penalty function derivation of the maximum likelihood decision rule 483
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
... and A Patel of cell fate Leukemias associated with loss -of -function or gain -of -function variants of MLL1 are prime examples of the importance of maintaining the enzymatic activity of MLL1 under ... present This is because the construct used to determine the structure of the MLL1 SET domain lacks the evolutionarily conserved Win motif in the region flanking the N-terminus of the SET domain [26], ... (green) bound to the central opening of WDR5 (PDB code 3EG6) The position of the conserved Arg 3765 is indicated On the left, a stick representation is used to show the position of the MLL1 Win motif...
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Báo cáo Y học: A novel gain-of-function mutation of the integrin a2 VWFA domain docx
... Structure of the C-terminal region of a2 VWFA domain, in the presence (B) or absence (C) of collagen peptide ligated The arrow indicates the position of the E318 side chain, which is altered by the ... form part of the ligand binding site In addition to the effects on ligand binding, the mutation also affected the use of cations by the ligand binding site Although the precise nature of the atomic ... contribution of E318 to the MIDAS We therefore propose that E318W functions by affecting the conformation of the VWFA domain This would be a highly specific effect, since the global conformation of the...
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Báo cáo khoa học: Structure–function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin pot
... Institute of Neurological Disorders and Stroke to WP The content is solely the responsibility of the authors and does not necessarily represent the of cial views of the National Institute of Neurological ... experiments (Fig 2A,B) The NMR spectra of these constructs perfectly resembled the spectra of unfolded proteins: they showed no signs of either amide proton dispersion, which is indicative of hydrogen bonding ... [38] In the presence of these ABD constructs, the concentrations of fluorescent actin polymers appeared to be higher because of the precipitation of crosslinked actin polymer networks onto the glass...
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Marketing of Vice Goods: A Strategic Analysis of the Package Size Decision pdf
... given the decisions of consumers in periods 1–3 The sequence of decision is as follows First, both firms decide on the packaging decision In other words, they decide whether they want to offer ... of the Consumer’s Decision In our paper, firms decide on the package size and then decide on prices Next, the consumers make their purchasing decisions in period 1, which is then followed by the ... analyze the firm’s pricing and packaging decisions, given the decisions of consumers in periods 1–3 We will first analyze the benchmark case of a monopoly We will then analyze the case when there...
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Báo cáo Y học: Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function doc
... considered the main ethiologic factor for skin cancers Thus, it can be hypothesized that an impairment of the normal function of the aMSH/MC1R system as a result of loss -of -function mutations in the ... to the responsive HBL cells The lack of functional coupling of these cell lines, particularly of DOR cells homozygous for the wild-type MC1R, is therefore perplexing and will be the subject of ... shift of the displacement curve and by the lower amount of radioactivity bound in the absence of competitor (in spite of the lack of statistically significant differences in the number of binding...
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Báo cáo toán học: " A Combinatorial Derivation of the PASEP Stationary Stat" pps
... address the issues of existence and uniqueness of solutions to the above equations by finding explicit examples of basic weights for certain values of the parameters of the model The main result of ... S, so the language is restricted to {N, S, E, E} Definition Let Pn be the set of bicoloured Motzkin paths of length n The weight of the path in P0 is and the weight of any other path is the product ... showing that the the weight of the paths obeys the same equations as the weight of the basic configurations We may specialise the above result to get the corollary: Corollary 14 If α = β = the paths...
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Báo cáo toán học: "The Maximum of the Maximum Rectilinear Crossing Numbers of d-regular Graphs of Order n" docx
... drawing by now deleting the n diagonals of length k There are k − vertices in one of the halfplanes each of the diagonals of length k divides the drawing into Each of these vertices will have ... diagonal of length k +1 connecting two vertices of these cycles For each of these diagonals of length k + we keep the diagonals of length k which emanate from their endpoints and then delete their ... In the same vein as the above proof for CR(Rn,2 ) we now offer a simpler proof of CR(Cn ) than that of Furry and Kleitman Note that for both Rn,2 and Cn where n ≡ (mod 2) the proof of the maximum...
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Báo cáo toán học: "A quasisymmetric function generalization of the chromatic symmetric function" pptx
... that the girth of a graph is the length of its smallest cycle Then, for an orientation O of G to be k-balanced, it is necessary that the girth of G be at least 2k This is not sufficient — the smallest ... of C4 are of two types: in Figure There are orientations of the O2 We then calculate the linear extensions {1234, 1243, 2134, 2143} Thus, Figure 5: O2 in practice, consider the 4-cycle C4 The ... Specifically, if {i1 < i2 < · · · < ik } is the image of f , then we obtain π by listing the elements of f −1 (i1 ) in increasing order, then the elements of f −1 (i2 ) in increasing order, and so...
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báo cáo khoa học: " Canada''''s implementation of the Paragraph 6 Decision: is it sustainable public policy?" ppsx
... when they can't really make use, or the bill doesn't provide the remedy at the end of the day If it stays the current way and we can't get any drugs to anybody, then I think it's one of the worst ... future In this sense, they see the importance of the Paragraph Decision and CAMR However, most respondents saw the TRIPS Agreement and the Paragraph Decision themselves as the fundamental frameworks ... but they are not notifying the Canadian Commissioner of Patents of their intent to use the legislation While no definitive reasons were given, he speculated as to whether there was a lack of clarity...
