platelet aggregation thrombus formation and inflammation
Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
... contribution of vWF to initiation of platelet adhesion and thrombus formation vWF promotes tethering of platelets to the injury site through binding to both the platelet GPIb and collagen, particularly ... recognizes (GPO)10 and GFOGER with lower affinity (Fig 4), and it effectively prevents GPVI interaction with collagen, blocks platelet aggregation, and attenuates integrin a2b1-dependent platelet adhesion ... their ligands and to mediate firm adhesion, spreading, coagulant activity and aggregation [7–10] This process is crucial for normal hemostasis, but may also lead to pathological thrombus formation, ...
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Báo cáo khoa học: Identification and characterization of a collagen-induced platelet aggregation inhibitor, triplatin, from salivary glands of the assassin bug, Triatoma infestans ppt
... Inhibition of platelet aggregation by triplatin-1 and -2 To investigate the function of triplatin-1 and -2, their effects on platelet aggregation were tested using platelet- rich plasma (PRP) and platelet ... involved in recruitment and subsequent aggregation of platelets It was reported that platelets from GPVI-deficient mice show no adhesion to collagen and no aggregation [9] In humans, platelets from GPVI-deficient ... on both platelets in plasma and washed platelets Furthermore, unlike other inhibitors of collageninduced platelet aggregation, such as LAPP [19–21] and Calin [22], they not inhibit the platelet...
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Báo cáo hóa học: "Research Article Segmentation, Reconstruction, and Analysis of Blood Thrombus Formation in 3D 2-Photon Microscopy Images" pot
... are inactivated platelets and fibrin in the blood flow) Further, some platelets and fibrin may form relatively small or sparse clusters that are disconnected from the target clot and therefore should ... neighborhood R and density D, it allows us to identify large dense clusters (clots) and discard regions of low density (i.e., the background and isolated or small groups of inactivated platelet and fibrin ... medical image clustering analysis and research,” Advances in Computer, Information, and Systems Sciences, and Engineering, pp 149–155, 2006 [16] P.-K Chan, S.-H Cheng, and T.-C Poon, “Automated segmentation...
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Báo cáo khoa học: " Systemic hypothermia increases PAI-1 expression and accelerates microvascular thrombus formation in endotoxemic mice" ppsx
... again for eight minutes at 300 × g and 0.5 μM prostacyclin (PGI2) was added The platelet pellet was resuspended and apyrase and Tyrode's buffer were added and centrifugation steps were continued ... activation and temperature Statistics and graphics were performed using the software packages SigmaStat and SigmaPlot (Jandel Corporation, San Rafael, CA, USA) times of 255 ± 35 s and 238 ± 58 ... further but only slight and non-significant acceleration of microvascular thrombus formation Arteriolar and venular vessel lumen were found clogged at an average time of 224 ± 35 s and 183 ± 35 s, respectively...
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Effect of red blood cell aggregation on arteriolar cell free layer formation and its physiological functions
... (c) Effect of aggregation and flow reduction on mean and SD of cell-free layer widths 60 (d) Effect of aggregation and flow reduction on dynamics of cell-free layer formation ... 43 3.3 Results and Discussion 43 STAGE II(a): EFFECT OF ERYTHROCYTE AGGREGATION ON CELL-FREE LAYER FORMATION IN ARTERIOLES 52 4.1 Arteriolar Cell-Free Layer Formation at Physiological ... Erythrocyte Aggregation 52 4.1.1 Objective 52 4.1.2 Materials and Methods 53 (a) Animal preparation 53 (b) Hematocrit, aggregation and pressure...
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Tài liệu Báo cáo khoa học: Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity pdf
... with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factormediated platelet aggregation FEBS J 274, 3611–3621 ... metalloproteinases and venom complexity J W Fox and S M T Serrano proteins are synthesized in the cytoplasm of secretory cells in the gland and transferred to the rough endoplasmic reticulum, and then ... among the toxins, and therefore understanding venom complexity and the source of such complexity represents an important challenge in the field Although recent transcriptome and proteome studies...
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Báo cáo khoa học: Amyloid oligomers: formation and toxicity of Ab oligomers ppt
... however, the biological and structural characteristics of Ab oligomers and their formation mechanism remain unclear Structure and size of soluble Ab oligomers Many types of natural and synthetic Ab ... living cells and animal models, may be required to elucidate the mechanism of formation of Ab oligomers Possible mechanism of soluble oligomer formation and toxicity The mechanism of formation of ... interactions between a-synuclein and Ab therefore indicate that AD and PD could be related Ab also promotes a-synuclein aggregation and toxicity These results suggest that the AD and PD pathologies could...
