proinflammatory signal transduction and the ans
Báo cáo khoa học: Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans docx
... about the molecular mechanisms of osmotic stress resistance, osmosensing and signal transduction in C elegans Osmosensing and signaling in C elegans Osmoregulatory organs in C elegans C elegans ... Osmosensing and signaling in C elegans K P Choe and K Strange cell Axons extend from the cell bodies of the amphid neurons to the central nervous system where they make synaptic contacts with other ... sensory transduction, epithelial transport of Ca2+ and Mg2+, Ca2+ signaling and modulation of membrane potential [16,17] OSM-9 was the first TRP-vanilloid (TRPV) channel to be identified at the molecular...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
... addressing how signal transduction and gene regulation control diverse and fundamental biological processes This was underscored at the 2008 meeting We look forward to the next meeting in 2010, and anticipate ... Numb and the transcription factor T-bet, become localized to the immunological synapse (proximal) side of the cell, whereas protein kinase C-ζ becomes partitioned to the distal side of the cell ... (unlike the constitutive pool that inhibits NF-κB activity) seems to function as a NF-κB coactivator at the TNFα promoter Transcriptional control of leukocyte development and differentiation The transcription...
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biochemistry of signal transduction and regulation 3d ed - gerhard krauss
... domain and a transactivating domain An incoming signal is registered by the effector domain and transduced to the chromatin and the transcription apparatus In the active state, the transcription ... sequences, and they form activating or inhibiting contacts to the basal transcription machinery The specific transcription factors receive signals for transcriptional regulation and transmit these signals ... domain - and of other subunits of the holoenzyme - effects the dissociation of the RNA polymerase from the initation complex, the association of further protein factors and the transition to the elongation...
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signal transduction and human disease
... host defense or signal transduction (Fig 1.7) 13 14 ATHEROSCLEROSIS: SIGNAL TRANSDUCTION BY OXYGEN AND NITROGEN RADICALS Figure 1.7 The divergent role of high and low levels of RNS and ROS A potential ... dysfunction and plaque for- Signal Transduction and Human Disease, Edited by Toren Finkel and J Silvio Gutkind ISBN 0-471-02011-7 Copyright © 2003 John Wiley & Sons, Inc ATHEROSCLEROSIS: SIGNAL TRANSDUCTION ... Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies 307 Michael A Beaven and Thomas R Hundley 11 Rheumatology and Signal Transduction 357 Keith M Hull and Daniel L Kastner 12 Molecular...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
... the C-terminus of this receptor, and the importance of these events for receptor sequestration, have been described in detail [7] Whether coupling of b-arrestin(s) then follows this, and whether ... grey, and the position number is indicated The grey box outside the membrane indicates the region of the putative cytosolic helix as found in the crystal structure of bovine rhodopsin [24] The ... patterns of B2wt and of B1 ⁄ B2 chimeras reflect their agonist-inducible internalization The segment between the NPXXY motif and the conserved cysteine represents one of the regions with the highest...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
... shown in the Appendix, this makes it possible to prove a summation law for: the maximum signal strength; the duration of the signal; the nal signal strength and the integral signal strength The summing ... features of the activity of a signaling cascade: the amplitude of signaling; the nal intensity of signaling; the duration of signaling and the integral signal intensity (which corresponds to the area-under -the- curve) ... in precisely the same way Consequently, the maximum signal strength and the nal signal strength will be the same, each signal magnitude will be reached 1% earlier and the integral signal intensity...
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Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
... expression through the same cis-acting element in the PR-1a promoter On the other hand, an as-1 containing PR-1a promoter responds differently from the wild-type promoter towards SA and the HR Therefore, ... view of the results presented, it seems plausible that two distinct signal transduction pathways could be targeted by SA and by signals released during the HR, respectively, resulting in the independent ... 14 days, the extension and the level of PR-1 protein synthesis increased significantly in the nahG transgenic plants in parallel with the induction of necrosis by the expanding lesions (Fig 6B)...
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báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt
... follicles were cut open and the theca and adherent granulosa cells peeled from the stroma The granulosa cells were then gently scraped from the theca and the granulosa and theca cells were snap ... [21,22] The objectives of the studies reported here were to examine the interactions of the gonadotrophins and IGF with the Akt and Erk signalling pathways in theca and granulosa cells in vitro and ... pathways that include activation of the Erk pathway [9,10], the Akt pathway [11,12] and the inositol triphosphate and diacylglycerol [13,14] pathways These signal transduction pathways, when activated,...
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Báo cáo y học: "Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain" docx
... situation and IL-4 or IL13 stimulation On the whole, these results help to understand the complex picture of signal transduction processes in the IL-4/IL-13 pathway These findings thus provide the ... variant R551 in the intracellular part of the IL-4Rα chain Influences from the other intracellular variants such as E375A and S478P on signal transduction were excluded for clarity Their effect ... 38 the interleukin-4 receptor α gene are associated with atopy and influence the signal transduction Immunology 1999, 96:365-371 Gessner A, Roellinghoff M: Biologic functions and signaling of the...
