physiologically based modeling of the toxicokinetics of soman
Dynamics in Human and Primate Societies: Agent-Based Modeling of Social and Spatial Processes pdf
Ngày tải lên :
14/03/2014, 21:20
... "the unity of the outside and inside of an event" are the true province of history, and to understand them we must enter into the thoughts of the agents One grand vision of the social world then, ... because they divide the phase space in the basins of attraction of the central fixed point (shaded in Figure 3(a)) on the one hand and those of the lateral attractors on the other hand The origin ... this." The actions change the state of the PATCH, the state of the currently active DWELLER, its spatial position, and the state of another DWELLER with which it interacts These changes affect the...
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Rating Based Modeling of Credit Risk: Theory and Application of Migration Matrices doc
Ngày tải lên :
22/03/2014, 23:20
... effects of X on the log of the odds of a birth versus a nonbirth On the other hand, the left side of the probit model can be thought of as being a score similar to the discriminant analysis In the ... function of the probability of Y , which will be explained later The difference between the logit and probit lies on the left side of the equation In the logit approach the left side is the logit of ... at the level of a single loan and thus the foundation of the Basel IRB function Let α0.999 denote the adverse 99.9% quantile of the state of the economy Xt , meaning that a worse outcome of the...
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Econophysics and agent based modeling of financial market
Ngày tải lên :
10/09/2015, 09:09
... due to the existence of fourth moment of returns As the measure autocorrelation of squared returns is directly related to the fourth moment, and there is an ongoing debate on whether the fourth ... initiated by one of them - either the buyer or seller There are usually two types of traders in the market in terms of order placement - market takers who place market orders to buy/sell, and the transaction ... distribution, and the market price is determined by excess demand of all agents – the difference between the number of buyers and sellers The set-up of the model has ensured the market behaves...
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Mechanism based modeling of ductile void growth failure in multilayer structures
Ngày tải lên :
10/11/2015, 12:35
... is of dimension D, where D is associated with the mean spacing of the larger, void-initiating inclusions The width of the process zone is incorporated into the model as being of the order of the ... studied the role of porosity on the cavitation instability of the voided cell It is found that the softening effect of a large void, though as it lowers the stress carrying capacity of the cell ... step sizing based on the rate of damage accumulation, and (iv) evaluation of the J-integral using a domain integral procedure The software architecture of Warp3D supports the analysis of very large,...
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Báo cáo y học: "Economic modeling of the combined effects of HIV-disease, cholesterol and lipoatrophy based on ACTG 5142 trial data" pps
Ngày tải lên :
13/08/2014, 11:22
... lipoatrophy The effects of CNS toxicities were not included in the model because of their often transient nature, and the effects of diarrhea were not included in the model because of short duration ... increase of 1.41 months per patient of quality adjusted survival for the PI -based cohort This difference was mainly due to the higher rate of lipoatrophy in the NNRTI-arm of the study It is not the ... variation in measurements We have tested the effects of the variations in the data and of the assumptions made in the model for progression after the end of the clinical trial by performing sensitivity...
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Báo cáo y học: "Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models" pot
Ngày tải lên :
13/08/2014, 16:21
... the liver intracellular volume was equal to the output of the CYP3A mediated elimination of MDZ (on a molar basis) In the same way, the source function of 1OHMDZ-Glu was equal to the output of ... protein binding of three compounds and their glucuronides, the unbound fraction of the glucuronide increased by factors of 2.2, 1.3 and 2.6 [39] For the purposes of the present study, the fraction ... k1,-1,2 as half of and two times the and max values, respectively, as determined during the optimization of the six Heizmann et al [11] individuals The mean values of the optimization of the Heizmann...
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Báo cáo y học: "Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strain" potx
Ngày tải lên :
14/08/2014, 07:21
... that the NTHi form biofilms on the respiratory mucosa of humans and other mammals and it has been hypothesized that this contributes to the chronicity of these infections [1,2] They are the most ... strains is found at the intersection of the row and column corresponding to the respective strains Strains are compared based on the number of genes shared between the pair, the number of genes found ... estimated by the A histogram of gene the expected number of genes of 13 H influenzae A histogram of gene clusters observed in exactly N of 13 H influenzae strains compared to the expected number of genes...
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Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
Ngày tải lên :
25/10/2012, 10:45
... on the prevalence in the population, and more reflective of the test itself, lessening the impact of any unique features of the VA population Moreover, we might expect that the PPV and NPV of the ... NC) Results The characteristics of the VARA participants measured at the start of each treatment episode were evaluated Because the characteristics of VARA patients at the start of non-biologic ... based upon the patient remaining on therapy and achieving either low disease activity (DAS28 1.2 unit improvement in their DAS28 The PPV of the administrative data-based...
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A capillary-based method determining the permeability of sand layer for geothermal applications
Ngày tải lên :
05/09/2013, 17:03
... to the experiment, a stable water level in the reservoir was kept by the overhead tank Once the bottom of the capillary tube contacted with water in the reservoir, the dynamic movement of the ... K is the permeability, L is the length of the capillary tube, Pc is the macroscopic capillary pressure, φ is the porosity, µ1 and µ are the viscosity of water and air, and ρ1 and ρ are the density ... With the background above, the purpose of the present work was to present a novel laboratory method determining the hydraulic permeability of sand layer based on the capillary rise (CR) theory...
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Tài liệu Báo cáo khoa học: Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay docx
Ngày tải lên :
14/02/2014, 19:20
... cRBCs Defining the glycans present on the surface of cRBCs will allow either for the design of strategies to optimize the agglutination assay or the design of alternative strategies for the detection ... analysis through the use of soft ionization conditions [16], which have been optimized for the detection of acidic, sialylated structures To validate the accuracy of the method, analysis of fetuin N-glycans ... detect the presence of several important signatures, including the H-1 anomeric protons, the H-2 protons of mannose (Man) (d 4.05–4.25 p.p.m.), and the methyl protons of the N-acetyl groups In the...
