progesterone glucocorticoid and mineralocorticoid
Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... C1 and C2; the double bond between C4 and C5 is not susceptible to reduction, and thus progesterone and related steroids (e.g 4-androstene3,17-dione), which lack a double bond between C1 and ... steroids are prednisone, progesterone and 1,4-androstadiene-3,17-dione (B) Sequence of PETN reductase and some PETN reductase related enzymes in the region of His181 and His184 The proteins are ... acid, 2,4-dinitrophenol and progesterone were performed as described for wild-type and the H181A and H184A enzymes Spectral changes were similar to those reported above and absorption changes...
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Báo cáo khoa học: " Effect of a povidone-iodine intrauterine infusion on progesterone levels and endometrial steroid receptor expression in mares" pptx
... 0, 2, 6, and 15 and 0, and of each cycle, respectively Progesterone concentrations were measured by radioimmunoassay Sensitivity was 0.13 ng/ml for low (0.6 ng/ml), medium (1.4 ng/ml) and high ... glandular epithelium, and superficial and deep stroma) and their interactions Progesterone levels were subjected to the same analysis; variables included day, treatment and their interactions ... other lesions (fibrosis, fibrotic nests, glandular atrophy and/ or cysts, hypertrophy, hypoplasia, and/ or lymphatic lacunae) were found Progesterone levels Progesterone reached maximum levels in early...
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Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains pptx
... co-activator (SRC-1), glucocorticoid receptor-interacting protein (GRIP1, also called TIF2), and activator for thyroid hormone and retinoid receptors (ACTR) (also called RAC3, pCIP, AIB1 and TRAM1) These ... modulation of self-transactivation (AD1 and AD2) and co-activator (AR, ER and TR) functions in HeLa cells The outcome of the relationship between GRIP1 transactivation and co-activator functions varies ... p160 co-activators can bind to AF-1 and AF-2 of NRs The p160 co-activators contain at least three NR-interacting boxes or LXXLL motifs (where L stands for leucine and X can be any amino acid) in...
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Báo cáo khoa học: G protein-coupled receptor 30 down-regulates cofactor expression and interferes with the transcriptional activity of glucocorticoid pdf
... specificity of transactivation by the mineralocorticoid or glucocorticoid receptor Endocrinology 138, 2537–2543 Kino, T & Chrousos, G.P (2001) Glucocorticoid and mineralocorticoid resistance/hypersensitivity ... C., Woon, C.T., Aw, S.E & Lin, V.C (2004) Glucocorticoid and mineralocorticoid cross-talk with Ó FEBS 2004 progesterone receptor to induce focal adhesion and growth inhibition in breast cancer cells ... GR and inhibited cell proliferation These results suggest a new mechanism underlying glucocorticoid resistance The data also point to cross-talk with G proteins and steroid receptor activity, and...
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Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
... and progesterone stimulate FAAH activity and expression in human U937 cells but not in CHP100 cells In previous studies, we have shown that leptin and progesterone up-regulate FAAH activity and ... Fig Effect of leptin and progesterone on FAAH activity and expression (A) Effect of leptin on the activity of FAAH in human U937 and CHP100 cells and on the protein content and the mRNA of FAAH ... activity and expression was additive, in fact treatment of U937 cells for 24 h with 10 nM leptin and lM progesterone enhanced FAAH activity, protein level and mRNA content up to 500%, 450% and 490%...
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Báo cáo y học: "Chlamydia trachomatis Infection of Human Trophoblast Alters Estrogen and Progesterone Biosynthesis: an insight into role of infection in pregnancy sequelae." doc
... human progesterone receptor to expose the ligand binding sites A competitive assay is then performed between fluormone tagged to progesterone epitope and the free progesterone in the sample or standard ... standard Progesterone displaces fluormone tagged progesterone causing increased fluorescence Briefly, 50µl of sample or standard was put in microtiter plate and 50µl of reaction mix (40µl PR LBD progesterone ... hormones (estrogen and progesterone) The levels of estrogen and progesterone are critical factors in pregnancy sustenance [31] They enrich the uterus with thick lining of blood vessels and capillaries...
