pylori and gastric cancer
MANAGEMENT OF OESOPHAGEAL AND GASTRIC CANCER ppt
... PRESENTATION AND REFERRAL RISK FACTORS Oesophageal and gastric cancers occur mainly in people over 55 years of age Male sex is a risk factor for squamous cancer of the oesophagus and for oesophagogastric ... oesophagogastric junction cancer Deprivation is a risk factor for development of squamous cancer of the oesophagus and for gastric cancer Tobacco smoking increases the risk of squamous cancer of the oesophagus ... adenocarcinoma and with a risk of oesophagogastric junction cancer The presence of Helicobacter pylori infection is associated with a two to threefold increase in the risk of developing gastric cancer...
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Management of oesophageal and gastric cancer doc
... females: 7% to 13%) and gastric cancer (males: 6% to 13%; females: 9% to 18%) it remains low Management of oesophageal and gastric cancer 1.2 Scottish audit of Gastric and Oesophageal cancer The Scottish ... 6.5% Oesophageal and gastric Cancer causes of death in Scotland 2004 (excluding non-melanoma skin cancer) 26.2% 10.3% Trachea, bronchus and lung Colorectal 9.4% Oesophageal and gastric 7.3% Breast ... Figure 1) Figure Cancer diagnoses and cancer deaths in Scotland1 Most common cancers in Scotland 2002 (excluding non-melanoma skin cancer) 17.7% 14.1% 13.0% 9.0% Trachea, bronchus and lung Breast...
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GASTRITIS AND GASTRIC CANCER – NEW INSIGHTS IN GASTROPROTECTION, DIAGNOSIS AND TREATMENTS docx
... Medici and Graciela Font de Valdez 153 Helicobacter Pylori Infection in Gastritis and Gastric Cancer 177 Chapter 10 Gastric Cancer Risk Diagnosis and Prevention in Subjects with Helicobacter pylori- related ... to the mucosal surface and the gastric lumen in a solubilized Gastritis and Gastric Cancer – New Insights in Gastroprotection, Diagnosis and Treatments Fig Composition of gastric mucus condition ... complaints; the gastric mucosa became to be negative (intact gastric mucosa) in 25%, and 75% of patients 36 Gastritis and Gastric Cancer – New Insights in Gastroprotection, Diagnosis and Treatments...
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Báo cáo y học: No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanes
... characteristics of patients according to H pylori infection and gastric atrophy are shown in Table 100 Age was significantly associated with H pylori infection and gastric atrophy There were no significant ... concentrations of 101 serum folate and tHcy were found between the positives and the negatives of H pylori infection and gastric atrophy according to the genotypes of MTHFR and TS in any subgroups defined ... the routes from H pylori infection to gastric atrophy and from low folate concentration to hyperhomocysteinemia are well established But the routes between H pylori infection and hyperhomocysteinemia...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... considered as the loss of H pylori infection following n 317 119 18 137 The combination of Gab1 and PTPN1 1and H pylori- related gastric atrophy We have got subjects narrowed down to H pylori seropositive ... Gab1 polymorphism and the step of atrophy/metaplasia -gastric cancer We assessed whether the Gab1 gene polymorphism was associated with the development of H pylori- related gastric cancer Table shows ... atrophy/metaplasia -gastric cancer sequence, proposed as the Correa cascade [20], we made a comparison between cases and controls with seropositive atrophy The ORs of the G/A and A/A for gastric cancer was...
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Nitrosamine and related food intake and gastric and oesophageal cancer risk: A systematic review of the epidemiological evidence ppt
... pylori infection and environmental factors in non-cardia gastric cancer in Japan Gastric Cancer 2004; 7: 46-53 De Stefani E, Deneo-Pellegrini H, Mendilaharsu M, Ronco A Diet and risk of cancer of the ... drinking, and esophageal cancer in Argentina Cancer Epidemiol Biomarkers Prev 1994; 3: 557-564 Rolon PA, Castellsague X, Benz M, Munoz N Hot and cold mate drinking and esophageal cancer in Paraguay Cancer ... A: Meat intake and gastric cancer (case-control studies); (a) Meat intake: (a1) meat (a2) pork (a3) grilled meat (a4) mutton (a5) beef (a6) red meat; B: Processed meat and gastric cancer (case-control...
