quality safety and efficacy of dna vaccines

Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"

Ngày tải lên : 26/10/2012, 09:48

... compliance Compliance was assessed by capsule count at visits 3, 4, and and review of subject diary Efficacy and Safety Variables Efficacy and safety measurements assessed Adverse events During the study, ... Canada) Appropriateness of Measurements The efficacy and safety assessments used in this study were standard for OA and are widely used and recognized as reliable, accurate, and relevant WOMAC scores ... common form of arthritis, and it is often associated with significant disability and an impaired quality of life Clinical and radiographic surveys have found that the prevalence of OA increases...

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Báo cáo khoa học: "The Safety and efficacy of a new self-expandable intratracheal nitinol stent for the tracheal collapse in dogs" ppt

Ngày tải lên : 07/08/2014, 20:23

... contrast to self-expanding stainless steel biliary wall stents and other nitinol stents [4,9-11], none of the nitinol expandable stents were broken, shortened or migrated The flared ends of the stent ... likely prevented stent migration and increased stent stability Dorsoventral radiographs comparing the length and location of each stent with the number of cervical and thoracic vertebrae showed ... implantation of only one stent for treatment of tracheal collapse, whereas dogs required multiple implantations of other nitinol stents [4,9,11] In conclusion, we found that implantation of self- expandable...

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Báo cáo khoa học: "The safety and efficacy of gamma knife surgery in management of glomus jugulare tumor" pptx

Ngày tải lên : 09/08/2014, 03:22

... degrees of success ranging from a maximum of 61-71% to an average of 23% Side-effects include osteoradionecrosis of the temporal bone, radiation necrosis of the temporal lobe, mastoiditis and second ... of radiotherapy for chemodectomas Mayo Clin Proc 1992, 67:537-540 doi:10.1186/1477-7819-8-76 Cite this article as: Hafez et al.: The safety and efficacy of gamma knife surgery in management of ... Materials and methods Objective To evaluate the safety and efficacy of gamma knife surgery (GKS) for controlling the glomus jugulare tumors Method Between 2004 and 2008, 13 cases with glomus jagulare...

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Báo cáo y học: " Safety and efficacy of a generic fixed-dose combination of stavudine, lamivudine and nevirapine antiretroviral therapy between HIV-infected patients with baseline CD4 " pot

Ngày tải lên : 10/08/2014, 05:20

... initiation of a FDC of d4T/3TC/NVP in HIV-infected patients with baseline CD4 cell count of 0.05) Group A patients had a median CD4 cell count of 85, 125, 158 and 198 cells/mm3 and group B patients had a median CD4 of 240, 280, 305 and 331 cells/mm3 at 12, 24, 36 and ... copies/ml, 2) the increment of the number of CD4 cell counts at 48 weeks of ART from baseline value and 3) the incidences of NVPassociated adverse reactions including skin rashes and hepatotoxicity that...

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Báo cáo khoa học: " Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]" pps

Ngày tải lên : 12/08/2014, 20:20

... effects of remifentanil compared with those of alfentanil [8] and fentanyl [9] are similar; remifentanil also has a safety profile similar to that of other opioids [8-10] The predictable offset of ... maximum rate of 60 µg kg-1 h-1 and/ or additional boluses and/ or increases in the infusion rate of propofol up to a maximum dose of mg kg-1 h-1 to attain and then maintain optimum analgesia and sedation ... and sedation beyond day 3, propofol was discontinued and replaced with midazolam in accordance with local transitioning protocols The infusion rates of fentanyl and morphine and bolus doses and...

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Báo cáo y học: "The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial" potx

Ngày tải lên : 13/08/2014, 18:21

... dose of 20 mg during the course of the study All 14 subjects who were randomized to placebo and completed weeks of treatment had their "dose" of blinded medication "increased" to 20 mg The rate of ... by a clinical evaluation by a child and adolescent psychiatrist Specification of abuse disorder (abuse vs dependence), age of onset of symptoms, and length of illness were based on data obtained ... a group of youths who were at risk for ongoing substance abuse, the dose of fluoxetine used in this study was limited to a maximum of 20 mg/day Although the efficacy of higher doses of fluoxetine...

