... Conjugation of drug with ligand for vascular targeting 15 1.3.2 Vascular targeted nanoparticle drugdelivery 19 1.4 Conclusion 22 Chapter Targeted nanoparticulate drugdelivery ... nanocapsule delivery system to investigate the capacity of temporal release of antiangiogenetic drugand anticancer drug in vitro We found that the drug release profiles of the encapsulated drugs, ... Dots: Preparation and Two-Photon Fluorescence J Am Chem Soc 2009; 131(32), 1130011301 Wang Z., Chui WK., Ho PC Integrin targeted drugand gene delivery Expert opinion on drugdelivery 2010; 7(2),...
... for DrugDeliverySystemsDrugdeliverysystems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drugdelivery ... J Frazier, and H Brem (2002) Local drugdelivery to the brain Adv Drug Deliv Rev., 54 (7), 987–1013 Anderson, J.M and Shive, M.S (1997) Biodegradation and biocompatibility of PLA and PLGA microspheres ... the ability to use nanotechnology and biological mimicry to create drugdeliverysystems that penetrate into 15.6 Examples of Biodegradable Polymer DrugDeliverySystems Under Development articular...
... demand fbrther research and New Materials andSystems for DrugDeliveryand Targeting Table Externally activated drugdeliverysystems EXTERNAL ACTIVATION FORMULATION SYSTEM MECHANISM FOR DRUGDELIVERY ... to advanced drugdeliverysystems Chemical Aspects of DrugDeliverySystems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE ... solubility and stability Chemical Aspects of DrugDeliverySystems Table Routes of administration and general classification of drugdeliverysystems ROUTES OF ADMINISTRATION DRUGDELIVERY CLASS...
... Generalities of drugdelivery Liposomes as drugdeliverysystems Polymers and polymeric systems for drugdelivery Dendrimers for drugdelivery GENERALITIES OF DRUGDELIVERYDRUGDELIVERY SYSTEM ... Targeted drugdelivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drugdelivery systems: preprogramed drug release By the route of delivery: ... Topical (local) drugdelivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation Systemic drugdelivery systems: drugs are delivered...
... Drug Metabolism: Chemical and Biochemical Aspects, Bernard Testa and Peter Jenner New Drugs: Discovery and Development, edited by Alan A Rubin Sustained and Controlled Release DrugDelivery Systems, ... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic DrugDelivery Systems: Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... actives and their delivery to where they are needed An ever increasing number of drug- and vaccinedelivery systems are being tested clinically, with many already marketed Recently, drug- delivery systems...
... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, anddrugbioavailability A schematic comparison of untargeted and targeted drugdeliverysystems is shown in Figure ... effectiveness of drugdeliverysystems can be attributed to their small size, reduced drug toxicity, controlled time release of the drugand modification of drug pharmacokinetics and biological ... the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drugdeliverySystems Nanoparticles can be used in targeted drugdelivery at the site of disease...
... Such nanocarrier-based drugdeliverysystems for doxorubicin could be more selective and effective than the free drugand have the promise to result in reduced toxicity and side effects in patients, ... the molecular transporter in drugdelivery Page 14 of 22 Drugdelivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drugdeliverysystems targeted to the lymphatic ... in anticancer drugdeliverysystems because there are many other anticancer drugdeliverysystems based on other nanomaterials, such as cationic polymers [98], fibrinogens [99], and PVP/PVAL nanoparticles...
... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic DrugDeliverySystems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... DrugDeliverySystems Manufacturing and Production Technology, edited by Praveen Tyle Topical DrugDelivery Formulations, edited by David W Osborne and Anton H Amann Drug Stability Principles and ... Practical and Clinical Applications, Second Edition, Revised and Expanded, Sanford Bolton Biodegradable Polymers as DrugDelivery Systems, edited by Mark Chasm and Robert Langer Preclmical Drug Disposition...
... L., and Anderson, J A (1985) Review: Corneal penetration and ocular bioavailability of drugs J Ocular Pharmacol., 1:309 Lee, V H L., and Robinson, J R (1986) Review: Topical ocular drug delivery: ... (1990) Ocular drugdeliveryPharmacokinetic considerations Clin Pharmacokinet., 18:255 Lang, J C., and Stiemke, M M Biological barriers to ocular delivery In: Ocular Therapeutics andDrugDelivery ... Mazuel, C., Quint, M., and Rozier, A (1977) Pharmacokinetics and biopharmaceutical aspects of some anti-glaucoma drugs In: Ophthalmic DrugDelivery Biopharmaceutical Technological and Clinical Aspects...
