port site metastasis in urologic laparoscopy
Báo cáo khoa học: "Port site metastasis following diagnostic laparoscopy for a malignant Gastro-intestinal stromal tumour" pot
... the paper Figure Port site metastasis Port site metastasis Uptake can be clearly seen in the Abdominal wall (Internal oblique) corresponding to the site of the laparoscopic port Page of (page ... port site metastasis (PSM), she is due to be discussed again in the MDT meeting prior to making a final decision regarding further treatment The evidence base for the treatment of port site recurrences ... could include surgical resection of the port site or the use of a second line agent such as sunitinib This latter decision would be made on the assumption that the development of a port site metastasis...
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Tài liệu Báo cáo khoa học: Disulfide bridge regulates ligand-binding site selectivity in liver bile acid-binding proteins ppt
... ligand binding [11] In the cellular retinoic acid-binding protein I, the introduction of a disulfide bond abolished the structural mobility of the portal region, thus leading to irreversible retinoic ... lead to distinct binding and functional properties [22,23] In line with this, we have shown here that the presence of a disulfide bridge, while maintaining the same binding stoichiometry, induces ... and site cross-peaks During the titration, site and site 1H linewidths were substantially unchanged (Fig 2A) The quantitative volume analysis of these predominant forms indicated that binding site...
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Tài liệu Báo cáo khoa học: Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis docx
... (N-terminal) contains the zinc-binding site, which faces into the deep cleft formed by the two subdomains connected at the base of the cleft The hinge-bending motion observed upon inhibitor binding ... Arg514 in ACE2 is displaced relative to Arg522 in ACE and is somewhat closer to the zinc-binding site The CL2 binding site is in close proximity to the catalytic site ˚ (10.4 A away from the zinc) ... R514/522 S511/P519 Fig Chloride binding to ACE2 (yellow) and tACE (white) (A) Binding site of CL1 in ACE2 and tACE; (B) binding site of CL2 in ACE2 and tACE Residue numbering for ACE2 is first The chloride...
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Tài liệu Báo cáo Y học: Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin pdf
... D-chymotrypsin trypsin Phe114 !Ile-D-chymotrypsin Phe114 !Ile-D-chymotrypsin ( –Ca21) Phe114 !Ile-D-chymotrypsin trypsin Wild-type trypsin Mutant trypsin Mutant trypsin trypsin Mutant trypsin D-chymotrypsin ... trypsin Interestingly, despite the presence of four potential chymotrypsin cleavage sites in its surface loop regions (the interdomain loop does not contain such sites), this mutant trypsin did ... chymotrypsin At first, D-chymotrypsin and the interdomain and autolysis loop mutants were subjected to digestion with trypsin For this protease there is no cleavage site in the interdomain loop...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... located in the substrate binding pocket Few examples exist in which the ratio between hydrolysis and aminolysis was changed by changing the catalytic nucleophile By replacing the activesite serine in ... Activity of site- directed mutants for NIPAB Three phenylalanines in the acyl-binding site of PA of E coli, bF24, bF57 and aF146, were investigated by sitedirected mutagenesis Each phenylalanine was ... chain of bF57 and PAA is 4.7 A, which is too long for a direct interaction between bF57 and the substrate However, residue bF57 may be important for maintaining the structure of the binding site...
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Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
... Aegyptin binds with high affinity to the vWF binding site in collagen, independently of hydroxyproline In an attempt to identify the binding sites involved in collagen interaction with aegyptin, ... 2A), indicating that the G primary sequence is indeed sufficient for the interaction Aegyptin binds with low affinity to GPVI and integrin a2b1 binding sites in collagen Sequences involved in collagen ... It is also plausible that aegyptin binding to the vWF binding site in collagen sterically interferes with collagen binding to integrin a2b1 as these sites are in close spatial proximity [40]...
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Báo cáo khoa học: The catalytic significance of the proposed active site residues in Plasmodium falciparum histoaspartic protease ppt
... using nickel-affinity and gel-filtration chromatography At this stage, samples contained predominately fusion protein and a small amount of zymogen protein as determined using N-terminal sequencing ... ultimately breaking the peptide bond and returning the active site to its original state Inhibition assays showed that HAP, H34A and S37A were effectively inhibited by the serine protease inhibitor ... according to the manufacturer’s instructions The following primers were designed to introduce the single point mutations at residues His34, Ser37 or Asp214 (numbering Catalytic residues in histoaspartic...
