... Magazzù G, Greco L. Duration of exposure togluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disor-ders in Celiac Disease. Gastroenterology ... Prevalence of celiacdisease in a sample of Turkish children and adoles-cents with type 1 diabetes mellitus. J Clin Gastroenterol2006; 40: 655-7.4. Tanure MG, Silva IN, Bahia M, et al. Prevalence of ... Development of ce-liac disease- associated antibodies in offspring of parentswith type I diabetes. Diabetologia 2000; 43: 1005-11.7. Jaeger C, Hatziagelaki E, Petzoldt R, et al. Comparativeanalysis of...
... Igs found in the serum of celiac disease patients.Keywords: autoimmunity; celiac disease; transglutaminase;epitope mapping; phage display. Celiac disease (CD) is a genetic disease strongly linked ... Greco, L. (1999) Duration of exposure to gluten and risk for autoimmune disorders inpatients with celiac disease. SIGEP Study Group forAutoimmune Disorders in Celiac Disease. Gastroenterology ... Schematic drawing of the cloning of 12 different tTG regions.Reference numbers of the amino acid residues at the ends of the clonedsequences are shown.Ó FEBS 2002 Epitope mapping of anti-tTG Igs...
... Ipadeola T. Clinical trial of riboflavin in sickle cell disease. East Afr Med J1993; 70:418–21.114 Clarke R. Homocysteine-lowering trials for pre-vention of heart disease and stroke. Semin ... levels of LH and FSHwere higher in patients than in controls atthe same stage of development of secondarysexual characteristics. This suggested avariation in the rate of maturation of thehypothalamic–pituitary ... benefits of nutritional interventions in relation to growth,nutritional status and the pathophysiologyof the disease. IntroductionIt is generally accepted that homozygoussickle cell disease...
... TBishigh,andbackgroundTh2responsestomycobacterialantigensarehigh• PeoplewithlatentTBwhodonotprogresstoactive disease haveincreasedexpression of anantagonist of IL4,kno wnasIL4d2• Asuccessfulvaccin emayneedto downregulatetheunwantedTh2(IL4)component,ratherthanincreasingTh1whichisrapidlyevokedby ... bythalidomideMoreiraetal.(1993)J.Exp.Med.177,16751680Theuse of IL4genekno ckou tBalb/cmicetolookattherole of IL4innecrosisan dfib rosisinpulmonaryTBHernan dezPandoetal (2004)EurJImmunol34,174183•Role of IL4innecrosisconfirmed•Whataboutfibrosis?Doeshu ... tedmacrophageIL4,IL5Th0TcyIL4easilydetectedbyELISAIL4notdetectedbyELISA;needRTPCR,orprestimulatedcellsandFACSIshi ghIL4inTBpatientsafeature of developingcountries?Rook,DhedaandZumla(2004),Vaccine,inpressLowlevels of IL4d2nowfoundinrodentsYatsenkoetalBullExpBiolMed2004;137:179IL4d2,competitive...
... and pathophysiologyof the SREBP familyFEBS Journal 276 (2009) 616–621 ª 2008 The Author Journal compilation ª 2008 FEBS 621SREBP-1c and lipogenesisThe SREBP family consists of three isoforms: ... summarize, SREBP-1c is a physiological regulator of lipogenesis, and activation of SREBP couldcontribute to obesity-related pathophysiology throughmodification of tissue-specific gene expression asshown ... exocytosis of insulin-containing gran-ules by uncoupling protein-2 through ATP consump-tion, and granuphilin through inhibition of the vesiclefusion machinery [29–31].Fatty acids as modulators of...
... Department of Neurodegenerative Disease, Institute of Neurology, London, UKParkinson’s disease (PD) is a common neurodegenera-tive disease which affects over 1% of people over theage of 65 years ... that some of the genes involved in thegenetics of Lewy body disease, have in common thefact that they impinge on ceramide metabolism. Oneshortfall of the present theory is the lack of neuro-pathological ... of thedisorder, which often results in severe distal sensoryloss and mutilating acropathy [32]. Although muta-tions in SPTLC1 cause neurological disease, there is,as yet, no description of...
... tuber--izations. Another way of estimating the morbidity burden ofdisease is to calculate years of living with disability (YLD). The Global Burden ofDisease Study estimates that COPD ... underdi-extent of the underreporting varies across countries and depends on the level of awareness and understanding of COPD among health professionals, the organization of health care services ... of disease burden that are consistent and measurable across nations. The authors of the Global Burden of Dis-ease Study designed a method to estimate the fraction of mortality...
