pdgf angiogenic and neurotrophic factors in the cerebral cortex of sham and t2vo samp

Báo cáo y học: "Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats" doc

Ngày tải lên : 13/08/2014, 14:20

... days before intratracheal instillation of BL to the end of the experimental phase of the study showed thin interalveolar septa, a lack of inflamed cells and normal-appearing bronchioles and alveolar ... pulmonary fibrosis [18,19] The gum resin of Boswellia serrata, a kind of deciduous tree found in parts of China and India has long been used for treating inflammatory and arthritic diseases [20] ... g of semisolid oleoresin The extract was then further fractionated Briefly, the Page of 14 semisolid oleoresin was dissolved in petroleum ether and the soluble fraction was discarded (95%) and...

14
294
0

Báo cáo khoa học: "Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back" pot

Ngày tải lên : 09/08/2014, 09:21

... alkylating chemotherapy both in the concomitant phase (50 mg in 78% and 75 mg in only 22%) as well as in the maintenance phase (no adjuvant treatment in 79 % and a mean of cycles in 21% of patients) ... entity in upcoming studies The low number of primary GBM exhibiting IDH1 mutations in our series indicates that our sample set consists indeed predominately of these tumors IDH1mutations in GBM ... approximately 60 – 80 % of diffusely infiltrating gliomas of the WHO grades II and III and in secondary GBM but only in around % of primary GBM (11;18-22) In our series we identified in of 140 patients...

18
365
0

Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf

Ngày tải lên : 12/08/2014, 14:20

... (Stage I) and tiny collagen fibers in the lung of rats in the silica+Lv-shCD36 group Compared to the silica and the silica+Lv-shCD36-NC groups, the number of nodules in the lungs of rats in the silica+Lv-shCD36 ... Lv-shCD36-NC in physiological saline, was instilled into the lungs using a 14-gauge needle inserted into the trachea through the epiglottis of the larynx The site of surgery was sutured and the rats ... draft the manuscript LL participated in the animal instillation and in the histological and immunohistochemical experiments JC initiated the project, participated in the design of the study and in...

9
365
0

báo cáo hóa học: " Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury" pptx

Ngày tải lên : 19/06/2014, 22:20

... only detected in three of them, IL-6, IL-1b and TNF For the other cytokines including the pro-inflammatory IL-2 and anti-inflammatory IL-4 and IL-10, no changes were detected in either the TAI or ... comparison to the cytokines measured in these experiments, IL-6 presented the highest concentration in the injured cortex By 2-way ANOVA, the overall increase of IL-6 (all time points within the group ... toxicity of TNF has been demonstrated with local TNF administration inducing breakdown down of the BBB and increased leukocyte recruitment [95-98] Clinically, high levels of TNF in the CSF of brain-injured...

16
335
0

Báo cáo khoa học: "Prophylactic effect of plaster and cataplasm contained ketoprofen in rats with adjuvant arthritis" pot

Ngày tải lên : 07/08/2014, 14:23

... mentioned In summary, the prophylactic effect of the CT and PT prominently suppressed swelling and bony changes in all regions of the femur, tibia and paw of the non-adjuvantinjected leg and the adjuvant-injected ... days 21 and 28 in the adjuvant-injected leg of the PT and the CT groups (p

6
270
0

Báo cáo khoa học: "Changes of biomarkers with oral exposure to benzo(a)pyrene, phenanthrene and pyrene in rats" ppt

Ngày tải lên : 07/08/2014, 20:23

... concentration of BaP, PH and PY in muscle and fat, and their metabolites in urine; in addition, we studied the EROD activity in the liver and the DNA adducts of BaP in blood lymphocytes as well as the ... housed in a cage specially designed to collect the overnight urine The urine samples were kept Determination of parent compounds in muscle and fat, and their metabolites in urine For the determination ... Ah-receptor (AhR) affinity, and the induction of the CYP1A enzymes leading to increased rates of formation of reactive metabolites [40] Therefore, PH and PY may interrupt BaP binding to AhR; however,...

