probability of success of the project is appropriate given the level of scientific originality and risk reward balance
The National Household HIV Prevalence and Risk Survey of South African Children ppt
Ngày tải lên :
15/03/2014, 03:20
... management and analysis, and strengths and limitations of the study This section draws on the main report of the Nelson Mandela/HSRC Study of HIV/AIDS of which the national survey of children is a ... cent of young people have had sex Cases of sexual assault and rape are another source of information on the exposure of children to the risk of sexual transmission of HIV infection At the end of ... Prevalence and Risk Survey of South African Children The study was commissioned by the Nelson Mandela Children’s Fund and the Nelson Mandela Foundation as part of the larger Nelson Mandela/HSRC Study of...
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The Effects of Funding Costs and Risk on Banks’ Lending Rates pot
Ngày tải lên :
29/03/2014, 01:20
... also fallen since the onset of the financial crisis, as the amortisation of the outstanding stock of residential mortgage-backed securities (RMBS) has exceeded new issuance Furthermore, Australian ... 3-month bank bills and overnight indexed swaps (OIS) around 10 basis points While the onset of the global financial crisis saw bank bill rates rise well above OIS rates, the sizeable risk premium has ... pricing decisions, the cost of equity is greater than that of debt This reflects the greater risk borne by shareholders (who only have a residual claim on the income and assets of the bank) T...
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Potential Actual Opioid Diversion in Vietnam, Methods of Preventing Diversion, and Barriers to “Balance”
Ngày tải lên :
22/06/2016, 14:14
... Prevention of diversion – Laws & regulations – Discretionary control of opioid prescribing by healthcare leaders • Evidence of diversion of controlled medicines • Ways forward History of Opioids ... to years in prison for collecting ~100 dispensed but unused vials of diazepam, selling it to private pharmacies • 2006: pharmacists from Kien Giang Province sentenced to years in prison for stealing ... Current epidemic of injected heroin dependence driving Vietnam’s HIV/AIDS epidemic Illicit opioid use – now mainly injected heroin – is a major problem in Vietnam: ~170,000 IDU …History of Opioids...
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Tài liệu Project (written version):“The problems of the “Citibus” (bus operating company) and their possible solutions. Drawing a contract.” doc
Ngày tải lên :
20/12/2013, 19:15
... sign the contract and we think that the drivers are enough motivated, they fulfil the terms and the conditions of the contract and the problem is solved * - for full written version of the contract ... they not their best, other thing which should be mentioned is the wrong schedule of the bus routes (which doesn’t take a proper account of the interests of the passengers); and finally, its the ... that the question of motivation is always of crucial importance so we’ve decided to try to increase the level of motivation of the Citibus’ drivers We consider the measures of increasing the level...
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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
Ngày tải lên :
14/02/2014, 19:20
... induces the hypersensitive response (HR), which is local and rapid cell death at the site of pathogen infection and limits growth of the micro-organism [22–24] Mutants with enhanced disease resistance ... proteins were then detected by western blot analysis with an anti-HIS IgG GST alone was used as a negative control One tenth of the input was loaded on to the gel and represents the amount of HIS-tagged ... MBP < HIS-OXI -55 GST: 7255- HIS-PTI > HIS-OXI > HIS-PTI > < MBP < HIS-OXI < HIS-PTI 55- B GST: Pre-incubation HIS-OXI1: + + + MPK3 K45R lofMPK3 MPK6 lofMPK6 K45R K45R K45R OXI PTI OXI PTI HIS:...
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Tài liệu Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study pdf
Ngày tải lên :
15/02/2014, 04:20
... detection of DCIS In view of the cost involved and the effort required to diagnose these tumors and in light of the debate about both the initial and subsequent treatment of patients with DCIS and the ... various levels of risk within the spectrum of risks associated with participants in the P-1 study Because of the importance of knowing whether or not the finding that tamoxifen reduces the incidence ... deaths On the basis of the P-1 findings and this commentary, it is necessary to consider the question of who should receive tamoxifen to decrease their risk of breast cancer The findings in this article...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
Ngày tải lên :
16/02/2014, 14:20
... mutant, induced 30% of the transfected cells to float off the dish and undergo apoptosis Interestingly, the cells could tolerate high levels of the myristoylationdeficient mutant and remain attached, ... as the presence of the SV40 large T antigen in these cells enhances their resistance to apoptosis Apoptosis is a tightly regulated mechanism for the disposal of damaged cells and to remove cells ... 2–3 and 4– 5) Notably, JSP1 seemed to stimulate preferentially the phosphorylation of the p46 isoform of JNK, whereas sorbitol treatment induced phosphorylation of both the p46 and p55 isoforms...
