pk and pharmacodynamic profiles of artemisinin derivatives influence drug neurotoxicity in animals
Annual and Diurnal Profiles of Cryptosporidium and Giardia in River Water in Japan
... sequencing batch mode, and the effluent discharge is normally performed in the morning and/ or evening Therefore, the concentration might increased in the morning and evening Actually, in the morning, ... performed in tributary rivers of the Tone River basin in Japan where the surface water is utilized for the main production of drinking water for people living in the Tokyo metropolitan area In addition, ... study is to investigate the annual and diurnal profiles of Cryptosporidium and Giardia in river water which is used for drinking water sources For this purpose, frequent monitoring of protozoans...
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báo cáo hóa học: "Toe clearance and velocity profiles of young and elderly during walking on sloped surfaces" potx
... measure and poincaré plot indexes of minimum foot clearance variability in the elderly during walking Journal of Neuroengineering and Rehabilitation (JNER) 2008, 5:4 Page 10 of 10 12 Winter DA: ... of NeuroEngineering and Rehabilitation 2010, 7:18 http://www.jneuroengrehab.com/content/7/1/18 Page of 10 Figure Median values of MTC and VelMTC at slopes Median values of MTC and VelMTC of individual ... maintain the same PWS on both positive and negative slopes b) Combined strategies using measures of MTC and VelMTC At level walking, IQRVelMTC (i.e VelMTC variability) in young adults maintains...
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Báo cáo khoa học: "Pharmacokinetics and Pharmacodynamic Effects of Flunixin after Intravenous, Intramuscular and Oral Administration to Dairy Goats" pptx
... according to Norwegian standards The same animals were used in all studies, i.e single intravenous administration (i.v.), single intramuscular administration (i.m.) and single oral administration ... routes of administration (Kruskal-Wallis, p >0.05) Discussion In this study we have investigated the pharmacokinetics of flunixin and its ability to inhibit of prostaglandin synthesis in Norwegian ... the assay of prostaglandin release Biochimica et Biophysica Acta 1982, 713, 555-569 Landoni MF Cunningham FM, Lees P: Determina, tion of pharmacokinetics and pharmacodynamics of flunixin in calves...
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Báo cáo khoa học: " Clinical features and hormonal profiles of cloprostenol-induced early abortions in heifers monitored by ultrasonography" doc
... participated in the planning of the experiment HG participated in the planning and coordination of the experiment MB took part in the planning of the experiment JFB supervised the laboratory analyses of ... Pregnancy-specific protein B in serum of postpartum beef cows J Anim Sci 1993, 71:2199-2205 Lindell J-O, Kindahl H, Edqvist L-E: Prostaglandin induced early abortions in the bovine Clinical outcome and endogenous ... Studies of prostaglandin F2α in the cow Prostaglandins 1973, 2:269-284 Kindahl H, Edqvist LE, Bane A, Granström E: Blood levels of progesterone and 15-keto-13, 14-dihydro-prostaglandin F2α during...
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Synthesis and biological evaluation of isoindigo derivatives as anti proliferative agents
... Structures of Indigo, Indirubin and Isoindigo……………………………… … Figure 1-2: Structures of selected indirubins with kinase inhibitory properties………… … Figure 1-3: Intramolecular hydrogen bonding in indirubin ... Notably, indirubin derivatives such as 5-chloroindirubin, indirubin-5-sulfonate and indirubin-3’-oxime (Figure 1-2) are potent inhibitors of CDK1, CDK2 and CDK5.2, 5-7 In other reports, derivatives of ... H H N O Indigo O O N H O NH N H O Indirubin Isoindigo Figure 1-1: Structures of Indigo, Indirubin and Isoindigo Indigo and its di-bromo derivatives are unique dyes that have been used since antiquity...
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Chemical components and aromatic profiles of citrus and coffee in asia
... understanding of these factors, insights on important aroma-active compounds in coffee could be gained Semmelroch and Grosch (52) include the following chemicals as contributing to coffee flavor and ... body and smooth mouthfeel while offering alternative choices to coffee lovers The coffee market has been gradually expanding in Asia owing to an increase in the number of urban dwellers in the ... these exotic and new coffees of different origins and processing methods has triggered the curiosity of flavor scientists for their volatile and aromatic profiles The quality of a cup of coffee is...
