prevention of hepatitis c
Báo cáo y học: "Epidemiology of Hepatitis C Virus (HCV) Infection"
Ngày tải lên :
02/11/2012, 09:56
...
Hepatitis C virus all need to be elucidated.
Conflict of interest
The authors have declared that no conflict of interest
exists.
References
1. WHO. Global surveillance and control of hepatitis C. ... world. Incidence rates across the world fluctuate and are
difficult to calculate given the asymptomatic, often latent nature of the disease prior to clinical presentation. Prevalence
rates across ... HCV
transmission to others. The physician should also offer
counseling on treatment, reducing alcohol usage and
immunization with hepatitis A, hepatitis B,
pneumococcal and influenza vaccines....
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Báo cáo y học: "The Natural History of Hepatitis C Virus (HCV) Infection"
Ngày tải lên :
02/11/2012, 09:56
... cirrhosis, hepatocellular carcinoma, HCV, HCC
1. Introduction
Chronic hepatitis C is the most common cause of
chronic liver disease and cirrhosis, and the most common
indication for liver transplantation ...
immunodeficient patients. The anti-HCV assay detects
greater than 90% of HCV infections after the initial 3
months.
4. Chronic Hepatitis C
Chronic hepatitis C is marked by the persistence of
HCV ... development of
complications, among different racial and ethnic groups
with HCV infection. For unclear reasons, African
Americans appear to have a higher rate of chronic HCV
infection than Caucasians...
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Báo cáo y học: "Molecular Virology of Hepatitis C Virus (HCV): 2006 Update"
Ngày tải lên :
02/11/2012, 10:00
... Comparison of different replicon systems. A selection of different bicistronic and monocistronic replicon constructs
including subgenomic and full-length HCV sequences is depicted schematically. ... Rice CM. Efficient initiation of HCV
RNA replication in cell culture. Science 2000; 290: 1972-4.
10. Bartosch B, Dubuisson J and Cosset FL. Infectious hepatitis C virus
pseudo-particles containing ... research focus includes molecular
biology and immunology of viral hepatitis B and C as well
as basic and clinical aspects of gastrointestinal
malignancies, especially hepatocellular and colorectal...
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Báo cáo y học: "Epidemiology and Prevention of Hepatitis B Virus Infection"
Ngày tải lên :
02/11/2012, 11:12
... adolescent vaccinatin programmes in Italy. Vaccine 2000;18:S31-S34.
77. Chang MH, Chen CJ,cLai MS. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. ... genotype C in China [34]. Accumulated data suggest the importance of genotype,
subgroup and recombination that may influence the biological characteristics of virus and clinical outcome of HBV infection. ... efficacy of newborn vaccination was 85.42%. In countries such as Italy and the United States, the incidence
of acute hepatitis B has declined dramatically during the past decade after vaccination...
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Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx
Ngày tải lên :
20/02/2014, 01:20
... Pasteur, Paris,
France). The primers used were VB1: 5¢-AAACATATGA
GCATGAGCTACCACCTGGACC-3¢ and VB3: 5¢-CTCG
AGCTTCACAAGAAACTTCTGC-3¢. The PCR fragment
was cleaved by the restriction enzymes Nde1 ... molecular clone
pCV-J4L6S [21] kindly provided by J. Bukh (NIH, Beth-
esda, MD, USA). The primers used were NS5Bj4s2:
5¢-GATATCATGTCAATGTCCTATACGTGGAC-3¢ and
NS5Bj4r 5¢-AAACTCGAGGCGGGGTCGGGCACGAGA
CAGG-3¢. ... relevance of sequences
and ⁄ or structures implicated in this step of viral RNA
replication in the infected cells.
Experimental procedures
Recombinant HCV RdRp
The recombinant HCV NS5B-D21 of H77...
