... mortality from that cancer, and the
rationale for the earlydetectionofbreastcancer is similar.
Fifty years ago, there was no established method for the detection of
breastcancer at an early stage ... $40,000 offered, detectionofearlybreast cancer, especially in
may be used over 3-year period. the areas of biological or immunological
methods for the detectionof early- stage
breast cancer.
New ... de-
Mammography and Beyond:
Developing Technologies for
the EarlyDetection of
Breast Cancer
Committee on Technologies for the EarlyDetectionofBreast Cancer
Sharyl J. Nass, I. Craig Henderson, and Joyce...
... 078. PreventionandEarly
Detection ofCancer
(Part 1)
Harrison's Internal Medicine > Chapter 78. PreventionandEarly
Detection ofCancer
Prevention andEarlyDetectionof Cancer: ...
Improved understanding of carcinogenesis has allowed cancerprevention
and earlydetection (also known as cancer control) to expand beyond the
identification and avoidance of carcinogens. Specific ... prevent
cancer in those at risk, and more sensitive and specific screening for early
detection ofcancer are the goals.
Carcinogenesis is not simply an event but a process, a continuum of
discrete...
... through use of protective clothing and changing
patterns of outdoor activities can reduce skin cancer risk. Sunscreens decrease the
Chapter 078. PreventionandEarly
Detection ofCancer
(Part ... effects of low-fat
diet on breastcancer recurrence in previously treated postmenopausal breast
cancer patients. Breastcancer patients, mean age 62 years, were randomly
assigned to a standard ... ofbreastand prostate cancer by
absorbing and inactivating dietary estrogenic and androgenic cancer promoters.
However, two large prospective cohort studies of >100,000 health professionals...
... thought to act as cancer initiators and/ or promoters.
Chapter 078. PreventionandEarly
Detection ofCancer
(Part 3)
Cancer Chemoprevention
Chemoprevention involves the use of specific natural ... gas
Cancer of the lung, head and neck,
nasal sinuses
Nickel dust Cancerof the lung, nasal sinuses
Phenacetin
Cancer of the renal pelvis and
bladder
Polycyclic hydrocarbons
Cancer of the ... before the development of
invasive malignancy.
Cancer develops through an accumulation of genetic and epigenetic
changes that are potential points of intervention to prevent cancer. The initial...
... of statin use showed no protective
effect of statins on overall cancer incidence or death.
Chapter 078. PreventionandEarly
Detection ofCancer
(Part 4)
Chemoprevention of Cancers of ... risk of lung cancer for those taking β-carotene; fewer of
its participants were smokers than those in the ATBC and CARET studies.
Chemoprevention of Colon Cancer
Many of the current colon cancer ... neck, esophagus, and
lung. Patients cured of squamous cell cancers of the lung, esophagus, head, and
neck are at risk (as high as 5% per year) of developing second cancers of the upper
aerodigestive...
...
head and neck cancer, and Helicobacter pylori is associated with gastric cancer
Chapter 078. PreventionandEarly
Detection ofCancer
(Part 5)
Chemoprevention ofBreastCancer
Hormonal ...
Vaccines andCancerPrevention
A number of infectious agents cause cancer. Hepatitis B and C are linked to
liver cancer, some human papilloma virus (HPV) strains are linked to cervical and
head and ... adjuvant breastcancer therapy, it is hoped that they also are
more effective in breastcancer prevention. However, no data are available on this
point.
Chemoprevention of Prostate Cancer
Finasteride...
... for the detection of
proteins and protein complexes: quantitation of HER1 and HER2 total
protein expression and homodimerization in formalin-fixed, paraffin-
embedded cell lines andbreastcancer ... 10
6
),
followed by BT-474 breastcancer cells (2.75 × 10
6
), MCF7 breastcancer cells (0.18 × 10
6
), and MDA-MB-231 breastcancer cells (0.11 × 10
6
). The
Chinese hamster ovary (non -breast) cell line ... × 10
4
Hathaway et al. BreastCancer Research 2011, 13:R108
http:/ /breast- cancer- research.com/content/13/5/R108
Page 11 of 13
Introduction
New cases of invasive breastcancer were predicted to
exceed...
... sensitivity of 89% and a specificity of 97% for the
detection ofearly stage ovarian cancer. Furthermore, the sensitivity and the specificity of this panel in
distinguishing between normal and mucinous ...
resulting from the lack of reliable, sensitive screening tests and our limited understanding of the
mechanisms of chemoresistance and relapse. More than two-thirds of cases of ovarian cancers are
diagnosed ... sensitivity of 94% and a specificity of 94% for serous
ovarian carcinoma in its early stage, and a sensitivity of 98% and a specificity of 98% for endometrioid
ovarian carcinoma in its early stage...
... Mediterranean
Atord Modjtabai
Professor of Pathology
United States of America
Cancer detection programmes
Early detectionof cancer
The objective of an earlydetection programme is diagnosing cancer at its earliest ... programmes.
26 Guidelines for the earlydetectionand screening ofbreast cancer
Screening for breastcancer
Breast cancer is most easily and effectively treated in its early stages. Survival rates ... the earlydetectionand screening ofbreast cancer
The Regional Office has been proactive in the development, implementation and
assessment of regional guidelines for the earlydetection and...
... design and conduct of a protocol for a breastcancerprevention trial.
These proposals were to be reviewed by the Cancer Control Protocol Review
Committee in the NCI Division ofCancerPreventionand ... invasive breast cancer
over the period of the study. Although tamoxifen prevented the
appearance of a substantial number ofbreast cancers over the
duration of this study, the term ‘ prevention ’ ... Cardiac and thromboembolic morbidity among
postmenopausal women with early- stage breastcancer in a randomized trial
of adjuvant tamoxifen. The Stockholm BreastCancer Study Group. J Natl
Cancer...
... online to:
Cancer. gov: http://www .cancer. gov /cancer_ information/
bladder cancer | breastcancer | colon cancer | liver cancer | lung
cancer | oesophageal cancer | ovarian cancer | prostate cancer
LocusLink: ... such as serum and urine have proven to
be a rich source of biomarkers for the early detection
of cancer. The blood proteome changes constantly as a
consequence of the perfusion of the diseased ... serum of prostate cancer patients
from non -cancer cohorts. A test set of serum samples
yielded a sensitivity of 83% and specificity of 97% for
the study population when comparing the prostate
cancer...
... breast
cancer, and as effect modifiers of the association of fat intake and risk ofbreast cancer. Cancer Causes Control, 8,
pp49-56.
18
Collaborative Group on Hormonal Factors in BreastCancer ... The protective role of pregnancy in breast cancer. Breast
Cancer Res., 7(3), pp131-42.
20
Collaborative Group on Hormonal Factors in BreastCancer (2002b). Breastcancerand breastfeeding: collaborative ... (1997). Breastcancerand hormone replacement therapy:
collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breastcancerand 108,411
women without breast cancer. ...
... during the etiology ofbreast carcinogenesis.
Review
Mouse models ofbreastcancer metastasis
Anna Fantozzi and Gerhard Christofori
Institute of Biochemistry and Genetics, Department of Clinical-Biological ... therapy.
Introduction
Breast cancer is the most frequently diagnosed form of
cancerand the second leading cause of death in Western
women [1]. Death, and most of the complications associated
with breast cancer, ... colonization of the target organ and,
finally, metastatic outgrowth [3,4].
In the recent past, our understanding ofbreast cancer
progression and metastasis has greatly profited from the use
of genetically...