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Báo cáo khoa học: Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity docx
... available and obtained from Sigma or Fluka (Buchs, Switzerland) DEAE Sephacel was from Amersham Biosciences, and cellulose phosphate (P11) was from Whatman (Kent, UK) DNA restriction and modification ... mm), 50 mm Mops, pH 7.5, and enzyme (1.25 lm for the wild-type and Ser127Ala mutant proteins or 12.5 lm of the Ser16Ala and Ser16AlaSer127Ala mutant proteins) Chorismate formation was monitored ... system and a likely candidate in a position for the abstraction of hydrogen from the substrate Single-mutant proteins in which Asp367 has been replaced with alanine or asparagine exhibit a 300- and...
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Influences of the si(1 1 3) anisotropy on ge nanowire formation and related island shape transition
... Higher island growth induces island relaxation along the direction of island elongation, which in turn causes the formation of ‘‘elongated islands’’ and ‘‘dot-like islands’’ During island shape ... of (a) the wire-like islands, (b) the elongated islands, and (c) the dot-like islands Fig 3b and c The dot-like islands adopt the facet structure of the elongated islands by simply re- placing ... the islands became either dot-like islands or a combination of dot-like and dislocated islands Volume measurements of each type of island demonstrate that the shape transition of the islands proceeds...
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Báo cáo khoa học: Mercury(II) binding to metallothioneins Variables governing the formation and structural features of the mammalian Hg-MT species pptx
... well and suggest two different scenarios The former includes all the species formed up to Hg5-MT, Hg4-aMT and Hg4-bMT, and consists of a positive very intense band with a maximum at 220 nm and ... pH allow the subsequent substitution of Zn(II) and thus formation of heterometallic Zn,Hg-MT species, and titrations at acidic pH values provide information on the binding of Hg(II) to the corresponding ... system required the performance and analysis of 18 Ó FEBS 2004 titrations and the corresponding duplicates The detailed and comparative analysis of the set of CD, UV-vis and difference electronic absorption...
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Báo cáo khoa học: The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster Implications for cellulose synthase complex formation and oxidative stress response potx
... domains III and IV is a U-shaped, positively charged patch The patch is formed by five lysine and three arginine residues (Lys223, Lys226, Arg238, Lys242, Lys249, Lys253, Arg256, and Arg291) and, in ... shares 72% identity with Anx24(Ca32) and probably belongs to the class of Sp32 annexins In the current study, we purified and crystallized recombinant Anx(Gh1) and determined its three-dimensional ... reduced forms and a methionine residue The cluster is likely to be involved in redox reactions and might constitute the molecular basis of oxidative stress response by annexins Materials and methods...
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Báo cáo khoa học: Metabolism of N-methyl-amide by cytochrome P450s Formation and characterization of highly stable carbinol-amide intermediate pdf
... Formation and characterization of stable carbinol-amide L Perrin et al intermediates remains scarce and frequently speculative, in both in vivo and in vitro studies Interestingly, ... quantication and isolation of metabolites starting with both natural and 14C-radiolabeled substrates using HPLC; (b) structural identication of metabolites by HPLC MS and MS-MS, and NMR spectroscopy; ... 2.0 to 1.6 and 0.18 for pH values of 6.8, 7.4 and 8.2, respectively Preliminary attempts to determine the structure of M1 and M2 using routine protocols revealed that: (a) isolated M1 and M2 both...
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Báo cáo khoa học: Limited proteolysis of Escherichia coli cytidine 5¢-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis potx
... ability of various ligands to protect both wild-type and mutant CTPS from proteolysis was examined using ATP (0.5, 1.0, 2.0, and 10 mM), UTP (0.5, 1.0, 2.0, and 10 mM), ATP and UTP together (10 ... CTPS in the absence and presence of ligands For each gel: lane contains molecular mass standards and lanes 26 contain wild-type CTPS treated with trypsin for 0, 10, 20, 30, and 60 min, respectively ... 25 and % 28 kDa In the presence of ATP and UTP (10 mM each) (B), and CTP (2.5 mM) (C), only production of the 10- and 53-kDa cleavage fragments is observed In the presence of GTP (2.5 mM) (D) and...
