public apos s attitudes about the abuse of women

DRUG DISCOVERY docx

Ngày tải lên : 29/03/2014, 21:20

... one of the main components of citrus fruits, such as tangerine Diosmin may increase the ab‐ sorption or bioavailability of co-administered drugs able to serve as P-gp substrates As a result, some ... that broccoli is able to induce the activity of phenolsulfo‐ transferases [123] These results suggest that other vegetables with a high content of isothio‐ cyanates, such as those of the family Cruciferae ... origins of cancer and predicted the existence of tumor suppressor genes that can suppress cancer cell growth It was later discovered that both classes of genes proto-oncogenes and tumor-suppressor...

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scientific american - 2001 08 - cyber cells - simulating life for drug discovery

Ngày tải lên : 12/05/2014, 16:09

... with the same relative strength no matter their size— the small ones seem to be strongest on certain scales known as peaks The size and strength of these peaks allow cosmologists to get at the ... chromosomes Because each chromosome hosts thousands of genes, aneuploidy creates massive genetic chaos inside the cell The cell becomes essentially a whole new species unto itself,” Duesberg says ... into bodies such as galaxies Boomerang s and Maxima s results were a case of good news and bad news The instruments saw the largest of the expected peaks, demonstrating that the universe is geometrically...

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computational medicinal chemistry for drug discovery - p. bultinck, et al., (marcel dekker, 2004)

Ngày tải lên : 12/05/2014, 17:28

... structural classes of compounds in terms of mean absolute errors The performance of the force elds for particular classes of compounds is discussed in the following sections Fig also includes the overall ... visualization of the theoretical results Indeed, it was discouraging to discuss theoretical results with a suspicious chemist on the basis of pages and pages of computer output This obstacle was dramatically ... describe the basic properties of the GB/SA model and to discuss some aspects of the model and its use that are of particular interest in computational medicinal chemistry 6.2 The GB/SA Model In the...

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fragment based drug discovery and x-ray crystallography

Ngày tải lên : 29/05/2014, 23:54

... Vernalis present the ﬁrst of a number of personal case studies of FBDD – in this case, the application of the fragment-approach to the development of Hsp90 inhibitors, with emphasis on the role of ... as Emerald Biostructures The scientists assembled a library of “fragments of life,” consisting of just over 1,300 compounds derived from metabolites, derivatives and isosteres of metabolites, ... researchers to use IC50 values instead of true dissociation constants Although this shortcut makes it difﬁcult to compare LE values across programs, it is useful for following the progress of...

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DRUG DISCOVERY RESEARCH IN PHARMACOGNOSY ppt

Ngày tải lên : 27/06/2014, 10:20

... activity of these dosas is necessary for health Pathogenesis of disease According to Ayurveda, there are three main causes of disease, namely asatmyendriyartha samyoga (indiscriminate use of senses ... annulations (transverse rings), fissures (splits), nodules (rounded outgrowth), scars (spot left after fall of leaves, stems or roots) Taste is specific type of sensation felt by epithelial layer of ... products are in restricted taxonomic groups and species of organisms They are from secondary metabolic processes and express individualities of organisms These are the areas of interest in phytochemistry...

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DRUG DISCOVERY AND DEVELOPMENT – PRESENT AND FUTURE pptx

Ngày tải lên : 27/06/2014, 17:20

... ancient Vedic science (Patwardhan & Mashelkar 2009) Discussion on all these aspects is beyond the scope of this book chapter Ayurveda, as a system of medicine, is one of the official systems of medicine ... Negative selection indicates a fitness cost to non-synonymous substitutions Furthermore, the lower the ω value, the stronger the stabilizing pressure as fewer and fewer non-synonymous substitutions ... impact of our publications Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher No responsibility...

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In silico drug discovery on computational Grids for finding novel drugs against neglected diseases

Ngày tải lên : 02/07/2014, 13:13

... strongyloidiasis, foodborne trematodiases, neurocysticercosis, scabies and infectious parasitic diseases including diseases such as Malaria, Dengue fever, Kalaazar, Toxoplosmosis Table describes some of the ... infections annually Trypanosomiasis (sleeping sickness, Chagas disease) T brucei (sleeping sickness) T cruzi (Chagas disease) HAT: 300,000 cases annually Chagas: 16 million existing infections Schistosomiasis ... tropical diseases of the world, organism responsible for the disease, scope of the disease and therapy needs Chapter Introduction Status on drug discovery related against neglected diseases More...

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Báo cáo y học: "Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery" doc

Ngày tải lên : 14/08/2014, 08:20

... the most important missions is to establish the chronology of the important biological events Thanks to the continuing efforts of chemists and biologists, the chronologies of the evolution of amino ... on the conclusion of the present study Age assignment for bio-ligands deposited research Descriptor calculation SPSS 13.0 (SPSS Inc., Chicago, IL, USA) was employed to the factor analysis The ... agents Of course, the new strategy should be treated with wariness, because of the potential side effects of the promiscuous ligands Implications for understanding the new paradigms in drug discovery...

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Báo cáo y học: "Meeting the challenges of drug discovery: a multidisciplinary re-evaluation of current practices" pptx

Ngày tải lên : 14/08/2014, 14:21

... host of proteomic tools to samples from human patients with the aim of establishing tissue- and serum-based markers for both diagnostics and functional classification of disease He described the ... Cancer Institute, Boston, USA) described gene-expression profiling of various human cancers combined with gene-set enrichment analyses to detect signatures of disease In addition, he suggested that ... Antibodies, antisense and RNAi were the focus of a session entitled ‘Biologics’, which does not justice to the enormous potential of these novel modalities Napoleone Ferrara (Genentech, San Francisco,...

