pauwelyn the role of public international law in the wto how far can we go
Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... assisting businesses in their provision of services to government Cheyney University Disadvantaged Business Enterprise – collaborating with business, industry and government agencies; providing ... value Increased lifetime real income Improved quality of life Focus on Society (Maximizing Social Welfare) Increased productivity, real wealth, civic responsibility and participation The Role of Public...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... satisfactory in the evaluation of nodal status in this patient group Since the highly cellular tissue in reactive lymph nodes may also show increased intensity, the role of DWI and ADC in distinguishing ... enhancing cervical cancer (arrow) The tumor invades the cervical stroma (arrowhead) c DWI with b = 1,000 s/mm2 shows a well-defined hyperintensity mass in the cervical area The shape of the uterine ... imaging technique (SENSE factor of 2) Imaging time of DWI was 90 s for 20 slices Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue On the other...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... Protein targeting to the microsomes requires the cotranslational insertion of the newly synthesized protein into the microsomal membrane, where the N-terminal hydrophobic signal sequence of the ... CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches The first approach involved measuring the level of mitochondrial targeting of wild-type CYP2E1 in PKA-deficient ... suggesting that an open N-terminal signal domain is critical for protein targeting to the ER (Fig 2D) In contrast to the targeting of CYP1A1 requiring N-terminal truncation, we have shown that intact...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin ... independent of the thermodynamic and kinetic properties of the binding process and is solely based on the detectability of the peptides of interest We have used this method to show that binding ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse ... chameleons, in which small alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... from the original position In the structural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table and Fig 3A) However, ... of His210 The size of the side-chain at residue 169 and the pK2 showed a clear linear relationship (Fig 3B) The pK2 increased as the size of the residue at position 169 increased The effect of ... effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of His210 (Fig 3C) When the accessibility of the side-chain of His210 increased, the...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... value in this temperature range is considerably lowered On the basis of the model, the behavior of the G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The ... [9] However, our incomplete understanding of the relation between enzyme properties and conformational flexibility limits the exploitation of the full potential of protein engineering in the redesign ... are shown respectively By introducing an Ala residue in the place of Gly it is expected that the conformational flexibility of the main chain can be constrained with a minimum perturbation of the...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... by the C domain of the initiation module of daptomycin That DptE and DptF are involved in the lipidation process of daptomycin was first shown by Miao et al [1] In their work, the daptomycin gene ... is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence To determine whether DptF is the putative partner of DptE, we expressed dptF using the pQTev ... a common ‘ping pong BI-BI’ mechanism [30–32], showed a KM of 18.3 lm for its cognate ACP In the case of CpPKS1-AL, the KM for the lipidation of ACP was 3.53 lm These findings are in good agreement...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... evaluate the OS-fitness of the clone, the ratio of the specific absorbance in the presence of 10 lgÆmL)1 HEL to that in the absence of HEL was taken as an index To analyze the effect of the type of each ... clear whether or not H39 is dominantly tuning the VH ⁄ VL interaction of other Fvs, including HyHEL-10 In addition, the effect of the H39 mutation on antigen binding has not yet been analyzed The ... in determining the interdomain interaction strength Results Construction of an FR2 combinatorial library To investigate the possible relationship between antigen-binding affinity and VH ⁄ VL interaction...
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Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt
... Luther King ?, by considering the synonym of killer, the noun assassin, the Q&A system retrieved paragraphs with the correct answer Similarly, for the question Q206: How far is the moon ?, since ... generating unications of the question and answer semantic forms: Class L2-1: there is a one-to-one mapping between the binary dependencies of the question and binary dependencies from the answer ... when the fth answer was correct and if none of the rst ve answers were correct The Mean Reciprocal Answer Rank (MRAR) is used to compute the overall performance of the systems participating in the...
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Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx
... followed by birthday This finding is just reverse of the finding of Belk (1973) Ruth, Brunel, Otnes (1999) classified categories of gift-giving into public occasion (i.e., Christmas, Chinese ... change their brand attitude, may suggest an interesting implication for the new brand advertising strategy Instead of focusing on the content of the message which only emphasizes the benefits of the ... (p.21) These results were the same if comparing between male and female behavior is the interesting finding of Othman and Lee’s study Givers will pay different attitude to these factors when choosing...
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The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College Attendance pdf
... apart from financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase in the probability of attending college Further, when net worth is included in the model, ... choose either of the latter two responses are defined as ―certain‖ youth, and there are 333 youth in the final weighted sample of certain youth Youth who respond that their chances of attending a ... important for explaining wilt In the case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%)...
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Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf
... [31], for evaluating the role of Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in hepatocytes incubated with 15 ... that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydrolysis in the absence of detectable changes in glucose phosphorylation S4048 causes inactivation of ... rather than the elevated concentration of Glc6P or Fru2,6P2, determines the increased glycolysis during activation of glucokinase However, following chronic elevation of Glc6P, an increase in...
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Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc
... some of these documents (particularly the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem ... First, we train a polarity classifier using all unigrams from the training set Second, we train another polarity classifier using all unigrams, bigrams, and trigrams We obtain an accuracy of 87.2% ... part of our verification of this hypothesis, we plot the learning curve for each of the above experiments We observe that a 99% accuracy was achieved in all cases even when only 200 training instances...
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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf
... strong indications for the involvement of a bacterial P450 in the hydroxylation of octane in Rhodococcus rhodochrous, the role of bacterial P450s in alkane degradation in addition to the well-established ... displaying the lowest similarity to the other P450s are those involved in oxylipin biosynthesis (2–6% amino acid identity) This can be explained in part by their bifunctional structure Conclusion In ... tight binding affinity was demonstrated towards lauric acid, resulting in the synthesis of mainly x-1 hydroxylated 216 lauric acid, suggesting a role in the lipid oxidative metabolism Interestingly,...
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