pi3k akt in the survival of androgen refractory prostate cancer cells

Báo cáo hóa học: "Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins" ppt

... neurogenesis The list of these genes is reported in additional file These results support the hypothesis of a possible role of E6 and E7 in the induction of neuroendocrine differentiation of SCLC ... Evaluation of the results obtained in the two systems showed deregulation of the same pathways in human SCLC and in that induced experimentally by the E6/E7 oncoproteins of HPV16 To further highlight the ... release the E2F transcription factor, subsequently leading to progression of the cell into the S-phase [14] Furthermore, E7 binds to inhibitors of cyclin-dependent kinases (p16, p21), increasing the...

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Báo cáo sinh học: " No relationship between the distribution of mast cells and the survival of stage IIIB colon cancer patients" pdf

Danh mục: Hóa học - Dầu khí

... on the infiltration of mast cells into primary colorectal cancers and the function of mast cells might vary with their location in cancer tissue, it is reasonable to examine the distribution of ... MCCstroma, the count of tryptase-positive mast cells in the cancer stroma of the primary colon tumor; MCCadjacent, the count of tryptase-positive mast cells in the normal mucosa adjacent to the colon cancer; ... MCCstroma, the count of tryptase-positive mast cells in the cancer stroma of the primary colon tumor; MCCadjacent, the count of tryptase-positive mast cells in the normal mucosa adjacent to the colon cancer; ...

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báo cáo hóa học:" No relationship between the distribution of mast cells and the survival of stage IIIB colon cancer patients" potx

Danh mục: Hóa học - Dầu khí

... on the infiltration of mast cells into primary colorectal cancers and the function of mast cells might vary with their location in cancer tissue, it is reasonable to examine the distribution of ... MCCstroma, the count of tryptase-positive mast cells in the cancer stroma of the primary colon tumor; MCCadjacent, the count of tryptase-positive mast cells in the normal mucosa adjacent to the colon cancer; ... MCCstroma, the count of tryptase-positive mast cells in the cancer stroma of the primary colon tumor; MCCadjacent, the count of tryptase-positive mast cells in the normal mucosa adjacent to the colon cancer; ...

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Báo cáo khoa học: "Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing xoft axxent electronic brachytherapy" ppt

Danh mục: Báo cáo khoa học

... approximately 15 minutes, the physicist then loaded the corresponding radiation plan onto the controller unit contaminating the field The catheter end was passed through a hole in the drape and a ... cavity through a small incision in the lateral breast and inflated with exactly 40 cc of saline (Figure 1) The conformity of the CED to the surrounding breast tissue was then evaluated under direct ... without Results The radiation oncologist then broke scrub, attached the XB controller to the catheter, and inserted the radiation source into the balloon The radiation therapy was then Figure and...

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Báo cáo khoa học: "cExternal beam radiation results in minimal changes in post void residual urine volumes during the treatment of clinically localized prostate cancer" ppt

Danh mục: Báo cáo khoa học

... variations in prostate positioning [12,13] Variables with the potential to influence prostate motion are an important aspect of clinical research in the delivery and treatment of prostate cancer The ... where y is either the PVR urine volume or the difference between the PVR urine volume and the baseline PVR urine volume, consistently outperformed linear regression by resulting in a larger correlation ... summarizes the variation in PVR urine volume readings over the course of the study, stratified by therapy cohort, alpha-blocker use, baseline PVR volume group and radiation cohort Of the 125 patients included...

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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt

Danh mục: Báo cáo khoa học

... associated with induction of T-cell tolerance and immune inhibition in the induction of oral tolerance in the murine CIA model We examined the change in the expression of IDO in CD11c+ DCs of Peyer's ... CD4+CD25- T cells (1 × 105 cells) obtained from Peyer's patch cells of tolerized mice in the presence or absence of CII To measure the amount of intracellular Foxp3 in CD4+CD25+ T cells, CD4+ T cells ... T cells induces the expression of IDO on DCs [40] Considering these findings, we next sought to determine whether IDO+ DCs increase the proportion of antigen-specific CD4+CD25+ regulatory T cells...

