pharmacology drug mechanism and effects
The Treatments of Social Phobia - Their Nature and Effects
... becoming less anxious and less handicapped and being more and better socially active remains uncertain Similarly, no studies to date have systematically observed the relapse rate on and after stopping ... relative effects of exposure and cognitive restructuring The backdrop to this line of research is a theoretical clash between two rival outlooks: behaviorism and cognitivism The design and outcome ... Responders Patients who continued to respond to active drugs were randomized and treated for another weeks Improvement was greater for both active drugs after 16 weeks than after weeks Patients who...
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Tài liệu Color Atlas of Pharmacology (Part 26 and the end): Further Reading doc
... Anacaine Anacin-3 Anacobin Anaesthesin Anamid Anarexol Ancef Ancotil Andriol Andro Androcur Androcyp Android Androlone Andronate Androviron Anectine Anergan Anethaine Anexate Ang-O-Span Angionorm ... Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 334 Drug Index Drug Name Trade Name (* denotes investigational drug status in USA) ... Neoral, Sandimmune, Sang-35 Anarexol, Nuran, Periactin, Peritol, Vimicon Androcur Udicil, Cytosar Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and...
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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... of seven a-helices, a three-stranded antiparallel b-sheet and loops connecting these secondary structure elements The contents of the a-helix and b-strand were 50% and 11%, respectively The monomer ... substrate and the other to product inhibition by hydrogen peroxide There are two mechanisms proposed for the reaction cycle of Mn ⁄ Fe-SOD: the 5-6-5 mechanism [27] and the associative displacement mechanism ... coordinated with six ligands: the five same ligands in the Mn-reconstituted enzyme and an additional water oxygen, which, together with the OD2 of Asp165, the NE2 of His79 and the NE2 of His169,...
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Tài liệu Implementation of the Asthma Practice Guideline in the Army Medical Department - Evaluation of Process and Effects pdf
... by RAND Arroyo Center, a federally funded research and development center sponsored by the U.S Army, and by the RAND Center for Military Health Policy Research For more information on the RAND ... patients for education, and limited patient attendance at the programs when referred Effects of the Demonstration on Service and Costs Effects on Performance Measures The RAND analysis found no ... AMEDD-RAND Guideline Implementation Project The three sequential demonstrations for low back pain, asthma, and diabetes guidelines have allowed AMEDD, RAND, and the participating MTFs to test and...
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Tài liệu Increasing Participation in Army Continuing Education - eArmyU and Effects of Possible Program Changes pptx
... the effects of removing the laptop or other eArmyU provisions were unknown These include (1) the willingness and ability of soldiers to participate and (2) the effects of the current program and ... research was conducted within RAND Arroyo Center’s Manpower and Training Program RAND Arroyo Center, part of the RAND Corporation, is a federally funded research and development center sponsored ... RAND Corporation is a nonprofit research organization providing objective analysis and effective solutions that address the challenges facing the public and private sectors around the world RAND’s...
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Tài liệu Báo cáo khoa học: Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates pdf
... dehydrogenase ligand complexes R Sundaramoorthy et al Fig (A) Catalytic reaction of PDH and two intermediate states (B) Structures and numbering of the inhibitors PEX (two resonance forms) and PEA deuterium ... acting as a high-energy-state mimic In our hands, TbPDH is unstable and has proven troublesome for crystallographic studies to characterize ligand binding and inhibition; therefore, an improved system ... II and III are in the monoclinic space group C2 and are isomorphous Three subunits constitute the asymmetric unit, one noncrystallographic symmetry related dimer is formed by subunits A and B and...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
... existence of SMO5 in human normal and tumor cell lines SMO5 cDNA was subcloned and sequenced, and active protein was produced, purified and assayed for kinetic properties and substrate specificities NCI-H157 ... to inclusion bodies, and therefore was denatured and refolded prior to analysis All SMO5 protein production and purification steps were performed in parallel with SMO ⁄ PAOh1 and PAOh4 proteins ... decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lines were...
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ECONOMIC AND SOCIAL CONSEQUENCES OF DRUG ABUSE AND ILLICIT TRAFFICKING doc
... between east and west in Europe facilitated contacts and communication that were also used by drug traffickers, increasing the number of transit routes for drugs and markets for drug consumption.21 ... Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland Sources: UNDCP country profiles United States Department of Health and Human Services (Substance Abuse and Mental Health ... widely abused synthetic drug, cutting across all social classes 11 II Economic consequences of drug abuse and trafficking A Apparent "benefits" and costs of drug abuse and trafficking “Benefits”...