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Báo cáo y học: "What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?" ppsx
... composed of part of region I with the highly conserved Trp11 while the functional region II, IV and V are well exposed to the solvent The extra residues in the C-terminus of Tat Eli are exposed to the ... representative of the five main HIV-1 subtypes Tat sequences representative of the five main HIV-1 subtypes The sequence length of Tat is variable and ranges from 86 to 101 residues as a function of the ... aid in these functions, but the mutation of F/ Y32W present in CRF_AE Tat interferes with chromatin remodeling of the TNF locus and with the recruitment of p300/CBP-associating factor to the TNF...
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Báo cáo y học: "Allometric scaling of the maximum metabolic rate of mammals: oxygen transport from the lungs to the heart is a limiting step" pdf
... the logarithm of the function Q defined in Equation (5) is a nonlinear function of the logarithm of M, it is clear from Figure that the logarithm of Q closely approximates a linear function of ... Therefore, the scaling of Fmax with body size depends largely on the scaling of Ip The impedance of the pulmonary venous network is a consequence of its physical structure and the viscosity of ... venous end of pulmonary capillaries minus the diastolic pressure in the left atrium (denoted PLA) The output of oxygen by the left ventricle of the heart into the aorta is equal to the input of oxygen...
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báo cáo khoa học: " A matched-pair cluster design study protocol to evaluate implementation of the Canadian C-spine rule in hospital emergency departments: Phase III" ppt
... Secondary objectives are to determine the sustainability of the intervention, to further evaluate the accuracy of the rule, and to conduct an economic evaluation of the potential for cost savings http://www.implementationscience.com/content/2/1/4 ... implement the rule The methodological standards for the derivation and validation of decision rules are summarized in Figure 2[14-17] Implementation to demonstrate the true effect on patient care is the ... support for a cervical spine radiography decision rule [39] Results of phase I: derivation The results of phase I, the derivation of the Canadian CSpine Rule (Figure 1), were published in JAMA in October...
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Báo cáo sinh học: " Research Article Maximum-Likelihood Semiblind Equalization of Doubly Selective Channels Using the EM Algorithm" docx
... Another contribution of the paper is the determination of a pilot positioning scheme that improves the equalizer’s performance In the context of our proposed algorithm, the main purpose of the ... description of the channel with the BE complex exponents and polynomial functions (below 1% error) This is also the number of basis functions used in [30] For the selection of eigenvectors as the functions ... is the ith row in the matrix B The matrix Bn is then built from the L rows in B that correspond to time instant n This description can then be used in the derivation of the EM procedure and the...
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Báo cáo hóa học: " Research Article Maximum Likelihood DOA Estimation of Multiple Wideband Sources in the Presence of Nonuniform Sensor Noise" pdf
... and the AC-ML in estimating the DOA of a single source in the presence of nonuniform sensor noise The setting of the simulation is the same as the previous example except now the covariance of the ... model, where q = [q1 , , qP ]T is the vector of the diagonal elements of Q, then the likelihood function of Ψ can be expressed as (7) It follows that the maximum likelihood estimator for Ω is simply ... under the uniform white noise assumption When the sensor noise is nonuniform, the CRB becomes a function of the DOAs and the dependency varies with the distribution of the noise variances In the...
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Báo cáo hóa học: " Research Article Maximum Likelihood DOA Estimation of Multiple Wideband Sources in the Presence of Nonuniform Sensor Noise" doc
... and the AC-ML in estimating the DOA of a single source in the presence of nonuniform sensor noise The setting of the simulation is the same as the previous example except now the covariance of the ... model, where q = [q1 , , qP ]T is the vector of the diagonal elements of Q, then the likelihood function of Ψ can be expressed as (7) It follows that the maximum likelihood estimator for Ω is simply ... under the uniform white noise assumption When the sensor noise is nonuniform, the CRB becomes a function of the DOAs and the dependency varies with the distribution of the noise variances In the...
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Báo cáo sinh học: "Restricted maximum likelihood estimation for animal models using derivatives of the likelihood" pptx
... straightforward the inverses of the matrices of residual covariances for all combination of numbers of traits recorded occurring in the data have been obtained (of maximum size equal to the maximum number of ... non-linear function is the Newton-Raphson (NR) algorithm It requires the Hessian matrix of the function, ie, the matrix of second partial derivatives of the (log) likelihood with respect to the parameters ... of the mixed model matrix As emphasised above, calculation of the derivatives of the Cholesky factor of M requires the corresponding derivatives of M to be evaluated Fortunately, these have the...
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Báo cáo sinh học: " Restricted maximum likelihood estimation of genetic parameters for the first three lactations in the Montbéliarde dairy cattle breed" pptx
... the computation of the information matrix, which is very extensive Therefore, in this part of the analysis, the fixed effects of the year-season of calving, of the age at 1st calving and of the ... generations (for the choice of the parents) and within a generation (by the end of each lactation) As the performance of the parents of the animals could not be analysed because of the computational ... Vleck (1987) The first data set consisted of the daughters of sampling bulls born in 1975 and the second of the daughters of sampling bulls born in 1976 For each of the data sets, the most widely...
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Tài liệu Decision of the finance minister (continue) doc
... require the consent of all the ventures or a specified majority of the ventures When the venturer can control the sharing of profits and it is probable that the profits will not be distributed in the ... when it recovers the carrying amount of the asset The difference between the carrying amount of 100 and the tax base of 60 is a taxable temporary difference of 40 Therefore, the enterprise recognizes ... and the nature of the evidence supporting its recognition, when: a) the utilisation of the deferred tax asset is dependent on future taxable profits in excess of the profits arising from the...
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