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Báo cáo y học: "Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment" pdf
... SO performed the immunohistochemistry and analyses, and drafted the manuscript KS and CM helped in design of experiment AB and JO conceived of the study JO and KS helped draft the manuscript TP ... of OPN protein in the nasal mucosa of healthy and AR subjects was predominantly in the nucleus of the epithelial and endothelial cells (glandular and vesicular) Similarly, OPN expression has Figure ... detection, and diagnosis J Allergy Clin Immunol 2001, 108:S2-8 Pullerits T, Praks L, Ristioja V, Lotvall J: Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and...
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Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" ppsx
... Univariate analysis Patients in the LE and ME groups were older (P = 0.002) and had longer disease duration (P < 0.001) and higher ESR (P = 0.031) and HAQ (P < 0.001) and more frequent joint replacement ... syndrome and GC exposure, thus acting as potential confounders, included age (P = 0.001 and P = 0.002, respectively), RA disease duration (P = 0.008 and P < 0.001), ESR (P = 0.006 and P = 0.031), and ... conception and design of the project and in the analysis and interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and...
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Báo cáo y học: "Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss" doc
... receiving progesterone, (e) ovariectomized rabbits receiving relaxin, (f) ovariectomized rabbits receiving β-estradiol and relaxin, (g) ovariectomized rabbits receiving progesterone and relaxin, and ... relative to NC and in knee articular cartilage relative to SC and NC In contrast, progesterone antagonized the effects of E, R, and ER on collagen content in TMJ disc, pubic symphysis, and the knee ... fibrocartilaginous and hyaline cartilaginous tissues to relaxin, β-estradiol, and progesterone We also show that progesterone has an important effect in minimizing the degradative effects of β-estradiol and...
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Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" pptx
... Univariate analysis Patients in the LE and ME groups were older (P = 0.002) and had longer disease duration (P < 0.001) and higher ESR (P = 0.031) and HAQ (P < 0.001) and more frequent joint replacement ... syndrome and GC exposure, thus acting as potential confounders, included age (P = 0.001 and P = 0.002, respectively), RA disease duration (P = 0.008 and P < 0.001), ESR (P = 0.006 and P = 0.031), and ... conception and design of the project and in the analysis and interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and...
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Báo cáo y học: "Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus" pps
... patients and controls Disease activity scores were determined before and after steroid treatment (Table 1) and the SLE patients were divided into the SR and the SS groups accordingly GR expression and ... collected and stored at -80°C for measurement of IL-12, TNF-α and IFN-γ levels by ELISA (ebioscience, San Diego, CA, USA) The minimum limits of detection for IFN-γ, IL-12 p40 and TNF-α were 8, 80 and ... GR expression and binding (mean ± standard error of the mean) For heterogeneity of variance, Kruskal-Wallis H test and Memenyi test were used Age, gender, dosage of prednisolone and years since...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
... designed and ran the in vivo model KFC participated in the study design and preparation of the manuscript IMA and PAK conceived of the study, participated in its design and coordination and helped ... GR and HDAC [21,26] Both Mi-2 and mSin3a are critical components of transcriptional corepressor complexes and changes in their expression may lead to the alteration of both the formation and ... both a chronic and relatively glucocorticoid insensitive inflammation However, a major hurdle in to our understanding of the roles of the various corepressors in oxidant mediated glucocorticoid...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... designed and ran the in vivo model KFC participated in the study design and preparation of the manuscript IMA and PAK conceived of the study, participated in its design and coordination and helped ... GR and HDAC [21,26] Both Mi-2 and mSin3a are critical components of transcriptional corepressor complexes and changes in their expression may lead to the alteration of both the formation and ... both a chronic and relatively glucocorticoid insensitive inflammation However, a major hurdle in to our understanding of the roles of the various corepressors in oxidant mediated glucocorticoid...