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The role of small GTPases rap1 and rhoa in growth hormone signal transduction
... molecule and the larger one is required for GH activity (Kopchick and Andry, 2000) The nucleotide and amino acid sequence of GH from several species has been determined (Kopchick and Andry, 2000) The ... hormone signal transduction 1.4.1 Growth hormone receptor (GHR) and protein tyrosine kinase JAK2 The cellular effects of GH are initiated by the binding of GH to the extracellular region of the transmembrane ... Kopchick and Andry, 2000) Ghrelin, a 28 amino acid peptide isolated from stomach extracts, is the endogenous ligand that binds and activates the GHS-R (Kojima et al., 1999) Another ligand for...
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Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf
... to the BCR and can amplify the BCR signal through ITAM phosphorylation The activation of Syk and its release from auto-inhibition involves at the same time a conformational change and its translocation ... generation of the circadian rhythmicity develops gradually from prenatal to postnatal period both in the SCN and in peripheral organs At the beginning, the maternal SCN sets the phase of the developing ... knowledge on mechanism of setting the time of the developing SCN and peripheral clocks It appears that signaling from mothers and from the outside world to the newborn circadian clocks might...
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Plant physiology - Chapter 14 Gene Expression and Signal Transduction potx
... that enhance the rate of transcription by facilitating the assembly of the initiation complex The DNA sequences themselves are Gene Expression and Signal Transduction (A) General transcription ... Receiver Figure 14.10 Signaling via bacterial two-component systems The sensor protein detects the stimulus via the input domain and transfers the signal to the transmitter domain by means of a conformational ... receives the environmental signal, and a transmitter domain, which transmits the signal to the response regulator The response regulator also has two domains, a receiver domain, which receives the signal...
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Digital Signal Processing and Applications with the C6713 and C6416 DSK (Topics in Digital Signal Processing) pot
... registers The C67xx (such as the C6701, C6711, and C6713) belong to the family of the C6x floating-point processors, whereas the C62xx and C64xx belong to the family of the C6x fixed-point processors The ... using many of the examples and experiments from Chapters 1–7 and Chapter The beginning of the semester can be devoted to short programming examples and experiments and the remainder of the semester ... on and generate a 1-kHz tone Connect the LINE OUT (or the HEADPHONE) on the DSK board to a speaker or to an oscilloscope and verify the generation of the 1-kHz tone The four connectors on the...
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Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx
... linked to multifunction and crosstalk between signal transduction networks, which explains how the same signal transduction pathway can be responsible for the transduction of signals resulting in ... r24 þ KS r31 2 Also, at the bifurcation, the a values and c values are equal On the other hand, the lower the KS value, the more a( ¼ c) and b values tend towards ⁄ 3; and as KS approaches ⁄ 2, ... value of the asymmetric factor, e.g H ¼ 4, the sign of the slope depends on the c value, and the curve displays two extrema points, and then the sign of the slope curve changes with the c value...
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Coupled Blind Signal Separation and Spectroscopic Database Fitting of the Mid Infrared PAH Features ppt
... feature, the precise peak position of the 11.2 µm band, and the weak features at 12.0, 12.7, and 13.5 µm In the following section we discuss these variations in the context of Signal 1, 2, and 3, ... (2007) The spatial distribution and the ree sults of Bern´ et al (2007) seem to suggest that Signal traces e the distribution of PAH cations, Signal the neutral PAH distribution, and Signal the ... concentration closest to the source star (located at the bottom left of this image) and Signal appears to trace the edge of the PDR farthest from the star The well defined regions where each signal is most...
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Báo cáo khoa học: A novel splicing variant form suppresses the activity of full-length signal transducer and activator of transcription 5A pot
... tissues, such as the cerebrum, kidney, and liver (Fig 1B) On the other hand, the PCR product of STAT5A_DE18 was detected in the brainstem, heart and lung, and thymus (Fig 1B), but not in the cerebrum ... STATs and decrease their activities [18] These heterodimers can translocate into the nucleus and bind to target sequences on DNA, but fail to activate transcription [18] On the other hand, we ... intron 18, and lack only the transactivation domain [18,20] These STAT b-isoforms are phosphorylated on the tyrosine residue after stimulation by cytokines or hormones, and translocate into the nucleus,...
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Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx
... clarify the involvement of PKC in the signal transduction mechanism participating in TCDD-induced cellular responses [14] We also looked for evidence of the involvement of PKC in the signal transduction ... in many signal transduction events in T cells 904 S Ahmed et al In the present study, we examined the functional participation of the PKC pathway, and in particular attempted to explore the possible ... of gene transcription) and cycloheximide (an inhibitor of de novo protein synthesis) to block this apoptosis, led us to focus on the possibility of a rapid post-translational signal transduction...
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Báo cáo Y học: Herbaspirillum seropedicae signal transduction protein PII is structurally similar to the enteric GlnK potx
... leguminosarium and Azorhizobium caulinodans The residue Thr107 is present in the majority of these organisms On the other hand, the PII C-terminal sequences are highly conserved between E coli and K pneumoniae ... labelled on the monomer (i) The negatively charge bottom face of the trimer; (ii) the top face of the trimer and (iii) molecular surface of the lateral cleft of the HsPII trimer The salt bridge ... sequences) (A) and phylogenetic tree of the PII and paralogue proteins in the proteobacteria (B) (A) The residues in blue show the conserved residues of the XGXDA motif in the nonenteric and enteric...
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