parkinson s disease and stem cells

Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc

Ngày tải lên : 23/03/2014, 04:20

... a fellowship from the American Parkinson s Disease Association A.B.W is supported by the Michael J Fox Foundation for Parkinson s Disease Research, the American Parkinson s Disease Association, ... kinase associates with lipid rafts Hum Mol Genet 16, 678–690 15 West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL & Dawson TM (2005) Parkinson s disease- associated mutations ... morphogenesis, with the caveat that successful LRRK2 knockdown and even veriﬁcation of endogenous expression is difﬁcult to assess in most cell lines as a result of the presumed low levels of protein and...

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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx

Ngày tải lên : 14/02/2014, 17:20

... degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES TOXIN Autosomal Recessive AGING PARKIN DJ-1 Protein O abnormal autophagy UPS ... basal ganglia and dopamine networks The motor system has been classically described as consisting of two parts: the pyramidal and the extra-pyramidal sub-systems The pyramidal system starts at ... McNaught, K .S and Jenner, P (2001) Proteasomal function is impaired in substantia nigra in Parkinson s disease Neuroscience Letters, 297 (3), 191 194 20 PARKINSON S DISEASE AND PARKINSONISM McNaught,...

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Tài liệu Parkinson’s Disease and Related Disorders docx

Ngày tải lên : 14/02/2014, 17:20

... L.: Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview Arnulf, I.: Sleep and wakefulness disturbances in Parkinson s disease ... Disease and Parkinsonism seen at the Columbia-Presbyterian Medical Center from 1949 to 1964 Nearly 85% had classic Parkinson s Disease and 13% had post-encephalitic associated Parkinsonism This ... nervous system infection and Parkinsonism, autonomic nervous system failure with special attention to orthostatic hypotension, and every aspect of the drug management of Parkinson s Disease His experience...

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PARKINSON''''S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN potx

Ngày tải lên : 05/03/2014, 23:20

... PARKINSON' S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN CURRENT CLINICAL PRACTICE Parkinson s Disease and Movement Disorders: Diagnosis and ... these motor systems For example, in patients with atypical parkinsonism (so-called parkinsonism plus syndrome), the clinical diagnosis is based on the additional systems involved If signs of parkinsonism ... disorders On the island of Guam, amyotrophic lateral sclerosis, parkinsonism, and dementia occur in various combinations, perhaps as manifestations of the same disease process Outside Guam, the association...

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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot

Ngày tải lên : 05/03/2014, 23:20

... disorders These diseases are conventionally categorized into either hypokinetic disorders, such as Parkinson s disease, or hyperkinetic disorders such as hemiballism or drug-induced dyskinesias ... disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases Another common misconception is that movement disorders are basal ganglia diseases ... this time 3.2 Dyskinetic Disorders In disorders associated with dyskinesias, basal ganglia output is thought to be reduced, resulting in disinhibition of thalamocortical systems and dyskinesias...

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An Atlas of PARKINSON’S DISEASE AND RELATED DISORDERS pdf

Ngày tải lên : 14/03/2014, 22:20

... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement ... Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: Tremor illustrated ... characteristics of Parkinson' s disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients with a clinical diagnosis of Parkinson' s disease, only...

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An Illustrated Pocketbook of Parkinson''''s Disease and Related Disorders pot

Ngày tải lên : 14/03/2014, 22:20

... PARKINSON S DISEASE Figure 16 Parkinson s disease: dystonic posturing of the big toe secondary to dopa therapy 15 16 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 17 Parkinson s disease: ... Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist clenching 11 12 AN ILLUSTRATED POCKETBOOK OF PARKINSON S ... RD, Bakay RA Neurosurgical horizons in Parkinson s disease Neurology 1993;43:l–7 Parkinson' s disease Any discussion of the clinical characteristics of Parkinson s disease must take into account...

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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc

Ngày tải lên : 19/06/2014, 10:20

... SOD1 G93A and wild-type control mice at age ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson' s disease, Huntington 's disease, and amyotrophic ... image analyses The treadmill belt was wiped clean between studies if necessary Statistics Data are presented as means ± SE ANOVA was used to test for statistical differences among saline-treated, ... in Parkinson' s disease and Huntington 's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability of stride...

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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 5 pot

Ngày tải lên : 09/08/2014, 16:21

... Figure 14 Positive glabellar tap Persistent blinking is a feature of Parkinson s disease, but is also seen in Alzheimer s disease Figure 15 6-[18F]-fluorodopa–PET scan appearance in a normal subject ... lined by reactive cells (astrocytes and macrophages) Debris and a few vascular channels can be seen (Luxol fast blue–H & E) Figure 24 CT of a patient with a Parkinsonian syndrome shows multiple lacunar ... Histological sections from Parkinson' s disease with dementia showing cortical Lewy bodies stained with ubiquitin (immunochemistry preparation, left; silver impregnation, right) Figure 28 Histology...