8
245
0

Báo cáo y học: "Inhibition by Natural Dietary Substances of Gastrointestinal Absorption of Starch and Sucrose in Rats and Pigs: 1. Acute Studies" pot

Ngày tải lên : 08/08/2014, 16:23

... inhibitors (amylase and sucrase) would diminish and/ or slow the breakdown of starch and sucrose in the gastrointestinal tract, diminishing glucose entrance into the blood stream The actions of ... were examined (Table 2) For bean extract, a 50% increase and a doubling of the initial dose caused further lowering of the absorption of rice starch compared to the standard dose after one and two ... quite effective in lowering the appearance of glucose in the circulation after sucrose and starch challenges alone and in combination Accordingly, these findings lend support to the concept that...

7
394
0

Báo cáo y học: "The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway" ppt

Ngày tải lên : 09/08/2014, 08:23

... 6c) These findings suggest that the activation of Erk and ETS1 is involved in the overgrowth of mouse synovial fibroblasts during CIA Based on these findings, we collectively concluded that the ... especially important in synovitis because they control the proliferation of synovial cells in the rheumatoid joint and induce the production of MMPs and cytokines that participate in the rheumatoid ... was induced by intradermal injection of DBA1 mice with 50 μl of emulsion containing 100 μg of collagen in CFA On day 21, the mice were boosted by intradermal injection with 100 μg of collagen in...

10
405
0

Báo cáo khoa học: "Prognosticators and Risk Grouping in Patients with Lung Metastasis from Nasopharyngeal Carcinoma: A more accurate and appropriate assessment of prognosis" doc

Ngày tải lên : 09/08/2014, 09:21

... diagnosis of NPC and/ or at the onset of primary therapies [35] In addition, the definition of LMS was influenced by the time of diagnosis of DM, which was in turn influenced by the regularity of follow-up ... collection and analysis of the complaints suggesting micrometastases in the course of managing the NPC patient which may improve the usefulness of this predictive factor The impact of the DFI on ... was defined as the time from the date of primary treatment to the date of death or the final clinical follow-up Lung metastatic survival (LMS) was defined as the interval between the date of first...

10
621
0

Báo cáo y học: "Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile Christine Lyn Le Maitre, Judith Alison Hoyland and Anthony J Freemont" ppsx

Ngày tải lên : 09/08/2014, 10:20

... observed in the matrix of the IVD or in blood vessels Staining was particularly prominent in the cytoplasm of the chondrocyte-like cells of the NP and IAF, with significantly lower numbers of cells in ... proportion of cells (30% of cells in the NP and 20% of cells in the IAF) were immunopositive for IL-1 RI than TNF RI (10% of cells in the NP and 5% of cells in the IAF) The percentage of cells ... the intervertebraldisc and its inhibition using IL-1Ra gene transfer Mol Therapy 2003, 5:S405 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral...

11
261
0

Báo cáo y học: " HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction" doc

Ngày tải lên : 10/08/2014, 05:21

... with either gp120 or Tat caused some discontinuous staining within the plasma membranes and appeared to increase the amount of punctate staining within the cytosol The magnification bar in the lower ... all of the figures), and wrote the initial draft of the manuscript XF determined tight junction (occludin and ZO-1) gene and protein expression (Figures and 5) PCJ determined alveolar epithelial ... during HIV infection The investigation of the mechanisms by which these HIVrelated proteins induce oxidant stress within the alveolar space was beyond the scope of this initial study Whether or...

12
334
0

Báo cáo y học: "Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung" potx

Ngày tải lên : 12/08/2014, 11:22

... of Oulu and the Finnish Cancer Society The funding body had no role in study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision ... well as in bronchial epithelium suggesting that these claudins in contrast to claudin-1 are also involved in the development of acinus and the differ- Page of 10 entiation of alveolar epithelial ... during the pseudo-glandular period, a finding which is concurrent with the results of immunohistochemistry Furthermore, the mRNAs of both claudin-3 and claudin-4 were at their highest during the...

10
319
0

Báo cáo y học: " Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis" ppsx

Ngày tải lên : 12/08/2014, 16:20

... observed in CF remains incompletely explained and most likely reflects the influence of multiple, interrelated factors These may include differences in CFTR mutation and presence of infective ... Clinic for their contribution in collecting the clinical data and in obtaining the samples for genotype analysis The authors also thank Ms Gisela Wirz for performing the lung function tests and database ... combinations of infection The impact of different types of infection on progression of lung function is shown in Figure Age and the most frequent types of infection were taken as fixed effects and...

