pharmacological modulation and clinical implications of sarcolemmal ca2 handling proteins in heart function
Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
Ngày tải lên :
09/08/2014, 06:22
... preparation used in the initial study was found to be contaminated with other proteins, and RA sera contained antibodies against some of these other proteins [81] Taken together, these findings indicate ... arthritis may be induced by systemic autoreactivity remains interesting and plausible G6PIinduced arthritis provides a model in which both the induction and modulation of arthritis induced by autoreactivity ... following one single immunization with recombinant human or murine G6PI in adjuvant [93] (Fig 1) The incidence of arthritis upon immunization is in excess of 90%, and the time course is uniform and...
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Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx
Ngày tải lên :
13/08/2014, 09:21
... emergence and implications of K70E and K65R viral mutants These data are important and timely, considering (i) the increased use of tenofovir in HAART regimens, and (ii) the ongoing clinical trials ... difficult to unravel, and that are relevant to the clinical use of tenofovir-containing regimens in HIV-1 infected humans In the current study, intravenous inoculation of the first group of macaques with ... levels in plasma and infectious titers in PBMC, and a similar decline in absolute counts and percentages of CD4+ T lymphocytes and CD4+/CD8+ T cell ratios during the first 20 weeks of infection...
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Báo cáo hóa học: " Evaluation of the diagnostic indices and clinical utility of qualitative cardiodetect® test kit in diagnosis of ami within 12 hours of onset of chest pain in the emergency department" pptx
Ngày tải lên :
20/06/2014, 23:20
... Evaluation of the diagnostic indices and clinical utility of qualitative cardiodetect®® test kit in diagnosis of ami within 12 hours of onset of chest pain in the emergency department International ... for the definition of AMI includes a combination of two out of three characteristics composed of clinical history, a rise and fall of cardiac biomarkers, and ECG changes Despite being guided ... http://www.intjem.com/content/4/1/67 Page of Figure Flow chart of the study 24 h of onset of chest pain Figure shows the initial ECG findings in the ED The majority of patients (72.5%) in this study...
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Báo cáo khoa học: "Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma" ppt
Ngày tải lên :
09/08/2014, 03:22
... novel and one known point mutations in the EGFR-TK domain in MPM patients All mutations are clustered and reside near the ATPbinding cleft of the tyrosine kinase domain Presence of each mutation in ... identified within the kinase domain of ERBB2 in this MPM sample set Page of 10 EGFR and ERBB2 copy number status was assessed using FISH and quantitative PCR, and no evidence of amplification of either ... analyzed a cohort of MPM samples (n = 29) by DHPLC and sequencing analysis, and identified eight mutations in the tyrosine kinase domain (TKD) of EGFR Of the mutations in the TK domain, were novel...
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Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot
Ngày tải lên :
09/08/2014, 14:20
... receptor chain with high affinity (1011/M) and slow off-rate, rendering it a useful and specific inhibitor in biologic systems Common γ-chain signalling cytokines – interleukin-15 and interleukin-21 ... of a variety of models, including CIA and several murine lupus models Clinical trials directly targeting IL-21 are in pre -clinical planning at this time The therapeutic utility of this cytokine ... Scientific Meeting 2008) The results of other ongoing clinical trials targeting IL-17 will certainly increase our understanding of the role of this cytokine in human diseases Conclusions The cytokine field...
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Báo cáo khoa học: "Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study" pptx
Ngày tải lên :
13/08/2014, 03:20
... (10/45) and virus influenza A (7/45) Rhinovirus detected in the lower respiratory tract was associated with clinical signs of acute COPD exacerbation, of pneumonia or of pulmonary edema in all ... rhinovirus and virus parainfluenza 3, one case of rhinovirus and cytomegalovirus, one case of herpes simplex virus type and virus influenza A, and one case of herpes Page of 10 (page number not ... sample, as shown in Table Clinical outcome by virus respiratory sample The Kaplan-Meier curves of survival according to the presence of respiratory viruses in group and in group are shown in Figure...
