phase iii trials in prostate cancer

Báo cáo y học: "rogesterone in traumatic brain injury: time to move on to phase III trials" doc

Ngày tải lên : 13/08/2014, 11:22

... benefit in preclinical models [5] Established and appropriately funded clinical networks of investigators working in unison to bring these agents through the various stages necessary from preclinical ... to clinical reality are vital to those of us seeking to expand our armamentarium of therapeutic options in the treatment of these injuries [6-8] Competing interests SMM is an investigator in the ... Brain Injury Clinical Trials Network JDK is a Principal Investigator in the Resuscitation Outcomes Consortium References Xiao G, Wei J, Yan W, Wang W, Lu Z: Improved outcomes from the administration...

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Tài liệu Clinical trials in gynecological cancer ppt

Ngày tải lên : 13/02/2014, 07:20

... Italian Trials in Ovarian Cancer www.mito-group.it/ MRC—Medical Research Council www.mrc.ac.uk NCI—National Cancer Institute—ctep .cancer. gov NCIC-CTG—National Cancer Institute of Canada Clinical Trials ... utilizing erythropoietin in head and neck squamous cell carcinoma showed a decrease in local-regional 2007 IGCS and ESGO, International Journal of Gynecological Cancer 17, 547–556 Clinical trials in ... valuable information for ﬁrst-line therapy Infrastructure for clinical trials In the remainder of the article, we have set forward our thoughts on infrastructure issues to support clinical trials...

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ADVANCES IN PROSTATE CANCER docx

Ngày tải lên : 22/03/2014, 22:20

... Activation in Prostate Cancer 589 Luis A Espinoza VII VIII Contents Section Cell Adhesion Proteins in Prostate Cancer 617 Chapter 25 Integrins in Prostate Cancer Invasion and Metastasis 619 Paulynn Chin ... of all prostate cancer cases The risk of getting prostate cancer increases nearly exponentially with increasing age This makes prostate cancer one of the most distinctive cancers in aging popu‐ ... of Prostate Cancer 331 Chapter 14 Stem Cells and Prostate Cancer 333 Vildan Bozok Çetintaş, Bur in Tezcanlı Kaymaz and Buket Kosova Chapter 15 Salinomycin-Induced Apoptosis in Human Prostate Cancer...

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báo cáo hóa học:" Can urinary exosomes act as treatment response markers in prostate cancer?" ppt

Ngày tải lên : 18/06/2014, 15:20

... produced by LNCaP -prostate cancer cell line Prostate cancer cell lines (LNCaP and DU145), as indicated, were maintained in culture as a source of positive-control prostate cancer exosomes (for ... of urine (for at least 18 hours at 37°C) (Figure 6c) Discussion We present the findings of a pilot study, investigating urinary exosomes in prostate cancer patients We had two main aims in the ... loading Bands for prostate- derived proteins PSA or PSMA were evident in patients (p1, p7, p8, p9, p10), indicating that at least some of the exosomes present in the urine were of prostate origin...

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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx

Ngày tải lên : 18/06/2014, 15:20

... Against HLA-A24-positive AMACR-positive Prostate Cancer Cell Lines To confirm that CTLs induced with AMACR peptides could exert cytotoxicity against AMACR-expressing prostate cancer cell lines in ... immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous tissue (Figure 2C) These data indicated that AMACR had a mostly cancer- specific expression ... Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Surgically resected prostate cancer tissue...

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Báo cáo sinh học: " Downregulation of APOBEC3G by Xenotropic Murine Leukemia-Virus Related Virus (XMRV) in Prostate Cancer Cells docx

Ngày tải lên : 18/06/2014, 18:20

... replicate in these cells Findings This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines We demonstrate the presence of A3G in prostate ... cell lines specifically in LNCaP cells [3,18] In addition, the prostate cancer cell line 22Rv1 has been shown to be chronically infected with XMRV and produces highly infectious virus [19] Since ... media containing FBS were added After 1–2 weeks, XMRV infection was confirmed by detecting XMRV p30 protein by using goat polyclonal anti-Rauscher MLV p30 Gag in uninfected (−) and XMRV infected...

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Báo cáo sinh học: " Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx

Ngày tải lên : 18/06/2014, 19:20

... MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus areas ... Biotechnologies, Inc (Santa Cruz, CA, USA), Akt inhibitor, SIS3 inhibitor, PLC-gamma inhibitor, JNK inhibitor, JAK inhibitor, MET inhibitor, Wortmannin, and Wiskostatin were from Calbiochem (Nottingham, ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the...

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báo cáo hóa học:" Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx

Ngày tải lên : 20/06/2014, 03:20

... MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus areas ... Biotechnologies, Inc (Santa Cruz, CA, USA), Akt inhibitor, SIS3 inhibitor, PLC-gamma inhibitor, JNK inhibitor, JAK inhibitor, MET inhibitor, Wortmannin, and Wiskostatin were from Calbiochem (Nottingham, ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the...