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Tài liệu SWIMMING IN SEWAGE: The Growing Problem of Sewage Pollution and How the Bush Administration Is Putting Our Health and Environment at Risk ppt
Ngày tải lên :
17/02/2014, 10:20
... be increasing, and there is evidence that the rate of infection is proportional to both the amount of time swimmers are exposed and the levels of pollution in the waters where they swim.60 According ... communities, as is the case for most of the interior portions of the United States, sewage overflows can put downstream users at risk The Missouri River, for instance, is the source of drinking water ... some of the major cities of the Midwest Yet the distance between wastewater discharges and water supply intakes is often very short In Michigan, for example, the distance between wastewater discharge...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
Ngày tải lên :
20/02/2014, 11:20
... fgl2 mRNA The left side of the figure is the sequence ladder using the same primer and the pM166 clone as template Arrow indicates the nucleotide that is matched to the band present in the primer ... the KpnI and XhoI sites in the vector and KpnI and SalI sites in the PCR2.1 clones of the promoter fragments All promoter constructs were sequenced to confirm their orientation and to verify their ... indicate the bands that are interacting with these probes All the lanes have labelled probes The adding of extracts and cold probe are indicated in the top of the panel Supershift, ss-Sp1 and ss-Sp3,...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
Ngày tải lên :
05/03/2014, 23:20
... nervous system, and the lack of induction of inflammatory responses [22] Despite a long-standing interest in the field of muramyl peptides, the impact of these molecules at the mitochondrial level has ... immunomodulators to reveal the mechanism of action of toxic MDPs on mitochondrial respiration by correlating the uncoupling effect induced by these molecules with the level and function of UCP2 and free radical ... reactive oxygen and nitrogen species production and upregulates UCP2 protein level, whereas MB does not We further show that the activity of UCP2 is consistent with the level of free radicals...
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Báo cáo khoa học: Expression of the Drosophila melanogaster ATP synthase a subunit gene is regulated by a transcriptional element containing GAF and Adf-1 binding sites pptx
Ngày tải lên :
07/03/2014, 16:20
... thickness of the black and white arrows is related to the intensity of the band Asterisks represent transcription start points from the 5¢ end amplification experiments (see Materials and methods) ... footprinting of the 5¢ upstream region of the a-F1-ATPase gene and found that the combination of GAF and Adf-1 binding sites is present both in other Drosophila species (D yakuba and D pseudoobscura) and ... parts of the body of the adult flies Although this may reflect the random selection of two poly(A) sites with different inherent properties, the possibility that the tissue-specific regulation of polyadenylation...
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Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
Ngày tải lên :
15/03/2014, 00:20
... peptides This model was built from the X-ray structure of the C-terminal domain of Ure2p and integrates the finding that the N-terminal domain of Ure2p is flexible An enlargement of the region of Ure2p ... with the theoretical monoisotopic mass of the identified peptide are given The presence of the modified peptides in the Ure2p, Ssa1p and Ure2p–Ssa1p complexes with apparent molecular masses 160 and ... in our list using the available softwares (gpmaw [30], xquest [31] and msx-3d [12]) with a mass tolerance of p.p.m We therefore used MALDITOF-TOF and ⁄ or nanoLC-Orbitrap tandem MS to further identify...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
Ngày tải lên :
16/03/2014, 04:20
... Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme ... lm) Figure 3C and Table show that the IC50 values of these two single mutants were similar and that they lay between the IC50 values of the human and pig CPT1B wild-type enzymes These results ... In this model, Asp17 does not face the C-terminal fragment A possible explanation for this is that, in the case of CPT1B, the docking of the N-terminal fragment might differ from that of the established...
