pathogenetic significance and clinical applications
Tài liệu Nutrition in Pediatrics Basic Science and Clinical Applications - THIRD EDITION docx
... residents, and fellows, who continue to provide me with the stimulation and inspiration to learn and ask new questions, and to my daughters, Sarah Watkins and Leah Watkins Beane, and my wife, ... Metabolism and Requirements In Health and Disease Ellen Butensky, RN, MSN, PNP Department of Gastroenterology and Nutrition Children’s Hospital and Research Center at Oakland Oakland, California ... (prescription and nonprescription) and foods, beverages, and dietary and vitamin/mineral supplements Alterations in drug metabolism and absorption by food or pharmacologic interactions may be clinically...
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VIRAL ONCOLOGY Basic Science and Clinical Applications pot
... VIRUS 40 AND MESOTHELIOMA Natalya Baranova and Michele Carbone MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER Timothy M Block and Anand S Mehta 191 211 11 HEPATITIS B VACCINE AND HEPATOCELLULAR ... MALIGNANCY: BASIC AND CLINICAL ASPECTS Melissa Agsalda and Bruce Shiramizu 317 17 HIV-RELATED LYMPHOMA Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini 337 18 BIOLOGY AND EPIDEMIOLOGY ... transformation, and the common and varying mechanisms used by different types of viruses Through such mechanistic understanding, we hope that safer and more effective therapeutics and additional...
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RADIATION IN TISSUE BANKING Basic Science and Clinical Applications of Irradiated Tissue Allografts doc
... UK and Australia, and has since been followed by other countries such as the USA, Scandinavian countries, and other European countries At present, more than 200 gamma irradiators of cobalt60 and ... Viruses and Prions, and How Radiation Can Overcome Them Nazly Hilmy and Paramita Pandansari 133 Chapter 11 Effects of Gamma Irradiation on the Biomechanics of Bone Aziz Nather, Ahmad Hafiz Zulkifly and ... Grafts for safe clinical use (RAS/7/008) Under the IAEA project (INT/6/052), two valuable standards were published: the IAEA International Standards for Tissue Banks (2002), and the IAEA Code...
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PEGylated Protein Drugs: Basic Science and Clinical Applications pptx
... emerging clinical challenges, e.g., use of stem R Duncan and F.M Veronese cells, and promotion of tissue engineering and repair, design of systems that self-assemble in the patient, and to fabrication ... antibodies, peptides and proteins, polymer therapeutics, and oligonucleotides and cell therapy will all play an important and complementary role in the prevention, control and cure of diseases ... Science and Clinical Applications Edited by F.M Veronese © 2009 Birkhäuser Verlag/Switzerland 11 Protein PEGylation, basic science and biological applications Francesco M Veronese, Anna Mero and...
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báo cáo khoa học: " Secretome: clues into pathogen infection and clinical applications" pptx
... concentrations and hydrophobic membrane proteins, limited sample capacity, and low linear range of visualization procedures In addition, this technique is time consuming and labor intensive and has ... bioinformatics data analysis and annotation http://genomemedicine.com/content/1/11/113 Clinical applications Identification of drug targets and vaccine development As more and more secretome analysis ... humans, and are predicted to promote parasite survival and development in the host environment A comparative secretome analysis [17] identified 11 proteins that are conserved across human- and rodent-infecting...
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Progestins and the Mammary Gland From Basic Science to Clinical Applications pdf
... Proceedings 2007-1 Progestins and the Mammary Gland Ernst Schering Foundation Symposium Proceedings 2007-1 Progestins and the Mammary Gland From Basic Science to Clinical Applications O Conneely, ... understood To further our understanding of progestin action in both mammary gland physiology and pathology, and to foster the interaction between basic research and drug development, the Ernst ... Axin/GSK3β/APC complex and phosphorylation of β-catenin at Ser residues 33, 37 and 45, and at Thr 41 by GSK3β and casein kinase (CK1) This ultimately allows recognition by BTrCP and degradation by...
