precise targeting is not needed in RA, unlike in the treatment of cancer Findings ... therefore this treatment with CRAds might not be effective in animals However, inducing cell toxicity by introducing the HSV thymidine kinase (TK) gene is effective in animal models HSV-TK can phosphorylate ... reduction in local production of proinflammatory cytokines, thereby reducing their circulating levels and abolishing a sensitizing effect on naïve joints A conflicting finding was the protection of...
- 14
- 578
- 0
Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... specifically out of the four human FGF8 isoforms, and showed little binding to other members of the FGF family Neutralizing activity of KM1334 was shown by the blocking of FGF8b binding to its receptors ... was administered intraperitoneally instead of the antibody solution In a saline group of animals, saline was injected in the knee joint instead of the administration of MIA After days, synovial ... significantly inhibited FGF8-induced incorporation of [3H]thymidine Articular destruction by intraarticular injection of FGF8 into the rat knee joint The activity of FGF8 on the knee joint was tested...
- 10
- 443
- 0
Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps
... severity of PGIA and proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c ... Arthritis Research & Therapy Vol 11 No Robinson same inbred strain of mouse, the universally studied BALB/c, which is the most susceptible to PGIA The goal of the research was to compare the incidence ... Although induction of disease by the usual immunisation regime did not reveal any differences in incidence and severity, the sub-lines of BALB/c mice showed modest but significant differences in immune...
- 2
- 234
- 0
Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... [25,26] CARR injection in the hind paw of the mouse is one of the most commonly used models of inflammation and inflammatory pain and it has a biphasic profile [27] Recent studies pointed out important ... processing of other cytokines and cytokine receptors [32-35] Interestingly, PTPH1 is known to inhibit TACE expression and activity in vitro [36] We therefore analyzed cytokines plasma levels in carrageenan-treated ... prostaglandins, nitric oxide and TNFα in the CARR-induced inflammatory response [27-29] In particular, it has been shown that TNFα is involved in both phases of mouse carrageenan-induced edema...
- 14
- 370
- 0
Anti inflammatory effects of inhibitors of the tyrosine kinase signaling cascade in animal models of asthma
... proteins include protein serine-threonine kinases (Akt and phosphoinositidedependent kinase (PDK1)), protein tyrosine kinases (Btk and Tec family), exchange factor for GTP-binding proteins (Grp1 ... than wortmannin (Walker et al., 2000) LY294002 exerts PI3K inhibition by competitively binding to ATP-binding site The ATP binding site of PI3K is located in a cleft between the N-terminal lobes ... Crosslinking of FcεRI with IgE and antigen is the triggering event of the activation of protein-tyrosine kinases (PTK), including those of the Src, Syk and Tec families (Scharenberg and Kinet,...
- 172
- 290
- 0
Anti inflammatory effects of inhibitors of the tyrosine kinase signaling cascade in animal models of asthma
... tyrosine kinase inhibitor; U0126, a specific MAPK/ERK kinase (MEK) inhibitor, and LY294002, a specific PI3K inhibitor in asthmatic animal models Guinea pigs were actively sensitized by intraperitoneal ... methacholine-induced acute bronchoconstriction 4.6 OVA-induced BAL fluid eosinophilia in sensitized guinea pigs 4.7 85 Effects of genistein on OVA-induced AHR to inhaled methacholine in sensitized guinea ... OVA-induced AHR to inhaled methacholine in sensitized guinea pigs 4.11 83 Histologic examination of inflammatory cell infiltration into the bronchioles in guinea pigs 4.10 82 Histologic examination...
- 19
- 280
- 0
Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining stable phenotypes We would argue that a single ... level of accumulated Ab in brain was similar in single- and doubletransgenic mice [96] The findings are relevant to the Lewy body variant of AD with a-synuclein inclusions Instead of cross-breeding ... results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples The ability to track pathogenic events in living animals with intravital...
- 21
- 559
- 0
Báo cáo toán học: " The impact of blood pressure hemodynamics in acute ischemic stroke: a prospective cohort study" ppt
... with stroke severity at presentation For our cohort this hypertension cutoff was a blood pressure of 170/110 mmHg With the ongoing discussion on management of blood pressure in acute stage of ... above definition The relative risk of mortality at 90 days for patients with baseline hypertension was 2.05 with a 95% confidence interval of 1.02-4.10 when compared to patients presenting with lower ... baseline hypertension and death at 90 days, when defining baseline hypertension as baseline sBP = 170 mmHg and/or baseline dBP = 110 mmHg A total of 41.07% patients had baseline hypertension using...
- 18
- 340
- 0
Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
... swelling and pain, which mimic the symptoms of arthritis in RP patients In the majority of the rodent strains, however, this inflammation is erosive and symmetric This is in contrast to symptoms in ... and in the laryngeal part of the respiratory tract (b) with an influx consisting mainly of neutrophils but also of lymphocytes, macrophages and eosinophils Hematoxylin and erythrosine staining ... alternative models for investigating the mechanisms of joint inflammation Aggrecan [31] and the aggrecan-associated link protein [32] are two examples of such cartilage proteins that trigger arthritis in...