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báo cáo hóa học: " Clinical implications of gait analysis in the rehabilitation of adult patients with "Prader-Willi" Syndrome: a cross-sectional comparative study ("Prader-Willi" Syndrome vs matched obese patients and healthy subjects)" docx
Ngày tải lên :
19/06/2014, 10:20
... displacement of the center of gravity creating instability during standing and walking Morbility and mortality of PWS are mainly related to severe obesity Hypothalamic dysfunction is a recognized cause of ... as standing up, bending, walking and running [1,2] The analysis of gait pattern of obese children shows a more flat-footed weight acceptance period in stance phase and greater out-toeing of the ... of left and right leg were separately assessed Then, for each patient at least five trials with kinematic and kinetic data were collected and comparing the different plots of kinematic and kinetics...
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Báo cáo khoa học: "Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury" pptx
Ngày tải lên :
12/08/2014, 19:22
... above the lower inflection point was more effective in maintaining gas exchange and minimizing inflammation and lung injury than was PEEP set at the maximum curvature of the deflation pressure–volume ... upregulation of an inflammatory response, with release of cytokines and chemokines and activation of neutrophils and macrophages that produce lung damage [2] Injurious MV can lead to end-organ dysfunction, ... the basis of our review of the literature on experimental and clinical studies, considerable uncertainty remains regarding the use of RMs in humans with ARDS RMs may have a role to play in patients...
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Báo cáo y học: " Changes in health-related quality of life and clinical implications in Chinese patients with chronic cough" pot
Ngày tải lên :
13/08/2014, 08:20
... analysis of data and took part in review of the manuscript, YW, XL and HL took part in the collection of cases and review of the manuscript, ZQ was in charge of design and coordination of the program, ... source document The Chinese version of LCQ was then finally determined [see Additional file 1] LCQ consists of 19 items, involving physical, psychological and social domains, and each item represents ... eligible for inclusion in case of the presence of an isolated persistent cough of > weeks, the absence of adventitious lung sounds on physical examination, normal findings on plain chest radiography,...
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Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"
Ngày tải lên :
02/11/2012, 09:56
... sustained (Figure 1B) [1, 18] HCV genotypes 4, and In the absence of any clinical trial including a sufficient number of patients, the likelihood of an SVR and the optimal treatment schedule remain ... University of Paris XII and a member of the Department of Virology and of INSERM Unit U635 at the Henri Mondor University Hospital in Créteil, France He focuses on teaching, diagnosis and research in ... the official journal of the American Association for the Study of Liver Diseases (AASLD), and of Current Hepatitis Reports, and a member of the Editorial Board of the Journal of Hepatology and of...
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Báo cáo y học: "Natural History and Clinical Consequences of Hepatitis B Virus Infection"
Ngày tải lên :
02/11/2012, 11:17
... a key role in the difficulties of managing hepatitis B infection Hence, further research and understanding in this sector may bring exciting new information and better understanding of the natural ... seroreversion Clinical Spectrum of HBV Infection Primary Infection –Subclinical Infection and Acute hepatitis B Majority of HBV infection in children are subclinical versus those in adults, about 30% to ... Europe, India, and Africa Genotype B and C are common in Asia; genotype D, in southern Europe, the Middle East, and India; genotype E, in West Africa and South Africa; genotype F, in South and Central...
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Tài liệu The Legal and Economic Implications of Electronic Discovery pptx
Ngày tải lên :
18/02/2014, 02:20
... mechanical means (including photocopying, recording, or information storage and retrieval) without permission in writing from RAND Published 2008 by the RAND Corporation 1776 Main Street, P.O Box ... state of e-discovery law and practices, including the main features of the new Federal Rules of Civil Procedure; we conducted an initial modeling effort to simulate the range of plausible effects of ... number of concerns about the effects of e-discovery on the legal system First, the most frequent point mentioned in interviews was the rising costs of reviewing information produced in e-discovery Interviewees...
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Tài liệu Pathophysiology and Clinical Aspects of Venous Thromboembolism in Neonates, Renal Disease and Cancer Patients Edited by Mohammed A. Abdelaal ppt
Ngày tải lên :
19/02/2014, 23:20
... Role of B vitamins and enzymes B vitamins function as coenzymes in the synthesis of purines and thymidylate during normal DNA synthesis Diminished levels of these vitamins may result in misincorporation ... (1) A point mutation in the coding region for the 5,10-MTHFR binding site (C677T), leading to the substitution of an alanine to a valine effectively increases homocysteine levels increase and decreases ... extrapolation of principles of therapy from adult guidelines, limited clinical information from registries, individual case studies and knowledge of current common clinical practice The following is...