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Efficient site directed in vitro mutagenesis using ampicillin selection potx
... in a restoration of function mutation at the Pst I site in the Testing pSELECT-1 with an Insert In order to test the functioning of pSELECT- with an insert, we first deleted the Eco R1 site in ... on the vector This insert carries a single unique Eco R1 site in the coding region and we inactivated the CAT gene by cutting at this site, filling with Klenow and religating We used a synthetic ... We inactivated the tetracycline resistance gene of a pBR322 derivative carrying an fl replication origin by cutting at the Bam HI site, blunting the ends with Klenow and religating Using single-stranded...
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Báo cáo Y học: Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis ppt
... 4.0) PMSF (1.0) TLCK (0.12) TPCK (0.2) DEPC (0.8–1.2) Cysteine Cysteine Serine Serine-Cysteine Serine-Cysteine Serine-Cysteine Histidine 100 0 20 12 100 Ó FEBS 2002 2892 E Mattern-Dogru et al ... regarding studies with cysteine and serine protease inhibitors The next clear information obtained was the necessity of histidine groups which proved the active role of at least one histidine in ... by primer walking using the dideoxy chain termination method [13] For protein purification, the mutated and the wild-type cDNAs were transformed into the E coli strain M15[pREP4] An inoculum of...
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Báo cáo hóa học: "The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer" docx
... Martinet N, Martinet Y, Vignaud JM: Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression J Lab Clin Med ... solution (3,3’-diaminobenzidine dihydrochloride [DAB]) for 3-5 minutes (brown reaction product) Sections were then counterstained with hematoxylin and mounted in non-aqueous mounting medium To analyze ... macrophage infiltration in the invasive front (81.0%) than in those with a lower macrophage infiltration (48.6%), which is in agreement with the previous studies [36-39] The mechanisms behind the...
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báo cáo hóa học:" Can the surgical checklist reduce the risk of wrong site surgery in orthopaedics? - can the checklist help? Supporting evidence from analysis of a national patient incident reporting system" pptx
... reporting is increasing as clinicians become more aware of its presence and furthermore develop confidence that there will not be any personal repercussions to making reports Convincing clinicians ... were 855 incidents reported to the NRLS relating to erroneous details being included on operating lists [30] Despite the fact that a large proportion of our incidents (91%) resulted in no harm, ... contribute should in due course further increase the frequency and quality of reporting Yet, it is increasingly likely that mandatory reporting offers the only viable solution to accruing reflective...
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báo cáo hóa học:" Can the surgical checklist reduce the risk of wrong site surgery in orthopaedics? - can the checklist help? Supporting evidence from analysis of a national patient incident reporting system" pdf
... reporting is increasing as clinicians become more aware of its presence and furthermore develop confidence that there will not be any personal repercussions to making reports Convincing clinicians ... were 855 incidents reported to the NRLS relating to erroneous details being included on operating lists [30] Despite the fact that a large proportion of our incidents (91%) resulted in no harm, ... contribute should in due course further increase the frequency and quality of reporting Yet, it is increasingly likely that mandatory reporting offers the only viable solution to accruing reflective...
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Báo cáo lâm nghiệp: "Tree density and site quality influence on Pinus halepensis Mill. reproductive characteristics after large fires" pdf
... depending on whether seeds are from serotinous or non-serotinous cones Pine provenance must also be regarded as an important factor in determining germination [9] The increase in forest fires in ... considered the main factor in uencing variations in stand development variables 2.2 Experimental design Six sites were selected in areas affected by significant fires in the summer of 1994 The sites were ... Figure Sites location in the Iberian Peninsula In Aleppo pine, a dual strategy with two different types of seeds for different scenarios has been described [28, 29] The serotiny level of pine stands...
