prediction of human pharmacokinetics
Báo cáo sinh học: "HuMiTar: A sequence-based method for prediction of human microRNA targets" ppt
... addition of predictions of competing methods to predictions of HuMiTar results in small or no improvement in sensitivity while it increases the total number of predictions; (6) union of the competing ... to provide predictions characterized by favorable sensitivity, which comes at a price of an increased number of predictions The HuMiTar's predictions cover majority of the predictions of the best-performing ... correctness of some of the HuMiTar predictions Evaluation and comparison of sensitivity/specificity trade-off based on ROC (receiver operating characteristic) analysis The predictions of HuMiTar...
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Báo cáo y học: "Computational prediction of human metabolic pathways from the complete human genome" ppt
... Our best estimate of the total number of human metabolic enzymes is the sum of the 1,653 known enzymes plus the 203 pathway holes, for a total of approximately 6.5% of the human genome allocated ... our understanding of the human metabolic network The query and visualization capabilities of the Pathway Tools software (such as the visual- The user of HumanCyc should be aware of several potential ... clusters of pathways The average length of HumanCyc pathways is 5.4 reaction steps Example HumanCyc pathways are shown in Figures and All HumanCyc pathways can be accessed online from the HumanCyc...
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Báo cáo y học: " Prediction of viral microRNA precursors based on human microRNA precursor sequence and structural features" pot
... for the discovery of novel human microRNAs Furthermore, methods have been recently proposed that not rely on conservation of microRNA sequences and have helped in discovery of human, mouse and ... experimentally validated a subset of the prediction [10,11] These provide evidence about the genome-wide applicability and reliability of our method for ab-initio prediction of microRNA precursors The ... 22 out of the 23, 11 out of 13 and 10/11 of the microRNAs expressed by EBV, KSHV and CMV respectively The comparisons of different programs are summarized in Table Average Frequencies of sequence-structure...
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Intelligent Software Agents on the Internet: an inventory of currently offered functionality in the information society & a prediction of (near-)future developments
... they be offered? 69 6.4.1 Who will be developing agents, and how will they be offered? 69 6.4.2 What kinds of agents will be offered? 71 6.4.2 What kinds of agents will be offered? ... interacting with human users 3.2 Examples of agent applications and entire agent systems Because of the fact that a lot of research is being done in the field of agents, and Intelligent Software Agents ... types of agents as well 1.3 Two statements This thesis consists of two parts For each of these two parts a separate statement will be formulated The first part of the thesis is an inventory of agent...
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Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"
... (concordant prediction and outcome) and (discordant prediction and outcome); a prediction of 50% has a score of 0.25 both when the outcome is or [42] The development and assessment of prognostic ... without imputation of missing data are 1.61 (1.13 to 2.31; P = 0.01) for the prediction of serious complications and 1.65 (0.97 to 2.79; P = 0.06) for the prediction of death ness of fit test) The ... also no indication of serious miscalibration of these models: A total of 36 serious complications were observed in nonCAP patients compared to predicted numbers of complications of 41.2 and 40.2...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... designing a mutation in the gene of GLP-1 (7-37) This mutation resulted in the substitution of glycolamine for alanine at the second site of GLP-1 (7-37) peptide A sequence of nucleotide including 45 ... function of protein, we designed an enterokinase cleavage site at the 5’ terminus of the gene of the gAd-GLP-1-A fusion protein, which was used to remove the His-tag [9] In our study, most of the ... effect of the whole fusion protein in this study We could not determine which part of the fusion protein has this effect The effect might due to either one part of fusion protein or both of them...
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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"
... total amount of pravastatin entrapped in 0.1 ml of the final packed erythrocytes Efficiency of entrapment The percentage of the loaded amount of pravastatin to the total amount of that added ... ml eppendorff tubes, 400 µl of suspension are added to 400 µl of PBS containing the known concentration of the drug and 2.5 mmol of ATP, 2.5 mmol MgCl2 and 2.5 mmol of CaCl2, gently mixing to ... improvement both pharmacokinetics and pharmacodynamic properties of statins including inhibition of the metabolism [5], administration of statins with certain juices [6] or inhibition of Pgp [3] Unfortunately...
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Báo cáo tiếng anh Ngoại thương Strategies of human resource development of MISA JSC.doc
... resource management and development of MISA JSC I Activities of human resource development of MISA JSC Strategies of human resource development Strategies of human resource development play an ... crystallization of intelligence and enthusiasm of youth MISA’s achievement is efforts of group of officials and staff who strive for company’s development CHAPTER Strategies of human resource ... medals, and a lot of certificate of merit from Minister of Finance, Minister of Education and Training, Minister of Information and Communication, Chairman of Accounting and Auditing of Vietnam, etc...
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Báo cáo y học: "Low temperature tolerance of human embryonic stem cells"
... bioreactors Conflicts of interest The authors have declared that no conflict of interest exists References Becker EW The roles of ATP in the dynamics of the actin filaments of the cytoskeleton ... the use of pre-warmed and pre-equilibrated culture media [15, 16] Indeed, minimizing low temperature exposure of human embryos and oocytes is a critical factor in determining the success of clinical ... cannot be said of human embryos, which are much less robust and hardy compared to mouse embryos Hence laboratories involved in handling human embryos in clinical assisted reproduction often have...
