... Results Patient characteristics The demographic, clinical, and therapy characteristics of the 103 patients with SLE are shown in Table The majority of the patients were female Caucasians with a ... Institute, or the Slotervaart Hospital These clinics provide primary through tertiary care for patients with SLE in Amsterdam, The Netherlands The local ethics committee approved the study All patients ... in Table 1, the median C4 deposition in patients with SLE was 71% versus 114% in the healthy controls and was less than 10% of the activity of the standard in 21% of the patients with SLE versus...
... without vascular risk factors Informed consent to participate in the study was obtained from them or their relatives This protocol was approved by the Ethics Committee before implementation The ... (22.3%) patients presented with neurological deterioration In the first 24 hours, 40 (42.6%) patients underwent intracranial surgery Forty-five (47.9%) patients had CT classification of or The mean ... and associatedwith GCS score and mortality after TBI Key messages • In patients with traumatic brain injury, plasma resistin level increased during the 6-hour period immediately, peaked within...
... is still in the research phase In conclusion, chorioretinal involvement, frequently asymptomatic and self-limited, is present in almost 80% of patients with WNV infection associatedwith neurologic ... of the routine evaluation of patients with clinically suspected WNV infection References Hayes EB, Gubler DJ West Nile virus: epidemiology and clinical features of an emerging epidemic in the ... associatedwith neurologic disease The unique pattern of multifocal chorioretinitis can help establish an early diagnosis of the disease while serologic testing is pending Therefore, an ocular examination,...
... syncope Patients were included in the study if they had either syncope or symptoms during monitoring which resembled the index syncope episode that lead to evaluation Patients included in the study ... consistent with those of other studies [13-15,23,24] In our study, ILR monitoring by guiding rhythm directed therapy in all patients who tested positive helped prevent further syncope None of the patients ... friends witnessing these episodes The study included only patients with unexplained syncope and thus the results can not be generalized Conclusion In the group of patients with recurrent unexplained...
... indicates the number of patients carrying the haplotype consisting of the -173 C and the -794 CATT7 allele Accordingly, these patients display the -173 SNP C/C or G/C genotype in combination withthe ... functional In the sepsis patient sub groups female and male patients as well as patients with age ≤60 years and in patients with non-pulmonary or non-abdominal focus the haplotype was associatedwith ... respectively Table indicates the association of the carriage of the -173 C allele and the -794 CATT7 allele with fatal outcome in patients with severe sepsis which are grouped by the covariates "gender",...
... for delayed union of the femur fracture withthe aim of allowing thepatient to walk on crutches, although, to the best of our knowledge, no familial cases were found in the reported cases Fortunately, ... Transverse fracture at the junction of proximal and middle thirds, and Paget's disease involving the entire femur of the fracture (Figure 5), thepatient is able to walk unaided with a single T-cane ... extensive exposure, and in the present patient this was not possible because of her poor medical condition Recently, there have been some reports of good fracture healing withthe use of intramedullary...
... years for these 35 patients The patients were divided into two groups based on whether the ascites isolated from these patients were protective or not against TRAIL-induced cell death The clinical ... the presence of ascites in The protein concentration was measured in the 54 peritoneal fluids The mean protein concentration was pre-treated for hrs with or without ascites and then treated with ... the Student’s t-test and with ANOVA when comparing the data with more than two treatments groups Clinical categorical variables were compared between the two groups with Fisher’s exact test The...
... patients, data for the clinical stage of the disease from 344 patients and data for the anti-cyclic-citrullinated peptide were available from 192 patients The stage of disease is defined by the ... [8,9] Patients withthe RA-specific allele PTPN22 were therefore significantly more often positive for rheumatoid factor or aCCP compared with controls [8] Moreover, all patients who had the combination ... could therefore be due to differences in linkage disequilibrium of the -168A>G polymorphism withthe hypothesized causal variant or due to a different haplotype structure in the population of the...
... Both the JSN and the cartilage volume loss were found to be positively correlated withthe worsening of pain The cartilage loss also correlates withthepatient global score, and JSN withthe ... On the femoral condyle, the loss was found in the central and anterior sections, followed by the trochlear area These findings are in line withthe work of Amin and colleagues [4] in patients with ... was associatedwiththe presence of a complete (severe) extrusion of the medial meniscus These findings support the hypothesis that the meniscus exerts a direct protective effect by reducing the...
... Research & Therapy Vol 10 No Wither et al The reduced proportion of NKT cells in the family members of lupus patients correlates withthe presence of a positive ANA To determine whether the presence ... overnight transport Because the majority of these cells are not contained within the lymphoid gate, the loss of this cell population had minimal impact on the proportions of the other cell populations ... status, or the relative proportions of the majority of cellular populations within the lymphocyte gate in lupus patients and control individuals However, the proportion of plasma cells within the PBMC...