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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx
Ngày tải lên :
16/03/2014, 23:20
... (2005) Twenty years of the Alzheimer’s disease amyloid hypothesis: a genetic perspective Cell 120, 545–555 Evin G & Weidemann A (2002) Biogenesis and metabolism of Alzheimer’s disease Abeta amyloid ... domain may be present in the Ab sequence of C99, we hypothesized that zinc may affect the oligomerization state of C101-3FLAG Therefore, the molecular mass of C101-3FLAG before and after zinc treatment ... clarify the mechanism by which zinc and copper inhibit in vitro c-secretase activity A universal characteristic of AD pathology is the post-mortem detection of Ab plaques, thus confirming the pathological...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
Ngày tải lên :
23/03/2014, 04:20
... 5835 Synoviolin is involved in the degradation of nicastrin T Maeda et al NCT is one of the essential cofactors of the c-secretase complex We therefore investigated the effect of the Synoviolin-mediated ... from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by a grant from the Ministry of Health, Labor and Welfare of Japan We thank Dr Paul Langman for assistance ... Right panel: the band intensities were quantified, and the percentage mature NCT level in the cell membrane relative to that of the total cell lysate is shown Data are the average of three independent...
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Báo cáo khoa học: A hydrophilic cation-binding protein of Arabidopsis thaliana, AtPCaP1, is localized to plasma membrane via N-myristoylation and interacts with calmodulin and the phosphatidylinositol phosphates PtdIns(3,4,5)P3 and PtdIns(3,5)P2 pptx
Ngày tải lên :
23/03/2014, 07:20
... determine the amount of PCaP1 in tissues and the distribution of PCaP1 in the membrane and soluble fractions (by an immunochemical method), we prepared the recombinant PCaP1 as the standard protein ... shoots and roots, respectively, of A thaliana seedlings (Fig 2) The aim of this study was to clarify the mechanism of the specific tight association of PCaP1 with the plasma membrane in vivo and ... indicate the position of PCaP1 ⁄ His and D2-25PCaP1 ⁄ His, respectively Calcium-dependent interaction of PCaP1 with CaM There is no motif of enzymatic function in PCaP1 In order to understand the...
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A Different Story of the History of Western Music and the Aesthetic Project pdf
Ngày tải lên :
23/03/2014, 13:20
... understand: Techné, empeiria, epistéme, mousiké and, not least, aisthesis The Edström, O (2003) A Different story of the history of Western music and the aesthetic project Action, Criticism, and Theory ... within musicology and other scholarly discourse for the concept of aesthetic and the use and frequency of the concept in daily discourse If this is so today, it is likely that the situation was ... contexts, the way music was used also slowly changed: one is the rise of public concerts, and the other is the role and function especially of song in private salons in the homes of the bourgeoisie.3...
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Model Policy Guidelines for the Appropriate Use of Social Media and Social Networking in Medical Practice ppt
Ngày tải lên :
24/03/2014, 02:20
... efforts of the members of the Special Committee on Ethics and Professionalism who provided input and direction for this project Model Guidelines for the Appropriate Use of Social Media and Social ... the patient; likewise, the patient may not be able to verify that a physician is on the other end of the communication For that reason, the standards of medical care not change by virtue of the ... protect the privacy and confidentiality of their patients as well as maintain a standard of professionalism in all social media and social networking interactions The FSMB is grateful for the efforts...
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THE INVESTIGATION ABOUT THE SUCCESS OF THE SAFETY BUS IN TYNE AND WEAR UNIVERSITY (TWU) potx
Ngày tải lên :
03/04/2014, 09:20
... and y; x2 and y; x3 and y; and x4 and y) The intensity of the relationship is indicated by the clustering of points and the spread of the data Moreover, although the satisfaction rating is ordinal ... not The size of sample, n=392 > 30 and the data is normal distribution Therefore, the one-sample T-test is the most appropriate toll for this analysis (Robson, Pemberton and McGrane, 2011) The ... the CLT is valid and the normal distribution is assumed Therefore, the ANOVA test will be the most suitable test in this case Hypothesis: • Null hypothesis: H0: µ =µ = µ3 = µ4 = µ5 (there is no...
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