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Báo cáo khoa học: Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A ⁄sodium butyrate-induced and 5-aza-2¢-deoxycytidine-induced PTEN upregulation ppt
... Krishnan AV (2000) Vitamin D and prostate cancer Endocrinology 141, 5–9 Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease ... Schmidt N, Dietzmann K & Malfertheiner P (2002) Reduced PTEN expression in gastric cancer and in the gastric mucosa of gastric cancer relatives Eur J Gastroenterol Hepatol 14, 297–303 Pan L, Lu J, ... D as a novel molecular target in gastric cancer therapies in association with the use of TSA ⁄ NaBu and 5-Aza Results Vitamin D induced apoptosis in gastric cancer cells through PTEN upregulation...
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báo cáo hóa học:" Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer" pptx
... 16.5 ± 27.4 42 46.3 ± 551.5 14.1 ± 13.2 EGC, early gastric cancer; ACG, advanced gastric cancer; GC, gastric cancer; H pylori, Helicobacter pylori; mucosa; sm, sub-mucosa; mp, muscularis propria; ... different between the AGC group (*) and M group (†) (ANOVA with Post HOC Scheffe, p > 0.05) GC, gastric cancer; EGC, early gastric cancer; AGC, advanced gastric cancer Page of 11 (page number not ... specimens in the non -cancer groups and via biopsy and surgical specimens in the cancer groups All cancer patients were diagnosed for the first time during the enrollment period and their blood samples...
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Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt
... transfection and cultured in the absence of H pylori; H pylori control, the cells without transfection and cultured in the presence of H pylori Figure Inhibition of PAR-2 expression augments H pyloriinduced ... treatment and cultured in the absence of H pylori; H pylori control, the cells without treatment and cultured in the presence of H pylori Page of Soybean trypsin inhibitor (SBTI) augments H pyloriinduced ... absence of H pylori; H pylori control, the cells without treatment and cultured in the presence of H pylori Figure Soybean trypsin inhibitor (SBTI) augments H pyloriinduced cell death and DNA fragmentation...
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Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx
... malignant gland compared to normal gland, especially nearby the BM (Figure 2C) High density of macrophages was observed at the juncture of cancer cells and stroma where BM integrity of gastric gland ... cancer microencironment and cancer cells and promoted by those components MMPs are major proteolytic enzymes to breakdown ECM during cancer invasion Traditionally, extracellular proteolysis and ... interface of tumor nest and stroma is the main location of infiltrating macrophages in gastric cancer, and phagocytosis of cancer cells by macrophage, indicating the coexistence of M1 and M2 phenotypes...
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Báo cáo sinh học: "Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer" pdf
... of gastric cancer, we previously established the gastric cancer cell lines mGC8 and 424GC from CEA424-SV40 TAg-transgenic C57BL/6 mice [25] These cell lines express epithelial cell markers and ... Germany) For tumorigenicity and immunogenicity assays female mice were used at 812 weeks of age The gastric cancer cell lines mGC8 and 424GC were established previously from gastric tumors which developed ... contributions NKE and HW designed the animal experiments DR provided support, discussed the data and reviewed the manuscript NKE and MR planned and conducted the experiments and discussed the...
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Báo cáo y học: "Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in n" potx
... recipe of the above mentioned Chinese herbs and yeast) on the growth of human gastric cancer using a unique subcutaneous implantation model of gastric cancer tissue In this connection, CKBM was ... tumorigenesis including cell proliferation and apoptosis [7], and also angiogenesis [8] were assessed in gastric tumors after drug treatment Materials and methods Chemicals and reagents CKBM-A01 (Batch no.: ... water/mouse) and CKBM-A01 (0.2, 0.4 or 0.8 ml/mouse) treatment groups They were fed intragastrically (i.g.) daily for 14 and 28 days Tumor areas were measured every days using a caliper, and the tumor...