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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 6 ppt

Ngày tải lên : 09/08/2014, 16:21

... normal subject (left) compared with that in Parkinson' s disease (middle) and in progressive supranuclear palsy (right) (11C-raclopride is a selective reversible antagonist of D2 receptors) Figure ... degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 CRC Press ... (lower) basis pontis secondary to olivopontocerebellar atrophy in multiple system atrophy Figure 38 Histological sections of basis pontis (arrowed) show the normal complement of pontine neurons in...

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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 7 pot

Ngày tải lên : 09/08/2014, 16:21

... 45 Histological section of cerebral cortex in corticobasal degeneration shows severe gliosis and an achromatic neuron (H & E) Figure 46 Histological sections of cerebral cortex showing swollen ... proved responsive to botulinum toxin ©2004 CRC Press LLC Figure 55 Abnormal neck posture in a patient with spasmodic torticollis Figure 56 Mechanisms of actions of various botulinum toxins (BTX) ... copy three hand postures (A–C, lower), in each instance, the patient 's version was defective (A–C, upper) ©2004 CRC Press LLC Figure 50 In this patient with corticobasal degeneration, sagittal T1-weighted...

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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 8 ppt

Ngày tải lên : 09/08/2014, 16:21

... Histology in Wilson 's disease shows atrophy and rarefaction of the putamen (black arrows) Loss of myelin bundles in the putamen contrasts with the more normal appearances in the globus pallidus ... Huntington 's disease is accompanied by DNA gels (lower) which indicate trinucleotide repeats of between 40 and 52 ©2004 CRC Press LLC Figure 68 Coronal section of brain in Huntington 's disease shows symmetrical ... fast blue) Figure 63 Histology of brain in Wilson 's disease shows a Bergmann type astrocyte within an atrophic putamen (H & E) ©2004 CRC Press LLC Figure 64 Histology of brain in Wilson 's disease...

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báo cáo hóa học:" Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson''''s disease" doc

Ngày tải lên : 18/06/2014, 15:20

... expression, 15 mg wet tissues with microcarriersRPE cells and tissues with microcarriers were lysed for ELISA assay The lysis buffer was prepared according to the manual in a ratio of mg tissue ... RPE cells were lysed for GDNF determination and tissues with transplanted microcarriers were used as control (B) Tissues with transplanted RPE cells were lysed for BDNF determination and tissues ... Independent ttest followed by post hoc Bonferroni tests were used for the analysis of other data via the SPSS 10.0 soft packages (SPSS Inc., USA) The criterion for statistical significance was set at...

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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression

Ngày tải lên : 25/10/2013, 05:20

... 11.3 Parkinson s Disease Parkinson s disease (also known as Parkinson disease or PD) is a degenerative disorder of the central nervous system that often impairs the sufferer s motor skills and speech ... functions, neurotransmitter levels, emotional stress, and progression of neurodegenerative conditions such as Parkinson s and Alzheimer s diseases (Rahman et al., 2008) 11.4 Heart Disease 11.4.1 Case ... ﬂesh, including essential fatty acids from seeds and seed oils, and ﬁbers, such as microcrystalline cellulose, pectins, lignins, cutin-like polymers, and condensed tannins, have been suggested...

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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx

Ngày tải lên : 15/02/2014, 01:20

... biology and oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4, 600–609 Lesage S & Brice A (2009) Parkinson s disease: from monogenic forms to genetic susceptibility factors ... represent a valuable starting-point for focused investigations aiming to better understand the key issues of PD pathogenesis Materials and methods Cells Human neuroblastoma SH-SY5Y cells were cultured ... a-syn cells with respect to b-gal cells, and the expression of the reporter gene in b-gal and a-syn cells was almost completely quenched after 24 h of dopamine treatment Because HSP70, a stress-inducible...

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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx

Ngày tải lên : 16/03/2014, 11:20

... nervous system neurons A recent study analyzed the enteric nervous system in PD and found that both Meissner s and Auerbach s plexuses were affected already in early stages of disease and terminal ... components Signal intensities were scored using a semiquantitative scale with ﬁve steps (–,+),+,++ and +++) Scores were based on several sections ⁄ animal and several animals ⁄ observation and conﬁrmed ... stomach, but not in small and large intestines Adh3 shows low and ubiquitous expression in all tissues and Aldh1 is observed at low to moderate levels in esophagus, stomach and jejunum, but not in...

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