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Báo cáo y học: "Digital drug discovery" pot

Ngày tải lên : 14/08/2014, 14:22

... out the implications of using a single hybridization protocol for the thousands of distinct probes that comprise a microarray, resulting in widespread cross-hybridization Szallasi cites several ... asked Marc Salit (NIST) sees NIST s role in this area as developing the tools needed to understand the performance of geneexpression microarrays Such tools are likely to include standards, reference ... ‘housekeeping’ genes The traditional approaches of metrology - the science of measurement - will be applied to these problems to establish microarray measurements of known quality Salit considers...

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synthesis of novel heterocycles for drug discovery using radical cascade reactions

Ngày tải lên : 14/11/2014, 06:18

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solid phase microextraction in drug discovery

Ngày tải lên : 14/11/2014, 09:52

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Drug discovery metformin and the control of diabetes

Ngày tải lên : 12/07/2015, 15:49

... emeritus professor of the history of science at the University of Derby, UK Pete Ellis is professor of psychological medicine at the School of Medicine and Health Sciences, University of Otago, ... was expensive and some parasites became increasingly resistant to it The supply of the drug – it was imported from Java – was also inconsistent during periods of global unrest By the 193 0s, the ... news of an effective oral alternative to insulin for some forms of diabetes spread www.rsc.org/eic of the 39 patients, 14 showed satisfactory control of the disease with metformin another six showed...

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In silico methodologies for selection and prioritization of compounds in drug discovery

Ngày tải lên : 08/09/2015, 22:12

... cell based assay results xii LIST OF TABLES Table 2.1 Datasets used in the analysis and the corresponding assay systems 23 Table 2.2 Fourteen descriptors selected for use in the analysis ... items and their corresponding descriptors One form of unsupervised learning is clustering It is the assignment of a set of input items into subsets (clusters) so that items in the same cluster ... MATERIALS AND METHODS 2.2.1 DATASETS Table 2.1 Datasets used in the analysis and the corresponding assay systems Name of Dataset Number of Compounds ATP Synthase vesicular assay ATPSyn.Prestwick...

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Chemical and pharmacological studies of ardisia elliptica antiplatelet, anticoagulant activities and multivariate data analysis for drug discovery

Ngày tải lên : 10/09/2015, 08:25

... the suspension of the pure form (3.83% vs 0.86%) In conclusion, the results presented in this thesis provide some scientific evidence for the traditional uses of A elliptica Further work is warranted ... warfarin to decrease the risk of recurrences of heart attack and stroke Despite the efficacy of current drugs used in the treatment of such diseases, drugs like aspirin and warfarin are associated with ... conducted on the use of GPIIb/IIIa antagonists (Table 1.1) These clinical trials show varying results While many of the trials showed a positive effect, there were also some trials which showed disappointing...

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Development of database and computational methods for disease detection and drug discovery

Ngày tải lên : 10/09/2015, 09:04

... LBVS is shown on the right Structure-based virtual screening (SBVS) starts with a 3-D structure of a target protein and a database of the 3-D structures of ligands as the screening pool It is usually ... types structures because it is also one goal of VS [75] 1.5 Objective and outline of this thesis The ultimate goal of this thesis is to develop comprehensive databases to facilitate disease detection ... progress in more extensive applications of SBVS and LBVS tools [69, 111] These problems include 20 the vastness and sparse nature of chemical space needs to be searched, limited availability of...

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Biointormatics of targeted therapeutics and applications in drug discovery

Ngày tải lên : 12/09/2015, 09:10

... not specifically designed for optimally supporting such tasks There is a need to introduce new access modes based on such widely-used disease classification systems as the International Classification ... resistance profiles For multigenic diseases, such as cancer, or diseases that act on different tissues or cell types, multi-target therapeutics can be more efficacious and less prone to resistance, ... trials (13) Overall, the phase I, phase II and phase III clinical trials are the most costly and time-consuming steps in the drug development processes And the success of clinical trials relies...

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Pharmacokinetics pharmacodynamics driven approach for lead optimization in anti mycobacterial and anti malarial drug discovery

Ngày tải lên : 22/09/2015, 15:17

... Anopheles mosquitos transmit the parasites to humans The mosquitos inject sporozoites into the bloodstream of the human host These sporozoites reach to the liver and rapidly invade the liver cells ... Drug Resistant xix Chapter Introduction 1.1 Infectious diseases Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi; the diseases can spread ... in these areas, ISIVIVC for the standard anti-mycobacterial compounds was investigated in this thesis; further, the PK-PD relationships for the compound classes of nitroimidazoles and spiroindolones,...

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Implementation of a drug discovery tool for the evaluation of anti fibrotic compounds application in fibrovascular disorders

Ngày tải lên : 09/10/2015, 11:07

... form of tissues in which they occur Appropriate mechanical strength is also essential for tissue-engineered constructs, especially when it is intended to resist significant mechanical stresses upon ... compromise the shape and the mechanical strength of the constructed tissues Furthermore, the amount of procollagen in the culture medium has been quantified to assess the effect of antifibrotic drugs ... Details Experimental Details The equipments and materials used in the research are presented in the first two sections of the chapter In the last section, the experimental procedures are discussed...

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Human embryonic stem cells as a cellular model for osteogenesis in implant testing and drug discovery

Ngày tải lên : 16/10/2015, 15:38

... materials, silicone, etc Most of these materials share similar physical properties -strength, resistance to abrasion and corrosions In our daily activities, we place high levels of mechanical stress ... using hESCs as a model In this study, taking hESCs differentiation towards osteogenic lineage as an example, we proposed a set of functional assays as a standard of hESCs as a model for drug discovery ... injuries and illnesses which our bodies are unable to recover by themselves The emergence of tissue engineering and cell therapy in the past decades has shown some progress in both research and...

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