protein glycation and oxidative stress in diabetes mellitus and ageing
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu-lating arginine and (b) recycling of citrulline ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... element binding protein, iso-citrate dehydrogenase is an RNA-binding protein, whilekgd2p is a mitochondrial DNA binding protein [81–84].Mitochondria from different brain regions containdifferent ... provided by proteins resi-ding in both the inner and outer mitochondrialmembrane, that is activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons ... neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease in [Ca2+]c, probably coincides with...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus ... therapeutic interventions suppressed brain inflammatory and oxidative stress responses in the mice. This effect was accompanied by significant reductionsof soluble and insoluble Aβ1-40 and Aβ1-42 in ... flurbiprofen, indomethacin) reducedbrain inflammation and Aβ levels in addition to the dep-osition of Aβ in brain [13,14]. Despite this evidence, and the considerable theoretical and therapeutic interest,...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-dative stress also promotes angiogenesis [13]. The linkbetween oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... nifedipine can ameliorate endothelium injury in SSc and that VEGF signalling may by impaired in this diseasewithout implication of the sVEGFR-1.Endothelium injury is critical in SSc and is ... VEGF signalling is impaired in SSc. However, more experimental evidence is needed todetermine whether the VEGF pathway is intrinsically defective in SSc.Keywords: nifedipine, oxidative stress, ...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... phos-phoproteins such as zonula occludens protein 1, zonulaoccludens protein 2, and P-130. Other possible signal-ing molecules include Ga subunits, tyrosine kinase,small GTPases (Rab ⁄ Rho), and ... In Changcells, stained occludin was observed in the cytoplasmicregion. Additionally, in OccWT-overexpressing Hep3B and Huh7 cells, regions stained with antibody to hem-agglutinin (HA), indicating ... levelincreased in OccWT-overexpressing cells, and that2-APB inhibited the effects of OccWT. Therefore,the increase in intracellular calcium may explain theinduction of apoptosis and reduction...
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Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
... PilA4competence proteins and raised antisera against theseproteins to visualize the proteins in the T. thermophiluswild-type strain. This is the first report on the detectionof competence proteins in T. ... secretin-like PilQ was detected in sufficientamounts in the inner and outer membranes. The pres-ence of PilQ in inner membranes is interesting, becausesecretin-like proteins of type IV pili and ... fattyacylation and, thereby, be involved in membraneanchoring of the pilin. Since PilA4 is similar to themeningococcal pilin and contains several central serineresidues, it is tempting to speculate...
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ADVANCES IN WAVELET THEORY AND THEIR APPLICATIONS IN ENGINEERING, PHYSICS AND TECHNOLOGY doc
... Processing, Electrical Systems, Fault Diagnosis and Monitoring, Image Processing and Applications in Engineering. The wavelet method is used in this book to extract more information than the standard ... of interest in red (b), the LP candidate in yellow (b), the 2D Haar WT edges (c) and post - processed 2D Haar WT edges (d) Advances in Wavelet Theory and Their Applications in Engineering, ... THEIR APPLICATIONS IN ENGINEERING, PHYSICS AND TECHNOLOGY Edited by Dumitru Baleanu Advances in Wavelet Theory and Their Applications in Engineering, Physics and Technology 38...
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Báo cáo khoa học: "Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers" pot
... year. During follow up, patients were evaluated b yhistory and physical examination, including digital rectalexamination and CEA level every three months. A chestradiograph and trans-abdominal ... 8:82http://www.wjso.com/content/8/1/82Page 4 of 11 In our analysis, other variables such as gender, tumourlocation, tumour characteristics - invasion margin(pushing vs. infiltrative), perineural and lymphovascularinvasion - did ... States [9], 3% in France [9] and 5.5% in NewZealand [ 6,15]. The high percentage reported in devel-oping countries may be due, in part, to the higher popu-lation of younger people in these countries.Young...
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Prevalence of Celiac disease in Turkish children with type 1 Diabetes Mellitus and their non-diabetic first-degree relatives pptx
... 559-65.18. Cronin CC, Shanahan F. Insulin-dependent diabetes melli-tus and coeliac disease. Lancet 1997; 349: 1096-7.19. Pocecco M, Ventura A. Coeliac disease and insulin-depen-dent diabetes mellitus: ... osteoporosis, infertility, ma-lignancy or other autoimmune disorders. Based onour study and a literature review, we think thatroutine screening should be carried out in diabeticchildren, and long-term ... IgA-tTG. Serum total IgA levels were within normal li-mits in these subjects. Intestinal histopathologyshowed sub-total villous atrophy in the sibling(Marsh type 3c). Both parents refused...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... protein kinase and wound-induced protein kinase, two MAPKs in group A, wereactivated by inoculation with the tobacco mosaic virus(TMV) [10]. Their orthologs in other plant species,including ... MPK3 and MPK6 in Arabidopsis (group AMAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro-tein kinase) and LeMPK3 (L. esculentum wound-induced protein kinase) ... accumulation in wild-type and transgenicplants in response to abiotic and abiotic stresses. (A) Virus infec-tion-induced H2O2accumulation detected by DAB staining. (B) Abi-otic stress- induced...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... indicating the presence of two catalyticallyindependent domains, the N-terminal domain, display-ing ALDH activity, and the C-terminal domain, con-taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for30 min in ... solubilized extract were incubated in such buffers for 4 hon ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N2-saturated buffer in the absence or presenceof...
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Báo cáo khoa học: The molecular chaperone a-crystallin incorporated into red cell ghosts protects membrane Na/K-ATPase against glycation and oxidative stress ppt
... 100% open chain that modifiesproteins more rapidly than glucose by an interaction witharginine and cysteine, in addition to lysine [2]. It has beenshown to cross-link proteins during glycation ... a-crys-tallin in a more physiological system in which a-crystallin wasincorporated into red cell ÔghostsÕ. Its ability to protect theintrinsic membrane protein Na/K-ATPase from externalstresses ... ghost cells and thesupernatants were taken for scintillation counting.Creatine kinase determinationCreatine kinase activity was assayed following the methodof Bernt and Bergmeyer [24], in the...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... Nrf2 protein in the PM2.5 - and PM10 -treated rat lung epithelial cell was determined by WesternBlotting. The lower shows the ratio of Nrf2/actin usingcalculatging by densitometor. In ... study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cellsJin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim1, Yoon-Shin Kim2, Nam-Hyun Chung3 and Myung-Haing Cho*Laboratory ... protectionstandards for PM by adding an indicator for even “fine”particles (PM2.5). In this trend, our government is trying toupdate on ongoing litigation over PM2.5 standard. However,relative less information...
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