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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses

Danh mục: Y - Dược

... resulting in the killing of 39 Chapter 1: Introduction these infected cells Under these circumstances, the dying cells, CD8 T -cells and other APCs such as macrophages and DCs within the inflammatory ... by inhibiting the differentiation of bystander non-infected monocytes into DCs through the release of interleukin-10 (Remoli et al., 2011) Therefore, the 41 Chapter 1: Introduction presence of ... 2000), suggesting that CD8 T cells were vital for the polarization of Th1 cells This was also supported by studies demonstrating the involvement of CD8 T cells in the generation of protective...

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Ethnic differences in the effect of parity on breast cancer incidence in premenopausal women in singapore

Danh mục: Tổng hợp

... Women with breast cancer have a fivefold increased incidence of developing cancer in the contralateral breast (46). In a meta-analysis of 55 trials on tamoxifen therapy  for early breast cancer, the incidence rate of contralateral breast cancer in women  ... between users (current and/or previous) with breast cancer. In women participating in the Canadian National Breast Screening Study, breast cancer risk was not related to  any of the B vitamins (folate, thiamin, riboflavin or niacin) or methionine (95)  ... cohorts. A more recent study (incident cases from 1968-2002) modeling the trends in the ethnic groups showed that the cohort effect was present in the Chinese and  Malays but absent in Indians (144). In Chinese the age-period-cohort model had the ...

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THE ROLE OF DMSO IN THE REGULATION OF IMMUNE RESPONSES BY DENDRITIC CELLS

Danh mục: Cao đẳng - Đại học

... macrophages therefore play an important role in protecting the host against invading pathogens as the pro-inflammatory cytokines produced would result in the killing and elimination of the invading pathogens ... effective interplay of the both arms in the immune system 1.2 Innate Immunity 1.2.1 Overview of Innate Immunity The innate immunity is known as the front line of host defence against invading pathogens ... concert to maintain the integrity of the immune system Cells of the immune system originate from their hemapoietic progenitors in the bone marrow Some cells leave the bone marrow after they were created,...

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báo cáo hóa học:" HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission" potx

Danh mục: Hóa học - Dầu khí

... benefit of shortening the usual duration of breastfeeding on HIV-free survival [42] When we investigated why we observed no benefit of early cessation of breastfeeding by examining what the women in ... matter In the absence of any interventions, about a third of infants born to HIV-infected mothers acquire HIV infection About 20% of infants born to HIV-infected mothers acquire HIV during pregnancy ... milk, and the quality and duration of breastfeeding [23,24] Susceptibility factors, including innate and acquired immune responses in the child, in the mother and in breast milk, protect against HIV...

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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot

Danh mục: Báo cáo khoa học

... Akt in PC3 and LNCaP prostate cancer cells Moreover, we compared the effects of ErPC3 to the effects of the PI3K inhibitor LY294002 LY294002 inhibits the upstream kinase PI3K thereby preventing ... down-regulation of p -Akt may be required for the anti-neoplastic action of small molecule inhibitors of the PI3K/ Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate ... for the development of innovative anticancer drugs The PI3K/ Akt pathway is one of the most important survival signaling cascades altered in human solid tumors including prostate cancer [5,6] In...

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Báo cáo khoa học: "Factors of influence upon overall survival in the treatment of intracranial MPNSTs. Review of the literature and report of a case" doc

Danh mục: Báo cáo khoa học

... http://www.ro-journal.com/content/5/1/114 radiotherapy (in another clinic), wrote the part of the paper concerning radiotherapy and followed up the patient at his out-patient clinic AK was the radiologist performing the preoperative ... minimising the risks of RT-inducing brain injury like radiation necrosis and cognitive decline The optimal radiation dose has not yet been defined We decided for a total dose of 60 Gy balancing ... and wrote the part of the paper concerning the illustrations PN was the pathologist who examined the tissue and wrote the part of the pathology evaluation IW performed the ETN examination preoperatively...