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Tài liệu Research evaluation of economic, social, and ecological implications of the programme for commercial tree plantations: case study of rubber in the south of Laos PDR pptx
Ngày tải lên :
21/02/2014, 04:20
... Laos, including the development of the meaning of “land”, the history of the land concessions, from the first beginnings to the present, rights and powers in the management and use of land, and ... the hinterland of Indochina Instead, most of the colonial rubber estates were established in the south of Vietnam and Cambodia The history of the expansion of the rubber estates in Indochina did ... developed In the context of the management and use of forest and land resources in the midst of the transition process of economic development of the country Changes in the meaning of “land” in Laos...
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Toxicology and Clinical Pharmacology of Herbal Products pdf
Ngày tải lên :
06/03/2014, 14:20
... Page i Toxicology and Clinical Pharmacology of Herbal Products Page ii Forensic Science and Medicine Steven B Karch, MD, SERIES EDITOR TOXICOLOGY AND CLINICAL PHARMACOLOGY OF HERBAL PRODUCTS, ... selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication Notwithstanding, as new research, changes in government regulations, and ... States of America 10 Library of Congress Cataloging in Publication Data Toxicology and clinical pharmacology of herbal products / edited by Melanie Johns Cupp p ; cm.—(Forensic science and medicine)...
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Handbook of Risk Theory Epistemology, Decision Theory, Ethics, and Social Implications of Risk doc
Ngày tải lên :
14/03/2014, 10:20
... for further research in the form of critical examination of the function of stereotypes in risk issues, and in the form of investigation of empirical studies of how women and men, respectively, ... these risks and the need to involve populations in the preparation, leads to a snowballing of uncertainty and indeterminacy from the scientific domain through the policy domain and into the wider ... principle or on the maximization of expected utility are capable of incorporating the uncertainty inevitably involved in climate modeling The author contends that in the case of decision making...
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Demographic and clinical characteristics of tuberculosis: A report of 2404 cases at a referral hospital pot
Ngày tải lên :
15/03/2014, 03:20
... Becton–Dickinson Diagnostic Instrument Systems) was used for routine testing of susceptibility to first line anti-TB drugs, including isoniazid, rifampin, ethambutol, and streptomycin The incidence of ... success of treatment and control of TB Conclusion Through the investigations of clinical and demographic features of the patients hospitalized in a referral hospital for treatment of TB during the ... tuberculosis and poverty have been closely linked since the scientific study of the disease began (Link and Phelan, 1995) With the rapidly increasing world population and the wider disparity of income,...
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Characteristics and Regulation of Exempt Institutions and the Implications of Removing the Exemptions pptx
Ngày tải lên :
15/03/2014, 09:20
... in the business of placing deposits, or facilitating the placement of deposits, of third parties with insured depository institutions, or any person in the business of placing deposits with insured ... collection of FDIC-insured institutions However, this definition of the market excludes many types of institutions that provide credit, including uninsured affiliates of FDIC-insured institutions, finance ... that involves trade-offs among a number of competing considerations, including potentially increasing concentration in certain credit markets and decreasing consumer choice and the availability of...
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Textbook of Sports Medicine Basic Science and Clinical Aspects of Sports Injury and Physical Activity pot
Ngày tải lên :
15/03/2014, 09:20
... Rehabilitation and Research Centre, University of Oulu, FIN-, Finland Axel Urhausen Institute of Sports and Preventitive Medicine, Department of Clinical Medicine, University of Saarland, D-, Saarbruecken, ... during the past two decades, e.g secondary impingement and internal impingement of the shoulder in overhead athletes On the basis of recognizing certain common patterns of injury and understanding ... University of Helsinki, FIN-, Helsinki, Finland Liying Zhang Bioengineering Center, Wayne State University, Detroit, Michigan, MI , USA Preface In past decades the number of exercising individuals and...
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