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handbook of seafood quality, safety, and health applications

Ngày tải lên : 29/05/2014, 16:40

... vour 7.3.6 Dietary and handling impacts on texture 7.3.7 Impact of aquaculture handling and killing procedure on post-mortem quality 7.3.8 Effect of feeding on post-mortem quality and technological ... assistance is required, the services of a competent professional should be sought Library of Congress Cataloging-in-Publication Data Handbook of seafood quality, safety, and health applications / edited ... oxidation in ordinary and dark muscle of fis Effects of bleeding and perfusion of yellowtail on post-mortem lipid oxidation of ordinary and dark muscles Conclusions References Blackening of crustaceans...

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báo cáo hóa học:" Efficacy, Safety and Pharmacokinetics of Once-Daily Saquinavir Soft-Gelatin Capsule/Ritonavir in Antiretroviral-Naive, HIV-Infected Patients" pot

Ngày tải lên : 20/06/2014, 08:20

... at least dose of study medication and had at least postbaseline safety assessment Efficacy and Safety Measures The primary efficacy variable was the proportion of patients with plasma HIV-RNA values ... population consisted of 110 patients: 52 and 58 patients in the saquinavir-SGC/ritonavir and efavirenz arms, respectively The safety population consisted of 161 randomized patients: 81 and 80 patients ... once daily in in the safety population of patients treated with either saquinavir-soft gelatin Figure Mean levels of triglycerides and total cholesterol in the safety population of patients treated...

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Báo cáo y học: " Efficacy, safety and pharmacokinetic of once-daily boosted saquinavir (1500/100 mg) together with 2 nucleos(t)ide reverse transcriptase inhibitors in real life: a multicentre prospective study" ppt

Ngày tải lên : 10/08/2014, 05:21

... the efficacy raised to 90.4%, with similar results regardless of baseline VL and CD4 counts The presence of more adherent patients in the “simplification” group may be the cause of the higher efficacy ... open-label characteristics of the study, the heterogeneity of the analyzed population and the lack of available genotypic resistance tests in some of the patients at baseline and after virological ... under 100 ng/ml, and of them had a satisfactory virological response No correlations were found between SQV levels and either weight, gender or the presence of chronic hepatitis and/ or cirrhosis...

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Báo cáo y học: "Ablation of atrial fibrillation with the Epicor system: a prospective observational trial to evaluate safety and efficacy and predictors of success" pptx

Ngày tải lên : 10/08/2014, 09:22

... suffered in 20% of cases of paroxysmal, in 37% of persistent, and in 41% of cases of long standing persistent AF There was no statistical significant correlation in between type of AF and diagnosis ... without the need of large thermal gradients and without jeopardizing adjacent structures (Figure 1) [6] The purpose of this study was to evaluate the efficacy of left atrial HIFU ablation of AF with ... Diagnosis and classification of AF were established by standard ECG and holter ECG in all patients prior to admission AF was defined paroxysmal in 29%, persistent in 31% and long standing persistent...

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Báo cáo y học: " Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses" doc

Ngày tải lên : 11/08/2014, 10:23

... Induction of anti-tumor effector T cells Since induction of cytolytic effector cells is pivotal in ensuring the success of tumor vaccines, we investigated relative efficacy of phytols and known ... effects on the production of anti -DNA Abs No signs of glomerulonephritis in phytol-treated mice Further evaluation of safety and toxicity was assessed by histopathology of the kidneys from mice ... Vaccine Formulation: Assessment of Safety and Efficacy in the Induction and Protective Immune Responses to Lethal Bacterial infections in Mice J Immune Based Therapies and Vaccines 2006, 4:5 Bendavid...

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Báo cáo y học: "Correction: Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses" pot

Ngày tải lên : 11/08/2014, 10:23

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Báo cáo y học: "Dose-associated changes in safety and efficacy parameters observed in a 24-week maintenance trial of olanzapine long-acting injection in patients with schizophrenia" pdf

Ngày tải lên : 11/08/2014, 16:23

... results of post hoc analyses of a 24-week maintenance study of olanzapine LAI [2] examining the potential association between olanzapine LAI dose and several safety and efficacy parameters of clinical ... discontinuation; rate of overall discontinuation; and rate of discontinuation due to efficacy- related reasons Efficacy- related reasons” was defined as discontinuation due to lack of efficacy or discontinuation ... changes make interpreting our findings regarding safety and efficacy more difficult Conclusions Analyses of several clinically important safety and efficacy measures revealed significant dose-associated...

