... involved in transcriptional and translational processes As shown in Table 1, the up-regulated genes were COBRA1, ITGB4, STAU2, and HMGN3 with a SLR of 3.30, 2.61, 1.68 and 1.52, respectively ANK3 ... induction of transcription factors (AP1, Elk1, Stat1, SRF and NFκB) and expression of apoptotic genes (Fas receptor, Fas ligand, FADD and caspase 8) [19] In addition, as confirmed by the functional ... to the reported ethanol-induced expression and activation of cytokines and chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the...
... for and trial designs will enable testing of multiple drugs specific trials; and monitor responses to therapy at once, and provide more meaningful insight into what does and doesn’t work, and ... researchers to more quickly and easily identify those that can guide research and patient care A SCO’s Blueprint for Transforming Clinical and Translational Research 11 yy Biomarkers and diagnostic assays ... Clinical and Translational Research 17 industry to convene stakeholders in trial develop- approaches, identify new standards and develop ment to examine current exclusionary criteria and strategies...
... space of translation surfaces of genus g ≥ For almost all translation surfaces (M, ω) ∈ H(κ), the translation flow Fθ on (M, ω) is weakly mixing for almost all θ ∈ S Translation flows and i.e.t.’s ... H(κ) of the moduli space of translation surfaces which is endowed with a natural complex structure and a Lebesgue measure class [V5], [Ko] A translation flow F on a translation surface M is the ... enough to deal with translation flows and yields an estimate on the Hausdorff dimension of the set of translation flows which are not weakly mixing Background 2.1 Strongly expanding maps Let (∆,...
... at 50 °C and 10 at 95 °C, followed by a total of 40 twotemperature cycles (15 s at 95 °C and at 60 °C) For the generation of standard curves, serial dilutions of a cDNA sample were used and mRNA ... against iPLA2c and visualization of immunoreactive bands by ECL Expressed recombinant polypeptides are designated according to their expected masses Lanes and 5, 88 kDa iPLA2c; lanes and 6, 74 kDa ... columns and 3) Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational...
... computers (or even PDAs) and uses a handheld scanner to get the input material In other words, TwicPen consists of (i) a simple hand-held scanner and (ii) parsing andtranslation software TwicPen ... structural representation below) in canonical positions, thereby creating a chain between the base (canonical) positionand the surface (extraposed) position of the “moved” constituent as illustrated ... References Breidt, E and H Feldweg, 1997 “Accessing Foreign Languages with COMPASS”, Machine Translation, 12:1-2, 153-174 Kay, M., M Gawron and P Norvig, 1994 Verbmobil : A Translation System for...
... of a parse stack and an input list The parse stack and the input list contain trees of frames of words or phrases Core slots of frames are surface and lexical form, syntactic and semantic category, ... more relevant for making parse andtranslation decisions, such as temporal, spatial and animate concepts A subcategorization table that describes the syntactic and semantic role structures for ... with the correct parse, effectively just testing the transfer and generation module The resulting translations, in randomized order and without identification, were evaluated by ten bilingual graduate...
... CSPs on transcription andtranslation Many CSPs have been shown to have a high afnity to single-stranded nucleic acids and therefore are thought to act on transcription and or translation For the ... BcCSP In vitro translation Template DNA for combined transcription /translation and in vitro transcription As template DNA the plasmid pK7CAT [36], pET14b CAT, pKRAS and pET14bRas and pET14bRas ... TmCSP, BcCSP, and BsCSP, respectively, are cDNAtotal ẳ 335 244 lM, N ẳ 4.01 1.35 lM, Kribo ẳ 32 1.3 nM, and cribototal 0.69 0.05 lM 4693 Inuence of CSPs on transcription andtranslation R...
... complete word, and is assumed to have constant cost Additionally, and because our proposal allows differences between its output and the reference translation, we will also present translation quality ... computerassisted translation system In Proc ACL, page G Foster, P Isabelle, and P Plamondon 1997 Targettext mediated interactive machine translation Machine Translation, 12:12–175 N Ueffing and H Ney ... SMT system) and 1.0 (equivalent to a conventional IMT system), for both the MEAN and RATIO CMs For each threshold value, we calculated the effort of the user in terms of WSR, and the translation...
... Perrault, X Ren and M Simard 1993 Translation Analysis andTranslation Automation In Pro-ceedings of the Fifth International Conference on Theoreti-cal and Methodological Issues in Machine Translation, ... assisted translationand language learning tool Currently, TotalRecll uses Sinorama Magazine and HKLEGCO corpora as the databases of translation memory We have already put a beta version on line and ... features of TotalRecall include highlighting of query and corresponding translations, clustering and ranking of search results according translationand frequency TotalRecall enable the non-native...
