pylori and uninvestigated dyspepsia

Báo cáo khoa học: "Helicobacter pylori and gastroesophageal reflux disease" pps

Ngày tải lên : 09/08/2014, 07:21

... the prevalence of both H pylori and cagA+H pylori and reflux disease, Barrett's oesophagus and oesophageal adenocarcinoma [47] Conclusion The exact association between HP and reflux disease continues ... helicobacter pylori positive and negative patients with gastroesophageal reflux disease? Gut 1998, 43(S1):14-20 Sharma VK, Howden CW: Decreased prevalence of H pylori and cagA+ H pylori in GERD and Barrett's ... Dowell AC, Axon AT: Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial Leeds HELP Study Group...

7
285
0

Báo cáo y học: " Helicobacter pylori induces mitochondrial DNA mutation and reactive oxygen species level in AGS cells"

Ngày tải lên : 25/10/2012, 11:18

... and light strands of the mtDNA, and contains essential transcription and replication elements The D-loop region is a hot spot for mtDNA alterations and the nucleotide positions 16024±16 324 and ... relationship between ROS and mtDNA mutation rate was assessed using a linear correlation test Results CagA and VacA proteins As shown in Fig 1a and b, the CagA protein (120 kDa) and VacA protein (95 ... activity and expression of base excision repair and mismatch repair are down-regulated both in vitro and in vivo Moreover, Hp induces genomic instability in nuclear CA repeats in mice and in mtDNA...

12
557
2

Báo cáo y học: No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanes

Ngày tải lên : 31/10/2012, 14:34

... Patients and Methods Differences in age, sex, smoking status, alcohol consumption, concentration of serum folate and tHcy, and genotype frequencies between the positives and the negatives of H pylori ... concentrations of 101 serum folate and tHcy were found between the positives and the negatives of H pylori infection and gastric atrophy according to the genotypes of MTHFR and TS in any subgroups defined ... between Cag A-positive H pylori and vascular risk [27, 28] On the other hand, there were many reports of positive associations of stroke and carotid artery disease with H pylori infection In addition,...

7
578
1

Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

Ngày tải lên : 31/10/2012, 15:37

... Helicobacer pylori (H pylori) antibody and pepsinogens Anti-H pylori IgG antibody tests, high-molecularweight campylobacter-associated-protein (HM-CAP) ELISA (Enteric Products Inc., Westbury, NY) and ... considered as the loss of H pylori infection following n 317 119 18 137 The combination of Gab1 and PTPN1 1and H pylori- related gastric atrophy We have got subjects narrowed down to H pylori seropositive ... culture and bacteriological tests (Gram-negative, oxidase, catalase, and urease test–positive spiral, curved rods) using biopsy specimens before gastric resection Pepsinogens I and II (PG I and PG...

6
541
0

Báo cáo y học: " Eradication rate of Helicobacter pylori according to genotypes of CYP2C19, IL-1B, and TNF"

Ngày tải lên : 31/10/2012, 16:57

... band for the 681G allele and a 105-bp band for 681A allele, with a 191-bp their common band, and a 377-bp band for 636G allele and a 255-bp band for 636A allele, with a 597-bp their common band ... genotype, and poor metabolizers (PM) with *2*2, *2*3, or *3*3 genotype; *1*1, with the 681GG and 636GG; *1*2, with the 681GA and 636GG; *1*3 with the 681GG and 636GA; *2*2, 137 with the 681AA and 636GG; ... region; G-238A, G-308A, C-857T, C-863A, and T-1031C Among Japanese, the -238A and -308A alleles are rare and C-863A is tightly linked with T-1031C With respect to H pylori seroposotivity, we have reported...