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Báo cáo y học: "Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors"
... same viral dose, the activities of rat and human BMP4 adenoviral vectors are very similar in all models Nevertheless, the activity of rat BMP6 is lower than that of human BMP6 in all three models; ... and compared with ADhBMP6 in the process of bone formation In the second set of experiments, human BMP6 cDNA was constructed to form a secondgeneration human BMP adenoviral vector ( [E1-,E2b]ADhBMP) ... models The roles of the viral genome and the sources of BMP cDNA in the process of bone formation were determined in this study 98 MATERIALS AND METHODS Cloning and identification of rat BMP4 and...
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Báo cáo y học: "ene expression analysis of human red blood cells"
... Analysis of total human RNA of RBCs (Bioanalyzer 2100 Agilent, USA): A) L- RNA 6000 ladder (Ambion, USA); 1-3 - total RNA of human RBCs from different donors; B) typical electropherogram of total ... mechanism of globin m-RNA stability in human RBCs Further experiments are needed to understand the mechanisms and the biological meaning of these findings But gene expression profiling of human erythrocyte ... proposed A part of human erythrocytic proteins were identified 6, 7, 8, The number of genomic studies of RBCs is at present limited and represented either by micronucleus assay as a marker of classification...
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PREDICTION OF ATRAZINE FATE IN RIPARIAN BUFFER STRIPS SOILS USING THE ROOT ZONE WATER QUALITY MODEL
... to improve the predictions of agricultural losses to runoff and seepage Previous research has shown that the use of RZWQM for simulating the pesticide and movement in the soil profile produces ... communication) The model requires the albedo of dry soil, albedo of wet soil, albedo of crop at maturity, and albedo of fresh residue Albedo is the refraction of incoming solar radiation reflected by ... the rest of the model that there is a crop growing Simulation of atrazine transport The focus of this simulation was on the movement of atrazine after entering the RBS RBS receive runoff from...
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Salts Transport in Alkali Soil Reclamation by Gypsum and Prediction of Na Leaching in Field in China
... inner diameter of 50 mm, outer diameter of 60 mm, and a height of 20 mm (Fig 2) This structure exposes 18 mm of the point of the current supply electrode and 12 mm of the point of the voltage ... conductivity of the soil in the center of the column The inner and outer diameters of the stainless steel rods were mm and 16 mm, respectively, and the ratio (I/V2) of the current of an outer ... height of 20 mm at a bulk density of 1.53 g/cm3 The acrylic rings were filled up to a height of 20 cm Degassed water was poured onto the top of the column at a rate of 1.0×10-3 to 2.0× 10-3 cm3/s...
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Prediction of deformation and hygro-thermal stresses distribution in PEM fuel cell vehicle using threedimensional CFD model
... realistic representation of the local activation overpotentials, which leads to improved prediction of the local current density distribution This leads to high accuracy prediction of temperature distribution ... durability of fuel cell stack components remains, in most cases, insufficiently understood Lengthy required testing times, lack of understanding of most degradation mechanisms, and the difficulty of ... the magnitude of phase change inside the GDL, expressions are required to relate the level of over- and undersaturation as well as the amount of liquid water present to the amount of water undergoing...
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THE INFLUENCE OF HUMAN ACTIVIES ON THE ENVIRONMENT
... as a fertiliser and set aside land for growth of wild plants Biological Control of Pests • This means using natural predators to eat pests instead of pesticides • It does not have harmful effects ... carbon dioxide traps heat in the atmosphere and causes the temperature of the earth to rise • This leads to disruption of the weather patterns eg drought, floods • Some weeds may thrive on the ... damages trees and pollutes rivers and lakes Acid rain causes erosion of buildings and statues particularly if they are made of limestone Deforestation • In may countries people are chopping down...
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an inventory of currently offered functionality in the information society & a prediction of (near-)future developments
... they be offered? 69 6.4.1 Who will be developing agents, and how will they be offered? 69 6.4.2 What kinds of agents will be offered? 71 6.4.2 What kinds of agents will be offered? ... interacting with human users 3.2 Examples of agent applications and entire agent systems Because of the fact that a lot of research is being done in the field of agents, and Intelligent Software Agents ... types of agents as well 1.3 Two statements This thesis consists of two parts For each of these two parts a separate statement will be formulated The first part of the thesis is an inventory of agent...
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Conclusion - In praise of human rights nihilism
... imposition of lawful restrictions on the exercise of these rights by members of the armed forces, of the police or of the administration of the State Article 12 (right to marry) Men and women of marriageable ... stance, I have intimated that human rights is a ‘system of persuasion’, a ‘kind of rhetoric’, an ‘expression of the will to power – even to domination – of those making the [human rights] truth-claims ... immutable, unchanging essence of either the divine, human or natural world.’20 This, of Conclusion course, is exactly what I have tried to show in respect of human rights orthodoxy Human rights are most...
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Tài liệu The Influence of Human Activity on the Environment ppt
... as a fertiliser and set aside land for growth of wild plants Biological Control of Pests • This means using natural predators to eat pests instead of pesticides • It does not have harmful effects ... carbon dioxide traps heat in the atmosphere and causes the temperature of the earth to rise • This leads to disruption of the weather patterns eg drought, floods • Some weeds may thrive on the ... damages trees and pollutes rivers and lakes Acid rain causes erosion of buildings and statues particularly if they are made of limestone Deforestation • In may countries people are chopping down...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25