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Therapeutic target analysis and discovery based on genetic, structural, physicochemical and system profiles of successful targets
... influenza A, B and C, and matrix protein of influenza A The identified marginally promising therapeutic targets are haemagglutinin of influenza A and B, and hemagglutinin-esterase of influenza C ... sequences of the drug- binding domain of 399 molecular targets into InterPro domains, and identified 130 protein families representing known drug targets Since proteins with similar profiles are ... characteristics of clinical trial target and that of successful one, and characteristics of clinical trial drug and that of approved drug and drug lead are given Chapter Introduction 31 We conclude in the...
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Synthesis and reactivity studies of cyclopentadienyl derivatives of ruthenium iridium and osmium iridium mixed metal clusters 5
... clusters (23 and 25) with a μ3-Se capping ligand resulting from Se transfer (b) tetranuclear cluster (17a) obtained by simple substitution of the deselenized phosphine ligand and (c) trinuclear (24) ... Scheme 5.3 The chemistry of tellurium-containing clusters can be quite different from those of sulphur and selenium analogues For instance, the difference in reactivity of the trinuclear iron clusters, ... synthesizing transition metal clusters containing bridging chalcogenido ligands involves the tertiary phosphine chalcogenides R3PE (E = S, Se, Te) This method takes advantage of the frailty of the...
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Synthesis and reactivity studies of cyclopentadienyl derivatives of ruthenium iridium and osmium iridium mixed metal clusters 1
... the trinuclear and tetranuclear clusters of the heavier groups and metals will be useful to gain a better understanding of their heteronuclear clusters 1.3.1 Trinuclear clusters of osmium and ruthenium ... are capable of displaying a variety of bonding modes like terminal (H), bridging (μ-H) and face capping (μ3-H) They can sometimes occupy interstitial sites to exhibit tetrahedral (μ4H) and octahedral ... disproportionate increase in reaction rate observed upon mixing multiple catalytic systems has created a resurgence of interest in the study of mixed metal clusters, in particular those of groups and For...
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Synthesis and reactivity studies of cyclopentadienyl derivatives of ruthenium iridium and osmium iridium mixed metal clusters 2
... singlet at δ 19.27 ppm, suggesting the fluxional nature of the hydrides (Figure 2.10) On cooling the sample to 195 K a total of five signals could be seen, of which two singlets of 45 equal intensity ... attached to a Cp* ring in clusters 3a, 3c, 4a and 4b and to a Cp ring in cluster 3b Selected bond lengths and bond angles are listed in Table 2.3 together with the cluster numbering scheme 52 Table ... J.S Plotkin, and S.G Shore, Inorganic Chemistry, 1982, 21, 627 20 M.R Churchill, and F.J Hollander, Inorganic Chemistry, 1979, 18, 843 21 W.E Lindsell, N.M Walker, and A.S.F Boyd, Journal of the...
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Synthesis and reactivity studies of cyclopentadienyl derivatives of ruthenium iridium and osmium iridium mixed metal clusters 3
... the nature of the metals and the alkynes played an important role in determining the products and the isomers obtained; the isomer with the heterometal atom in the hinge was the kinetically favoured ... Schematic diagram of 16 97 3.4.3 Role of amine The most intriguing aspect of this study, however, was the mechanistic role that the amine played in these reactions Monitoring the reaction of 4b with ... The reaction of tetrahedral clusters with internal and terminal alkynes often results in cluster opening to give butterfly structures [9] The butterfly clusters are quite interesting because they...
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Synthesis and reactivity studies of cyclopentadienyl derivatives of ruthenium iridium and osmium iridium mixed metal clusters 4
... Bruce and coworkers who determined the structures of 12 different monoand disubstituted phosphine derivatives of Ru3(CO)12 and Os3(CO)12 to investigate the steric and electronic influences of phosphine ... than that of 3c Since amines are more electron donating than the carbonyls, substitution of electron donating amines for the carbonyls would result in lowering of the νCO It is interesting to note ... metalloselectivity of these clusters have revealed that the selectivity could be influenced by factors such as the nature of the metals and the nature of both the existing and incoming ligands For example,...
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FLUORIDE RELEASE AND UPTAKE PROFILES OF GLASS IONOMER CONTAINING RESTORATIVES
... occur in their absence and there could be no sign of caries in the presence of mutans streptococci (Marsh, 2006) Saliva directly and indirectly helps in maintaining oral homeostasis and the integrity ... formation of bacterial biofilms on all the hard surfaces of the mouth is inevitable Therefore the need of preventing or minimizing the formation of cariogenic biofilm is also one of the requirements of ... presence of fluoride as part of its chemistry, which is a key element in remineralisation and preventing demineralization of tooth structure The chemical and biological role of these cements in caries...