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Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt
Ngày tải lên :
08/03/2014, 02:20
... protein
truncated 159 aa from the amino terminus, was amplified
by PCR using the following primers: forward, 5¢-CATGCC
ATGGCGCCATTTTTCTTGAGACATGCC-3¢; reverse,
5¢-CTGGGATCCGTCCGAATCAGGTTCCTTC-3¢
(purchased ... benzimidazoles/benzotriazoles.
Hepatitis C virus (HCV) infection, which results in chronic
or acute hepatitis, and may lead to liver cirrhosis and
hepatocellular carcinoma, is currently known to affect more
than 3% of the population ... under
conditions described above.
Effect of preincubation of compounds with enzyme
on unwinding and hydrolysis efficacy
The selected enzyme was preincubated with a given
compound at 30 °Cin20lL of...
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Diagnosis, Management, and Treatment of Hepatitis C: An Update docx
Ngày tải lên :
08/03/2014, 14:20
... adjunct to treat-
ment of HCV infection (Class IIa, Level C) .
Treatment of Persons with Psychiatric
Illnesses
Patients with chronic HCV infection have a higher
prevalence of psychiatric illness compared ... the
presence of HCV infection (Table 2) (Class I, level B).
Counseling. Good clinical practice dictates that per-
sons found to be HCV-infected are counseled regarding
prevention of spread of the ... from child to child is rare. Therefore, the
American Academy of Pediatrics does not recommend
restricting children with chronic HCV infection from
school attendance or participation in routine activities,
including...
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Management of hepatitis C pot
Ngày tải lên :
08/03/2014, 14:20
... family, or close contacts, and sexual partners. Cohort
studies of couples discordant for HCV indicated an HCV incidence of 0-2 per 1,000 years of
sexual contact.
Those with HIV co-infection, ...
5 Children and hepatitis C 10
6 Acute hepatitis C 12
7 Assessment of liver disease 13
8 Progression of untreated disease 15
9 Treatment of chronic hepatitis C 18
10 Treatment of advanced infection ... Medical Association
Scottish General Practice Committee
Professor Hilary Capell Royal College of Physicians and
Surgeons of Glasgow
Ms Anne Marie Hawthorne Royal College of Nursing
Professor...
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Báo cáo khoa học: Recent contributions of in vitro models to our understanding of hepatitis C virus life cycle pdf
Ngày tải lên :
16/03/2014, 05:20
... of primary cell culture
HCV-LP Infection, morphogenesis cell attachment
vaccination
morphogenesis
no secretion of particles
independence of CD81 for entry
HCVpp Infection entry process no budding ... ER
exogenous core
no association of particles with lipoproteins
HCVcc Entire life cycle entry process
replication mechanisms
intracellular host defence
evasion mechanisms
virus production
antiviral screening
restricted ... are chronically infected worldwide [1]. HCV infec-
tion causes major health problems because it is a
principle cause of chronic liver diseases, including cir-
rhosis and hepatocellular carcinoma....
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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C ppt
Ngày tải lên :
06/03/2014, 01:20
... prevention of chronic hepatitis B and chronic
hepatitis C prevents the majority of HCC cases because HBV and HCV are the leading causes of
this type of cancer.
Although the incidence of acute ... to Hepatitis B Vaccination 105
Hepatitis C Vaccine 111
Feasibility of Preventing Chronic Hepatitis C 111
Need for a Vaccine to Prevent Chronic Hepatitis C 112
Cost Effectiveness of a Hepatitis ... prevention coordinators
CDC Centers for Disease Control and Prevention
CHIP Children's Health Insurance Program
CI Confidence interval
CIA Enhanced chemiluminescence
CMS Centers for Medicare...
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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C doc
Ngày tải lên :
06/03/2014, 01:20
... Preventing Chronic Hepatitis C, 136
Need for a Vaccine to Prevent Chronic Hepatitis C, 137
Cost Effectiveness of a Hepatitis C Vaccine, 137
References, 138
5 VIRAL HEPATITIS SERVICES 147
Current ... important risk factors for HCC are chronic HBV
and HCV infections. As stated above, an estimated 78% of HCC cases and
57% of liver cirrhosis cases are caused by chronic HBV and HCV infections
(Perz ... Prevalence and Incidence of Hepatitis B and Hepatitis C
in the United States, 25
Hepatitis B, 25
Hepatitis C, 28
Liver Cancer and Liver Disease from Chronic Hepatitis B Virus and
Hepatitis C...