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Báo cáo khoa hoc:" Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance" docx
... obtained and the standard streptavidin biotin peroxidase immunohistochemical method was used for the expression of estrogen and progesterone receptors Estrogen receptor (Clone 1D5, Dako, USA) and progesterone ... schwannoma is a benign cerebellopontine angle tumor and it expresses various hormone receptors for examples estrogen, progesterone, androgen, somatostatin and glucocorticoid The clinical significance of ... ranging from ligand binding studies and immunohistochemical methods to molecular techniques like polymerase chain reaction and Northern blot analysis Positivity of estrogen and progesterone receptors...
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Báo cáo y học: " Early The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils" pot
... Spontaneous IL-8 and MCP-1 production was low and ionomycin (1 μM) increased MCP-1 and IL-8 production 6–10-fold (figure 3a &3b) Mometasone (1 μM) and dexamethasone (1 μM) inhibited IL-8 and MCP-1 generation ... assistance in the design and drafting of the manuscript HK conceived the study, and participated in its design and coordination and helped to draft the manuscript All authors read and approved the final ... control in the absence of glucocorticoids onto Ficoll and centrifuged at 700 g for 30 at 20°C Mononuclear cell layer was removed and the remaining pellet containing granulocytes and red blood cells...
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Báo cáo khoa học: "15-Ketodihydro-PGF2α, Progesterone and Cortisol Profiles in Heifers after Induction of Parturition by Injection of Dexamethasone" pot
... the Swedish red and white breed (A, B and C) and one of the Swedish black and white breed (D)) were used The animals were divided into groups (A and B in the first group and C and D in the second) ... desoxycorticosterone 8%, progesterone 8% and testosterone 3% Parallelism between standards and unknowns in plasma were demonstrated for the range between and 44 nmol/L plasma The intraand interassay coefficients ... progesterone and PGF2α metabolite are calculated as the mean and standard deviation of the first and 10 samples, respectively PGF2α metabolite levels during luteolysis are calculated as mean and range...
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Báo cáo y học: "Human receptor kinetics and lung tissue retention of the enhanced-affinity glucocorticoid fluticasone furoate" doc
... propionate and Structural comparison the new glucocorticoid fluticasone Structural formulae of the new glucocorticoid fluticasone furoate in comparison with fluticasone propionate and mometasone ... concentrations of [3H] -glucocorticoid in the absence and presence of excess unlabelled glucocorticoid For the assay of non-specific binding, 10 parts of cytosol, volume part of [3H] -glucocorticoid (1.2 ... mol/L) and volume part of cold glucocorticoid (1.2 × 10-4 mol/L) were mixed in glass vials and incubated at 20°C The assay for total binding was carried out accordingly, but the unlabelled glucocorticoid...
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Báo cáo y học: "The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and metaanalyses" pptx
... results and interpretation included variability of sampling frame, inclusion and exclusion criteria, definition of comparison groups, and time-varying GC exposure Reporting of methods and results ... Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data Ann Rheum Dis 2006, 65:285-293 10 Vandenbroucke JP: Benefits and harms of drug ... using the complete manuscript Hand searching of reference lists from obtained articles and selected review articles also was performed Abstract-only publications and unpublished studies were not...
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Báo cáo y học: "Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines" doc
... oxide synthase (iNOS) mRNA and protein levels, and the role of glucocorticoid receptors A disintegrin and metalloproteinase with thrombospondin motifs-4,-5 (ADAMTS-4 and -5) are the primary aggrecanases ... transcription, effects of DEX on iNOS mRNA and protein levels, and inhibition of glucocorticoid receptors and proprotein convertases Bovine cartilage harvest and culture Cartilage disks were harvested ... the data, conceived of and designed the studies, confirmed data analysis and wrote the manuscript CE and AJG conceived of and designed the studies, confirmed data analysis and wrote the manuscript...
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