platinum ii complexes with nitrogen and sulfur bonding bio molecules in chronic lymphocytic leukemia
Báo cáo khoa học: Human kynurenine aminotransferase II – reactivity with substrates and inhibitors potx
... b-chloro-L-alanine Biochem Biophys Res Commun 50, 1061–1067 77 Cooper AJ (2004) The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation ... (2003) L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II Neurosci Lett ... (f) and mM OPS (g) in the presence of 2.2 lM KATII is shown in lines and In lines 9–12, each molecule was tested for inhibition of the transamination reaction in the presence of 10 mM AAD and...
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Báo cáo khoa học: Regulation of the muscle-specific AMP-activated protein kinase a2b2c3 complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme docx
... mutations, with red borders indicating the mutations that have been described in vivo in pigs (V224I and R225Q in c3) or humans (mutations in c2, R225W and R307C in c3), and red letters indicating the ... (2004) CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations J Clin Invest 113, 274–284 Kemp BE (2004) Bateman domains and adenosine derivatives ... (2002) Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate J Mol Biol 317, 309–323 44 Sanders MJ, Grondin PO,...
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báo cáo hóa học:" Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance" docx
... poor clinical outcome in CLL [2-8] In the present review, the main factors playing a role in defining the biological features of CLL cells, hence eventually influencing the clinical aggressiveness ... factor activated by strand breaks in DNA that is involved in triggering cell apoptosis and/ or cell-cycle arrest, with the aim to maintain the genome integrity by hindering clonal progression [31] The ... [14] miRNAs represent a large class of regulating non-coding small RNA molecules, acting by binding messenger RNAs and determining their degradation or inhibition of translation [17] Over-expression...
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báo cáo hóa học:" Aflatoxin levels, plasma vitamins A and E concentrations, and their association with HIV and hepatitis B virus infections in Ghanaians: a cross-sectional study" pdf
... vitamins, chronic hepatitis B virus infection and urinary aflatoxin B1-DNA adducts Carcinogenesis 1997, 18:1189-1194 Ross AC, Hammerling UG: Retinoid and the immune system In The Retiniods: Biology, ... as contaminants in human and animal food [18-21] Crops can become contaminated with aflatoxin-producing fungi during growth, but fungal proliferation and toxin production increase during storage ... aflatoxin and vitamin E; our finding of a lack of association between aflatoxin and vitamin E in the HIV-positive population might be confounded by high prevalence of vitamin E deficiency in the...
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báo cáo khoa học: "Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia" pot
... chemotherapy consisting of CMOP regimen (cyclophosphamide, mitoxantone, vincristine and prednisone) and FLAG regimen (fludarabine, cytoarabine and granulocyte-cloning stimulating factor), respectively, ... in 0.8% agarose gel stained with ethidium bromide Two μg RNA was reversely transcribed into the first singlestrand cDNA with random hexamer primers, using reverse transcriptase, Superscript II ... Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia Journal of Hematology...
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Báo cáo hóa học: "Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients" ppt
... BD Pharmingen (fluorescein isothiocyanate anti-CD3 and -CD45RA, peridin-clorophyll protein-Cy5.5 anti-CD8 and allophycocyanin-H7 anti-CD4), BioLegend (phycoerythrin antiCD25 and peridin-clorophyll ... obtained by extrapolating the respective sample quantities from the standard curve obtained by serial dilutions (106, 105, 104, 103, 102, and 10) of a linearized plasmid DNA, containing three inserts ... during the rearrangement of IGK chain that remain stably present in the genome and are duplicated during each cell division deletion at FISH analysis, and (25%) patients with b2-microglobulin...
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Báo cáo y học: "Inhaled Corticosteroids, Corticosteroid Osteoporosis, and the Risk of Fracture in Chronic Asthma" pps
... asthma control may be achieved with a lower and safer daily dose of ICS.17,18 Alternatively, in patients with unstable moderate to severe chronic asthma, administering Inhaled Corticosteroids, Corticosteroid ... larger number of patients with Z-scores indicating no increase in fracture risk.4 approved doses of a standard formulation of budesonide (without the adrenergic component) in four rather than two ... for osteoporosis and/ or common clinical features of hypercortisonism and/ or records of their current or past inhaled and/ or oral corticosteroid exposure, with or without accompanying measurement...
