... use of vitamin E and vitamin C in combi-nation reduced the prevalence and incidence of AD in anelderly population; however, the use of either of thesevitamins alone had no effect [110]. Finally, ... complex leads to theinitiation of complex signaling events leading to proteintyrosine phosphorylation and activation of the src-familykinases Lyn and Fyn as well as the tyrosine kinase Syk[30,32,52]. ... inhibition of phosphati-dylinositol-3 kinase (PI3K) attenuates ROS production.These findings suggest that these kinases are involved in upstream signaling cascades responsible for activatingNADPH...
... activation of p38 induced by oxidative stress, we further examined whether its activationis responsible for the induction of apoptosis in F9 cells usingSB202190, a potent inhibitor of p38. As shown in ... important role in protection of neuronal cellsagainst stress- induced apoptosis [26]. In accordance withthese findings, ischemia/reperfusion in the rat forebraininduces the expression of HSP105/110 ... mitogen-activated protein kinase(p38). Furthermore, oxidative stress- induced apoptosis wassuppressed by SB202190, a potent inhibitor of p38, in F9cells. These findings indicated that the activation of p38...
... depolarization ofin situ mitochondria by oxidative stress parallels a decrease in NAD(P)H level in nerve terminals. Neurochem Int 36, 483–488.61 Chinopoulos C & Adam-Vizi V (1999) Depolarization of in ... imposing a continuous load of calcium to the neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease ... element binding protein, iso-citrate dehydrogenase is an RNA-binding protein, whilekgd2p is a mitochondrial DNA binding protein [81–84].Mitochondria from different brain regions containdifferent...
... oxidative stress- induced changes in D. discoideum development. Interestingly, oxidativestress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative stress- induced ... confirming PARP activation in D. discoideum under oxidative stress. PARP inhibition during oxidative stress- inducedgrowth changes in D. discoideumPARP inhibition conferred protection against ... observed during oxidative stress (Fig. 4A,B). Under oxidative stress, partial inhi-bition of PARP activity led to altered growth, suggest-ing that oxidativestress could be leading to cell...
... cellactivity of several LOX inhibitors, including aesculetin (anonselective LOX inhibitor), MK886 (an inhibitor of the5-LOX-activating protein), zileuton (a 5-LOX inhibitor),baicalein (a 12/15-LOX inhibitor), ... apoptosis. In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of manyantineoplastic agents [13,14].To investigate whether oxidativestress is involved in the ... treatment of H460 cells with 1 μM of NSC-741909 induced cluster formation of MKP1 and MKP7 atall time points examined (2 - 8 h after the treatment) (Fig.1A, B), suggesting that oxidative stress...
... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stressin the Tg2576 mice [16]. This finding sug-gests ... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus ... brain sections from mice on placebo or receiving indomethacin plus vitamin EFigure 6Representative pictures of brain sections from mice on placebo or receiving indomethacin plus vitamin E.IndomethacinVitamin...
... response of the organism to particle-induced oxida-tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat-ing from a response to oxidative ... only 10% of urate is excreted in the urine (theremaining 90% being recirculated by the renal system[3]), an increase of this antioxidant in blood will alsolead to an increase in urine. The ... beenreported to increase the serum levels of uric acid in North Carolina police officers [4]. A similar increase of plasma antioxidants in response to an increased oxid a-tive stress was observed in newborns...
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... influx (41). The increased activity of NOS and the increased for-mation of NO in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of ... supply of oxygen in reperfusion group. The increased activity of arginase in reperfusion group may be beneficial by the way of competing NOS for arginine. In a recent study using GS inhibitor,...
... not die within 24 h of observation.Determination of lipid peroxidation and nitritecontentFor all of the experimental procedures, 10% (w ⁄ v) homo-genates of the area of the brain investigated ... (2002)Attenuating effects of melatonin on pilocarpine-inducedseizures in rats. Comp Biochem Physiol C PharmacolToxicol Endocrinol 131, 521–529.20 Marinho MMF, Sousa FCF, Bruin VMS, Vale MR ... and catalase activity are involved in mechanisms responsible for elim-inating oxygen free radicals during the establishment of status epilepticus in the hippocampus. In contrast, no correlations...
... earlypregnancy findings of increased levels of angiogenic fac-tors secreted by uterine NK cells [165], as well asincreased in vivo and in vitro endothelial cell angiogen-esis induced by uterine NK ... I: Role of oxidativestressin intrauterine growth restriction. Gynecol Obstet Invest2007, 64:187–192.228. Karowicz-Bilinska A: Lipid peroxides concentration in women withintrauterine growth ... hypotaurine [43,44].The concentrations of many amino acids, includingtaurine, fluctuate considerably during folliculogenesis.Taurine and hypotaurine are scavengers that help main-tain redox...