parting of the ways transcript
Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... and phylogeny. How-ever, the nature of the connections between thesefactors needs to be understood at the level of the pro-tein domain. The global properties of the HTFNtopology are partially ... property of the bHLH domains. Therefore, this seems to be a topo-logical constrain derived from the evolution of thisfamily.Evolution based on domain reusing might explain the abundance of certain ... TFIIE-a, TFIIE-bF 57 42% Zn finger domains. It contains the 90% of the members of nuclear receptorsuperfamily (they are Zn fingersalso) of the HTFN.14-3-3 zeta, STAT1a, STAT1b, dCREB, ATF-1,FTF,...
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Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
... more than 50% of the GlnK–TnrA interaction in the presence of 2 mm ATP.On the other hand, 2-oxoglutarate did not influence the GlnK–TnrA interaction, either alone, in the absence of divalent metals, ... was shown to depress the transcriptional activ-ity of TnrA [9,10,18].Taken together, the results from this investigationprovide indications of the physiological role of the GlnK–TnrA interaction, ... resolve the inhibitoryeffect of ATP on the GlnK–TnrA interaction in the absence of divalent cations more clearly, ATP wastitrated to the binding assays in the absence or pres-ence of 2-oxolguatarate....
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... whether these cytokines areproduced by CD4+CD25+Foxp3+Tregor whetherthey induce the production of these cytokines fromanother population of cells [20].To date, our knowledge about the ... important in the development of a number of these cell types.They were found within the zebrafish genome, using a synteny approach in the case of t-bet and foxp3. Multiple alignments of zebrafish ... domainsimportant in the functioning of these transcriptionfactors. T-bet (also known as Tbox-21) belongs to the T-box family of genes, consisting of over 20 memberscharacterized in mammals [35]. They contain...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... increase in apoptosis [73]. The authors of this studyascribe the regulation of outgrowth of limb buds andpatterning of the digits to the chicken AP-2. The role of AP-2a was further studied in zebrafish.It ... because of the severe skeletal defects in growthand the development of face and limbs [17–19]. Don-ner et al. tried to link the expression of AP-2a in thesetissues to upstream signaling pathways. ... further analyze their interactions with AP-2 and the functional role of these in chondrocytes.Furthermore, it is speculated that in melanoma,where AP-2a acts as a tumor suppressor, the loss of AP-2a...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves werestained in the vascular tissue of the leaf blade, whereas the petiole and older parts of ... this has the potential to predict possible pro-tein binding to the BPMs. It will also be of importanceto define the functional impact of the BPM family on the activity of ERF ⁄ AP2 transcription ... staining within the vascular tissue at the end of the leaf blade, whereas the basal parts close to the petiole remained almost unstained. We observed clearGUS expression in the primary root of 7-day-old...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... interruption of the geometry of the recognition helix for either Antp or the TTF-1HD, the anomalous amide exchange pattern and the NOE connectivity data of the C-terminal portion of helix III ... conflict with the global interpretation of the data. With the exclusion of the N-terminal octapeptidyl and C-terminal nonapept-idyl fragments of Glu17, Leu34 and Lys46, the average of the {1H}–15N ... Lorentzian model of J(x) calculated over avery wide range of correlation times, s. Most of the experimental points accumulate rather close to the upper intercept of the theoretical curve and the fitting(solid)...
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Tài liệu Báo cáo khóa học: Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure pptx
... and the cleavage of DNA by alkali [31]. The method allows easy detection of DNA–protein interactions via the N7 position of guaninesin the major groove and via the N3 position of adenines in the ... coupled with the topologychanges resulting from the loss of 1.5 superhelical turns of the DNA over the whole construct, suggest that the chromatin is indeed more relaxed in the absence of hormone. ... inhormone-induced transcription ( 50% of full inductionwhen added early, compare lanes 3, 4 and 11, 12). Neither of these effects depended on the TSA concentration over the range used in these experiments,...
