principles of clinical pharmacology atkinson pdf
PRINCIPLES OF CLINICAL PHARMACOLOGY Second Edition potx
Ngày tải lên :
22/03/2014, 23:20
... basic principles of clinical phar-
macology currently are being applied in the process of drug
development.
Journals
Clinical Pharmacology and Therapeutics
British Journal of Clinical Pharmacology
Journal ... effective use of
medicine can be traced back at least to Rudolph
Bucheim (1820–1879), who has been credited with
1
PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION
20 Principles of Clinical Pharmacology
Therefore, ... 6 Principles of Clinical Pharmacology
TABLE 1.1 Status of Renal Function in 44 Patients with
Digoxin Toxicity
a
Serum creatinine
(mg/dL)
No. of patients with CL
CR
of
Percentage of
group
50...
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Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
Ngày tải lên :
06/07/2014, 08:20
... Chapter 005. Principles of Clinical
Pharmacology
(Part 1)
Harrison's Internal Medicine > Chapter 5. Principles of Clinical
Pharmacology
Principles of Clinical Pharmacology: Introduction ... accompaniment of drug
therapy, this is not the case. The goal of this chapter is to describe the principles of
clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context
in which the drug-target interaction occurs to achieve drug effects.
Two important goals of the discipline of clinical...
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Chapter 005. Principles of Clinical Pharmacology (Part 2) ppt
Ngày tải lên :
06/07/2014, 08:20
... P-glycoprotein, the product of the
normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical
aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5-
2). The extent of absorption may be reduced because a drug is incompletely
released from its dosage form, undergoes destruction at its site of administration, ...
a
Inhibitors affect the molecular pathway, and thus may affect substrate.
b
Clinically important genetics variants described.
A listing of CYP substrates, inhibitors, and inducers is maintained at
http://medicine.iupui.edu/flockhart/table.htm....
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Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
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06/07/2014, 08:20
... intravenous infusion, plasma concentrations at steady
Chapter 005. Principles of Clinical
Pharmacology
(Part 3)
Clinical Implications of Altered Bioavailability
Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared
to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can
result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than
any physiologic space. For example, the volume of distribution of digoxin and
tricyclic antidepressants is hundreds of liters, obviously...
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Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
Ngày tải lên :
06/07/2014, 08:20
...
Chapter 005. Principles of Clinical
Pharmacology
(Part 4)
Clinical Implications of Drug Distribution
Digoxin accesses its cardiac site of action slowly, over a distribution phase
of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than-
normal loading regimens are required to achieve equivalent plasma drug
concentrations and to avoid toxicity.
Rate of Intravenous ... prevent elimination by
very rapid (t
1/2
of seconds) uptake into erythrocytes and endothelial cells before
the drug can reach its clinical site of action, the atrioventricular node.
Plasma...
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Tài liệu Ten Principles of Economics - Part 6 pdf
Ngày tải lên :
15/12/2013, 11:15
... pound of potatoes costs the rancher 8 pounds of meat,
1 pound of meat costs the rancher 1/8 pound of potatoes. Similarly, because 1
pound of potatoes costs the farmer 1/2 pound of meat, 1 pound of ... opportunity
cost of producing 1 pound of meat is 2 pounds of
potatoes. Explain why the rancher’s opportunity cost of
producing 1 pound of meat is 1/8 pound of potatoes.
2. Maria can read 20 pages of economics ... The rancher buys 1
pound of potatoes for a price of 3 pounds of meat. This price of potatoes is lower
than her opportunity cost of 1 pound of potatoes, which is 8 pounds of meat. Thus,
the rancher...
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Tài liệu Ten Principles of Economics - Part 8 pdf
Ngày tải lên :
15/12/2013, 11:15
... quantity of ice cream you are willing to produce
and offer for sale? Here are some possible answers.
Price
The price of ice cream is one determinant of the quantity supplied. When
the price of ice ... MARKET FORCES OF SUPPLY AND DEMAND 77
MARKET SUPPLY VERSUS INDIVIDUAL SUPPLY
Just as market demand is the sum of the demands of all buyers, market supply is
the sum of the supplies of all sellers. ... the price of the good. This
relationship between price and quantity supplied is called the law of supply:
Other things equal, when the price of a good rises, the quantity supplied of the
good...
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Tài liệu Ten Principles of Economics - Part 9 pdf
Ngày tải lên :
15/12/2013, 11:15
... responsiveness of
quantity demanded or quantity
supplied to one of its determinants
price elasticity of demand
a measure of how much the quantity
demanded of a good responds to a
change in the price of that ... price of flour or a fall in
the price of milk? Illustrate and explain your
answer.
b. Suppose instead that the equilibrium price of
cream cheese has risen but the equilibrium quantity
of bagels ... events
certainly raise the price of ice cream, but their impact on the amount of ice
cream sold is ambiguous.
Price of
Ice-Cream
Cone
2.00
$2.50
047
Quantity of
Ice-Cream Cones
Demand
New
equilibrium
Initial...
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Tài liệu Ten Principles of Economics - Part 11 pdf
Ngày tải lên :
15/12/2013, 11:15
... THE
P
RICE
E
LASTICITY OF
S
UPPLY
C
AN
V
ARY
. Because
firms often have a maximum
capacity for production, the
elasticity of supply may be very
high at low levels of quantity
supplied and very low at high
levels of ... Concepts
1. Define the price elasticity of demand and the income
elasticity of demand.
2. List and explain some of the determinants of the price
elasticity of demand.
3. If the elasticity is greater ... reducing the supply of farm products may raise the in-
comes of farmers, but it does so at the expense of consumers.
WHY DID OPEC FAIL TO KEEP THE PRICE OF OIL HIGH?
Many of the most disruptive...
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