6
650
1

Tài liệu Báo cáo khoa học: Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori docx

Ngày tải lên : 19/02/2014, 05:20

... gene encoding SDH from H pylori strain SS1 The recombinant H pylori shikimate dehydrogenase (HpSDH) was cloned, expressed, and puriﬁed in E coli system, and its biochemical and enzymatic characterizations ... (Eqn 2) On the other hand, compounds 1, 4, and are noncompetitive inhibitors, and compounds and are competitive inhibitors with respect to NADP Table summarizes the IC50 values and kinetic inhibition ... against H pylori The results show that compounds 1, 2, and display moderate inhibitory activity against the growth of H pylori strains ATCC 43504 and SS1 in vitro with MIC values of 16, 16, and 32...

11
529
0

Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc

Ngày tải lên : 06/03/2014, 00:21

... cagPAI and the properties of both conserved and unique components of the Cag-T4SS, together with potential implications for the current understanding of its mode of action The cagPAI and the ... transcribed among all cag genes in vitro and in vivo, and transcripts of cagS, cagQ and cagP were also found [25] Moreover, a recent determination of the complete H pylori transcriptome identiﬁed a number ... additional components, CagM and Cagd Both proteins have N-terminal signal sequences and were shown to be associated with the outer membrane and to interact with CagT, with CagX, and with each other [22,33]...

10
393
0

Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx

Ngày tải lên : 06/03/2014, 00:21

... be distinguished Helices B, E, F and H, arranged in an up -and- down topology, form the structural core, whereas the short helices C, D and G on one side, and A, I and J on the other, represent types ... glutamate and aspartate residues conﬁned to the portion of the molecule involving a-helix A, the nearby loop, the ﬁrst and last turns of helices E and F, and the C-terminus helices I and J In ... expression levels and the stability of Cagd and CagT proteins Unique type IV components of H pylori cag PAI [22] Taken together, these results suggest that Cagd represents a unique and essential...

9
496
0

Báo cáo khoa học: Structural and mutational analysis of TenA protein (HP1287) from the Helicobacter pylori thiamin salvage pathway – evidence of a different substrate speciﬁcity doc

Ngày tải lên : 16/03/2014, 00:20

... Helicobacter pylori virulence and genetic geography Science 284, 1328–1333 Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N & Sibley RK (1991) Helicobacter pylori infection and ... 4-amino-5-aminoethyl-2methylpyrimidine: with a kcat and KM of 1.7 ± 0.2 min)1 and 58 ± 22 lm, respectively The F47Y variant appears to be poorly active as well: with a kcat and KM of 0.06 ± 0.006 min)1 and 68 ± 16 lm, respectively ... H pylori genome includes two genes that code for enzymes possibly involved in the phos6230 phorylation of HMP and hydroxyethylthiazole (HET), ThiD (HP0844) and ThiM (HP0845), respectively, and...

9
491
0

Báo cáo khoa học: Puriﬁcation and characterization of Helicobacter pylori arginase, RocF: unique features among the arginase superfamily doc

Ngày tải lên : 16/03/2014, 16:20

... activity (Figs 3, and and Table 1), and (e) the rocF gene and RocF protein shared homology with the arginase/agmatinase superfamily [8] These results demonstrate that rocF is necessary and sufﬁcient ... of Helicobacter pylori infection: bacterial factors In Current Topics in Microbiology and Immunology Gastroduodenal Disease and Helicobacter Pylori: Pathophysiology, Diagnosis and Treatment (Westblom, ... other divalent cations was detected in H pylori arginase-containing extracts (data not shown) Viable H pylori and transformed E coli containing the H pylori arginase gene had signiﬁcantly more...

11
575
0

Báo cáo khoa học: Helicobacter pylori single-stranded DNA binding protein – functional characterization and modulation of H. pylori DnaB helicase activity pptx

Ngày tải lên : 30/03/2014, 02:20

... ﬂuoride and 10% glycerol For helicase and ATPase assays, HpSSB (Wt) and DC20SSB were dialysed against MonoQ and MonoS buffers and subjected to ion exchange chromatography using MonoQ and MonoS ... containing 540 bp and 480 bp of H pylori SSB full length and C-terminal deletion mutant pET28a derivative containing 1.5 kb of H pylori dnaB pGEX derivative containing 1.5 kb of H pylori dnaB F ± ... Wt and DC20 SSB protein in varying concentrations (0, 0.45, 0.9, 1.8, 2.7 and 3.6 lg, respectively) with 300 ng of M13mp18 single-stranded circular DNA and ⁄ or 300 ng of pUC18 double-stranded...