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Tài liệu Báo cáo khoa học: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation ppt
... connected to the DEC1 E-boxes(Fig. 2), while deletion of the Orange domain ( DEC1DOr-ange) had no effect on the suppressive activity, indicating the importance of t he bHLH region of DEC1. The HXXXXXXXR ... conclude that the basic region, p artic-ularly the conserved A rg65, but not His57, is essential for the suppressive activity of DEC1.Determination of the binding domain of DEC1 to BMAL1 The interaction ... that the C-terminal region, including the PAS-Bdomain of BMAL1, is required for the binding to DEC1,Fig. 4. Identification of the domain of D EC1that interacts with BMAL 1. Interactions of various...
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
... acetylation of H3 and H4histones, and the remaining DHSs in the deleted cellswere examined to determine the roles of these DHSson the transcription of Ig-b gene and on the mainten-ance of the active ... Thus,there again has been no description either of the region involved in DNase I general sensitivity or of the region for the formation of DHSs, althoughchromatin opening activity of the LCR ... )13 kb in the Na channel gene and the other at +13 kb downstream of the GH gene, haveFig. 6. H3 and H4 acetylation of the Ig- b locus in the region II dele-tion cells. The acetylation of wild...
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
... factors as the mutation of the CRE site within the COX-2 promoter or the expression of a dominant negative mutant of CREBreduces inducibility of the COX-2 promoter [9,12–14]. The transcription ... observed across the different studies as well as the similarity of the recognition sites of the NFAT and Ets factors led us toinvestigate the potential involvement of the epithelialspecific ... convertsarachidonic acid into the prostaglandin H2. This prod-uct is the critical point of the synthetic pathway of numerous members of the prostaglandin family. COXexists as two major isoforms derived from...
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Tài liệu Báo cáo khoa học: Mg2+-modulated KMnO4 reactivity of thymines in the open transcription complex reflects variation in the negative electrostatic potential along the separated DNA strands ppt
... T)11and T+2. Therefore, the measured contribution of theseforms to the integrated intensity of these two bases wasused in the calculation of the contribution of individualbases to the integrated ... and elements of the b subunitthat make up the back wall of the RNAP active-sitechannel, until it passes near the active site [11]. The very low reactivity of the thymines close to the cata-lytic ... charges of both DNA phosphates and the carboxylic groups of three aspartates of the NADFDGD motif involved in the binding of catalytic Mg2+ions [23,42]. Chelation of these ions to the carboxylic...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... upstream of the major transcription start site. The presence of a CCAATbox and the absence of a TATA box seem to be one of the characteristics of the mouse integrin a3 gene.We identified two transcription ... (where A/C is the transcription start site). The role of the sequence containing CCT is unknown but itmight play a role in the initiation of transcription. The active promoter region of the mouse ... upstream of the SacI) sites (Fig. 1).Sequence analysis of the 5Â-anking region anddetermination of transcription start sites of mouseintegrin a3 subunit gene The nucleotide sequence of the 0.5...
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Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc
... clarify the distinct roles of Sp1 and Sp3 atdifferent phases of the cell cycle. The transcriptional cofactor p300 is coprecipitated incomplexes with Sp1 [38]. The activation of the promoter of thegeneforp21Waf1/Cip1by ... Characterization of the promoter of the mouse Dnmt1 gene. (A)Transcriptional activity of the mouse Dnmt1promoterinNIH3T3cells. The top diagram shows the mouse Dnmt1geneandthelowerdiagram shows the variously ... revealed the activation of the promoter of the Dnmt1 gene in the presence of Sp3. The transcriptional coactivator p300 interacted with Sp3 invivo and in vitro. Our results indicate that expression of the...
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Báo cáo khoa học: Differential recognition of heat shock elements by members of the heat shock transcription factor family ppt
... promoters. These results show that the configuration of nGAAn units in the promoter isimportant in determining which hHSF members areinvolved in the regulation of the gene.Footprint analysis of the ... withoutchanging the magnitude of the heat shock response(cp3). The mutational analysis of the CRYGA andCRYGC HSEs suggests that the nucleotide sequencesand configuration of nGAAn-like units ... as judged from the amount andmobility of the complex (Fig. 1B). Notably, the amount of complex formed with hHSF4 and HSEgapor HSEstep was more than 70% that of hHSF4–HSE3P. Therefore, like...
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