- 6
- 264
- 0
Báo cáo y học: " Epitope spreading in animal models: array of hope in rheumatoid arthritis and multiple sclerosis" pot
... BH, Kanter JL, Steinman L, Robinson WH: Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination Arthritis Res Ther 2008, 10:R119 Kinloch A, Lundberg ... Lopez-Hoyoz M, Merino J, Merino R, Joosten LA: Absence of citrulline-specific autoantibodies in animal models of autoimmunity Arthritis Rheum 2004, 50:2370-2372 Page of (page number not for citation purposes) ... and arginine-containing control peptides [6] In RA, the anti-CCP response reflects the genotype-serotypephenotype model, with antibodies to citrullinated proteins being closely correlated with the...
- 2
- 278
- 0
Báo cáo y học: "Arterial blood pressure monitoring in overweight critically ill patients: invasive or noninvasive" pdf
... and appears to be explained not by an inability to record the first audible Korotkoff sound but by the increasing critical closing pressure with increasing levels of blood pressure [8] Conclusion ... Biases and limits of agreement between blood pressure measurement techniques for each level of blood pressure Arterial blood pressure Mean bias Upper limit of agreement Lower limit of agreement ... patients requiring intensive care treatment are becoming increasingly common and, because of their body size and habitus, it is unclear whether invasive and noninvasive blood pressure measurements...
- 5
- 488
- 2
Báo cáo khoa học: "Blood glucose measurements in the critically ill: more than just a blood draw" doc
... about benefit versus potential harm of intensive insulin therapy in critically ill patients Competing interests The authors declare that they have no competing interests crit when whole blood samples ... Spanjersberg R, Lind JSW, Tulleken JE, Meertens JHJM, Zijlstra JG: Accuracy and feasibility of point -of- care and continuous blood glucose analyzing in critically ill ICU patients Crit Care 2006, ... Tierney M, Meggison H, McIntyre L, Hebert PC: Standardization of intravenous insulin therapy improves the efficiency and safety of blood glucose control in critically ill adults Intensive Care Med...
- 2
- 262
- 0
Báo cáo y học: "Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models" doc
... Anti-inflammatory effects of KHU14 on animal models of acute inflammation Anti-inflammatory effects of KHU14 on animal models of acute inflammation (A) Ear edema in mice (n = 10) (B) Paw edema in ... effects of KHU14: (1) inhibition of croton oil-induced ear edema in mice; (2) carrageenan-induced paw edema in rats; and (3) acetic acid-induced permeability test in mice In the croton oil-induced ... Antiallergic activity of hesperdine is activated by intestinal microflora Pharmacology 2004, 71(4):174-180 Sasaki K, Yoshizaki F: Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit Biol...
- 7
- 340
- 0
The function of anxiety fear related genes in animal models 3
... of CCK4 on context- and tone-dependent fear conditioning after i.h injection Mice were injected with 50ng CCK4 30min before training Context- and tone-dependent fear conditioning were determined ... 5HT3R The integrated density of the bands corresponding to different mRNAs was measured by NIH image-processing software Ratios of the corresponding density (e.g.Arc/β-actin or 5-HT3R/β-actin) were ... in the coding region of the CCK2 receptor gene CCK2 gene contains 1,764 base pairs, which includes three introns (showed as double lines) and four exons (showed as rectangles) The positions of...
- 41
- 190
- 0
The function of anxiety fear related genes in animal models 2
... increase brain levels of 'free CRF' in Alzheimer's disease (AD) and show cognition-enhancing properties in models of learning and memory in animals without the characteristic stress effects of ... in the brain (Innis and Snyder, 1980) The gastrin receptor mediating acid secretion in the stomach was initially thought to constitute a third type of high-affinity receptor on the basis of its ... previous findings of the role of 5-HT2 receptors in anxiety 3.3.3 5-HT3 receptors The highest density of 5-HT3 binding sites is found in the area postrema, with lower but significant densities also...
- 160
- 262
- 0
The function of anxiety fear related genes in animal models
... Role of CRF2 receptors in anxiety 35 Table of Contents 4.5 Role of the CRF system in memory and learning Animal Models vi 37 39 5.1 Introduction 39 5.2 Validity criteria of an animal model 40 5.3 ... (Glu11,16)-astressin I.c.v injection of CCK4 before training, but not after training, reduced the freezing behavior of mice on both context- and tone-dependent fear conditioning This impairment ... with (Glu11,16)-astressin 15 minutes before the application of CCK4, while injection of (Glu11,16)-astressin alone did not exhibit any significant effect The finding that (Glu11,16)-astressin...
- 13
- 280
- 0
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... had implicated abnormally increased activity of RhoA in vitro A role for increased RhoA activity in vivo was suggested by the ability of statins – known inhibitors of Rho GTPases [43] – to rescue ... phenotype was seen in only a small percentage of fish Combining this low dose of rap1b morpholino with a similarly low dose of san morpholino resulted in a synergistic increase in both the intracerebral ... protein function in vivo, especially in development where the proof of essential function is often embryonic lethality in complete knockouts Indeed, mice lacking either Krit1 or Ccm2 die in mid-gestation...
- 8
- 416
- 0
báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... murine models utilize genetic inactivation of p53 to produce brain tumors In general, such inhibition is achieved via either germ line p53 deletions, or by functional p53 inhibition utilizing ... by the use of germ line p53 inactivation alters immune system function in a number of significant ways in these animals, limiting the use of these models for evaluating the effect of anti-tumor ... Germline mutation, Oligodendrocyte mutation Germline mutation or Conditional KO Germline mutations RCAS GFAP-conditional KO Nestin-conditional KO Nestin-conditional KO GFAP-conditional KO Animal...
- 9
- 438
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008