13
438
0

Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt

Ngày tải lên : 18/06/2014, 16:20

... transfection and cultured in the absence of H pylori; H pylori control, the cells without transfection and cultured in the presence of H pylori Figure Inhibition of PAR-2 expression augments H pyloriinduced ... treatment and cultured in the absence of H pylori; H pylori control, the cells without treatment and cultured in the presence of H pylori Page of Soybean trypsin inhibitor (SBTI) augments H pyloriinduced ... treatment and cultured in the absence of H pylori; H pylori control, the cells without treatment and cultured in the presence of H pylori Figure Soybean trypsin inhibitor (SBTI) augments H pyloriinduced...

7
399
0

báo cáo hóa học: " Reliability and validity of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in dyspepsia: A six-country study" pptx

Ngày tải lên : 18/06/2014, 22:20

... GSRS and QOLRAD, respectively, were as follows: South Africa, 2.7% and 2.7%; Germany, 6.4% and 12.7%; Hungary, http://www.hqlo.com/content/6/1/12 8.8% and 8.8%; Italy, 6.3% and 1.1%; Poland, ... correlating the GSRS and the QOLRAD with the SF-36 dimensions; and (c) correlating the GSRS and the QOLRAD with the HAD (except in South Africa) and with clinician-rated severity of dyspepsia symptoms ... been validated in patients with dyspepsia in clinical trials: the Severity of Dyspepsia Assessment (SODA) [24], the Nepean Dyspepsia Index (NDI) [25] and the Dyspepsia Symptom Severity Index...

12
590
0

báo cáo hóa học:" Psychometric validation of the Dutch translation of the quality of life in reflux and dyspepsia (QOLRAD) questionnaire in patients with gastroesophageal reflux disease" ppt

Ngày tải lên : 20/06/2014, 16:20

... Reflux and Dyspepsia (QOLRAD) questionnaire [9] The QOLRAD questionnaire measures the impact of reflux symptoms on patients’ emotional health, sleep, vitality, eating and drinking, and physical and ... symptom relief and patient satisfaction Patients satisfied with the treatment and with sufficient symptom relief entered the maintenance phase and were randomized to receive Page of on-demand esomeprazole ... 0.30 and 0.60, and a low correlation below 0.30 [17] † As assessed by the clinician GERD, gastroesophageal reflux disease; QOLRAD, Quality of Life in Reflux and Dyspepsia Engels et al Health and...

8
431
0

diagnosis and treatment of helicobacter pylori infection in vietnamese children

Ngày tải lên : 23/07/2014, 04:05

... to determine H pylori status in the treatment trial and in the reinfection study Culture of H pylori from biopsies was performed by standard methods Susceptibility testing of H pylori to all three ... gastric and duodenal mucosa for histopathology, rapid urease test (RUT) and culture of the biopsies for H pylori are invasive techniques [8, 9] Culture of H pylori is considered the gold standard ... Marshall and Warren were awarded the Nobel Prize in Physiology or Medicine for their discovery of the bacterium H pylori and its role in gastritis and peptic ulcer disease 1.1.2 Microbiology H pylori...