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Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function docx

Danh mục: Báo cáo khoa học

... that pharmacological inhibition of Akt causes an increase in the expression of these genes in PC12 (WT -Akt) cells Therefore, it is alleged that Akt downregulates the expression of MafK, SytI, and ... showed that the transcript levels of these three genes were lower in PC12 (WT -Akt) cells than in PC12 (DN -Akt) cells, but increased following treatment with an Akt inhibitor Taken together, these results ... downregulation of transcription for the genes examined here PC12 (DN -Akt) cells were treated with TWS119, a Gsk3β inhibitor [35] Before examining the effect of this inhibitor on the transcript levels of the...

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Báo cáo y học: " Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial" ppsx

Danh mục: Báo cáo khoa học

... findings of CTs conducted before inclusion of the patients in the study The CT findings on inclusion were regarded to be the worst of the hospital stay; the prognostic value of such CT findings ... [CSF]): infection of the CNS with a positive culture in the CSF eSOFA pre: value of the Sepsis related Organ-Failure Assessment (SOFA) score before the beginning of the barbiturate coma fSOFA maximum: ... to the BTF Guidelines Nevertheless, these findings should be interpreted with caution because of the imbalance in CT characteristics and the different dosages employed in the two arms of the...

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The Duality of Memory and Communication in the Implementation of a Multiprocessor Operating System

Danh mục: Hệ điều hành

... Finally, the kernel informs the hardware physical map module of the new virtual to physical mapping With the exception of the hardware validation, all of these steps are implemented in a machine-independent ... efficiently support the large body of UNIX software used within the academic community [16] In addition, from the point of view of a system designer, the Accent style of message/memory integration lacked ... once, possibly in different tasks The memory region specified by address in the vm_allocate_with_pager call will be mapped to the specified offset in the memory object The offset into the memory...

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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

Danh mục: Y học thưởng thức

... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous peritoneal ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of...

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Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"

Danh mục: Y học thưởng thức

... surrounding cytoplasmic membrane in at least 10% of invasive carcinoma cells or presence of membranous staining in less than 30% provided that the staining is intense (++) Score 3: Presence of intense ... CHAPS) at the ratio of 5:1 Sera were then diluted again with binding solution at the ratio of 10:1 and were applied in 100 µL amounts in the wells on the chip Protein chips on which the samples ... groups The relevance of this finding is that it was the result of the first subgroup analysis for these biomarkers Bc1 should therefore be studied in terms of tumoral development and inflammatory...

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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"

Danh mục: Y học thưởng thức

... the angles of the dural opening The most significant step involves constructing small supporting pillars on the bilateral sides of the vessels as they pass the edge of the dural window (the pillars ... and in most reports the involved patient populations are small, these experiences are valuable At present, in the absence of definite proof of the efficacy of decompressive craniectomy in the ... was introduced by Cushing,11 involves removing the part of the skull beneath the temporal muscle by opening the dura This was an important surgical method for the treatment of severe TBI with refractory...

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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"

Danh mục: Y học thưởng thức

... in the development of the oxidative stress (68) If our findings are proven by further studies involving a larger number of patients, ultra-low microcurrent therapy might change the concept of ... pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy Obesity (Silver Spring) 2006;14 (Suppl 1): 34S–40S 31 Boden G Role of fatty acids in the pathogenesis of insulin resistance ... http://www.medsci.org Int J Med Sci 2010, cellular senescence (40-45) Source of reactive oxygen species in insulin secreting pancreatic β -cells and cells that are targets for insulin action is considered to be the...

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Báo cáo y học: "Godoy & Godoy technique in the treatment of lymphedema for under-privileged populations."

Danh mục: Y học thưởng thức

... variations in working pressures of the main groups of muscles of the limbs whilst using compression mechanisms during exercising This is a new line of research that aims at developing facilitating devices ... technique aims at draining lymph (already in the collectors) and stimulating the formation of lymph (the flow of interstice fluid to the lymphatic capillaries) Increases in interstice pressures, ... which can be used in the control of exercising Eight devices have been developed that involve the main muscle groups with the objective of improving the mobility of joints and reducing trophic muscle...

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