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Báo cáo khoa học: Protein glycation in Saccharomyces cerevisiae Argpyrimidine formation and methylglyoxal catabolism ppt
... molecular weights of 52, 40 and 35 kDa (Figs 2B and 3) Protein glycation in yeast cells is a fast and nonrandom process whereby specic protein targets for argpyrimidine formation appear to exist ... glyoxalase I and aldose reductase Argpyrimidine formation is a much faster process in this strain In all immunoblots, the same three major immunoreactive protein bands are visible (52, 40 and 35 kDa) ... yeast and enzymatic defences Methylglyoxal (nmol) per 108 cells derived AGE formation This result led us to investigate argpyrimidine formation in a yeast strain lacking both aldose reductase and...
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neural network models for formation and control
... trajectory and the associated motor command (torque) can be determined simultaneously That is, the three problems of trajectory formation, coordinates transformation and generation of motor command ... visual coordinates, (2) transformation of trajectory from visual coordi- nates to body coordinates and (3) generation of motor command Based on physiological information and previous models, computational ... the standard whether they can cope with the ill-posedness inherent in these problems Formation of trajectory: minimum torque-change model Flash and Hogan [3] provide a mathematical model and experimental...
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Tài liệu tiếng Anh thương mại quản lý Chapter 17 Contract formation and legal issues
... should appear above the agent’s signature 17-21 Letters of Intent • Letters of Intent and Memorandums of Understanding – precontracts to cover informal agreements • LOI’s can be used as a planning ... Consideration, or mutual obligation » Competent parties » Lawful purpose » “The Written and the Spoken Word” 17-15 Offer and Acceptance • Purchase order constitutes a legal offer • Supplier’s quotation ... obligation” • Statements regarding material quantity, price, delivery, and so on must be specific enough to bind both the buyer’s firm and the supplier to definable levels of performance 17-18 Competent...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... antagonizing flRAGE and other receptors by binding DAMPs and other ligands and inhibiting leukocyte recruitment in a variety of acute and chronic inflammatory conditions [4] Both esRAGE and sRAGE act ... sustain inflammation and impaired tumor elaboration and growth Thus, RAGE drives and promotes inflammatory responses during tumor growth at multiple stages and has a central role in chronic inflammation ... cytokines and proinflammatory adhesion molecules [24,67,68] Conclusion RAGE and its ligands play essential roles in inflammation, neurobiology, cancer, and numerous other conditions Each ligand distinctly...
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báo cáo hóa học:" Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study" potx
... effects of platelet inhibiting drugs Consequently, static platelet adhesion is not measured by any of the current candidate assays for clinical evaluation of platelet function The static platelet ... several different platelet activators on platelet function In this study, platelet adhesion to albumin, collagen and fibrinogen was investigated in the presence of soluble platelet activators ... concentration) and 25 μL of platelet activators The soluble platelet activators were ADP and LPA from Sigma-Aldrich (St Louis, Missouri, USA), adrenaline from Merck NM AB (Stockholm, Sweden) and ristocetin...
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báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... necrosis and natriuretic peptides are well known indicators of cardiac dysfunction and filling pressures In addition, certain other biomarkers are known to be indicators of inflammation and apoptosis, ... manufacturer protocol and using standard curves and software The kits for NTproBNP (fmol/ml) were purchased from ALPCO Diagnostics, Salem, New Hampshire; for IL-6 (pg/ml) and TNFα (pg/ ml) from ... was non-random and uncontrolled in design Since inotropic agents are currently considered to carry excess risk and thus are used only when thought to be absolutely clinically necessary, randomization...
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Báo cáo hóa học: "Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque" ppt
... platelet aggregation stimulated by ADP, and that the mechanism is independent of platelet prostaglandin-endoperoxide and thromboxane formation NSC23766 inhibits human plaque-induced platelet thrombus ... stimulation of platelets in PRP and blood (Rother E, Khandoga AL, Siess W, unpublished data), and PGI2, in contrast to washed platelets and PRP, was reported to be unable to inhibit platelet aggregation ... platelets in blood and (2) NSC23766 inhibits a-granule secretion and platelet aggregation stimulated by ADP independent of platelet prostaglandin-endoperoxide and thromboxane formation Conclusion...
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