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Báo cáo y học: " Efficacy, safety and tolerability of escitalopram in doses up to 50 mg in Major Depressive Disorder (MDD): an open-label, pilot study" doc

Ngày tải lên : 11/08/2014, 16:23

... associated higher rates of discontinuation due to intolerance The objectives of this open-label, pilot study were to investigate the efficacy, safety and tolerability of escitalopram in doses ... Improvement of Illness (CGI-I) scale [11] Outcome measures: Safety and tolerability Safety and tolerability outcomes were assessed from adverse events (AEs), vital signs, weight, physical examination and ... relationship between age group, gender and history of anxiety and the probability of achieving remission at the end of the study A repeated measures analysis of covariance (ANCOVA) was carried out...

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Báo cáo y học: " A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults" pdf

Ngày tải lên : 13/08/2014, 21:20

... http://ccforum.com/content/14/3/R125 Page of 13 Figure Mean ibuprofen concentrations (hour to 4), by treatment group and randomization stratum In a secondary analysis of efficacy, the efficacy of IV ibuprofen was analyzed ... the efficacy, safety, and pharmacokinetics of IV ibuprofen in adult subjects with fevers greater than or equal to 101.0°F Subjects were randomized to receive a placebo or one of three doses of ... multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and...

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Báo cáo sinh học: "Liposomal delivery of p-ialB and p-omp25 DNA vaccines improves immunogenicity but fails to provide full protection against B. melitensis challenge" pptx

Ngày tải lên : 14/08/2014, 19:22

... protective regimen of four doses of naked DNA vaccine, (b) a single dose of naked DNA vaccine or (c) a single dose of lipoplexed DNA vaccine Commander et al Genetic Vaccines and Therapy 2010, ... backbone and the nature of antigen presentation and T cell priming from both the Page 10 of 12 IalB and Omp25 candidate vaccines may be useful in guiding further development of these vaccines and ... re-evaluate our two candidate DNA vaccines as single doses of naked DNA (100 μg per mouse) and an equivalent quantity of the DNA surface adsorbed to a novel formulation of cationic liposomes...

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Báo cáo khoa học: Recognition of DNA modiﬁed by trans-[PtCl2NH3(4hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex potx

Ngày tải lên : 16/03/2014, 14:20

... pairing of single-stranded DNA containing 1,3-GNG intrastrand CL of transplatin with their complementary DNA sequences results in a rearrangement of these intrastrand adducts into interstrand CLs ... corresponding to single strands of DNA and interstrand cross-linked duplex were quantiﬁed Rearrangement of intrastrand cross-links The platinated oligodeoxyribonucleotide (top strand of the duplex TGTGT, ... Autoradiogram of denaturing 1% agarose gels of linearized DNA which was 3¢-end labeled The interstrand cross-linked DNA appears as the top bands migrating on the gel more slowly than the single-stranded DNA...

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synthesis and application of dna-templated silver nanowires

Ngày tải lên : 20/03/2014, 13:08

... saturation of the adsorption sites gradually on the nanowires 3.2.2 Response and recovery of the DNA- templated silver nanowires exposed to ammonia The response and recovery of the DNA- templated ... to dense growth of Ag on DNA With extension of the reduction time, not only the diameters of the nanowires increased but also the entire DNA chain was covered more uniformly and densely by silver ... diameter of the DNA- Ag nanowires could be controlled by changing the reduction time Fig TEM images of DNA- Ag nanowires after h reduction time (a) shows a large scale networks structure of DNA- templated...

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WATER QUALITY MANAGEMENT AND CONTROL OF WATER POLUTION docx

Ngày tải lên : 23/03/2014, 00:20

... field of wastewater reuse and for control of water pollution: Water quality management and control of water pollution Promote and assist in the modernization of policies, regulations, laws and ... water quality management Usually the selection of water quality parameters is out -of- date, methodologies are often very old, the data are often not quality controlled or quality assured and may ... comparison, and evaluation of pollution sources, water quality and pollution loads throughout the basin, including evaluation of data quality; identification and characterization of areas and issues...

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BEER: QUALITY, SAFETY AND NUTRITIONAL ASPECTS potx

Ngày tải lên : 29/03/2014, 04:20

... will be on foam and colour as a haze-free or bright beer is generally mandatory for consumer acceptance The presence of haze is often a result of the deterioration of beer with time and so is discussed ... system and therefore retain a degree of amphipathicity Other Components Polyphenols Beers contain a range of monomeric and condensed polyphenol struc- Beer Quality and the Importance of Visual ... esterification of alginic acid with propylene oxide (Figure 2.5) The degree of esterification is important in determining the efficacy of foam stabilisation and colloidal stability of the final beer, and...

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