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Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt
Ngày tải lên :
18/02/2014, 11:20
... Od1 of the side chain of Asn87 in the S4 strand, with ˚ ˚ distances of 2.82 A and 2.97 A, respectively The plane of the base of A20 and the end plane of the carbamoyl group of Asn87 are out of ... formation of the hydrogen bond between O2 of the carboxyl group of the cognate amino acid and the 2¢-OH group of the ribose moiety of A76 maintains the appropriate orientation of the carboxyl group of ... tRNAArgICG These facts indicate that the framework of tRNAArg of the L-shape is conserved in these two cases The anticodon loop of tRNA In the complex of P horikoshii ArgRS, the base of C35 of tRNAArgCCU...
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Tài liệu Báo cáo khoa học: "Lexicalized Stochastic Modeling of Constraint-Based Grammars using Log-Linear Measures and EM Training" ppt
Ngày tải lên :
20/02/2014, 18:20
... disambiguation of the test suites, and the anonymous ACL reviewers for helpful suggestions This research was supported by the ParGram project and the project B7 of the SFB 340 of the DFG References ... subject to the constraints p i ] = q i ] i = : : : n is the model in the parametric family of log-linear distributions p that maximizes the likelihood L( ) = q ln p ] of the training data 1 If the ... measures the disambiguation power of the pure symbolic parser The results of an exact-match evaluation on the Helbig-Buscha corpus is shown in Fig The random baseline was around 33% for this case The...
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Tài liệu RESULTS BASED MANAGEMENT IN THE DEVELOPMENT CO-OPERATION AGENCIES: A REVIEW OF EXPERIENCE docx
Ngày tải lên :
21/02/2014, 11:20
... Sustainability - the capacity for results to extend beyond the formal life of the project • Relevance - the continued appropriateness of a project's results - to the needs of the target population, to the ... introduction of Accruals -based Outcome and Output Budgeting In Canada, the Office of the Auditor General and the Treasury Board Secretariat have been the primary promoters of reforms across the federal government ... from the partner country government, etc The range of measures needs to be sufficiently broad to serve the demands of all these key groups of stakeholders and management levels Many of these...
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Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx
Ngày tải lên :
21/02/2014, 15:20
... to binding by analyzing the surface of the residues covered by the protein They also see an interaction of the C-terminal part RPAP with the surface of the antibody In the shorter peptide that ... 36% of the interaction of the full peptide with the binding cavity of SM3 The sizes of the surfaces were determined using distances between ligand ˚ atoms and protein atoms of less than A These ... reference pairs The build-up of the trNOE between Asp2-b and b¢ is much faster than that of the other two reference points indicating differences of the rotational correlation times of these proton...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
Ngày tải lên :
21/02/2014, 15:20
... illustrates the overall saddle shape of the dimeric structure and the key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top of the hollow (Fig 1A) The ... established Of two possible dimeric structures of LPL, the head-tohead and the head-to-tail models, the studies of the chimeric proteins of hepatic lipase and LPL and the tandem repeat approach of LPL ... and was based on the structures of the human and porcine pancreatic lipases for the open form and on the horse pancreatic lipase for the closed form [16,18,19,30] For homology modeling, the 11...
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Evidence-Based Medicine and the Changing Nature of Health Care: Meeting Summary docx
Ngày tải lên :
06/03/2014, 09:20
... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... as the prospect of new ways of meeting the need, provides the back-drop for the discussions at the 37th Annual Meeting of the Institute of Medicine (IOM) Entitled Evidence -Based Medicine and the ... president of the National Academy of Sciences The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding...
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Báo cáo khoa học: A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin pot
Ngày tải lên :
07/03/2014, 06:20
... level match-sets are the reference gels of the respective quadrants from the 2D gel sections of each condition and the four higher-level match-sets are the reference gels of the two different conditions ... PAGE -based image analyses of the second quadrant Fig S2 2D IEF ⁄ SDS ⁄ PAGE -based image analyses of the third quadrant Fig S3 2D IEF ⁄ SDS ⁄ PAGE -based image analyses of the fourth quadrant This ... gels of the same condition and thereafter to reference gels common to both conditions The stepwise annotation of protein spots to two independent levels of reference gels allowed for detection of...
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Báo cáo khoa học: Functional fine-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein pdf
Ngày tải lên :
08/03/2014, 08:20
... induced against the linear isoform of the HNE peptide Although the binding pattern may be somewhat blurred by these antibodies and by the polyclonal nature of the sera, the importance of residues ... crossreactivity with the intact protein (Fig 8B,F) For the binding of the sera to the HNE peptide, the importance of the Cys residues was relatively low, in comparison to the binding with the mAbs BH216, ... In some of the conformers a hydrogen bond was predicted between the carbonyl atom of the Cys386 residue and the main chain nitrogen atom of residue Ile390 The total contact surface of the epitope...
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Báo cáo khoa học: "A Memory-Based Approach to the Treatment of Serial Verb Construction in Combinatory Categorial Grammar" pdf
Ngày tải lên :
08/03/2014, 21:20
... SVCs: the series of V1 to V3 and the series of V4 to V5 , because they not share their tenses The directional verb p©j ‘go’ performs as an adverb identi fying the outward direction of the action ... (subject or object) of arbitrary np’s in (13) from the directionality (the subject on the left and the object on the right) With these reasons, I therefore adapted the notions of MICG’s memory modalities ... respectively For example, the syntactic category 2< 3> s has a filler of type np on the left side and np np a gap of type np on the right side The filler 2d and the gap 3d of the same dic c rectionality...
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