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Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"
Ngày tải lên :
02/11/2012, 09:56
... and 6 (C) .
Int. J. Med. Sci. 2006, 3
37
Chronic hepatitis C
In patients with clinical or biological signs of chronic
liver disease, chronic hepatitis C is certain when both anti-
HCV antibodies ... marker profiles can be observed according to the
presence or absence of either marker. The presence of
HCV RNA in the absence of anti-HCV antibodies is
strongly indicative of acute HCV infection, ... time of diagnosis. It is difficult, in
this case, to distinguish acute hepatitis C from an acute
exacerbation of chronic hepatitis C or an acute hepatitis of
another cause in a patient with chronic...
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Tài liệu Báo cáo khoa học: Limited suppression of the interferon-b production by hepatitis C virus serine protease in cultured human hepatocytes pptx
Ngày tải lên :
18/02/2014, 16:20
... (accession no. AB093555) were
5¢-AAGCCATGATGAGCAACCTC-3¢ and 5¢-GTGTCC
TGTTCCTTCCTCCAC-3¢. The sequences of sense and
antisense primers for RIG-I (accession no. NM_014314)
were 5¢-AATGAAAGATGCTCTGGATTACTTG-3¢ ... 6C. The black and white
arrowheads indicate Cardif and the cleaved Cardif, respectively. (B)
Cardif is cleaved by NS3-4A in the cured Oc cells. The Oc cells
were cotransfected with the myc-Cardif ... efficiency
of transfection, up to 0.4 lg of pCX4bsr was added instead
of HCV protein expression vectors. In some cases, 20 ng of
pCX4pur ⁄ myc-Cardif or pCX4pur ⁄ myc-TRIF were added
as the effector...
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Báo cáo khoa học: A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus potx
Ngày tải lên :
07/03/2014, 11:20
... spectra of unactivated and activated 1C
zymogen are shown in Fig. 4A. Although deconvolu-
tion of the contribution of distinct secondary-structure
elements to the CD spectra of unactivated and activa-
ted ... therapy, the HCV
NS3 protease has a well-characterized structure and
function [27]. The HCV NS3 protease cleaves the HCV
viral polyprotein at four speci c locations, and the
sequences of the cleavage ... linker of activated
2C zymogen also influences the catalytic activity, as
both its k
cat
and K
m
values remain lower than those of
activated 1C zymogen.
The ratio of the (k
cat
⁄ K
m
)
activated
value...
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Báo cáo khoa học: Prevalence of intrinsic disorder in the hepatitis C virus ARFP/Core+1/S protein doc
Ngày tải lên :
15/03/2014, 09:20
... sense, 5¢-CAT G
CC ATG GCA CCA ACC
GCC GCC CAC A-3¢; and antisense, 5¢-CCC
AAG CTT
GGG GGG CGC CGA CAA GC-3¢ (underlined sequences
indicate NcoI and HindIII sites, respectively). The PCR
product was ... G-3¢; HCV-1b
Core+1/S sense, 5¢-ATC CGG GGT CTC
CCATG GCA
ATG AGG GCC TGG GGT G-3¢; HCV-1a Core+1/S
antisense, 5¢-AT CCG GGT CTC
GGTACC TTA TCA
CGC CGT C TT CCA GAA C- 3¢; and HCV-1b Core+1/S
antisense, ... carbon
chemical shifts and random coil values as a
function of sequence number. (C) SSP of
HCV-1b Core+1/S. Carbon chemical shifts
were used to calculate the residue-speci c
SSP scores of HCV-1b Core+1/S...
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