15
385
0

Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in ﬁbrinolysis and plasmin-induced cell detachment and apoptosis docx

Ngày tải lên : 20/02/2014, 01:20

... Lysine ⁄ fibrin binding sites of kringles modeled after the structure of kringle of prothrombin Proteins 3, 85–96 20 Thorsen S (1975) Differences in the binding to fibrin of native plasminogen and ... was further explored by measuring the effect of the mAbs on the interaction of purified plasmin and Lys-Pg with fibrin and cells The binding of Lys-Pg was partially inhibited by both 34D3 and A10.2 ... effects of intact mAbs, including the reproduction of 3390 similar results with their Fab fragments and the absence of effect on plasminogen binding and activation in the presence of the unrelated...

14
558
0

Reproductive System Structure, Development and Function in Cephalopods with a New General Scale for Maturity Stages pot

Ngày tải lên : 14/03/2014, 16:20

... lay their eggs in rigid capsules, capsule glands and albumin glands are present in a complex of pallial glands These differ in their origin and function (Chukchin, 1984) Oviductal glands in octopus ... situated between the entrance of the gonoduct and the coelom, the second between the gonoduct and accessory glands and the third at the exit of the sexual viae (Fig 1) In octopus and cuttlefish ... extruded from the testis ampullae and the edges of the testis show erosion Functional maturation and maturity The remaining stages involve expelling the mature sexual cells from the coelom and their...

12
623
0

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) pptx

Ngày tải lên : 17/03/2014, 10:20

... the skin, even untrapped in inaccessible sites Spray rinsing at several points along the processing line is an effective means of minimising contamination but is not so effective especially in ... amino acids obtained by hydrolysis of the proteins of the control poultry carcasses was identical to the distribution in the disinfected carcasses The concentration of amino acids like cysteine, ... resulting from the use of chlorine dioxide Chlorite and chlorate formation increase (in a ratio of 7:3) with increasing concentration of chlorine dioxide and increased treatment time Chlorine dioxide...

27
530
0

Báo cáo khoa học: Role of extracellular signal regulated kinases 1 and 2 in neuronal survival docx

Ngày tải lên : 30/03/2014, 14:20

... circuitry Some or all of these factors may also affect the ultimate outcome of ERK1/2 activation in the nervous system A number of these issues are further discussed in the accompanying review by Chu ... protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1 ... depolarization in trophicdeprived neurons (reviewed in [2]) Importantly, as the studies indicating a lack of ERK1/2 involvement in antiapoptotic signaling used a variety of neuronal cells, the role of ERK1/2...

6
440
0

báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot

Ngày tải lên : 18/06/2014, 15:20

... for ligand binding, therefore reducing apoptotic signaling Procedures All treatments including milrinone dosing was at the discretion of the patient's attending physician, with initial dosing between ... change in TnI or MYO after 24 hours of milrinone compared to baseline On the other hand, there were significant reductions in inflammatory and apoptotic signaling with milrinone infusion This is the ... the setting of more routine decompensated heart failure, and the effect milrinone in ischemic subset of patients deserves further investigation Conclusion Initiation of milrinone therapy in patients...

6
465
0

Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot

Ngày tải lên : 18/06/2014, 16:20

... estramustine-based combinations and the activity of combined navelbine and mitoxantrone, supporting the testing of combination therapy with estramustine, mitoxantrone, and vinorelbine in patients with CRPC ... cycles and and completion of treatment In the case of missing responses in the FACT measures, if at least half of the subscale items were answered, the subscale score was the average of the completed ... resulted in clinically meaningful decline in QOL, warranting the study of other novel agents that target Bcl-2 family proteins Effects of therapy on PBMC Bcl-2 protein supports the feasibility of measuring...

9
462
0

Báo cáo hóa học: " Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies" doc

Ngày tải lên : 18/06/2014, 16:20

... chemotherapy in the 21 days preceding the commencement of the carboplatin/paclitaxel regimen (see Materials and Methods for further details) FIGO = International Federation of Gynecology and Obstetrics ... The extent of FITC-dextran incorporation was expressed as the ratio between the mean fluorescence intensity (MFI) of samples kept at 37°C and the MFI of samples cultured at 4°C, as detailed in ... pegfilgrastim administration We were also interested in evaluating whether pegfilgrastim induced the release of immune suppressive HGF and TGF-b1 HGF is a pro -angiogenic and tumor-promoting cytokine HGF...

15
796
0