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Báo cáo lâm nghiệp: "Site index in relation to edaphic variables in stone pine (Pinus pinea L.) stands in south west Spain" ppt
... classes are important indicators in new plantations as well as in their future site index classification Site class may help in defining what silviculture should be applied during the first years ... based on site index (base age 75 years) were defined according to site index curves developed by Montero and Ruiz-Peinado [38] The plots were assigned to a site index class resulting in plots for ... influence in cone and wood production in Pinus pinea L forests in the south of Huelva province, in: IUFRO meeting on Mediterranean silviculture with emphasis on Quercus suber, Pinus pinea and...
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Báo cáo lâm nghiệp: "Habitat distribution of dipterocarp species in the Leyte Cordillera: an indicator for species – site suitability in local reforestation programs" ppt
... tracks entering the Philippines [11] Typhoons are responsible for excessive rainfalls, which trigger landslides and cause heavy mechanical damage in the forests through wind throws and wind breaks ... a continuous decrease of individuals from the U2 layer via the different size classes towards the mature trees (T1) Shorea polysperma even shows an inverse trend, showing an increase of individuals ... chance process The information on tree species -site preferences is important if such species are planned to be used in reforestation The presented data on site- specificity are mainly based on a...
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Báo cáo khoa học: "Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer" potx
... survival in invasive breast cancers [24] In conclusion, we found that the incidence of sentinel lymph node metastasis in cases of pure DCIS was 0.39% This incidence was lower than that in IDC-predominant ... stromal invasion Furthermore, having less than 0.5 cm of stromal invasion increases the incidence of sentinel lymph node metastases [15,16] As a result, many investigators insist that sentinel lymph ... patients having an IDC-predominant invasive lesion with the same profile as mentioned above IDC-predominant invasive lesions are those with a predominant IDC including one or more invasive foci,...
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Báo cáo khoa học: "Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature" doc
... ≤35 IU/L in 12 patients (36.4%), between 35-500 in 17 patients (51.5%) and ≥500 in the remaining four patients (12.1%) Tumor histology was serous in seven patients (22.1%), mucinous in eight ... serous and mucinous carcinoma (grade 2) The patient with omental metastasis had mucinous carcinoma (grade 3) One patient with contralateral ovarian involvement too had mucinous carcinoma (grade ... mixed type in four, transitional in three, anaplastic in one and squamous in one patient Discussion Lymphadenectomy is a routine part of surgical staging in epithelial ovarian carcinomas [8]...
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Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3 pdf
... predicted to line the S1 pocket Mutation of this residue to alanine removes the bulky side chain and results in a drastic increase in Km thus suggesting a function in substrate binding rather than ... participates both in substrate binding by providing salt bridge or hydrogen bond interactions with the substrate P1 arginine as well as in the catalytic mechanism of the NS3 protease T134 Alanine substitutions ... a role in substrate binding by formation of a hydrogen bond with the substrate P1 arginine D129 Substitution of the invariant residue D129 by alanine induced a large (39-fold) decrease in catalytic...
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báo cáo khoa học: "Long-term follow-up after en bloc resection and reconstruction of a solitary paraganglioma metastasis in the first lumbar vertebral body: a case report" ppt
... review of the literature Spine (Phila Pa 1976) 2010, 35:E152-E154 23 Boriani S, Weinstein JN, Biagini R: Primary bone tumors of the spine Terminology and surgical staging Spine 1997, 22:1036-1044 ... extension of the tumor within the vertebral body, which occupied zones to 9, according to the staging system of Boriani et al [23], (Weinstein Boriani Biagini (WBB) staging system) made en bloc ... body, only a marginal resection could be obtained The pseudocapsule was examined and considered intact With posterior bisegmental transpedicular screw instrumentation using a rigid internal fixator...
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Báo cáo y học: " Papillary renal cell carcinoma with metastatic laparoscopic port site and vaginal involvement: a case report" pot
... carcinoma with metastasis to the vagina, with the second such report of a laparoscopic port- side metastasis Our case report documenting a second port- site metastasis in a rare tumor provides support ... that the single previous report of a port- site metastasis in type papillary RCC had a similar profile of metastatic sites involving the peritoneum and liver in addition to the port site [13], ... Vaginal metastasis revealing colon adenocarcinoma Int J Colorect Dis 2006, 21:861-862 Eng MK, Katz MH, Bernstein AJ, Shikanov S, Shalhav AL, Zorn KC: Laparoscopic port- site metastasis in urologic...
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