... mM dTTP, and mM mSdCTP 50X second-strand RX nucleotides: 7.5 mM dATP, 7.5 mM dGTP, 7.5 mA4 dTTP, and 35 mM dCTP 50X second-strand XR nucleotides: 7.5 n&f dATP, 7.5 mM dGTP, 7.5 mM dTTP, and 10 ... UTP The fulllength probes and protected fragmentsare 404 and 329 bp for IL-4 and 193 and 143 bp for P,-MG RNA was extracted from murine EL4 cells stimulated with PMA and ionomycin using the guanidinium ... nuclease- and protease-free if purchased racked) and sterile pipets The use of gloves is strongly advised to reduce nuclease and protease contaminations, and to uphold safety regulations for the handling...
... chain of translational research and therefore biobanks are actively contributing to advances in translational research by offering opportunities to safely collect and store these samples and link ... activities, extending beyond technical and educational skills, such as planning and problem solving, communication skills, and the ability to share research programs and experimental results with other ... microscope and a light emitting source such as lasers; the most commonly used lasers include argon-ion with usable power at 257, 477, and 514 nm and helium neon lasers with usable power at 534, 567, and...
... molecules and cells, tissues and organs, individuals, and populations) The crossing of translational barriers (T1, T2, and T3) can be enabled using translational bioinformatics and clinical research ... informatics approaches to enable the assessment and moving of basic science innovations from the T1 translational barrier and across the T2 and T3 translational barriers (as depicted in Figure ... relevance for translational medicine: (1) Decision Support; (2) Natural Language Processing; (3) Standards; (4) Information Retrieval; and, (5) Electronic Health Records For each topic, progress and activities...
... and peripheral CD4+ T cells in humans and mice, and arise during normal thymic lymphocyte development T reg cells are characterized by the constitutive expression of the IL-2Ra chain (CD25) and ... Treg defect, and in turn, mark the transition to d’Hennezel et al Journal of Translational Medicine 2010, 8:113 http://www.translational-medicine.com/content/8/1/113 overt autoimmunity; and 2) the ... genetic and physiological hallmarks of disease risk and progression have previously been thoroughly reviewed [101] d’Hennezel et al Journal of Translational Medicine 2010, 8:113 http://www.translational-medicine.com/content/8/1/113...
... treated for 0, 3, 6, 12, and 24 hrs with TNFa (100 u/mL) and/ or IFNg (200 u/mL), and in cultured HUVEC (bottom panels) treated for 0,4,8,12, and 24 hrs with TNFa (100 u/mL) and/ or IFNg (200 u/mL) ... design and supervision of all experiments, performed data analysis and interpretation of data, supervised and coordinated all studies, and drafted the manuscript All of the authors have read and ... cytokines TNFa (100 units/ ml) and/ or IFNg (200 units/ml) for various periods of time Analysis of F11R in HAEC and HUVEC lysates and cell culture media Monolayers of arterial and venous endothelial cells...
... unknown, and consequently the MT position has to be determined from scratch This positioning problem is more difficult because multiple and distinct hypotheses have to be handled The three defined positioning ... undergoes power management However, the position tracking and Mohamed Khalaf-Allah Mean positioning error 67% positioning error 320 450 400 280 Positioning error (m) Positioning error (m) 300 260 240 ... the performed translationand σ orient between 1◦ and 6◦ The quality of performance is determined according to reliability and positioning errors in meters We consider the MT position is reliably...
... suspension height, pedal position, transmission gear position, and vehicle acceleration In clothes-washing machines, sensors measure water level and temperature, load size, and drum position variation ... cavity, and LVDT, core, and signalconditioning electronics in the upper cavity 1.2 POSITION VERSUS DISPLACEMENT Since linear position sensors and transducers are presented in this work and many ... the terms positionand displacement, the difference between positionand displacement should be understood by the reader 4 SENSOR DEFINITIONS AND CONVENTIONS Permanent magnet Measured position...
... used to train the translation model can be used to increase the coverage of statistical machine translation by adding translations of previously unseen words and phrases If the translation of a ... of automatic evaluation of translation quality, and show that the current standard evaluation methodology cannot be guaranteed to correlate with human judgments of translation quality Whereas ... machine translation group and allowed us to form a coherent whole He has been a wonderful collaborator and I value the time that I had to work with him v • I owe much to the other outstanding...
... paraphrasing templates (Ravichandran and Hovy, 2002; Barzilay and Lee, 2003; Pang et al., 2003; Dolan and Brockett, 2005) This thesis proposes a method for extracting lexical and phrasal paraphrases ... paraphrasing: multiple translations, comparable corpora, and monolingual corpora Sources for multiple translations include different translations of classic French novels into English, and test sets which ... to machine translation such as example-based machine translation (Nagao, 1981), and statistical machine translation (Brown et al., 1988) Both approaches learn sub-sentential units of translation...