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báo cáo khoa học: "P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia" pps
... of point mutations within the ABL kinase domain of BCRABL Such mutations inhibit the ability of imatinib to bind to BCR-ABL by corrupting the binding sites or preventing the kinase domain from ... BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance Blood ... HM: Nilotinib is associated with minimal cross intolerance to imatinib in patients with imatinib-intolerant Philadelphia-positive (Ph+) chronic myelogenous leukemia (CML) in either chronic phase...
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báo cáo khoa học: "Persisting right-sided chylothorax in a patient with chronic lymphocytic leukemia: a case report" pot
... Persisting right-sided chylothorax in a patient with chronic lymphocytic leukemia: a case report Godehard A Scholz1, Horia Sirbu2, Sabine Semrau3, Katharina Anders4, Andreas Mackensen1 and Bernd ... not uncommon in non-Hodgkin’s lymphoma, is less often seen in CLL [10] The differential diagnosis of pleural effusion in a patient with CLL includes infection, pleural involvement and lymphatic ... parenteral nutrition in combination with pleural drainage, has been shown to be able to reduce chyle production and resolve chylothorax without increasing mortality [13] In our patient, total...
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Báo cáo y học: " Improvement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report" pps
... after the incident the patient remains clinically in very good health without any signs of bleeding and continues to be in complete molecular remission Discussion The pathologic changes in CML affect ... by continuous bleeding with a further increase in size of the hematoma and extension into the left leg, renewed deterioration of coagulation parameters, and onset of fever (< 38.5°C) Continuous ... we therefore continued a single-agent treatment strategy with imatinib in an outpatient setting No further episodes of bleeding occurred during the follow-up of the patient During that time, the...
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Báo cáo y học: "Subacute herpes simplex virus type 1 encephalitis as an initial presentation of chronic lymphocytic leukemia and multiple sclerosis: a case report" doc
... Honkanen MD for discussing the pathological findings of the brain biopsy with the authors and procuring the images in Figure 2, trainee physician Pavan Panchavati MD for reviewing the initial abstract ... phases of illness, often being associated with clinical relapse and viral persistence and sometimes showing demyelination in addition to edema, inflammatory change, and viral inclusions on a microscopic ... Caucasian woman with a history of migraines and herpes labialis presented to our emergency department (ED) with headache, and numbness and tingling in the left side of the face and her left leg...
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Báo cáo y học: " Spontaneous regression of Merkel cell carcinoma in a patient with chronic lymphocytic leukemia: a case report" pps
... was performed with formalin-fixed and paraffin embedded material, using the avidin-biotin peroxidase method (all antibodies from Dako Japan, Co Ltd, Kyoto) Immunolabeling of infiltrating lymphocytes ... Merkel cell tumor in a woman with chronic lymphocytic leukemia Leukemia Lymphoma 1996, 20:509-511 Warakaulle DR, Rytina E, Burrows NP: Merkel cell tumor associated with chronic lymphocytic leukaemia ... participated in the design of the study ZCO, IS and AN carried out the hematological examination and participated in coordination and drafting of the manuscript IS performed the cytological examination and...
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Báo cáo y học: " Successful long-term monotherapy with rituximab in a patient with chronic lymphocytic leukemia of the B-cell-lineage: a case report" pdf
... as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network J Clin Oncol ... life-threatening abscessing pneumonia that was empirically treated with different broad-spectrum antibiotics including linezolid and additional amphotericin B Cultures from sputum, bronchoscopy and blood ... found in patients suffering from multiple myeloma and are associated with a poor prognosis The meaning of del 14q32 mutations in B-CLL is not yet clear [3] Although fludarabine as monotherapy or in...
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Light sheet based fluorescence correlation and cross correlation spectroscopy for quantitative measurements of bio molecules in live cells
... vitro enzyme-kinetics and ligand-receptor stoichiometry [121, 122] and in vivo protein-protein interaction in live cells and even in live organisms [33, 123127] 2.5 Principles and Theoretical ... imaging method can provide spatio-temporal dynamics and binding maps of proteins localized in membrane, cytosol and nucleus This particular study combines fast SPIM imaging (single plane illumination ... trajectories, and rates of binding and dissociation in both in vitro and in vivo environments [7477] They have been applied even to single small organic uorophores [78] and uorescent proteins [79]...