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Báo cáo Y học: Structure, mechanism and function of prenyltransferases docx
... condensation kinetics and mechanism of trans-IPPS and cis-IPPS for the production of linear polyprenyl pyrophosphates, and the reaction mechanism and structures of protein prenyltransferases and isoprenyl ... molecular dyad axis The seven a helices and six b strands are shown in red and green, respectively, for subunit A, and in magenta and cyan for subunit B, and they are labelled separately The blue ... of Ras FTase and (B) the molecular ruler mechanism for substrate specificity of FTase and GGTase (A) The heterodimeric enzyme consists of two subunits, a and b, colored in cyan–blue and yellow–green,...
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Báo cáo khoa học: Phosphorylation mechanism and structure of serine-arginine protein kinases pot
... SRPK1 and SRSF1, together with crystal structures of SRPK1 bound to peptide and protein substrates and the recent structures of CLK1 and CLK3, suggest an elegant mechanism of recognition and phosphorylation ... SRPK structure and mechanism G Ghosh and J A Adams spliceosome, a macromolecular complex composed of five small nuclear ribonucleoproteins (U1, U2, U4, U5, and U6) and over 100 auxiliary ... (U1-70K and U2AF35) early during spliceosome development, and help to establish the 5¢ and 3¢ splice sites [5,6] Later, they recruit the U4 ⁄ U6ÆU5 tri-small nuclear ribonucleoprotein [7] and also...
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BANKING REGULATION: Its Purposes, Implementation, and Effects docx
... offered, and how banks can expand Consequently, a familiarity with regulatory objectives and goals is essential for understanding how the U.S system of bank regulation and supervision arose and what ... (NOW), and share draft accounts nationwide; phased out interest ceilings on time and savings deposits; and broadened the investment and lending powers of savings and loan associations and savings ... organization and its subsidiaries, intercompany transactions and relationships, holding company debt and the potential demands it places on subsidiary bank earnings, and compliance with applicable laws and...
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Pancreatic Cancer – Molecular Mechanism and Targets Edited by Sanjay K. Srivastava potx
... overexpression of receptor ligands, and/ or the loss of negative regulatory pathways The overexpression of EGFR and its ligands (EGF and others) and/ or the loss of the mechanisms that down-regulate ... MAPK, and JAK/STAT3 pathways, and result in anti-apoptosis and growth-stimulating effects IGF and its receptors have been extensively studied in various cancers, such as colon, breast and prostate ... Lankisch, P.G., Andersen, J.R., Dimagno, E.P., Andren-Sandberg ,A., &Domellof, L (1993) Pancreatitis and the risk of pancreatic cancer International Pancreatitis Study Group New England Journal of...
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solvent-controlled synthesis of tio2 1d nanostructures growth mechanism and characterization
... bands at 3435 and 1635 cmÀ1, which correspond to the presence of the OH group and water, absorbed on the surface of the TiO2 samples [23–25] In addition, for samples S2–S4, two bands at 2860 and ... 8, 16 and 24 h, respectively, and (d) TiO2 nanotubes (sample S2); (e) HRTEM image of the sample S2 and the inset shows the enlarged picture of the tube wall; (f) HRTEM image of sample S1 and the ... nanorods, nanowires and nanotubes with different diameters and lengths were formed To understand the formation of the different 1D nanostructures controlled experiments were carried out and the products...
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synthesis, growth mechanism and room-temperature blue luminescence emission of uniform wo3 nanosheets with w as starting material
... WO3 nanosheets The blue emissions were attributed to arise from the band–band indirect transition of WO3 And a new growth mechanism for the as-synthesized WO3 nanosheets was proposed 317 tungsten ... spaces are 0.385 and 0.376 nm in the 2D plane of a single nanosheet, which correspond to the plane distances of (0 2) and (0 0) planes, respectively And the angle between the (0 2) and (0 0) plane ... consistent with the XRD result Fig 2a and b shows the FESEM image and TEM image of the as-synthesized WO3 nanosheets Uniform WO3 nanosheets with a thickness of $80 nm and length of $500 nm can be observed...