... the right upper lobe The bronchial branch for the right upper lobe is not identifiable (b) Axial image of the right lower lobe allows the characterization of a malformed multicystic area of the ... stillborn babies, with involvement of the same lobe [3] Depending primarily upon the volume of the lung affected, the abnormality may present at birth, or most commonly, in the neonatal period, ... information relevant to the pathogenetic models and theories However, these findings suggest new insights into the pathogenesis of congenital malformations of the lung Moreover the presence of BA...
... However, the microsatellite was demonstrated to modulate the activity of the mouse promoter in T cells such that the shorter the microsatellite the greater the promoter activity [7] To determine if there ... sought to determine whether the length of the microsatellite is associatedwith SLE The microsatellite-containing region of the Fli1 promoter was amplified and length measured in the Carolina Lupus ... SLEIGH Without multiplex patients 97 11-74 (42) 123 10-69 (37) SLEIGH With multiplex patients 97 11-74 (42) 154 10-70 (39) The number of patients and controls and the median age ranges for the Carolina...
... been associatedwith IR in the general population It is therefore reasonable to consider whether IR relates primarily to these factors rather than the inflammatory diease process per se [11] There ... dysfunction is hypothesised to be a primary step in the development of the insulin resistant state The development of RF and ACPA have also been associatedwiththe shared epitope, and with smoking ... ACPA status were associatedwith HOMA-IR In the small number of patients positive for only RF or ACPA (15% and 3% respectively) there was no association with HOMA-IR However, there was a significant...
... significantly from the control values The We have shown that the plasma concentrations of acids usually associatedwiththe Krebs tricarboxylic acid cycle are significantly increased in patients with lactic ... at the time the sample was taken Furthermore, it seems unlikely that the acidaemia per se is responsible for the increased levels of Krebs intermediates within our patient population given the ... given the normal values found in the patients with normal anion gap acidosis and the lesser elevation seen in the patients with DKA An alternative explanation may be the generation of intermediates...
... those with extra-digestive bleeding) were compared with those of the patients without bleeding (Table 3) Survival was significantly better in patients without bleeding than in patients with clinical ... blood cell transfusion The mean number of units of red blood cells per transfused patient was 5.5 (range to 69) for these latter patients The characteristics of the patients with clinical evidence ... manufacturer's instructions The test was positive if the ratio between the optical density of the specimen and the mean optical density of the control was or more Clinical data The following clinical...
... intake (≥ 40 kcal/kg) in order to determine whether and how they differed from the rest of the cohort These patients were similar to the rest of the study population in terms of age, sex, admission ... Number of patients with and without bloodstream infections plotted on the y axis against the quartile of maximum parenteral caloric intake on the x axis There is a progressive increase in the proportion ... were measured at the discretion of the attending physicians and dietitians involved in the patients' care A catheter-related infection was defined as a positive culture from the catheter tip and...
... prudent to withhold therapy with APC from all patients with ALD until data from trials that include these patients, or further postmarketing data, are available Competing interests The authors ... independently associatedwiththe risk of a bleeding event (P = 0.02, odds ratio = 23.5, 95% confidence interval = 1.75–315) Of the five patients with ALD who had bleeding episodes, four died within ... initiation of APC Of the 34 remaining patients, nine had major bleeding episodes The clinical characteristics of these 34 patients are presented in Table Five out of 10 patients (50%) with ALD had major...
... predicted by the model The Hosmer–Lemeshow test divides the data into 10 groups and compares the observed mortality in these groups withthe expected mortality predicted by the model The C statistic ... admission is associatedwith a poorer outcome in patients with haematological malignancy • 10 A low haematocrit on admission to the ICU is also associatedwith a poor outcome in patients with haematological ... Readmissions Readmissions to the unit within the same hospital stay were identified from the postcode, date of birth and sex of the patient, and were confirmed by the participating units Analyses...
... adherence to the vascular wall and phagocytosis by macrophages [20] In addition, in these patients the presence of different comorbidities and the severity of the disease could have influenced the development ... septic patients are associatedwith increased hepcidin-25 concentrations • The increase in hepcidin concentrations observed in early sepsis correlates withthe decrease in Hb levels during their ... drafting the manuscript MT collected demographic and SIRS data, built the database and collected the blood samples JGH revised the manuscript and participated in the design of the study DWS revised the...
... isolated from the serum samples of the patients with acute coronary syndrome Furthermore, using combination of bacteriological and PCR-based methods we show herein that patients with acute coronary ... predicted size (194 bp) The TaqMan probe was labelled at the 5' end with 6-carboxyfluorescein as the reporter dye and at the 3' end with 6-carboxytetramethylrhodamine as the quencher An additional ... attempts Thus, TaqMan assay validates the presence of C.pneumoniae DNA in the serum samples of the patients with ACS However it is clear that TaqMan PCR is associatedwith some sensitivity and reproducibility...