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Identifying key signatures of high productivity from transcriptome and proteome profiles of CHO cells
... producing cell lines 2.1.2.1 DNA delivery and integration The establishment of a recombinant cell line begins with the introduction of a linearized expression vector containing the transgene and ... showing low levels of recombinant protein production during cell cultivation Thus, the initial stages of screening involves the maintenance of hundreds Chapter Literature review and thousands of ... expression profile of hybridomas in insulin and zinc-supplemented cultures to determine the effect of zinc as an insulin replacement The relatively new technique of iTRAQ has not gained wide usage,...
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Transcriptomics and immune profiles of asymptomatic filarial infected individuals
... vaccine components [60] In the following section, the different immune profiles in W bancrofti- and O volvulus-infected individuals are reviewed 1.10 Immune profiles in filarial infected individuals ... containing phorbol 12-myristate 13acetate (PMA), Ionomycin, Brefeldin A, and Monensin for 6hrs Thereafter, staining was performed using in distinct panels; single stain panels Th1, Th2 and Th17 and ... thereby providing more insights into molecular mechanisms of infection and allowing identification of distinct gene expression profiles associated with the outcome of infection 18 Kwarteng A Introduction...
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Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients
... objective of identifying the pharmacokinetic profile of total and free mycophenolic acid (MPA), and mycophenolic acid glucuronide (MPAG) and pharmacodynamic profile of MPA in mycophenolate mofetil ... study and population PK- PD modeling after chronic oral dosing of MMF for more than months (n=49) 53 xv 4.1 (A) Characteristic pharmacokinetic and pharmacodynamic profiles of MPA and MPAG in patients ... Indications and clinical uses Immunosuppression therapy in clinical transplantation has evolved since the routine use of the triple drug regimen of a calcineurin inhibitor cyclosporine A (CsA),...
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Experimental investigations and CFD study of temperature distribution during oscillating combustion in a crucible furnace
... Ph.D candidate in the Department of Mechanical Engineering, Osmania University He obtained his Bachelor’s degree in Mechanical Engineering from Institution of Engineers (India) in 1991 and Master’s ... Narsaiah, working as Assistant Professor in PRRMEC, Shabad He has done his M.Tech in Industrial Engineering and Management from JBIET ( JNTU Hyderabad) in 2009 and B.Tech., in Mechanical Engineering from ... of Engineering (OU) in 2003 His area of interest is in the field of combustion and reduction in emissions E-mail address: jaligari_jns@yahoo.co .in ISSN 2076-2895 (Print), ISSN 2076-2909 (Online)...
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Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
... culled No information is available on the costs of culling, diagnostic testing of samples, cleaning and disinfection, and other administrative costs (Obi, Oparinde, and Maina 2008) Regarding the ... their role in poultry rearing, women should also be encouraged to be actively involved in training programs and in dissemination of information regarding biosecurity technologies Finally, our ... Oparinde, and Maina 2008; Omiti and Okuthe 2008) Therefore, information regarding the role of poultry in the livelihoods of small-scale poultryproducing households and the livelihoods impacts of...
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Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx
... the first and last turns of helices E and F, and the C-terminus helices I and J In addition, there is a lysine-rich N- and C-terminus, in accordance with the basic isoelectric point of CagS However, ... H pylori strains harbouring a functional cagPAI, is the activation of nuclear transcription factor-jB and the induction of pro -in ammatory production of cytokines, mainly interleukin (IL)-8 [12] ... anti-parallel to the same strand of a second monomer, allowing for the formation of the dimer The surface of interaction between monomers also involves portion of chains D and E of the two monomers,...
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Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt
... and difference of DCp of mutant from wild-type (%) were determined and the results for the wild-type protein and 20 mutants are given in Table The DHcal and Tm of the wild-type protein were in ... local stable segments: interactions of G75 with H121 and K9, and of G129 with K110 and K133 Other charged amino acids such as D73, D83 and E101 reinforce the interactions of E75 and E129 ˚ (OE1 ⁄ ... flexible C terminus of SNase Changes in the fluorescence intensity of W140 reflect a change in the surrounding hydrophobic environment of the tryptophan and thus indicate a change in the overall...
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