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Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance doc
... lung cancer and coexisting TB in the same lobe as the cancer There were 51 such patients (48 males and three females), and their age ranged from 48 to 79 (mean, 64.5) years The presence and localization ... the detection of such lesions at CT MATERIALS AND METHODS Between January 1993 and May 1999, 335 patients with coexisting bronchogenic carcinoma and pulmonary TB were selected on the basis of ... adrenal gland, n=1; jejunum, n=1) Histological types were squamous cell carcinoma (n=32), adenocarcinoma (n=15), and small cell lung cancer (n=4) Forty-six patients (90.2 %) were smokers, and the...
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Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx
... MMP9, MMP2 and type IV collagen, and macrophages infiltration in each slide were scored as the sum of intensity and positive rate scores Negative was defined as the score ≤ for MMP9, MMP2 and type ... malignant gland compared to normal gland, especially nearby the BM (Figure 2C) High density of macrophages was observed at the juncture of cancer cells and stroma where BM integrity of gastric gland ... macrophages, and microvessels A BM was revealed by type IV Collagen staining B MMP9 was secreted by GC cells and mesenchymal C MMP2 expression is higher in malignant gland versus normal gland, especially...
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Báo cáo y học: "Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis" doc
... hypothesis that immune responses to endogenous citrullinated antigens are unique to RA and are potentially of pathogenetic significance in this disease Although it has been speculated the anti-Sa antibodies ... 72–86) and the other (residues 283–293) was present in both vimentin and a related neural intermediate filament component, peripherin [10] Because of the polyclonal nature of the autoimmune sera, and ... of fibrin and fibrinogen in RA synovium [13] From a pathogenetic viewpoint, this autoantigen would seem more likely to be relevant to RA than filaggrin, which is found in the epidermis and not...
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Báo cáo y học: "Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance" ppt
... follow-up and 4700 have initiated ART according to WHO and Uganda Ministry of Health guidelines The clinic has 15 exam rooms and is staffed by 20 physicians, 30 nurses, and 10 counselors and patients ... and sustained HIV-RNA viral load ≤ 400 copies per ml at 6, 12 and 24 months The chi square test was used to compare the baseline clinical characteristics of patients with and without SO-CD4 and ... of SO-CD4 with clinical morbidity and susceptibility to opportunistic infections [4,5,10] We hypothesize that patients with SO-CD4 are at increased risk of clinical events (death and/ or recurrent...
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Báo cáo y học: "Pain as a symptom of peripheral nerve sheath tumors: clinical significance and future therapeutic directions" potx
... between benign and malignant lesions as early as possible in the clinical work-up and management of these lesions, as they are treated very differently, and exhibit very different clinical and intraoperative ... with benign tumors and pre-operative pain [2] Current evidence suggests that in most cases, benign and malignant lesions can be differentiated pre-operatively based on clinical and radiographic ... pain generation in PNST and future therapeutic directions The dichotomy seen clinically between pressure induced pain (which occurs in both benign and malignant tumors) and rest pain (largely...
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Báo cáo y học: " Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases" pptx
... inflammation/infection and may represent a promising marker and therapeutic target in respiratory diseases The expression, regulation and clinical significance of sCD14 and mCD14 in pediatric ... TLR1/2 ligand), zymosan A (Saccharomyces cerevisiae, TLR2/6 ligand) and LPS from E coli (TLR4 ligand)were from Invivogen (San Diego, CA, USA) R848 (resiquimod hydrochloride; a single-stranded RNA ... incubated PBMCs in short-term (1 hour) and long-term culture (40 hours) conditions at 37°C with PMA, fMLP and several purified TLR ligands and analyzed sCD14 and mCD14 levels after the Marcos et...
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Báo cáo y học: "Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults" pot
... genetic, and biochemical factors associated with the development and progression of OA at multiple sites (hand, knee, hip, and spine) Subjects between the ages of 50 and 80 years where randomly ... using a quantitative measure; and 2) examine the clinical correlates of BMLs, including pain, function, and stiffness scores and total knee replacement surgery Materials and methods Subjects This ... individual and examine the association between changes in WOMAC scores (pain, function, and stiffness) and continuous changes in BML size Standard diagnostic checks of model adequacy and unusual...
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Báo cáo y học: "Clinical review: High-frequency oscillatory ventilation in adults — a review of the literature and practical applications" ppsx
... heart, and the abdomen, and difficulty in recognizing pneumothorax, right mainstem bronchus intubation, and endotracheal tube dislodgement (in these situations, patient wiggle will decrease and ... regarding HFOV in neonates, and are two of the largest to date in this field Johnson and colleagues randomized 800 infants to HFOV versus conventional ventilation, and found no significant difference ... in Germany and Canada found a system that oscillated gas into and out of an animal’s lungs was effective at CO2 elimination [28,29] Commercial products are now available for children and for adults...