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Iron(III) and copper(II) complexes bearing 8 quinolinol with amino acids mixed ligands synthesis, characterization and antibacterial investigation
... iron(III) and copper (II) complexes of mixed ligands, 8-hydroxyquinoline and alanine or methionine amino acids: [M(HQ)(AA)nH2O, n = 0–2; M = Fe(III) and Cu (II) ] Experimental Pseudomonas aeruginosa ... Hydroxyquinoline (HQ) and amino acids (AA) mixed ligands with Fe(III) and Cu (II) ions producing four bioactive metal complexes have been synthesized The results of spectroscopy, elemental analyses and ... Iron(III) and copper (II) complexes bearing 8-quinolinol with amino-acids mixed ligands 743 aeruginosa (ATCC27853) of 43 mm at 10 lg/ml signalling its potential as pharmaceutical...
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Synthesis and reactivity of group 6 and group 8 organometallic complexes with sulfur containing ligands
... 11A N III III Ru PF6 Cl Ru Cl 12 Me O Cl Cl RuII RuII Cl N II RuII Ru O Me 13 11B Synthesis and Reactivity of Group and Group Organometallic Complexes with Sulfurcontaining Ligands VIII ... complexes with sulfur containing ligands In an extension of our interest in the reactivity of half-sandwich chromium and ruthenium complexes towards sulfur containing ligand, the synthesis and reactivity ... ligand, [(pzBmMe)Mn(CO)3] in which the ligand adopts a 3S,S’,N coordination (Chart 1.6 III).80 Synthesis and Reactivity of Group and Group Organometallic Complexes with Sulfurcontaining Ligands...
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Tài liệu Báo cáo khoa học: Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters docx
... Dashed lines indicate van ˚ der Waals interactions and dotted lines show C-HÆÆÆO interactions Interatomic distances are shown in A with black lines indicating PRWT and ˚ red lines indicating the ... compared with PRI84V–SQV Dashed ˚ lines indicate van der Waals contacts with interatomic distances in A Dotted lines indicate C-HÆÆÆO interactions Black lines indicate interactions in SQV complexes ... P2 and P2¢ groups, THF in APV or Asn in SQV at P2 and aniline in APV or t-butyl group in SQV at P2¢, are accommodated by these shifts, as shown in Fig 4C A WT The side chain interactions within...
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Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx
... network with the enzyme [14] Tyr42 (in RNase T1) or an arginine (in RNase Sa, barnase, and binase) has an important role in closing the guanine-binding site [10,15–17] However, although the interactions ... and binase (brown, 1GOY) The main changes in the active sites, which are in the Arg45 and Arg34 positions in RNase Sa2, correspond to Val43 and Gln32 in RNase Sa, Arg61 and Lys26 in binase, and ... glucoses, and waters) were removed, and input files containing protein molecules were preprocessed using the Protein Preparation command of glide Interactions of probe atoms with proteins were...
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Tài liệu Báo cáo khoa học: Agrobacterium tumefaciens type II NADH dehydrogenase Characterization and interactions with bacterial and thylakoid membranes ppt
... organism and the environmental conditions For example, in the aerobic nitrogen- fixing bacteria Azotobacter vinelandii, a NDH-2 protects nitrogenase from O2 inhibition, by drastically increasing the ... observed in the absence of IPTG, likely indicating significant IPTG-independent expression of the protein Using an antibody raised against the recombinant protein, AtuNDH-2 was detected in protein extracts ... (http://prodes.toulouse.inra.fr/multalin/ multalin.html) The phylogenetic tree was obtained by neighbour-joining analysis of 50 whole protein sequences using clustalw algorithm, with default parametrization, and with...
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Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... and agmatine Agmatine, which results from decarboxylation of arginine by arginine decarboxylase, is a metabolic intermediate in the biosynthesis of putrescine and higher polyamines and may have ... 53% and 95% of the corresponding wild-type activity, with the Km value for l-arginine remaining essentially unaltered (Table 1) Considering His120 and His145 as metal ligands in arginase II [9], ... replacements with asparagine In fact, in contrast with arginase II, dialysis against EDTA results in species of the His101Asn variant of arginase I which are half active and contain Mn2+Æsubunit)1, and...
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