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Báo cáo khoa học: "Choline PET based dose-painting in prostate cancer - Modelling of dose effects" potx

Ngày tải lên : 09/08/2014, 08:22

... value concerning the primary detection and the staging of prostate cancer [27] In principle, signal-generation is based on an increased choline metabolism in prostate cancer leading to an increased ... planning in prostate cancer Q J Nucl Med Mol Imag 2009, 53(2):245-268 28 Reske SN, Blumstein NM, Glatting G: [C-11]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy ... [39] In such a geometrical setting it is defined as: TCP  e  n i SFi i SF i is the surviving fraction within the single subvolume with the running index i (ranging from to m = V/vi) Using the...

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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot

Ngày tải lên : 09/08/2014, 09:20

... inhibitors of the PI3K/Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate cancer cell lines Up to now our data revealed that ErPC3 is a potent inhibitor ... lost or inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) ... alkylphosphocholine ErPC3 when used as single drug or in combination with ionizing radiation in prostate cancer Recent phase- I trials already demonstrated feasibility and tolerability of an intravenous...

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Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx

Ngày tải lên : 09/08/2014, 09:20

... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination ... training, testing and validating the network showed curve flattening after a few training epochs, this indicated that no overtraining occurred However, if such a model is to be applied on clinical ... cannula with saline-diluted Gd-DTPA (Magnevist ® , Schering, Berlin, Germany) was inserted into the tail vein Dynamic T1-weighted (T1W) imaging was acquired by performing 20 minutes of dynamic...

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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt

Ngày tải lên : 09/08/2014, 09:20

... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became a major concern in prostate cancer; ... participating in the non-self recognition of prostate cancer cells Thus we can hypothesize, according to results of Hurwitz et al [12] that the enhanced immune function, involving resting and terminally ... M, Morris J, Pai H: Urinary incontinence in prostate cancer patients treated with external beam radiotherapy Radiother Oncol 2005, 74:197-201 A Phase III Trial Comparing Whole Pelvic Irradiation...

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Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot

Ngày tải lên : 09/08/2014, 09:22

... were in S -phase, 65% in G0/G1 and 20% in G2/M In the following, the S -phase was reduced to 5%, while G0/G1 increased to 73% The proportion of cells in G2/M showed minimal changes After incubation ... FCS-containing media during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression ... Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways Int...

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Báo cáo khoa học: "Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking" pps

Ngày tải lên : 09/08/2014, 09:22

... Kemmerling L, Born EJ, Mini R, Greiner RH, Aebersold DM: Daily organ tracking in intensitymodulated radiotherapy of prostate cancer using an electronic portal imaging device with a dose saving acquisition ... summarized in Table Incidence of single symptoms (dysuria, incontinence, retention, frequency/urgency, hematuria) as well as the highest toxicity occurred in a given patient concluding all single ... rectum and bulb of the penis using MRI delineation for radiotherapy of the prostate Int J Radiat Oncol Biol Phys 2003, 57:1269-79 Sobin LH, Wittekind CH: The prostate In TNM Classification of Malignant...

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Báo cáo khoa học: " Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy" docx

Ngày tải lên : 09/08/2014, 09:22

... performed on-line by repositioning the target according to the internal markers, moving the treatment couch manually To calculate the minimum required margin width around the clinical target ... 90%inthe median values (lines percentile 75% values10%variability, prostate line), format, Measured deviations in and Measured deviations in LR, SI and AP directions in a box plot format, showing ... the interobserver variability is low Therefore implanted markers and EPID based methods are used for targeting in radiotherapy of prostate cancer with increasing frequency Our results provide information...

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Báo cáo khoa học: " Consistency in electronic portal imaging registration in prostate cancer radiation treatment verification" pptx

Ngày tải lên : 09/08/2014, 10:21

... participated in study design, data interpretation, manuscript drafting and revising for intellectual content SZ participated in study design, data interpretation and manuscript revising for intellectual ... Bolognesi A, Cattaneo GM, Calandrino R: Intraand inter-observer variability in contouring prostate and seminal vesicles: implications for conformal treatment planning Radiother Oncol 1998, 47:285-292 ... Shinohara N, Harabayashi T, Miyasaka K: Threedimensional intrafractional movement of prostate measured during real-time tumor-tracking radiotherapy in supine and prone treatment positions Int...

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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx

Ngày tải lên : 10/08/2014, 10:20

... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP, ... cell lines We found that somatostatin and Octreotide up-regulated XAF1 mRNA and protein expression in prostate cancer cell lines The enhanced XAF1 expression by somatostatin indicates a promising ... [23] In the current study, we examined XAF1 mRNA and protein expression in four cell lines, and determined regulatory effects of somatostatin and Octreotide on XAF1 expression in prostate cancer...

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báo cáo khoa học: "Possible immunotherapeutic potentiation with D-Fraction in prostate cancer cells" pps

Ngày tải lên : 10/08/2014, 22:20

... HM: IFNγ induction of p21waf1 in prostate cancer cells: Role in cell cycle, alteration of phenotype and invasive potential Int J Cancer 1998, 77:138-145 Sica G, Iacopino F, Recchia F: Interferon ... chemosensitizing effect of PDF has been postulated on conventional anticancer drugs being currently used [13] http://www.jhoonline.org/content/1/1/25 Accordingly, we are interested in investigating whether ... IFN-α2b/PDF combination caused an ~63% decrease in cell number in the S phase with a concomitant 55% increase in the G1 -phase cell population compared to those in controls (Fig 3) These results indicate...

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