... Study of Sickle Cell Disease (CSSCD) identified earlypredictors of clinical severity such as dactylitisbefore 12 months of age, average Hb level of less than 7 g/dL in the second year of life, ... frequency of urinary tract infection in a large study of patients in U.S.Department of Veterans Affairs’ hospitals (9). AUTOSOMAL DOMINANT POLYCYSTICKIDNEY DISEASE The incidence of end-stage ... M.D.President Emeritus, Sickle Cell Disease Association of AmericaDistinguished Professor of Pediatrics and Associate DeanWayne State University School of MedicineScott Hall, Room 1201540...
... Technical report13. Validation studies14. Review of reported cases (review of known cases of a disease) 15. Case reportsUpon examination of the yield of the initial literaturesearch, it was determined ... hematologists). Ad hoc members of thePanel represented the Division of Blood Diseases and Resources of the NHLBI. The Panel was coordinated by the Division for the Application of Research Discoveries ... approximately 98 percent of indexcases, 89 percent of affected relatives, 32 percent of unaffected relatives, and 12 percent of healthy controls. The major symptoms of affected persons(excluding...
... dis-ease, mothers of children with CHD also reportedhigher levels of uncertainty. Linde (1982) reportedthat the mothers of children with CHD had problemsnot with the severity ofdisease but with ... adjustment of childrenwith CHD was significantly related to the level of parenting stress. The poor psychological adjustmentParenting Stress in Mothers of Childrenwith Congenital Heart Disease Sunhee ... PhD1PhD Candidate, College of Nursing, Yonsei University, Seoul, Korea2Professor, College of Nursing, Yonsei University, Seoul, KoreaPurpose The main purposes of this study were to examine...
... Mesquita Ciconelli5Objectives. To assess the impact of chronic disease and the number of diseases on the vari-ous aspects of health-related quality of life (HRQOL) among the elderly in São Paulo, ... high prevalence of chronic diseases among the elderlypopulation and found that the degree of impact on HRQOL depends on the type of disease. Theresults highlight the importance of preventing ... importance of the present studycomes from the fact that it is the firstBrazilian population-based report toquantify the impact of several diseases,as well the impact of the number of chronic...
... development of effective therapeutic strategiesis hampered by a paucity of information on the biolo-gical mechanisms underlying the disease. The severity of AD relates to a multitude of age-related ... ameliorate several of the dysfunctional events characteristic of Alzheimer’s disease. Metal-basedtherapeutics have already provided promising results for the treatment of Alzheimer’s disease, and ... loss of biometal homeostasis placed central to all of theseAD-related neurodegenerative mechanisms, the modu-lation of metal bio-availability has strong potential inthe therapeutic treatment of...
... about 15 percent of the total. At the same time, indicators of receipt of dental care, including the proportion of children who had received dental care in the past year and use of sealants, ... receipt of dental care showed some improvement; for example, use of sealants went up significantly between the 1988 through 1994 and 1999 through 2004 time periods. Rates of dental disease, ... which we estimate to be about 16 percent of the total. More information on our analysis of NHANES and MEPS for changes in dental disease and receipt of dental care for children in Medicaid...
... effect[22].Tissue inhibitor of metalloproteinasesThe catalytic activity of MMPs can be inhibited by thefamily of tissue inhibitor of metalloproteinases(TIMP), of which there are four members ... of syndecan-1 and aggrecan [51,52]. A recentstudy also reported that syndecan-4 may regulate acti-vation of ADAMTS-5 via engagement of HS chainsand regulation of MAPK-dependent synthesis of MMP3 ... graft-ver-sus-host disease [75].A key inflammatory response is chemokine-mediatedrecruitment of leukocytes into sites of inflammation[76]. Many chemokines bind HS chains of syndecansand evoke...
... al Celiac Disease. EvidenceReport/ Technology Assessment No. 104. AHRQ Publication No. 04-E029-2, 2004NICE Clinical Guidelines 86. Coeliac Disease: Recognition and assessment of coeliac disease. ... N Engl J Med 20031:99561.5%9Development of symptomatic coeliac disease in EMA positive subjectsRecommendation: (↑↑) offer testing for CD of children and adolescents with the following ... 2009Conclusions1. The new guidelines will offer the option of omitting biopsies in selected cases with symptoms suggestive of CD without increasing the risk of misclassification.2. Preconditions...