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ultra-sharp a-fe2o3 nanoflakes growth mechanism and field-emission
... 245, 291, 408 and 499 cm−1 correspond to the α-Fe2 O3 phase [20], namely two A1g modes (225 and 499 cm−1 ) and three Eg modes (245, 291 and 408 cm−1 ) Those peaks locating at 552 and 671 cm−1 ... points of Fe and α-Fe2 O3 (1535 and 1350 ◦ C, respectively) [15], the growth of α-Fe2 O3 nanoflakes is inexplicable by the vapor phase mechanism such as the vapor–liquid–solid (VLS) and vapor–solid ... [110] and the growth plane may be (110) where the oxygen is rich and Fe is deficient [13] Driven by the O-rich and Fe-deficient, at low temperatures (260 – 300 ◦ C), the diffusion of Fe atoms and...
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A review of the environmental fate and effects of hazardous substances released from electrical and electronic equipments during recycling: Examples fromChina and India doc
... illegal and clandestinely executed processes which have consequences of great concern to the environment and human health The businesses collect, sort and manually separate electrical and electronic ... al., 1992) Chlorinated and brominated dioxins and furans (PCDD/Fs and PBDD/Fs), and mixed halogenated compounds like the polybrominatedchlorinated dibenzo-p-dioxins (PBCDDs) and polybrominatedchlorinated ... Assunỗóo et al., 2005; Lohmann and Jones, 1998; Hassanin et al., 2006), while PBDD/Fs levels documented for Kyoto and Osaka, Japan, range between 1.8 and 12.1 pg m and 4.2 and 17 pg m 3, respectively...
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Báo cáo khoa học: Characterization of inhibitory mechanism and antifungal activity between group-1 and group-2 phytocystatins from taro (Colocasia esculenta) pdf
... lane, two bands corresponding to GST-FL (upper band) and GST (lower band); Nt lane, GST-Nt peptide (upper band) and GST (lower band); Ct lane, only one band (GST-Ct peptide) (B) SDS ⁄ PAGE analysis ... amplification of the FL peptide; F1 and R2 was for the Nt peptide, and F2 and R1 was for the Ct peptide The PCR products were digested with BamHI and EcoRI, and ligated to pGEX-2TK vector (Amersham ... peptides showed two bands, each with the lower band corresponding to a 27 kDa glutathione S-transferase (GST) protein, with the upper band corresponding to 56 kDa for GST-FL and 40 kDa for GST-Nt...
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MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
... Chemistry 43 Amit S Kalgutkar Drug- Metabolizing Enzymes, Transporters, and Drug Drug Interactions 83 Steven W Louie and Magang Shou Experimental Models of Drug Metabolism and Disposition 151 Gang ... of drug metabolism and disposition These concepts are intended to build a unique foundation of knowledge for drug metabolism and the subsequent studies performed during drug discovery and drug ... White RE Short and long-term projections about the involvement of drug metabolism in drug discovery and development Drug Metab and Dispos 1998;26:1213À1216 Wu CY, Benet LZ Predicting Drug Disposition...
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Báo cáo khoa học: Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase pptx
... state-stabilizing arginine, and triphosphate-binding arginine and lysines [79] The guanine base-recognition residues glutamic acid and cysteine in Cyg12 [79] and glutamic acid and glycine in Cya2 [80] ... [11], cartilage [12], and other peripheral tissues, and plays a variety of local regulatory roles The physiological and pathophysiological roles of natriuretic peptides and receptor systems are ... exons 1–6, 8–15 and 17–22 (approximately) encode the ECD, PKLD and GCD, respectively The intervening sequences, the transmembrane sequence and a linker region between the PKLD and the GCD are...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... incoming drugs before they reach the cytoplasm and at a transient high local concentration Moreover, in the latter case, Pgp is expected to handle incoming drugs more efficiently compared to drugs ... By contrast, in the case where drug concentrations in the cytoplasm and the cytoplasmic leaflet are in equilibrium, Pgp is expected to treat incoming drugs and drugs already present within the ... only transports a variety of drugs conjugated to glutathione, sulfate or glucuronate, as well as anionic drugs and dyes, but also neutral ⁄ basic amphipathic drugs and even oxyanions Previously,...
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