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Báo cáo khoa học: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells" doc
... trioxide is an effective anticancer agent with potential for human gastric cancer Arsenic trioxide can reduce proliferation and induce apoptosis in SGC7901 human gastric cancer cells There are two ... contributions YZ and AY are researchers working in cancer biology and carried the study QL and YB undertook the Statistical analysis QZ along with MZ designed the work and interpreted the results QZ and MZ ... whether arsenic trioxide inhibits proliferation and induces apoptosis in SGC7901 human gastric cancer cells, accompanied by conformational changes of Bcl-2 and changes in total Bcl2 levels Methods Page...
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Báo cáo khoa học: "Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis" docx
... doxorubicin, and methotrexate in advanced gastric- cancer Cancer 1993, 72:37-41 Pyrhonen S, Kuitunen T, Nyandoto P, Kouri M: Randomised comparison of fluorouracil, epidoxorubicin and methotrexate ... Y: Docetaxel and S-1 as a First-line Treatment in Patients with Advanced or Recurrent Gastric Cancer Anticancer Res 2009, 29:2775-2779 Fujii M: Chemotherapy for advanced gastric cancer: ongoing ... out the studies TS, NT, and HY participated in its design and coordination and helped to draft the manuscript KY conceived of the study and participated in its design and coordination HO, chief...
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Báo cáo khoa học: "Unresectable gastric cancer with gastric outlet obstruction and distant metastasis responding to intraperitoneal and folfox chemotherapy after palliative laparoscopic gastrojejunostomy: report of a case" pdf
... patients with gastric cancer and GOO and several incurable factors curatively treated by multimodal treatments In this report, we describe our experience of a patient with unresectable gastric cancer ... as firstline therapy with locally advanced and metastatic gastric cancer or second-line treatment in advanced or metastatic gastric cancer patients, and may be considered a viable treatment alternative ... malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial Gastrointest Endosc 2009 doi:10.1186/1477-7819-8-109 Cite this article as: Park and Chi: Unresectable gastric cancer...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... in human gastric cancer cell lines and to determine its precise signaling pathway Methods Cell culture and drug treatment Two human gastric adenocarcinoma (HGC) cell lines, BGC-823 and SGC-7901, ... eagle medium (Gibco, Grand Island, NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained ... COX-2, VEGF and EGFR genes in gastric cancer cells, which was mainly due to the decrease in expression of NF-B via inhibited b-ARs Discussion Gastric cancer is one of the major causes of cancer mortalities...
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báo cáo khoa học: " The function and mechanism of COX-2 in angiogenesis of gastric cancer cells" pdf
... growth and tumorigenecity of gastric cancer cells As Figure showed, SGC7901 cells were transfected and then one resistant clone (SGC7901-siRNA) with significantly decreased COX-2 expression and ... down-regulation of COX-2 could significantly inhibit the in vitro and in vivo growth of gastric cancer cell line SGC7901, and suppress the migration and tube formation of human umbilical vein endothelial ... SCYA2, SPARC, TNFSF15, PECAM1, MMP2, SERPINF1, THBS2 and OPN To confirm the microarray findings, RT-PCR and western blot were undertaken in gastric cancer cells Down-regulation of COX-2 might inhibit...
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báo cáo khoa học: " Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications" ppsx
... expression of COX-2 and VEGF-C protein and the levels of lymphatic vessel density (LVD) in human gastric cancer and analyze their correlations with clinicopathological characteristics and prognosis ... human cancer including colon, lung, stomach, pancreas and breast cancer and is usually associated with poor prognostic outcome Cox-2 mRNA and protein were first found to be expressed in human gastric ... 1-4, weak; and 0, negative In statistical analysis, COX-2 and VEGF-C scores were placed in a high expression group (strong and moderate immunoreactivity) and a low expression group (weak and negative...
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báo cáo khoa học: " Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells" docx
... regulating proliferation and drug resistance The expression of P-glycoprotein, cyclin D1, p21 and p27 was detected in the gastric cancer cells using real-time PCR (Figure 3) and western blot (Figure ... proliferation and drug resistance of gastric cancer cells Journal of Experimental & Clinical Cancer Research 2011 30:55 Conclusions In conclusion, down-regulation of miR-27a might inhibit proliferation and ... in cancer cells and might function Zhao et al Journal of Experimental & Clinical Cancer Research 2011, 30:55 http://www.jeccr.com/content/30/1/55 Page of Figure ZNRD1 suppressed growth of gastric...
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