77
682
1

Báo cáo y học: " Significant association between Helicobacter pylori infection and serum C-reactive protein" docx

Ngày tải lên : 08/08/2014, 17:20

... and 0.020-0.082 in YTI, 0.023-0.072 and 0.018-0.071 in ENUH, and 0.016-0.143 and 0.010-0.061 in PIC In total, the geometric mean of hsCRP level was 0.047mg/dl for H pylori positive subjects and ... hsCRP level was 0.051 mg/dl for H pylori positive subjects and 0.042 mg/dl for H pylori negative subjects in YTI, 0.043 mg/dl and 0.036 mg/dl in ENUH, 0.045 mg/dl and 0.028 mg/dl in PIC, respectively ... H pylori infection and serum hsCRP levels, supporting that H pylori infection may increase the serum CRP The possible attribution of H pylori infection to CRP elevation could be a route to H pylori...

6
364
1

Báo cáo khoa học: "High grade B-cell gastric lymphoma with complete pathologic remission after eradication of helicobacter pylori infection: Report of a case and review of the literature" pdf

Ngày tải lên : 09/08/2014, 07:21

... performed bibliographic research and participated in manuscript revision process, AZ and CP performed pathological diagnosis and histological pictures All authors read and approved the final manuscript ... Staging was completed with neck, chest and abdominal computed tomography and with bone marrow biopsy There were not other lymphoma-deposits outside the stomach, and a clinical stage E I2 was established ... [7,10-25] and 42 of them showed a complete response There were anecdotal cases reported and patients belonging to prospective studies Four trials studied the effect of eradication of Helicobacter pylori...

7
373
0

CHARACTERISATION OF GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI

Ngày tải lên : 09/09/2015, 17:58

... Association of Helicobacter pylori and gastroduodenal diseases 1.2 Virulence factors of H pylori 1.3 γ-glutamyl transpeptidase (GGT) 1.3.1 H pylori GGT 1.3.2 GGT and H pylori pathogenesis 1.4 Objectives ... of H pylori infection on host 2.5.1 Oxidative stress 19 20 2.5.1.1 H pylori and reactive oxygen species (ROS) generation 20 2.5.1.2 H pylori decreases antioxidant levels 21 2.5.2 H pylori and ... conserved within the H pylori species and has been reported to be expressed in all H pylori strains (Chevalier et al., 1999) Introduction 1.3.2 GGT and H pylori pathogenesis H pylori GGT was found...

281
306
0

Characterization of helicobacter pylori y glutamyl transpeptidase and its role in pathogenesis

Ngày tải lên : 12/09/2015, 09:55

... Helicobacter pylori and gastroduodenal diseases 1.2 Virulence factors of H pylori 1.3 γ-glutamyl transpeptidase (GGT) 1.3.1 GGT in H pylori 1.3.1.1 GGT and H pylori colonization 1.3.1.2 GGT and H pyloriinduced ... 2.6.2.3 H pylori activates NF-κB, AP-1 and MAPK 29 2.6.2.4 Virulence factors and H pylori - induced IL-8 production 30 2.6.3 H pylori infection and cell apoptosis 31 2.6.3.1 The intrinsic and extrinsic ... diagnosis of H pylori infection (Anderson and Gonzalez, 2000; Markristathis et al., 2004), epidemiology of H pylori infection (Mitchell and Megraud, 2002; Perez-Perez et al., 2004), H pylori and gastroduodenal...

270
206
0

Cloning, expression and characterization of novel helicobacter pylori differentiating antigen heat shock protein 20

Ngày tải lên : 12/09/2015, 10:19

... mutagenesis study in Helicobacter pylori 34 2.9 Animal model of Helicobacter pylori 35 MATERIAL AND METHODS 3.1 Propagation of bacteria and cell lines 39 3.1.1 H pylori and E coli 39 3.1.2 Gastric ... thereby enriched our understanding on interactions between H pylori and host xiv INTRODUCTION Introduction 1.1 Helicobacter pylori and gastroduodenal diseases Helicobacter pylori is a gram-negative, ... duodenal ulcer and increased risk of gastric cancer About 90% of chronic gastritis is caused by H pylori (Dixon and Sobala, 1992) The association of non-ulcer dyspepsia (NUD) and H pylori infection...

301
525
1