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Báo cáo khoa học: "Clinical review: Agitation and delirium in the critically ill – significance and management" ppt
... between agitation and delirium, on the one hand, and mortality and cerebral dysfunction, on the other, are poorly understood In particular, it would be of great interest to understand if the brain ... agitation and delirium, or if it is an active player, participating and contributing to the extracerebral organ dysfunction [14,15] The indication and type of treatment for agitation and delirium ... Health-System Pharmacists (ASHP), and in alliance with the American College of Chest Physicians, and approved by the Board of Regents of ACCM, and the Council of SCCM and the ASHP Board of Directors...
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Báo cáo y học: "Anatomic and functional leg-length inequality: A review and recommendation for clinical decision-making. Part I, anatomic leg-length inequality: prevalence, magnitude, effects and clinical significance" pdf
... not related to back pain, and does not seem to be clinically significant The next, more difficult and controversial question is, what is the clinical significance of LLI, and at what magnitude? ... detection and some clinical results Rheum Phys Med 1972, 11:385-390 Fisk JW, Baigent ML: Clinical and radiological assessment of leg length NZ Med J 1975:477-480 Friberg O: Clinical symptoms and biomechanics ... questions and help in clinical decision-making Methods In the 1970's studies began to show that clinical measurements of LLI were inaccurate and the use of x-ray, controlling for magnification and...
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Cardiac Pacemakers - Biological Aspects, Clinical Applications and Possible Complications
... Chapter Clinical Applications of Pacemakers in Patients with Bradycardia and Other Specific Conditions 47 Guillermo Llamas-Esperón, Vitelio Mariona, Santiago Sandoval-Navarrete and Rocío Muñoz-Sandoval ... Loop Recorder in Clinical Practice 113 Dominique Babuty, Bertrand Pierre, Nicolas Clémenty, Bénédicte Lallemand, Olivier Marie and Laurent Fauchier Part Chapter Complexities and Possible Complications ... atrium and right ventricle, is already in common clinical use Moreover, left ventricle pacing in cardiac synchronization therapy (CRT) is also introduced and used clinically in different ways and...
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Polo like kinase 1 in hepatocellular carcinoma clinical significance and its potential as a therapeutic target
... in Hepatology and Gastroenterology research laboratory for all their helps and guidance I would also like to take this opportunity to thank my parents and friends for their loves and supports ... (Bharadwaj and Yu, 2004) PLK1 may directly regulate these components such as BubR1 (Matsumura et al., 2007) and possibly Mad2 (Eckerdt and Strebhardt, 2006) in order to prevent APC/C inhibition and ... (El-Serag and Rudolph, 2007) Chronic Hepatitis B and C are the two most well-known risk factors for HCC among other risk factors such as heavy alcohol intake and aflatoxin poisoning (Bruix and Sherman,...
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Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"
... genotypes and (B), and genotypes 4, and (C) Int J Med Sci 2006, HCV genotypes and Patients infected with HCV genotypes or have a 70%-80% likelihood of an SVR with a low dose of ribavirin and only ... to treat patients with mild lesions and to re-assess their liver disease after to years The patients with inflammation and/ or fibrosis (Metavir score A ≥ and/ or F ≥ 2) have an indication for ... at the end of therapy and 24 weeks later in order to determine whether the virological response is sustained (Figure 1B) [1, 18] HCV genotypes 4, and In the absence of any clinical trial including...
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Báo cáo y học: "Natural History and Clinical Consequences of Hepatitis B Virus Infection"
... Europe, India, and Africa Genotype B and C are common in Asia; genotype D, in southern Europe, the Middle East, and India; genotype E, in West Africa and South Africa; genotype F, in South and Central ... activity, and with or without HBeAg seroreversion Clinical Spectrum of HBV Infection Primary Infection –Subclinical Infection and Acute hepatitis B Majority of HBV infection in children are subclinical ... infection Hence, further research and understanding in this sector may bring exciting new information and better understanding of the natural history of HBV and supplement our existing armamentarium...
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