... L., and Cringle, I J (1989) Pharmacokinetics of intravitreal injection Invest Ophthalmol Vis Sci 30:1055–1061 23 Urtii, A (1993) Animal pharmacokinetics studies In Ophthalmic DrugDelivery Systems, ... Ohtori, A., and Tojo, K In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation Biol Pharm Bull 17:283–290, 1994 11 Tojo, K., and Ohtori, A Pharmacokinetic ... area, thickness, concentration gradient, compartment volume, and ligand diffusion coefficient (43) Tissue and plasma proteins often bind drugs and other low molecular weight compounds Hypothesis regarding...
... 128 Peyman, G A., and Ganiban, G J (1995) Deliverysystems for intraocular routes, Adv DrugDelivery Rev., 16:107–123 129 Geroski, D H., and Edelhauser, H F (2000) Review: Drugdelivery for posterior ... U., and Mondino, B J (1991) Device drugdelivery to the eye Collagen shields, iontophoresis, and pumps, Ophthalmology., 98:725–732 147 Hill, J M (1991) Symposium on drugdelivery V Ocular drug delivery; ... peptide and protein drugs, Adv DrugDelivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic delivery of polypeptide drugs through ocular route, J Ocul Pharmacol., 10:93–99 82 Morgan, R V (1995) Delivery...
... M., and Leesman, G D (1989) Absorption of difficult drug molecules: Carrier mediated transport of peptides and peptide analogues In: Novel DrugDeliveryand Therapeutic Application L F Presscot and ... insulin, Int J Pharm., 62:53 51 Su, K S E (1991) Nasal route delivery of peptide and protein drugdelivery In: Peptide and Protein DrugDelivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 ... from ophthalmic timolol and their prevention, J Ocul Pharmacol., 3:177 22 Robinson, J R (1989) Ocular drugdelivery Mechanism(s) of corneal drug transport and mucoadhesive systems, S.T.P Pharma.,...
... Coa, Y., and Suresh, M R (2000) Bispecific Mab aided liposomal drugdelivery J Drug Target, 8(4):257–266 160 Cristiano, R J., and Roth, J A (1995) Molecular conjugates: a targeted gene delivery ... nonpathogenic and cannot replicate; (d) immunogenicity, toxicity, and inflammation are minimized with their use; and (e) they can become completely synthetic While these are safe gene delivery systems, ... straightforward and relatively simple to perform and bypasses the need for complex viral or non viral deliverysystems Subretinal or intravitreal injections are common routes of delivery to the...
... clinical investigations and NDAs for marketing approval The terms drugand new drug are inclusive of the drug substance and the drug product It is important to understand that a new drug is not just ... toxicity and pharmacokinetics of antisense oligonucleotides Anticancer Drug Des., 6:609–646 166 Y Rojanasakul (1996) Antisense oligonucleotide therapeutics: drugdeliveryand targeting Adv DrugDelivery ... NDA drugs approved since 1962 and thereby increase competition and lower drug prices An abbreviated NDA (ANDA) is required to be submitted for approval and must demonstrate that the generic drug...
... Revised and Expanded, edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic DrugDeliverySystems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery ... DrugDeliverySystems Manufacturing and Production Technology, edited by Praveen Tyle Topical DrugDelivery Formulations, edited by David W Osborne and Anton H Amann Drug Stability Principles and ... Practical and Clinical Applications, Second Edition, Revised and Expanded, Sanford Bolton Biodegradable Polymers as DrugDelivery Systems, edited by Mark Chasm and Robert Langer Preclmical Drug Disposition...
... L., and Cringle, I J (1989) Pharmacokinetics of intravitreal injection Invest Ophthalmol Vis Sci 30:1055–1061 23 Urtii, A (1993) Animal pharmacokinetics studies In Ophthalmic DrugDelivery Systems, ... Ohtori, A., and Tojo, K In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation Biol Pharm Bull 17:283–290, 1994 11 Tojo, K., and Ohtori, A Pharmacokinetic ... area, thickness, concentration gradient, compartment volume, and ligand diffusion coefficient (43) Tissue and plasma proteins often bind drugs and other low molecular weight compounds Hypothesis regarding...